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Atrial fibrillation is associated with different levels of physical activity levels at different ages in men.

https://arctichealth.org/en/permalink/ahliterature103073
Source
Heart. 2014 Jul;100(13):1037-42
Publication Type
Article
Date
Jul-2014
Author
Nikola Drca
Alicja Wolk
Mats Jensen-Urstad
Susanna C Larsson
Author Affiliation
Department of Cardiology at the Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Source
Heart. 2014 Jul;100(13):1037-42
Date
Jul-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Aging
Atrial Fibrillation - diagnosis - epidemiology - physiopathology - prevention & control
Bicycling
Confounding Factors (Epidemiology)
Exercise
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prognosis
Proportional Hazards Models
Prospective Studies
Questionnaires
Registries
Risk factors
Sex Factors
Sweden
Time Factors
Walking
Abstract
This study examines the influence of physical activity at different ages and of different types, on the risk of developing atrial fibrillation (AF) in a large cohort of Swedish men.
Information about physical activity was obtained from 44 410 AF-free men, aged 45-79 years (mean age=60), who had completed a self-administered questionnaire at baseline in 1997. Participants reported retrospectively their time spent on leisure-time exercise and on walking or bicycling throughout their lifetime (at 15, 30 and 50 years of age, and at baseline (mean age=60)). Participants were followed-up in the Swedish National Inpatient Register for ascertainment of AF. Cox proportional hazards regression models were used to estimate relative risks (RR) with 95% CIs, adjusted for potential confounders.
During a median follow-up of 12 years, 4568 cases of AF were diagnosed. We observed a RR of 1.19 (95% CI 1.05 to 1.36) of developing AF in men who at the age of 30 years had exercised for >5 h/week compared with 5 h/week at age 30 and quit exercising later in life (1 h/day vs almost never) and the association was similar after excluding men with previous coronary heart disease or heart failure at baseline (corresponding RR 0.88, 95% CI 0.77 to 0.998).
Leisure-time exercise at younger age is associated with an increased risk of AF, whereas walking/bicycling at older age is associated with a decreased risk.
Notes
Comment In: Heart. 2014 Jul;100(13):999-100024829372
PubMed ID
24829373 View in PubMed
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Cardiorespiratory fitness and atrial fibrillation: A population-based follow-up study.

https://arctichealth.org/en/permalink/ahliterature272309
Source
Heart Rhythm. 2015 Jul;12(7):1424-30
Publication Type
Article
Date
Jul-2015
Author
Hassan Khan
Danesh Kella
Rainer Rauramaa
Kai Savonen
Michael S Lloyd
Jari A Laukkanen
Source
Heart Rhythm. 2015 Jul;12(7):1424-30
Date
Jul-2015
Language
English
Publication Type
Article
Keywords
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Exercise Test - methods - statistics & numerical data
Finland - epidemiology
Humans
Incidence
Male
Middle Aged
Oxygen consumption
Physical Fitness - physiology
Proportional Hazards Models
Risk factors
Statistics as Topic
Abstract
Atrial fibrillation (AF) is the most common arrhythmia worldwide and has a complex association with physical fitness. The relationship of cardiorespiratory fitness (CRF) with the risk for AF has not been previously investigated in population-based studies.
The purpose of this study was to determine the relationship of CRF with incident AF.
CRF, as assessed by maximal oxygen uptake (VO2max) during exercise testing, was measured at baseline in 1950 middle-aged men (mean age 52.6 years, SD 5.1) from the Kuopio Ischaemic Heart Disease (KIHD) study.
During average follow-up of 19.5 years, there were 305 incident AF cases (annual AF rate of 65.1/1000 person-years, 95% confidence interval [CI] 58.2-72.8). Overall, a nonlinear association was observed between CRF and incident AF. The rate of incident AF varied from 11.5 (95% CI 9.4-14.0) for the first quartile of CRF, to 9.1 (95% CI 7.4-11.2) for the second quartile, 5.7 (95% CI 4.4-7.4) for the third quartile, and 6.3 (95% CI 5.0-8.0) for the fourth quartile. Age-adjusted hazard ratio comparing top vs bottom fourth of usual CRF levels was 0.67 (95% CI 0.48-0.95), attenuated to 0.98 (95% CI 0.66-1.43) upon further adjustment for risk factors. These findings were comparable across age, body mass index, history of smoking, diabetes, and cardiovascular disease status at baseline.
Improved fitness as indicated by higher levels of CRF is protective of AF within a certain range, beyond which the risk of AF rises again. These findings warrant further replication.
PubMed ID
25778429 View in PubMed
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Incidence and clinical predictors of subsequent atrial fibrillation requiring additional ablation after cavotricuspid isthmus ablation for typical atrial flutter.

https://arctichealth.org/en/permalink/ahliterature286614
Source
Scand Cardiovasc J. 2017 Jun;51(3):123-128
Publication Type
Article
Date
Jun-2017
Author
Alessandro De Bortoli
Li-Bin Shi
Ole-Jørgen Ohm
Per Ivar Hoff
Peter Schuster
Eivind Solheim
Jian Chen
Source
Scand Cardiovasc J. 2017 Jun;51(3):123-128
Date
Jun-2017
Language
English
Publication Type
Article
Keywords
Aged
Anti-Arrhythmia Agents - therapeutic use
Anticoagulants - therapeutic use
Atrial Fibrillation - diagnosis - epidemiology - physiopathology - surgery
Atrial Flutter - diagnosis - epidemiology - physiopathology - surgery
Catheter Ablation - adverse effects
Cerebrovascular Disorders - epidemiology
Chi-Square Distribution
Female
Flecainide - therapeutic use
Humans
Incidence
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Multivariate Analysis
Norway - epidemiology
Odds Ratio
Reoperation
Retrospective Studies
Risk factors
Time Factors
Treatment Outcome
Tricuspid Valve - physiopathology - surgery
Vena Cava, Inferior - physiopathology - surgery
Abstract
We sought to investigate the incidence of atrial fibrillation after catheter ablation for typical atrial flutter and to determine the predictors for symptomatic atrial fibrillation that required a further additional dedicated ablation procedure.
127 patients underwent elective cavotricuspid isthmus ablation with the indication of symptomatic, typical atrial flutter. The occurrence of atrial flutter, atrial fibrillation, cerebrovascular events and the need for additional ablation procedures for symptomatic atrial fibrillation was assessed during long-term follow-up.
The majority of patients (70%) manifested atrial fibrillation during a follow-up period of 68?±?24 months, and a significant proportion (42%) underwent one or multiple atrial fibrillation ablation procedures after an average of 26 months from the index procedure. Recurrence of typical atrial flutter was rare. Ten patients (8%) suffered cerebrovascular events. Earlier documentation of atrial fibrillation (OR 3.53), previous use of flecainide (OR 3.33) and left atrial diameter (OR 2.96) independently predicted occurrence of atrial fibrillation during the follow-up. A combination of pre- and intra-procedural documentation of atrial fibrillation (OR 3.81) and previous use of flecainide (OR 2.43) independently predicted additional atrial fibrillation ablation.
Atrial fibrillation occurred in the majority of patients after ablation for typical atrial flutter and 42% of them required an additional dedicated ablation procedure. Pre- and intraprocedural documentation of atrial fibrillation together with previous use of flecainide independently predicted atrial fibrillation occurrence and a need for additional ablation. Anticoagulation treatment should be continued in high-risk patients in spite of clinical disappearance of atrial flutter.
PubMed ID
28335638 View in PubMed
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The incidence of phrenic nerve injury during pulmonary vein isolation using the second-generation 28 mm cryoballoon.

https://arctichealth.org/en/permalink/ahliterature259942
Source
J Cardiovasc Electrophysiol. 2014 May;25(5):466-70
Publication Type
Article
Date
May-2014
Author
Andreas Metzner
Peter Rausch
Christine Lemes
Bruno Reissmann
Alexander Bardyszewski
Roland Tilz
Andreas Rillig
Shibu Mathew
Sebastian Deiss
Masashi Kamioka
Tobias Toennis
Tina Lin
Feifan Ouyang
Karl-Heinz Kuck
Erik Wissner
Source
J Cardiovasc Electrophysiol. 2014 May;25(5):466-70
Date
May-2014
Language
English
Publication Type
Article
Keywords
Aged
Atrial Fibrillation - diagnosis - epidemiology - physiopathology - surgery
Cardiac Catheters
Cryosurgery - adverse effects - instrumentation
Diaphragm - innervation
Equipment Design
Female
Germany - epidemiology
Humans
Incidence
Male
Middle Aged
Muscle Contraction
Peripheral Nerve Injuries - diagnosis - epidemiology - physiopathology
Phrenic Nerve - injuries
Pulmonary Veins - physiopathology - surgery
Recovery of Function
Time Factors
Treatment Outcome
Abstract
The second-generation cryoballoon (CB; Arctic Front Advance, Medtronic Inc., Minneapolis, MN, USA) has demonstrated greater procedural efficacy compared to the original CB. Whether increased efficacy translates into a higher incidence of phrenic nerve (PN) injury needs further evaluation.
In patients with drug-refractory paroxysmal atrial fibrillation (AF) or short-standing persistent AF, pulmonary vein isolation (PVI) was performed using the 28 mm second-generation CB. During cryoenergy delivery along the septal PVs, continuous PN pacing was performed. The freeze cycle was aborted in case of weakening or loss of diaphragmatic contraction.
A total of 115 patients (42 female, mean age 61 ± 11 years, mean LA-diameter 43 ± 6 mm) with a history of paroxysmal AF (93/115 patients [81%]) or short-standing persistent AF (22/115 patients [19%]) underwent CB-based PVI. A total 445 of 448 (99%) PVs were isolated successfully. PN palsy (PNP) occurred in 4 of 115 (3.5%) patients, while applying cryoenergy to the right superior PV. Despite prompt interruption of the freezing cycle, PN function failed to recover during the periprocedural phase. PN recovery was observed as late as 10 months postablation.
Using the second-generation 28 mm CB, PNP occurred in 4 of 115 (3.5%) patients. While 1 of 4 PNP recovered 10 months after ablation, long-term outcome in the remaining 3 patients is currently unknown due to the rather short follow-up period.
PubMed ID
24400647 View in PubMed
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Interatrial block, P terminal force or fragmented QRS do not predict new-onset atrial fibrillation in patients with severe chronic kidney disease.

https://arctichealth.org/en/permalink/ahliterature304525
Source
BMC Cardiovasc Disord. 2020 10 07; 20(1):437
Publication Type
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Date
10-07-2020
Author
Tapio Hellman
Markus Hakamäki
Roosa Lankinen
Niina Koivuviita
Jussi Pärkkä
Petri Kallio
Tuomas Kiviniemi
K E Juhani Airaksinen
Mikko J Järvisalo
Kaj Metsärinne
Author Affiliation
Kidney Center, Turku University Hospital and University of Turku, Hämeentie 11, PO Box 52, 20521, Turku, Finland. tapio.hellman@tyks.fi.
Source
BMC Cardiovasc Disord. 2020 10 07; 20(1):437
Date
10-07-2020
Language
English
Publication Type
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Keywords
Action Potentials
Aged
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Atrial Function, Left
Atrial Remodeling
Electrocardiography
Female
Finland - epidemiology
Follow-Up Studies
Heart Conduction System - physiopathology
Heart rate
Humans
Incidence
Male
Middle Aged
Predictive value of tests
Prevalence
Prospective Studies
Renal Insufficiency, Chronic - diagnosis - epidemiology - physiopathology
Risk factors
Severity of Illness Index
Time Factors
Abstract
The prevalence of left atrial enlargement (LAE) and fragmented QRS (fQRS) diagnosed using ECG criteria in patients with severe chronic kidney disease (CKD) is unknown. Furthermore, there is limited data on predicting new-onset atrial fibrillation (AF) with LAE or fQRS in this patient group.
We enrolled 165 consecutive non-dialysis patients with CKD stage 4-5 without prior AF diagnosis between 2013 and 2017 in a prospective follow-up cohort study. LAE was defined as total P-wave duration =120?ms in lead II ± >?1 biphasic P-waves in leads II, III or aVF; or duration of terminal negative portion of P-wave >?40?ms or depth of terminal negative portion of P-wave >?1?mm in lead V1 from a baseline ECG, respectively. fQRS was defined as the presence of a notched R or S wave or the presence of =1 additional R waves (R') or; in the presence of a wide QRS complex (>?120?ms), >?2 notches in R or S waves in two contiguous leads corresponding to a myocardial region, respectively.
Mean age of the patients was 59 (SD 14) years, 56/165 (33.9%) were female and the mean estimated glomerular filtration rate was 12.8?ml/min/1.73m2. Altogether 29/165 (17.6%) patients were observed with new-onset AF within median follow-up of 3 [IQR 3, range 2-6] years. At baseline, 137/165 (83.0%) and 144/165 (87.3%) patients were observed with LAE and fQRS, respectively. Furthermore, LAE and fQRS co-existed in 121/165 (73.3%) patients. Neither findings were associated with the risk of new-onset AF within follow-up.
The prevalence of LAE and fQRS at baseline in this study on CKD stage 4-5 patients not on dialysis was very high. However, LAE or fQRS failed to predict occurrence of new-onset AF in these patients.
PubMed ID
33028216 View in PubMed
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J-shaped association between QTc interval duration and the risk of atrial fibrillation: results from the Copenhagen ECG study.

https://arctichealth.org/en/permalink/ahliterature114762
Source
J Am Coll Cardiol. 2013 Jun 25;61(25):2557-64
Publication Type
Article
Date
Jun-25-2013
Author
Jonas Bille Nielsen
Claus Graff
Adrian Pietersen
Bent Lind
Johannes Jan Struijk
Morten Salling Olesen
Stig Haunsø
Thomas Alexander Gerds
Jesper Hastrup Svendsen
Lars Køber
Anders Gaarsdal Holst
Author Affiliation
Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark. jonas.bille.nielsen@gmail.com
Source
J Am Coll Cardiol. 2013 Jun 25;61(25):2557-64
Date
Jun-25-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Cohort Studies
Denmark - epidemiology
Electrocardiography - methods
Female
Follow-Up Studies
Heart Rate - physiology
Humans
Male
Middle Aged
Risk factors
Time Factors
Abstract
The aim of this study was to investigate whether the heart rate-corrected QT (QTc) interval on the electrocardiogram (ECG) is associated with the onset of atrial fibrillation (AF).
Patients with hereditary short-QT or long-QT syndromes, representing the very extremes of the QT interval, both seem to have a high prevalence of AF.
A total of 281,277 subjects were included, corresponding to one-third of the population of the greater region of Copenhagen. These subjects underwent digital ECG recordings in a general practitioner's core facility from 2001 to 2010. Data on drug use, comorbidities, and outcomes were collected from Danish registries.
After a median follow-up period of 5.7 years, 10,766 subjects had developed AF, of whom 1,467 (14%) developed lone AF. Having a QTc interval lower than the first percentile (=372 ms) was associated with a multivariate-adjusted hazard ratio of 1.45 (95% confidence interval: 1.14 to 1.84; p = 0.002) of AF, compared with the reference group (411 to 419 ms). From the reference group and upward, the risk of AF increased with QTc interval duration in a dose-response manner, reaching a hazard ratio of 1.44 (95% confidence interval: 1.24 to 1.66, p
PubMed ID
23583581 View in PubMed
Less detail

Low atrial fibrillatory rate is associated with spontaneous conversion of recent-onset atrial fibrillation.

https://arctichealth.org/en/permalink/ahliterature115366
Source
Europace. 2013 Oct;15(10):1445-52
Publication Type
Article
Date
Oct-2013
Author
Mariam B Choudhary
Fredrik Holmqvist
Jonas Carlson
Hans-Jörgen Nilsson
Anders Roijer
Pyotr G Platonov
Author Affiliation
Department of Cardiology, Center for Integrative Electrocardiology at Lund University (CIEL), Lund, Sweden.
Source
Europace. 2013 Oct;15(10):1445-52
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Aged
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Electrocardiography
Female
Heart Conduction System - physiopathology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Prognosis
Registries
Remission, Spontaneous
Retrospective Studies
Risk factors
Sweden - epidemiology
Time Factors
Abstract
Atrial fibrillatory rate (AFR) is considered a non-invasive index of atrial remodelling. Low AFR has been associated with favourable outcome of interventions in patients with persistent atrial fibrillation (AF). However, AFR has never been studied in unselected patients with short duration of AF, prone to regain sinus rhythm (SR) spontaneously. The aim of the study was to assess if AFR can predict spontaneous conversion in patients with recent-onset AF.
Files of consecutive patients with AF
PubMed ID
23515337 View in PubMed
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Low heart rates predict incident atrial fibrillation in healthy middle-aged men.

https://arctichealth.org/en/permalink/ahliterature108567
Source
Circ Arrhythm Electrophysiol. 2013 Aug;6(4):726-31
Publication Type
Article
Date
Aug-2013
Author
Irene Grundvold
Per Torger Skretteberg
Knut Liestøl
Gunnar Erikssen
Kristian Engeseth
Knut Gjesdal
Sverre E Kjeldsen
Harald Arnesen
Jan Erikssen
Johan Bodegard
Author Affiliation
Department of Cardiology, Oslo University Hospital, Ullevaal, Norway.
Source
Circ Arrhythm Electrophysiol. 2013 Aug;6(4):726-31
Date
Aug-2013
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Arterial Pressure
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Chi-Square Distribution
Exercise Test
Heart rate
Humans
Hypertension - epidemiology - physiopathology
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Norway - epidemiology
Physical Fitness
Predictive value of tests
Proportional Hazards Models
Prospective Studies
Risk factors
Sex Factors
Stroke Volume
Time Factors
Abstract
Low resting heart rate (HR) has been associated with atrial fibrillation (AF) in athletes. We aimed to study whether low HR at rest or during exercise testing was a predictor of AF in initially healthy middle-aged men.
A total of 2014 healthy Norwegian men participated in a prospective cardiovascular survey, including a standardized bicycle exercise test in 1972 to 1975. During =35 years of follow-up (53,000 person-years of observation), 270 men developed incident AF, documented by scrutiny of health charts in all Norwegian hospitals. Risk estimation was analyzed with Cox proportional hazard models. Low exercise HR after 6 minutes exercise on the moderate workload of 100 W (HR100W) was a predictor of incident AF. Men with HR100W
Notes
Comment In: Circ Arrhythm Electrophysiol. 2013 Dec;6(6):e10124347601
Comment In: Circ Arrhythm Electrophysiol. 2013 Dec;6(6):e10224347602
PubMed ID
23873309 View in PubMed
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Reduced forced expiratory volume is associated with increased incidence of atrial fibrillation: the Malmo Preventive Project.

https://arctichealth.org/en/permalink/ahliterature256991
Source
Europace. 2014 Feb;16(2):182-8
Publication Type
Article
Date
Feb-2014
Author
Linda S B Johnson
Tord Juhlin
Gunnar Engström
Peter M Nilsson
Author Affiliation
Department of Clinical Sciences, Lund University, Skåne University Hospital, Inga-Marie Nilssons väg 49, S-20502 Malmö, Sweden.
Source
Europace. 2014 Feb;16(2):182-8
Date
Feb-2014
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Female
Follow-Up Studies
Forced expiratory volume
Humans
Incidence
Kaplan-Meier Estimate
Lung - physiopathology
Male
Middle Aged
Proportional Hazards Models
Risk factors
Smoking - adverse effects - epidemiology
Sweden - epidemiology
Time Factors
Vital Capacity
Abstract
Reduced forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) have been associated with increased incidence of cardiovascular diseases. However, whether reduced lung function is also a risk factor for incidence of atrial fibrillation (AF) is still unclear. We aimed to determine whether lung function predicted AF in the Malmö Preventive Project, a large population-based cohort with a long follow-up.
The study population consisted of 7674 women and 21 070 men, mean age 44.6 years. The cohort was followed on average for 24.8 years, during which time 2669 patients were hospitalized due to AF. The incidence of AF in relationship to quartiles of FEV1 and FVC and per litre decrease at baseline was determined using a Cox proportional hazards model adjusted for age, height, weight, current smoking status, systolic blood pressure, erythrocyte sedimentation rate, and fasting blood glucose. Forced expiratory volume in one second was inversely related to incidence of AF (per litre reduction in FEV1) hazard ratio (HR): 1.39 [95% confidence interval (CI): 1.16-1.68; P = 0.001] for women, and HR: 1.20 (95% CI: 1.13-1.29; P
PubMed ID
23960091 View in PubMed
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Reduced kidney function is a risk factor for atrial fibrillation.

https://arctichealth.org/en/permalink/ahliterature280703
Source
Nephrology (Carlton). 2016 Aug;21(8):717-20
Publication Type
Article
Date
Aug-2016
Author
Jari A Laukkanen
Francesco Zaccardi
Jouni Karppi
Kimmo Ronkainen
Sudhir Kurl
Source
Nephrology (Carlton). 2016 Aug;21(8):717-20
Date
Aug-2016
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Albuminuria - etiology - physiopathology
Atrial Fibrillation - diagnosis - epidemiology - physiopathology
Biomarkers - blood
Creatinine - blood
Cystatin C - blood
Female
Finland - epidemiology
Glomerular Filtration Rate
Humans
Incidence
Kidney - physiopathology
Kidney Diseases - blood - diagnosis - epidemiology - physiopathology
Male
Middle Aged
Predictive value of tests
Prospective Studies
Risk factors
Time Factors
Abstract
There is limited knowledge on the relationship between kidney function and incidence of atrial fibrillation. Thus, this prospective study was designed to evaluate whether various biomarkers of kidney function are associated to the risk of atrial fibrillation. The study population consisted of 1840 subjects (615 women and 1225 men) aged 61-82?years. Cystatin C- and creatinine-based estimation of glomerular filtration rate (eGFRcys and eGRFcreat , respectively) and urinary albumin/creatinine ratio (ACR) were assessed to investigate their relationship with the risk of atrial fibrillation. During a median follow-up of 3.7?years, a total of 159 incident atrial fibrillation cases occurred. After adjustment for potential confounders, the risk of atrial fibrillation was increased (hazard ratio 2.74, 95% confidence interval (CI) 1.56-4.81, P?
PubMed ID
26780558 View in PubMed
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15 records – page 1 of 2.