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Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature159355
Source
Clin Sci (Lond). 2008 Nov;115(9):265-71
Publication Type
Article
Date
Nov-2008
Author
Terho Lehtimäki
Nina Hutri-Kähönen
Mika Kähönen
Jukka Hemminki
Vera Mikkilä
Marika Laaksonen
Leena Räsänen
Nina Mononen
Markus Juonala
Jukka Marniemi
Jorma Viikari
Olli Raitakari
Author Affiliation
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, 33014 Tampere, Finland. terho.lehtimaki@uta.fi
Source
Clin Sci (Lond). 2008 Nov;115(9):265-71
Date
Nov-2008
Language
English
Publication Type
Article
Keywords
Adult
Atherosclerosis - epidemiology - etiology - genetics - physiopathology
Brachial Artery - physiopathology - ultrasonography
Carotid Arteries - pathology - ultrasonography
Dairy Products - statistics & numerical data
Diet - statistics & numerical data
Epidemiologic Methods
Female
Finland - epidemiology
Genetic Predisposition to Disease
Genotype
Humans
Lactase - deficiency
Lactase-Phlorizin Hydrolase - genetics
Lactose Intolerance - complications - epidemiology - genetics - pathology
Male
Polymorphism, Genetic
Tunica Intima - pathology - ultrasonography
Tunica Media - pathology - ultrasonography
Vasodilation
Abstract
Individuals suffering from ATH (adult-type hypolactasia), defined by the LCT (gene encoding lactase-phlorizin hydrolase) C/C(-13910) genotype (rs4988235), use less milk and dairy products and may have higher plasma HDL (high-density lipoprotein) and lower triacylglycerol (triglyceride) concentrations than their counterparts without ATH. To investigate the effects of ATH status on the early markers of atherosclerosis, we examined its association with CIMT (carotid intima-media thickness), CAC (carotid artery compliance) and brachial artery FMD (flow-mediated dilation) in a young population-based cohort of otherwise healthy individuals. As part of the Cardiovascular Risk in Young Finns Study, we performed CIMT, CAC and FMD analyses, LCT C/T(-13910) genotyping and risk factor determination in 2109 young subjects 24-39 years of age (45% males) at the time of the examination. The consumption of both milk and dairy products was lowest and the consumption of alcohol highest in subjects with the C/C(-13910) genotype (P
PubMed ID
18194137 View in PubMed
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Arterial intima-media thickness in 13-year-old adolescents and previous antichlamydial antimicrobial use: a retrospective follow-up study.

https://arctichealth.org/en/permalink/ahliterature155386
Source
Pediatrics. 2008 Sep;122(3):e675-81
Publication Type
Article
Date
Sep-2008
Author
Iina Volanen
Katariina Kallio
Maiju Saarinen
Mikko J Järvisalo
Raija Vainionpää
Tapani Rönnemaa
Jorma Viikari
Jukka Marniemi
Olli Simell
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland. iina.volanen@utu.fi
Source
Pediatrics. 2008 Sep;122(3):e675-81
Date
Sep-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Anti-Bacterial Agents - therapeutic use
Antibodies, Bacterial - analysis
Aorta, Abdominal - ultrasonography
Atherosclerosis - epidemiology - etiology - prevention & control
Carotid Artery, Common - ultrasonography
Child
Child, Preschool
Chlamydophila Infections - complications - drug therapy - microbiology
Chlamydophila pneumoniae - immunology - isolation & purification
Female
Finland - epidemiology
Follow-Up Studies
Humans
Infant
Male
Prevalence
Prognosis
Retrospective Studies
Risk factors
Tunica Intima - ultrasonography
Abstract
Children with persistent Chlamydia pneumoniae infection may be at increased risk for atherosclerosis. The impact of antimicrobial therapy for primary prevention of atherosclerotic cardiovascular disease is unsolved.
The purpose of this study was to determine whether treatment with antimicrobial agents effective against C pneumoniae during childhood, regardless of indication, has a favorable influence on the arterial wall-thickness in children by the time they reach adolescence.
The association of macrolide, tetracycline, quinolone, and rifamycin use (number of exposure events) between ages 5 and 13 years with carotid and aortic intima-media thickness at age 13 years was investigated among 508 healthy children. Information about the use of medications was obtained from the Finnish prescription register. Arterial intima-media thickness was measured with a high-resolution ultrasound.
Mean aortic intima-media thickness showed a significant direct association with the number of antichlamydial antimicrobial exposure events also after controlling for established atherosclerotic risk factors. Elevated C-reactive protein level had an additional effect on aortic intima-media thickness in a multivariable model. Carotid intima-media thickness was not associated with the number of preceding antichlamydial treatments.
Recurrent antichlamydial treatments in childhood have no favorable influence on early vascular changes but are associated with increased intima-media thickness in the abdominal aorta. These findings suggest that the use of antimicrobial agents does not offer protection against the potential atherogenicity of repeated infectious insults.
PubMed ID
18762502 View in PubMed
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The associations of oxidized high-density lipoprotein lipids with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature106859
Source
Free Radic Biol Med. 2013 Dec;65:1284-90
Publication Type
Article
Date
Dec-2013
Author
Petri Kresanov
Markku Ahotupa
Tommi Vasankari
Jari Kaikkonen
Mika Kähönen
Terho Lehtimäki
Jorma Viikari
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland. Electronic address: ppakre@utu.fi.
Source
Free Radic Biol Med. 2013 Dec;65:1284-90
Date
Dec-2013
Language
English
Publication Type
Article
Keywords
Adult
Aging
Alcohol Drinking
Apolipoproteins B - blood - immunology
Atherosclerosis - epidemiology - etiology
C-Reactive Protein
Cross-Sectional Studies
Female
Finland - epidemiology
Humans
Insulin - blood
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Male
Oxidation-Reduction
Risk factors
Smoking
Waist Circumference
Young Adult
Abstract
Scavenging and reverse transport of atherogenic oxidized lipids by high-density lipoprotein (HDL) was recently suggested to contribute to atheroprotection. We investigated the associations of oxidized HDL lipids (oxHDLlipids) with known risk factors for atherosclerosis in a population-based cross-sectional study of 1395 Finnish adults ages 24-39 years (54.9% women). Analysis of oxidized lipids in isolated HDL and LDL (oxLDLlipids) was based on the determination of conjugated dienes. Oxidized LDL was measured also with a method based on antibodies against oxidized Apo-B (oxLDLprot). Serum lipids and risk factors were measured. In multivariable models, oxHDLlipids were associated inversely with age (partial R(2)=2.9% in men, 0.8% in women) and directly with oxLDLlipids (partial R(2)=3.4% in men, 4.2% in women) after adjustment for Apo-A1 (partial R(2)=9.6% in men, 25.2% in women). In men, oxHDLlipids were also associated inversely with insulin (partial R(2)=1.1%). In women, oxHDLlipids were additionally inversely associated with waist circumference (partial R(2)=1.8%) and daily smoking (partial R(2)=0.7%) and directly with C-reactive protein (CRP; partial R(2)=0.5%) and alcohol use (partial R(2)=0.5%). We conclude that an elevated risk profile characterized primarily by advanced age is associated with lower oxHDLlipid levels in a population of young Finnish men and women. Higher levels of oxHDLlipids are additionally associated with higher oxLDLlipid levels. In men, higher insulin levels are also associated with lower oxHDLlipid levels. In women, increased waist circumference and daily smoking are also associated with lower oxHDLlipid levels, and higher CRP levels and alcohol use are associated with higher oxHDLlipid levels.
PubMed ID
24095850 View in PubMed
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Atherosclerotic vascular events in a single large lupus cohort: prevalence and risk factors.

https://arctichealth.org/en/permalink/ahliterature166426
Source
J Rheumatol. 2007 Jan;34(1):70-5
Publication Type
Article
Date
Jan-2007
Author
Murray B Urowitz
Dominique Ibañez
Dafna D Gladman
Author Affiliation
University of Toronto Lupus Clinic, Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada. m.urowitz@utoronto.ca
Source
J Rheumatol. 2007 Jan;34(1):70-5
Date
Jan-2007
Language
English
Publication Type
Article
Keywords
Adult
Atherosclerosis - epidemiology - etiology
Case-Control Studies
Cohort Studies
Coronary Artery Disease - epidemiology - etiology
Disease Progression
Female
Humans
Logistic Models
Lupus Erythematosus, Systemic - complications
Male
Middle Aged
Multivariate Analysis
Ontario
Prevalence
Risk factors
Vasculitis - etiology
Abstract
To determine prevalence and type of atherosclerotic vascular events (AVE) occurring after entry to the University of Toronto Lupus Clinic; and to compare risk factors in patients with systemic lupus erythematosus (SLE) with AVE to matched SLE controls without AVE.
Patients with SLE attending the University of Toronto Lupus Clinic who did not have AVE prior to clinic entry were included. Patients have been followed at 2-6 months since 1970 according to a standard protocol. Cases with AVE were matched for sex, era at first clinic visit (1970s, 1980s, 1990s +), inception status, age at first visit, and duration of followup. Chi-square, Fisher's exact, paired T test, and McNemar test were used. Comparison of risk factors for the development of AVE was done using a stepwise conditional logistic regression model for matched pairs.
In a total cohort of 1087 SLE patients followed from 1970 until 2004, the prevalence of AVE was 10.9%, and in 561 inception patients it was 9.6%. In multivariate analyses, neuropsychiatric involvement was significantly associated with AVE in both the total and inception cohorts. Smoking was also associated with AVE in the inception cohort, whereas the number of coronary artery disease (CAD) risk factors and vasculitis were significant in the total cohort.
AVE are major contributors to the clinical presentation of late-stage lupus. A combination of lupus related factors and classic CAD risk factors contributed to the development of AVE.
PubMed ID
17117488 View in PubMed
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Chitin-glucan fiber effects on oxidized low-density lipoprotein: a randomized controlled trial.

https://arctichealth.org/en/permalink/ahliterature121000
Source
Eur J Clin Nutr. 2013 Jan;67(1):2-7
Publication Type
Article
Date
Jan-2013
Author
H E Bays
J L Evans
K C Maki
M. Evans
V. Maquet
R. Cooper
J W Anderson
Author Affiliation
Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, USA.
Source
Eur J Clin Nutr. 2013 Jan;67(1):2-7
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Adult
Anticholesteremic Agents - administration & dosage - adverse effects - therapeutic use
Atherosclerosis - epidemiology - etiology - prevention & control
Body mass index
Chitin - chemistry
Double-Blind Method
Female
Fruit - chemistry
Glucans - chemistry
Humans
Hypercholesterolemia - blood - complications - diet therapy - physiopathology
Lipoproteins, LDL - blood
Male
Middle Aged
Midwestern United States - epidemiology
Olea - chemistry
Ontario - epidemiology
Overweight - complications
Plant Extracts - adverse effects - therapeutic use
Polysaccharides - administration & dosage - adverse effects - therapeutic use
Prebiotics - adverse effects
Risk
Abstract
Elevated oxidized low-density lipoprotein (OxLDL) may promote inflammation, and is associated with increased risk of atherosclerotic coronary heart disease and worsening complications of diabetes mellitus. The primary objective of this study was to evaluate the efficacy of chitin-glucan (CG), alone and in combination with a potentially anti-inflammatory olive oil (OO) extract, for reducing OxLDL in subjects with borderline to high LDL cholesterol (LDL-C) levels.
This 6-week, randomized, double-blind, placebo-controlled study of a novel, insoluble fiber derived from the Aspergillus niger mycelium, CG, evaluated 130 subjects free of diabetes mellitus with fasting LDL-C 3.37-4.92?mmol/l and glucose = 6.94?mmol/l. Participants were randomly assigned to receive CG (4.5?g/day; n=33), CG (1.5?g/day; n=32), CG (1.5?g/day) plus OO extract (135?mg/day; n=30), or matching placebo (n=35).
Administration of 4.5?g/day CG for 6 weeks significantly reduced OxLDL compared with placebo (P=0.035). At the end of study, CG was associated with lower LDL-C levels relative to placebo, although this difference was statistically significant only for the CG 1.5?g/day group (P=0.019). CG did not significantly affect high-density lipoprotein cholesterol, triglycerides, glucose, insulin or F2-isoprostane levels. Adverse events did not substantively differ between treatments and placebo.
In this 6-week study, CG (4.5?g/day) reduced OxLDL, an effect that might affect the risk for atherosclerosis.
Notes
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PubMed ID
22948945 View in PubMed
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[Chronic asymptomatic hyperuricemia as a marker of atherogenic risk in children].

https://arctichealth.org/en/permalink/ahliterature163598
Source
Kardiologiia. 2007;47(3):62-6
Publication Type
Article
Date
2007
Author
S I Maliavskaia
A V Lebedev
V A Ternovskaia
Source
Kardiologiia. 2007;47(3):62-6
Date
2007
Language
Russian
Publication Type
Article
Keywords
Adolescent
Age Factors
Atherosclerosis - epidemiology - etiology
Biological Markers
Blood Glucose - analysis
Blood pressure
Chi-Square Distribution
Child
Chronic Disease
Humans
Hyperlipidemias - complications - diagnosis
Hyperuricemia - complications - epidemiology
Male
Risk factors
Russia - epidemiology
Sex Factors
Uric Acid - blood
Abstract
A cross-sectional study of a representative sample of boys aged 7-17 years (n=569) was carried out in Arkhangelsk. The rate of asymptomatic hyperuricemia was 27.59 %. Serum level of uric acid correlated with levels of triglycerides, total cholesterol, low density lipoprotein cholesterol, fasting glycemia, systolic and diastolic blood pressure (r = 0.49; 0.27; 0.27; 0.26; 0.34 u 0.35, respectively; p
PubMed ID
17495850 View in PubMed
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Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus.

https://arctichealth.org/en/permalink/ahliterature282603
Source
Lupus. 2016 Dec;25(14):1602-1609
Publication Type
Article
Date
Dec-2016
Author
C. Lourdudoss
A-C Elkan
I. Hafström
T. Jogestrand
T. Gustafsson
R. van Vollenhoven
J. Frostegård
Source
Lupus. 2016 Dec;25(14):1602-1609
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Adult
Atherosclerosis - epidemiology - etiology
Carotid Arteries - diagnostic imaging
Case-Control Studies
Diet
Female
Humans
Logistic Models
Lupus Erythematosus, Systemic - complications
Male
Micronutrients - analysis
Middle Aged
Phosphorus - analysis
Plaque, Atherosclerotic - diagnostic imaging
Riboflavin - analysis
Risk factors
Selenium - analysis
Severity of Illness Index
Sweden
Thiamine - analysis
Ultrasonography
Abstract
The aim of this study was to investigate the role of dietary micronutrient intake in systemic lupus erythematosus (SLE).
This study included 111 SLE patients and 118 age and gender-matched controls. Data on diet (food frequency questionnaires) were linked with data on Systemic Lupus Activity Measure, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and carotid atherosclerotic/echolucent plaque (B-mode ultrasound). Dietary micronutrient intake were compared between SLE patients and controls and in relation to lupus activity and atherosclerosis in SLE. Associations between micronutrient intake and plaque were analyzed through logistic regression, adjusted for potential confounders.
Micronutrient intake did not differ between patients and controls, and between lower and higher lupus activity, apart from the fact that phosphorus was associated with SLEDAI?>?6. In SLE patients, some micronutrients were associated with atherosclerotic plaque, left side. Lower intake of riboflavin and phosphorus was associated with atherosclerotic plaque, left side (odds ratio (OR) 3.06, 95% confidence interval (CI) 1.12-8.40 and OR 4.36, 95% CI 1.53-12.39, respectively). Higher intake of selenium and thiamin was inversely associated with atherosclerotic plaque, left side (OR 0.28, 95% CI 0.09-0.89 and OR 0.26, 95% CI 0.08-0.80, respectively). In addition, higher intake of thiamin was inversely associated with echolucent plaque, left side (OR 0.22, 95% CI 0.06-0.84). Lower intake of folate was inversely associated with bilateral echolucent plaque (OR 0.36, 95% CI 0.13-0.99).
SLE patients did not have different dietary micronutrient intake compared to controls. Phosphorus was associated with lupus activity. Riboflavin, phosphorus, selenium and thiamin were inversely associated with atherosclerotic plaque, left side in SLE patients, but not in controls. Dietary micronutrients may play a role in atherosclerosis in SLE.
PubMed ID
27334936 View in PubMed
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Does childhood nutrition influence adult cardiovascular disease risk?--insights from the Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature125309
Source
Ann Med. 2013 Mar;45(2):120-8
Publication Type
Article
Date
Mar-2013
Author
Jari E Kaikkonen
Vera Mikkilä
Costan G Magnussen
Markus Juonala
Jorma S A Viikari
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Source
Ann Med. 2013 Mar;45(2):120-8
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Atherosclerosis - epidemiology - etiology
Cardiovascular Diseases - epidemiology - etiology
Carotid Intima-Media Thickness
Child
Child Nutritional Physiological Phenomena
Child, Preschool
Female
Finland - epidemiology
Food Habits
Humans
Male
Nutritional Status
Questionnaires
Risk factors
Abstract
There is a paucity of detailed information about the role of childhood food patterns or on the impact of individual nutrients on adulthood cardiovascular disease (CVD). We review here the reports that have investigated these questions in the Young Finns Study with its 3596 subjects at baseline, aged 3 to 18 years. All the participants filled in a food habit questionnaire, and half of them provided a 48-hour dietary recall interview. In adulthood, cardiovascular risk factors as well as structural and functional markers of subclinical atherosclerosis were measured, i.e. carotid artery intima media thickness (IMT), and measurements of arterial elasticity and brachial artery endothelial function. Our data demonstrate that dietary patterns can already be identified in childhood. These patterns remain relatively stable over the life-course and associate with cardiovascular risk factors and vascular markers of subclinical atherosclerosis. For example, a traditional dietary pattern characterized by low intakes of fruits and vegetables was associated with elevated increased adulthood IMT especially in men, whereas a diet with a high intake of vegetables was independently associated with increased arterial elasticity in both genders. Our findings and the current literature suggest that childhood nutrition has a significant role in the progression of CVD.
PubMed ID
22494087 View in PubMed
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Early life origins of low-grade inflammation and atherosclerosis risk in children and adolescents.

https://arctichealth.org/en/permalink/ahliterature149704
Source
J Pediatr. 2009 Nov;155(5):673-7
Publication Type
Article
Date
Nov-2009
Author
Idoia Labayen
Francisco B Ortega
Michael Sjöström
Jonatan R Ruiz
Author Affiliation
Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain. idoia.labayen@ehu.es
Source
J Pediatr. 2009 Nov;155(5):673-7
Date
Nov-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Age of Onset
Atherosclerosis - epidemiology - etiology - physiopathology
Birth weight
Body mass index
C-Reactive Protein - analysis - metabolism
Cardiovascular Diseases - etiology - prevention & control
Child
Chronic Disease
Complement C3 - analysis - metabolism
Complement C4 - analysis - metabolism
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Inflammation - diagnosis - epidemiology
Inflammation Mediators - analysis - metabolism
Male
Multivariate Analysis
Predictive value of tests
Regression Analysis
Risk factors
Severity of Illness Index
Sex Factors
Sweden - epidemiology
Abstract
To examine the relationship between birth weight and later low-grade inflammation in children and adolescents.
We selected 166 children (49.4% boys; aged, 9.5 +/- 0.3 years) and 126 adolescents (43.7% males; aged, 15.5 +/- 0.4 years) from the Swedish part of the European Youth Heart Study. Birth weight data were collected from parental recall. Low-grade inflammatory markers include C-reactive protein, fibrinogen, and complement factors C3 and C4. Fatness was measured by the sum of 5 skinfold thicknesses. Cardiorespiratory fitness was measured with a maximal ergometer bike test. The association between birth weight and low-grade inflammatory markers was examined with multiple regression analyses.
Birth weight was negatively associated with fibrinogen (beta = -0.059; P = .036), C3 (beta = -0.019; P = .010), and C4 (beta = -0.024; P = .031), after controlling for sex, pubertal status, mother's body mass index and socioeconomic status, fatness and fitness. Birth weight was not associated to later C-reactive protein level (all P > .1).
Our results showed that smaller birth weight is associated with chronic low-grade inflammation in children and adolescents. Because of the implication of complement factors on atherosclerosis process, these results contribute to explain the increased cardiovascular risk associated with low birth weight.
PubMed ID
19595364 View in PubMed
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[Epidemiology of arterial hypertension and atherosclerosis risk factors in female Internal Ministry officers].

https://arctichealth.org/en/permalink/ahliterature161704
Source
Med Tr Prom Ekol. 2007;(5):23-9
Publication Type
Article
Date
2007
Author
A B Shogenova
A M Murtazova
A G Shogenov
A A El'garov
Source
Med Tr Prom Ekol. 2007;(5):23-9
Date
2007
Language
Russian
Publication Type
Article
Keywords
Adult
Atherosclerosis - epidemiology - etiology
Female
Humans
Hypertension - complications - epidemiology
Middle Aged
Military Personnel
Morbidity - trends
Occupational Diseases - epidemiology
Occupational Exposure - adverse effects
Risk factors
Russia - epidemiology
Abstract
The authors revealed prevalence of arterial hypertension and atherosclerosis risk factors among female Internal Ministry officers, demonstrated influence of occupational activities on frequency of the studied parameters and on cardiovascular risk.
PubMed ID
17722635 View in PubMed
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22 records – page 1 of 3.