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The effect of immunotherapy on T-cell subsets in peripheral blood and bronchoalveolar lavage fluid in pollen-allergic patients.

https://arctichealth.org/en/permalink/ahliterature16003
Source
Allergy. 1993 Aug;48(6):460-5
Publication Type
Article
Date
Aug-1993
Author
S. Rak
G. Hallden
S. Sörenson
V. Margari
A. Scheynius
Author Affiliation
Department of Lung Medicine, Central Hospital, Västerås, Sweden.
Source
Allergy. 1993 Aug;48(6):460-5
Date
Aug-1993
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asthma - complications - diagnosis - immunology - therapy
Bronchoalveolar Lavage Fluid
Conjunctivitis, Allergic - complications - diagnosis - immunology - therapy
Desensitization, Immunologic
Female
Flow Cytometry
Forced expiratory volume
HLA-DR Antigens - immunology
Humans
Leukocyte Count
Leukocytes, Mononuclear - immunology
Male
Middle Aged
Pollen
Research Support, Non-U.S. Gov't
Rhinitis, Allergic, Seasonal - complications - diagnosis - immunology - therapy
T-Lymphocyte Subsets - immunology
T-Lymphocytes - immunology
Abstract
The effect of immunotherapy (IT) on T-cell subsets in peripheral blood and bronchoalveolar lavage fluid (BAL) was examined in 15 patients with rhinoconjunctivitis and asthma caused by sensitivity to birch pollen. They were treated with IT for 3 years. Seven patients were treated with highly standardized birch-pollen extract (Pharmacia, Sweden). Eight untreated patients served as controls. Histamine challenge, blood sampling, and BAL were performed before (January, February), and at the peak of, the birch-pollen season (May). The subpopulations of T cells in peripheral blood and BAL fluid were investigated by immunocytochemistry and flow cytometry. During the birch-pollen season, the percentage of CD3+ and CD4+ cells of blood mononuclear cells in the IT patients increased significantly (P
PubMed ID
8238803 View in PubMed
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