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Inter-pregnancy Weight Change and Risks of Severe Birth-Asphyxia-Related Outcomes in Singleton Infants Born at Term: A Nationwide Swedish Cohort Study.
PLoS Med. 2016 Jun;13(6):e1002033
Publication Type
Martina Persson
Stefan Johansson
Sven Cnattingius
PLoS Med. 2016 Jun;13(6):e1002033
Publication Type
Asphyxia Neonatorum - epidemiology - pathology
Body mass index
Infant, Newborn
Prospective Studies
Risk factors
Sweden - epidemiology
Term Birth
Weight Gain
Young Adult
Maternal overweight and obesity are associated with increased risks of birth-asphyxia-related outcomes, but the mechanisms are unclear. If a change of exposure (i.e., maternal body mass index [BMI]) over time influences risks, this would be consistent with a causal relationship between maternal BMI and offspring risks. Our objective was to investigate associations between changes in maternal BMI between consecutive pregnancies and risks of birth-asphyxia-related outcomes in the second offspring born at term.
This study was a prospective population-based cohort study that included 526,435 second-born term (=37 wk) infants of mothers with two consecutive live singleton term births in Sweden between January 1992 and December 2012. We estimated associations between the difference in maternal BMI between the first and second pregnancy and risks of low Apgar score (0-6) at 5 min, neonatal seizures, and meconium aspiration in the second-born offspring. Odds ratios (ORs) were adjusted for BMI at first pregnancy, maternal height, maternal age at second delivery, smoking, education, mother´s country of birth, inter-pregnancy interval, and year of second delivery. Analyses were also stratified by BMI (
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PubMed ID
27270217 View in PubMed
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Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder.
Psychol Med. 2014 Apr;44(5):975-85
Publication Type
U K Haukvik
T. McNeil
E H Lange
I. Melle
A M Dale
O A Andreassen
I. Agartz
Psychol Med. 2014 Apr;44(5):975-85
Publication Type
Amygdala - pathology
Asphyxia Neonatorum - epidemiology - pathology
Bipolar Disorder - epidemiology - pathology
Fetal Hypoxia - epidemiology - pathology
Hippocampus - pathology
Magnetic Resonance Imaging
Norway - epidemiology
Registries - statistics & numerical data
Young Adult
Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown.
Magnetic resonance imaging brain scans, clinical examinations and data from the Medical Birth Registry of Norway were obtained for 219 adults, including 79 patients with a DSM-IV diagnosis of bipolar disorder (age 29.4 years, s.d. = 11.8 years, 39% male) and 140 healthy controls (age 30.8 years, s.d. = 12.0 years, 53% male). Severe hypoxia-related OCs throughout pregnancy/birth and perinatal asphyxia were each studied in relation to a priori selected brain volumes (hippocampus, lateral ventricles and amygdala, obtained with FreeSurfer), using linear regression models covarying for age, sex, medication use and intracranial volume. Multiple comparison adjustment was applied.
Perinatal asphyxia was associated with smaller left amygdala volume (t = -2.59, p = 0.012) in bipolar disorder patients, but not in healthy controls. Patients with psychotic bipolar disorder showed distinct associations between perinatal asphyxia and smaller left amygdala volume (t = -2.69, p = 0.010), whereas patients with non-psychotic bipolar disorder showed smaller right hippocampal volumes related to both perinatal asphyxia (t = -2.60, p = 0.015) and severe OCs (t = -3.25, p = 0.003). No associations between asphyxia or severe OCs and the lateral ventricles were found.
Pre- and perinatal hypoxia-related OCs are related to brain morphometry in bipolar disorder in adulthood, with specific patterns in patients with psychotic versus non-psychotic illness.
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PubMed ID
23803260 View in PubMed
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