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[Brain metabolites ratio as a prospective marker in assessment of the therapy efficacy in children with epilepsy]

https://arctichealth.org/en/permalink/ahliterature9288
Source
Lik Sprava. 2004 Oct-Nov;(7):47-9
Publication Type
Article
Author
V O Svystil'nyk
Source
Lik Sprava. 2004 Oct-Nov;(7):47-9
Language
Ukrainian
Publication Type
Article
Keywords
Adolescent
Anticonvulsants - therapeutic use
Aspartic Acid - analogs & derivatives - metabolism
Biological Markers - analysis
Brain - drug effects - metabolism
Child
Child, Preschool
English Abstract
Epilepsy - drug therapy - metabolism
Humans
Infant
Inositol - metabolism
Magnetic Resonance Imaging
Treatment Outcome
Abstract
Influence of ratio between N-acetylaspartat (NAA) and myoinositol brain tissue metabolites as well as ratio beween myoinositol and kreatinine on the therapy efficacy in children with epilepsy has been studied by authors. The obtained results allowed detecting the derangement in one section of cerebral metabolism, recovery of which on the background of effective antiepileptic treatment finds its reflection in ratio between N-acetylaspartat (NAA) and myoinositol and between myoinositol and kreatinine.
PubMed ID
15724613 View in PubMed
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Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.

https://arctichealth.org/en/permalink/ahliterature282328
Source
Neurology. 2016 May 10;86(19):1754-61
Publication Type
Article
Date
May-10-2016
Author
Olga Voevodskaya
Pia C Sundgren
Olof Strandberg
Henrik Zetterberg
Lennart Minthon
Kaj Blennow
Lars-Olof Wahlund
Eric Westman
Oskar Hansson
Source
Neurology. 2016 May 10;86(19):1754-61
Date
May-10-2016
Language
English
Publication Type
Article
Keywords
Aged
Alzheimer Disease - diagnostic imaging - epidemiology - genetics - metabolism
Amyloidogenic Proteins - metabolism
Apolipoprotein E4 - genetics
Aspartic Acid - analogs & derivatives - metabolism
Brain - diagnostic imaging - metabolism
Brain Mapping
Choline - metabolism
Cognition Disorders - diagnostic imaging - epidemiology - genetics - metabolism
Cross-Sectional Studies
Female
Humans
Inositol - metabolism
Longitudinal Studies
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Positron-Emission Tomography
Prodromal Symptoms
Prospective Studies
Sweden - epidemiology
tau Proteins - cerebrospinal fluid
Abstract
We aimed to test whether in vivo levels of magnetic resonance spectroscopy (MRS) metabolites myo-inositol (mI), N-acetylaspartate (NAA), and choline are abnormal already during preclinical Alzheimer disease (AD), relating these changes to amyloid or tau pathology, and functional connectivity.
In this cross-sectional multicenter study (a subset of the prospective Swedish BioFINDER study), we included 4 groups, representing the different stages of predementia AD: (1) cognitively healthy elderly with normal CSF ß-amyloid 42 (Aß42), (2) cognitively healthy elderly with abnormal CSF Aß42, (3) patients with subjective cognitive decline and abnormal CSF Aß42, (4) patients with mild cognitive decline and abnormal CSF Aß42 (Ntotal = 352). Spectroscopic markers measured in the posterior cingulate/precuneus were considered alongside known disease biomarkers: CSF Aß42, phosphorylated tau, total tau, [(18)F]-flutemetamol PET, f-MRI, and the genetic risk factor APOE.
Amyloid-positive cognitively healthy participants showed a significant increase in mI/creatine and mI/NAA levels compared to amyloid-negative healthy elderly (p
Notes
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PubMed ID
27164711 View in PubMed
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Neuroimaging and neurophysiology studies in carriers of cree leukoencephalopathy.

https://arctichealth.org/en/permalink/ahliterature137060
Source
Can J Neurol Sci. 2011 Mar;38(2):347-8
Publication Type
Article
Date
Mar-2011

Quantification of metabolites from single-voxel in vivo 1H NMR data of normal human brain by means of time-domain data analysis.

https://arctichealth.org/en/permalink/ahliterature11357
Source
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Publication Type
Article
Author
M. Ala-Korpela
J P Usenius
J. Keisala
A. van den Boogaart
P. Vainio
J. Jokisaari
S. Soimakallio
R. Kauppinen
Author Affiliation
Department of Physical Sciences, University of Oulu, Finland.
Source
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Language
English
Publication Type
Article
Keywords
Aspartic Acid - analogs & derivatives - metabolism
Brain - anatomy & histology - metabolism
Choline - metabolism
Comparative Study
Creatine - metabolism
Humans
Magnetic Resonance Spectroscopy - methods
Protons
Research Support, Non-U.S. Gov't
Signal Processing, Computer-Assisted
Abstract
We present here a combination of time-domain signal analysis procedures for quantification of human brain in vivo 1H NMR spectroscopy (MRS) data. The method is based on a separate removal of a residual water resonance followed by a frequency-selective time-domain line-shape fitting analysis of metabolite signals. Calculation of absolute metabolite concentrations was based on the internal water concentration as a reference. The estimated average metabolite concentrations acquired from six regions of normal human brain with a single-voxel spin-echo technique for the N-acetylaspartate, creatine, and choline-containing compounds were 11.4 +/- 1.0, 6.5 +/- 0.5, and 1.7 +/- 0.2 mumol kg-1 wet weight, respectively. The time-domain analyses of in vivo 1H MRS data from different brain regions with their specific characteristics demonstrate a case in which the use of frequency-domain methods pose serious difficulties.
PubMed ID
8749730 View in PubMed
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