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Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.

https://arctichealth.org/en/permalink/ahliterature23824
Source
Mol Aspects Med. 1994;15 Suppl:s231-40
Publication Type
Article
Date
1994
Author
K. Lockwood
S. Moesgaard
T. Hanioka
K. Folkers
Author Affiliation
Private Outpatient Clinic, Copenhagen, Denmark.
Source
Mol Aspects Med. 1994;15 Suppl:s231-40
Date
1994
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Antioxidants - therapeutic use
Ascorbic Acid - therapeutic use
Biological Markers
Breast Neoplasms - drug therapy - radiotherapy - surgery
Carotenoids - therapeutic use
Chemotherapy, Adjuvant
Combined Modality Therapy
Fatty Acids, Essential - therapeutic use
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Mastectomy
Middle Aged
Neoplasm Metastasis - prevention & control
Quality of Life
Remission Induction
Risk
Selenium - therapeutic use
Treatment Outcome
Ubiquinone - analogs & derivatives - therapeutic use
Vitamin E - therapeutic use
beta Carotene
Abstract
Thirty-two typical patients with breast cancer, aged 32-81 years and classified 'high risk' because of tumor spread to the lymph nodes in the axilla, were studied for 18 months following an Adjuvant Nutritional Intervention in Cancer protocol (ANICA protocol). The nutritional protocol was added to the surgical and therapeutic treatment of breast cancer, as required by regulations in Denmark. The added treatment was a combination of nutritional antioxidants (Vitamin C: 2850 mg, Vitamin E: 2500 iu, beta-carotene 32.5 iu, selenium 387 micrograms plus secondary vitamins and minerals), essential fatty acids (1.2 g gamma linolenic acid and 3.5 g n-3 fatty acids) and Coenzyme Q10 (90 mg per day). The ANICA protocol is based on the concept of testing the synergistic effect of those categories of nutritional supplements, including vitamin Q10, previously having shown deficiency and/or therapeutic value as single elements in diverse forms of cancer, as cancer may be synergistically related to diverse biochemical dysfunctions and vitamin deficiencies. Biochemical markers, clinical condition, tumor spread, quality of life parameters and survival were followed during the trial. Compliance was excellent. The main observations were: (1) none of the patients died during the study period. (the expected number was four.) (2) none of the patients showed signs of further distant metastases. (3) quality of life was improved (no weight loss, reduced use of pain killers). (4) six patients showed apparent partial remission.
PubMed ID
7752835 View in PubMed
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[Effect of combined therapy, including galascorbin, on the glucocorticoid function of the adrenal glands in chronic angiocholecystites and gastrites in children]

https://arctichealth.org/en/permalink/ahliterature44606
Source
Pediatr Akus Ginekol. 1968;3:16-7
Publication Type
Article
Date
1968

[Effect of different methods of treatment on the complete convalescence of children with Botkin's disease]

https://arctichealth.org/en/permalink/ahliterature45086
Source
Pediatr Akus Ginekol. 1965 Nov-Dec;6:17-9
Publication Type
Article

Effects of endogenous N-nitrosodiethylamine and blocking of its synthesis with ascorbic acid on the condition of the liver monooxygenase system.

https://arctichealth.org/en/permalink/ahliterature21348
Source
Technol Health Care. 1998 Sep;6(2-3):131-7
Publication Type
Article
Date
Sep-1998
Author
O R Melnikov
Author Affiliation
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev. aos@public.ua.net
Source
Technol Health Care. 1998 Sep;6(2-3):131-7
Date
Sep-1998
Language
English
Publication Type
Article
Keywords
Animals
Antioxidants - therapeutic use
Ascorbic Acid - therapeutic use
Carcinogens - metabolism
Cytochrome P-450 Enzyme System - chemistry - drug effects
Diethylnitrosamine - metabolism
Disease Models, Animal
Drug Evaluation, Preclinical
Liver Neoplasms, Experimental - chemically induced - enzymology
Male
Oxidation-Reduction
Protein Isoforms
Rats
Abstract
Comparative investigations were performed to study the effect of endogenous and exogenous N-nitrosodiethylamine on the dynamics of content variations of oxidized cytochrome P-450 and its isoforms in the monooxygenase system of rat liver. The variations of cytochrome P-450 contents in both cases were demonstrated to be of the same character correlating with hepatocarcinogenesis stages. Higher quantities of oxidized cytochrome P-450 and its isoforms with MM 52, 53, and 56 kDa in the rat liver when acted upon by NDEA precursors are seen as the precondition of enhancing the monooxygenase reaction of NDEA bioactivation and, as a result, of the carcinogenic effects. Ascorbic acid is assumed to block the synthesis of NDEA from its precursors giving use to a compound whose metabolism does not influence the activity of the monooxygenase system of liver cells.
PubMed ID
9839859 View in PubMed
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22 records – page 1 of 3.