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Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK.

https://arctichealth.org/en/permalink/ahliterature82868
Source
Dent Mater. 2007 Jan;23(1):34-9
Publication Type
Article
Date
Jan-2007
Author
Samuelsen Jan T
Dahl Jon E
Karlsson Stig
Morisbak Else
Becher Rune
Author Affiliation
NIOM-Nordic Institute of Dental Materials, PO Box 70, N-1305 Haslum, Norway. jts@niom.no
Source
Dent Mater. 2007 Jan;23(1):34-9
Date
Jan-2007
Language
English
Publication Type
Article
Keywords
Animals
Antioxidants - pharmacology
Apoptosis - drug effects
Ascorbic Acid - pharmacology
Blotting, Western
Caspases - metabolism
Cell Line
Dental Materials - pharmacology
Enzyme Activation - drug effects
Flavonoids - pharmacology
Fluorescent Dyes - diagnostic use
MAP Kinase Kinase 4 - antagonists & inhibitors - metabolism
Methacrylates - pharmacology
Mitogen-Activated Protein Kinases - antagonists & inhibitors - metabolism
Polyethylene Glycols - pharmacology
Polymethacrylic Acids - pharmacology
Rats
Reactive Oxygen Species - metabolism
Signal Transduction - drug effects
Time Factors
p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors - metabolism
Abstract
OBJECTIVES: Cytotoxic methacrylate monomers have been identified in aqueous extracts of freshly cured compomers. Some of these compounds, including HEMA and TEGDMA, induce apoptosis and necrosis in vitro. The aim of the present study was to elucidate possible signaling pathways involved in apoptosis following exposure to HEMA or TEGDMA in a salivary gland cell line. METHODS: The cells were exposed to various concentrations of HEMA or TEGDMA. ROS formation was determined by dichlorofluorescein assay. Phosphorylated MAP-kinases ERK1/2, p38 and JNK, as well as specific caspases were identified by Western blotting. Apoptosis was assayed by fluorescence microscopy. RESULTS: HEMA or TEGDMA exposure resulted in ROS formation and concentration-dependent apoptosis as well as phosphorylation of ERK. Phosphorylation of JNK and p38 was induced by HEMA. Selective inhibitors of ERK and JNK modified the apoptotic response after HEMA and TEGDMA exposure, whereas p38 inhibition modified the apoptotic response only after HEMA exposure. Vitamin C reduced HEMA-induced apoptosis. SIGNIFICANCE: ROS formation and differential MAP kinase activation appear to be involved in the apoptotic response following exposure to HEMA and TEGDMA.
PubMed ID
16430953 View in PubMed
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Covalent binding of acetaldehyde to type III collagen.

https://arctichealth.org/en/permalink/ahliterature12351
Source
Biochem Biophys Res Commun. 1989 Feb 28;159(1):163-9
Publication Type
Article
Date
Feb-28-1989
Author
A. Jukkola
O. Niemelä
Author Affiliation
Department of Medical Biochemistry, University of Oulu, Finland.
Source
Biochem Biophys Res Commun. 1989 Feb 28;159(1):163-9
Date
Feb-28-1989
Language
English
Publication Type
Article
Keywords
Acetaldehyde - metabolism
Animals
Ascorbic Acid - pharmacology
Borohydrides - pharmacology
Cattle
Cells, Cultured
Collagen - metabolism
Comparative Study
Electrophoresis, Polyacrylamide Gel
Fibroblasts - metabolism
Humans
Immunosorbent Techniques
Lysine
Macromolecular Substances
Research Support, Non-U.S. Gov't
Serum Albumin, Bovine - metabolism
Abstract
Incubation of neutral salt soluble type III pN-collagen with [14C]acetaldehyde in vitro resulted in the formation of spontaneously stable acetaldehyde-protein adducts. This reaction occurred primarily at lysine residues and it was not affected by 0.2-2 mM concentrations of ascorbate but addition of sodiumcyanoborohydride increased the stable adducts by 3-5-fold. When confluent cultures of human skin fibroblasts were incubated with physiologically relevant concentrations of acetaldehyde, it became covalently bound to type III procollagen secreted into the medium. We propose that acetaldehyde binding to collagen fibrils occurs in vivo following chronic alcohol consumption.
PubMed ID
2493786 View in PubMed
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Dietary antioxidants and the risk of lung cancer.

https://arctichealth.org/en/permalink/ahliterature225751
Source
Am J Epidemiol. 1991 Sep 1;134(5):471-9
Publication Type
Article
Date
Sep-1-1991
Author
P. Knekt
R. Järvinen
R. Seppänen
A. Rissanen
A. Aromaa
O P Heinonen
D. Albanes
M. Heinonen
E. Pukkala
L. Teppo
Author Affiliation
Research Institute for Social Security, Social Insurance Institution, Helsinki, Finland.
Source
Am J Epidemiol. 1991 Sep 1;134(5):471-9
Date
Sep-1-1991
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Carotenoids - pharmacology
Cohort Studies
Dairy Products
Diet
Eating
Finland
Follow-Up Studies
Fruit
Humans
Lung Neoplasms - etiology - prevention & control
Male
Meat products
Middle Aged
Proportional Hazards Models
Retinoids - pharmacology
Risk
Selenium - pharmacology
Smoking
Vegetables
Vitamin E - pharmacology
Abstract
The relation between the intake of retinoids, carotenoids, vitamin E, vitamin C, and selenium and the subsequent risk of lung cancer was studied among 4,538 initially cancer-free Finnish men aged 20-69 years. During a follow-up of 20 years beginning in 1966-1972, 117 lung cancer cases were diagnosed. Inverse gradients were observed between the intake of carotenoids, vitamin E, and vitamin C and the incidence of lung cancer among nonsmokers, for whom the age-adjusted relative risks of lung cancer in the lowest tertile of intake compared with that in the highest tertile were 2.5 (p value for trend = 0.04), 3.1 (p = 0.12), and 3.1 (p less than 0.01) for the three intakes, respectively. Adjustment for various potential confounding factors did not materially alter the results, and the associations did not seem to be due to preclinical cancer. In the total cohort, there was an inverse association between intake of margarine and fruits and risk of lung cancer. The relative risk of lung cancer for the lowest compared with the highest tertile of margarine intake was 4.0 (p less than 0.001), and that for fruits was 1.8 (p = 0.01). These associations persisted after adjustment for the micronutrient intakes and were stronger among nonsmokers. The results suggest that carotenoids, vitamin E, and vitamin C may be protective against lung cancer among nonsmokers. Food sources rich in these micronutrients may also have other constituents with independent protective effects against lung cancer.
Notes
Comment In: Am J Epidemiol. 1992 Nov 1;136(9):1167-9; author reply 1169-701462977
PubMed ID
1897503 View in PubMed
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Dietary benzo(a)pyrene intake during pregnancy and birth weight: associations modified by vitamin C intakes in the Norwegian Mother and Child Cohort Study (MoBa).

https://arctichealth.org/en/permalink/ahliterature107027
Source
Environ Int. 2013 Oct;60:217-23
Publication Type
Article
Date
Oct-2013
Author
Talita Duarte-Salles
Michelle A Mendez
Helle Margrete Meltzer
Jan Alexander
Margaretha Haugen
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: duartesallest@fellows.iarc.fr.
Source
Environ Int. 2013 Oct;60:217-23
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Adult
Ascorbic Acid - pharmacology
Benzo(a)pyrene - administration & dosage - analysis - toxicity
Birth Weight - drug effects
Child
Cohort Studies
Diet - statistics & numerical data
Female
Fetal Development - drug effects
Food - classification
Food Contamination - analysis - statistics & numerical data
Heredodegenerative Disorders, Nervous System - chemically induced
Humans
Infant
Maternal Exposure - statistics & numerical data
Microphthalmos - chemically induced
Multivariate Analysis
Mutagenicity Tests
Norway - epidemiology
Parity
Polycyclic Hydrocarbons, Aromatic - toxicity
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Abstract
Maternal exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy has been associated with reduced fetal growth. However, the role of diet, the main source of PAH exposure among non-smokers, remains uncertain.
To assess associations between maternal exposure to dietary intake of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy and birth weight, exploring potential effect modification by dietary intakes of vitamins C, E and A, hypothesized to influence PAH metabolism.
This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Dietary B(a)P and nutrient intakes were estimated based on total consumption obtained from a food frequency questionnaire (FFQ) and estimated based on food composition data. Data on infant birth weight were obtained from the Medical Birth Registry of Norway (MBRN). Multivariate regression was used to assess associations between dietary B(a)P and birth weight, evaluating potential interactions with candidate nutrients.
The multivariate-adjusted coefficient (95%CI) for birth weight associated with maternal energy-adjusted B(a)P intake was -20.5g (-31.1, -10.0) in women in the third compared with the first tertile of B(a)P intake. Results were similar after excluding smokers. Significant interactions were found between elevated intakes of vitamin C (>85mg/day) and dietary B(a)P during pregnancy for birth weight (P
PubMed ID
24071023 View in PubMed
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[Effect of ascorbic acid and glascorbin on extracellular and intracellular distribution of some electrolytes and water in skeletal muscles during experimental scurvy]

https://arctichealth.org/en/permalink/ahliterature62659
Source
Ukr Biokhim Zh. 1968;40(1):99-103
Publication Type
Article
Date
1968

[Effect of ascorbic acid on the oxidative homeostasis of skin]

https://arctichealth.org/en/permalink/ahliterature10165
Source
Fiziol Zh. 2001;47(3):103-5
Publication Type
Article
Date
2001

[Effect of vitamin B-1 and galascorbin on some indices of carbohydrate-phosphorus metabolism in the liver during toxic conditions]

https://arctichealth.org/en/permalink/ahliterature57206
Source
Ukr Biokhim Zh. 1965;37(3):391-6
Publication Type
Article
Date
1965

17 records – page 1 of 2.