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Addressing arsenic bioaccessibility in ecological risk assessment: a novel approach to avoid overestimating risk.

https://arctichealth.org/en/permalink/ahliterature91571
Source
Environ Toxicol Chem. 2009 Mar;28(3):668-75
Publication Type
Article
Date
Mar-2009
Author
Ollson Christopher A
Koch Iris
Smith Paula
Knopper Loren D
Hough Chris
Reimer Ken J
Author Affiliation
Jacques Whitford, Burlington, Ontario, Canada.
Source
Environ Toxicol Chem. 2009 Mar;28(3):668-75
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Animals
Arsenic - chemistry - pharmacokinetics
Biological Availability
Environmental Monitoring - methods
Industrial Waste
Mining
Northwest Territories
Peromyscus
Risk assessment
Soil Pollutants - chemistry - pharmacokinetics
Trees
Abstract
The risk of arsenic exposure to deer mice (Peromyscus maniculatus) living in areas of naturally and anthropogenically elevated arsenic levels was determined using three separate calculations of arsenic daily intake: Estimated daily intake (EDI), bioaccessible EDI (BEDI), and actual daily intake (ADI). The present work is of particular interest, because the risk assessments were determined for animals naturally exposed to arsenic. Gastric fluid extraction was used to obtain bioaccessibility data for soil and plant samples collected from three study sites (background, mine forest, and tailings) in Yellowknife (NT, Canada). Calculations using the EDI indicated that deer mice living in tailings habitat (average soil arsenic concentration, 1,740 +/- 2,240 microg/g) should have been experiencing serious health effects as a result of their exposure to arsenic. Using BEDI and ADI in the risk assessment calculation, however, resulted in an order-of-magnitude decrease in calculated risk. In addition, results calculated using the BEDI and ADI were not significantly different, suggesting that using bioaccessibility provides a more realistic estimate of potential risk. The present results provide evidence that the use of EDI in traditional risk assessments may seriously overestimate the actual risk, which in some instances may result in expensive and unnecessary clean-up measures.
PubMed ID
18939889 View in PubMed
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