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ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin.

https://arctichealth.org/en/permalink/ahliterature152450
Source
Clin Pharmacol Ther. 2008 Oct;84(4):457-61
Publication Type
Article
Date
Oct-2008
Author
J E Keskitalo
K J Kurkinen
P J Neuvoneni
M. Niemi
Author Affiliation
Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Source
Clin Pharmacol Ther. 2008 Oct;84(4):457-61
Date
Oct-2008
Language
English
Publication Type
Article
Keywords
Area Under Curve
Cross-Over Studies
Female
Finland
Half-Life
Haplotypes
Heptanoic Acids - pharmacokinetics
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Lactones - pharmacokinetics
Male
P-Glycoprotein - genetics
Polymorphism, Single Nucleotide
Pyrroles - pharmacokinetics
Simvastatin - pharmacokinetics
Abstract
ABCB1 haplotypes were determined in 534 healthy Finnish volunteers, of whom 24 participated in a pharmacokinetic study on simvastatin and atorvastatin. The frequencies of occurrence of haplotypes c.1236T-c.2677T-c.3435T and c.1236C-c.2677G-c.3435C were 42.7 and 34.4%, respectively. The simvastatin acid AUC(0-12h) was 60% larger, the atorvastatin AUC(0-infinity) 55% larger, and the atorvastatin half-life 24% longer in subjects with the ABCB1 TTT/TTT genotype (n = 12) than in those with the CGC/CGC genotype (n = 12) (P
PubMed ID
19238649 View in PubMed
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ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

https://arctichealth.org/en/permalink/ahliterature150732
Source
Clin Pharmacol Ther. 2009 Aug;86(2):197-203
Publication Type
Article
Date
Aug-2009
Author
J E Keskitalo
O. Zolk
M F Fromm
K J Kurkinen
P J Neuvonen
M. Niemi
Author Affiliation
Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Source
Clin Pharmacol Ther. 2009 Aug;86(2):197-203
Date
Aug-2009
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Adult
Anticholesteremic Agents - pharmacokinetics
Area Under Curve
Cross-Over Studies
Drug Resistance, Multiple
European Continental Ancestry Group - genetics
Female
Finland
Fluorobenzenes - administration & dosage - blood - pharmacokinetics - urine
Genotype
Heptanoic Acids - administration & dosage - blood - pharmacokinetics - urine
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Linear Models
Male
Neoplasm Proteins - genetics
Polymorphism, Single Nucleotide
Pyrimidines - administration & dosage - blood - pharmacokinetics - urine
Pyrroles - administration & dosage - blood - pharmacokinetics - urine
Reference Values
Sulfonamides - administration & dosage - blood - pharmacokinetics - urine
Abstract
The ABCG2 c.421C>A single-nucleotide polymorphism (SNP) was determined in 660 healthy Finnish volunteers, of whom 32 participated in a pharmacokinetic crossover study involving the administration of 20 mg atorvastatin and rosuvastatin. The frequency of the c.421A variant allele was 9.5% (95% confidence interval 8.1-11.3%). Subjects with the c.421AA genotype (n = 4) had a 72% larger mean area under the plasma atorvastatin concentration-time curve from time 0 to infinity (AUC(0-infinity)) than individuals with the c.421CC genotype had (n = 16; P = 0.049). In participants with the c.421AA genotype, the rosuvastatin AUC(0-infinity) was 100% greater than in those with c.421CA (n = 12) and 144% greater than in those with the c.421CC genotype. Also, those with the c.421AA genotype showed peak plasma rosuvastatin concentrations 108% higher than those in the c.421CA genotype group and 131% higher than those in the c.421CC genotype group (P
PubMed ID
19474787 View in PubMed
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Abdominal fat from spine dual-energy x-ray absorptiometry and risk for subsequent diabetes.

https://arctichealth.org/en/permalink/ahliterature144207
Source
J Clin Endocrinol Metab. 2010 Jul;95(7):3272-6
Publication Type
Article
Date
Jul-2010
Author
William D Leslie
Sora M Ludwig
Suzanne Morin
Author Affiliation
University of Manitoba, Winnipeg, Canada R2H 2A6. bleslie@sbgh.mb.ca
Source
J Clin Endocrinol Metab. 2010 Jul;95(7):3272-6
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon
Adult
Aged
Aged, 80 and over
Area Under Curve
Body Composition
Bone Density
Canada
Cohort Studies
Diabetes Mellitus, Type 2 - complications - diagnosis
Female
Health Surveys
Humans
Insulin Resistance
Middle Aged
Obesity, Abdominal - complications - diagnosis
Predictive value of tests
Risk factors
Abstract
Abdominal obesity is a major risk factor for diabetes. Dual-energy x-ray absorptiometry (DXA) of the lumbar spine provides an index of abdominal fat.
Our objective was to examine the hypothesis that DXA-derived abdominal fat measurement in women undergoing osteoporosis investigation predicts risk for subsequent diagnosis of diabetes.
This historical cohort study was derived from the Manitoba Bone Density Program Database for the Province of Manitoba, Canada.
30,252 nondiabetic women aged 40 yr and older were referred for baseline osteoporosis assessment with DXA between January 1990 and March 2007.
Each woman's longitudinal provincial health service record was assessed for the presence of diabetes diagnosis codes after DXA testing.
During 5.2 + or - 2.6 yr of observation, 1252 (4.1%) women met the case definition for diabetes. A greater proportion of abdominal fat from spine DXA was strongly related to subsequent diabetes diagnosis in models adjusted for age, body mass index, and other comorbidities. Those in the highest quintile had 3.56 (95% confidence interval = 2.67-4.75) times the risk for subsequent diabetes diagnosis compared with those in the lowest (reference) quintile. Fat from hip DXA was not predictive of subsequent diabetes after adjustment for the same variables (1.00, 95% confidence interval = 0.79-1.26).
Predictive information about diabetes risk can be obtained from spine DXA scans performed for osteoporosis risk assessment. This is consistent with evidence linking abdominal fat with insulin resistance and the metabolic syndrome.
PubMed ID
20392865 View in PubMed
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The ability of hand digital X-ray radiogrammetry to identify middle-aged and elderly women with reduced bone density, as assessed by femoral neck dual-energy X-ray absorptiometry.

https://arctichealth.org/en/permalink/ahliterature139761
Source
J Clin Densitom. 2010 Oct-Dec;13(4):418-25
Publication Type
Article
Author
Alvilde Dhainaut
Gudrun E Rohde
Unni Syversen
Villy Johnsen
Glenn Haugeberg
Author Affiliation
Department of Neuroscience, Rheumatology Division, INM Norwegian University of Science and Technology, Trondheim, Norway. alvilde.dhainaut@ntnu.no
Source
J Clin Densitom. 2010 Oct-Dec;13(4):418-25
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon - instrumentation
Aged
Area Under Curve
Bone Density
Case-Control Studies
Female
Femur Neck - radiography
Humans
Middle Aged
Norway - epidemiology
Osteoporosis - epidemiology - radiography
Quality of Life
Radius Fractures - epidemiology
Risk assessment
Statistics, nonparametric
Abstract
In this study, we evaluate the ability of digitized digital X-ray radiogrammetry (DXR) bone mineral density (BMD) to identify women with reduced BMD at femoral neck, assessed by dual-energy X-ray absorptiometry (DXA). The study population contained women with recent low-energy distal radius fracture and women recruited from the general population, all aged 50 yr or older. The correlation between hand BMD and femoral neck BMD was r=0.65 (p
PubMed ID
21029976 View in PubMed
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Acceptability of dental appearance in a group of Finnish 16- to 25-year-olds.

https://arctichealth.org/en/permalink/ahliterature151199
Source
Angle Orthod. 2009 May;79(3):479-83
Publication Type
Article
Date
May-2009
Author
Anna-Liisa Svedström-Oristo
Terttu Pietilä
Ilpo Pietilä
Tero Vahlberg
Pentti Alanen
Juha Varrela
Author Affiliation
Department of Oral Development and Orthodontics, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, Finland. anlisve@utu.fi
Source
Angle Orthod. 2009 May;79(3):479-83
Date
May-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Area Under Curve
Diastema - pathology
Esthetics, Dental
Female
Finland
Humans
Incisor - pathology
Male
Malocclusion - classification - psychology
Needs Assessment
Orthodontics, Corrective - psychology
Personal Satisfaction
ROC Curve
Self Concept
Sex Factors
Young Adult
Abstract
To define a grade in the Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN) that would differentiate between esthetically acceptable and unacceptable occlusions and that would also be both subjectively and objectively meaningful.
Dental appearance and self-perceived orthodontic treatment need were analyzed in a group of Finnish young adults (171 males, 263 females, age range 16-25 years). Subjective data were gathered using a questionnaire, and the respondents were requested to score their dental appearance on a visual analog type 10-grade scale. Professional assessment of dental appearance was performed by two orthodontists using the AC of the IOTN. The cutoff value between esthetically acceptable and unacceptable occlusions was defined using receiver operating characteristic curves.
Sixty-six percent of orthodontically treated and 74% of the untreated respondents were satisfied with their own dental appearance. Every third respondent reported one or more disturbing traits in their dentition. The most frequently expressed reason for dissatisfaction was crowding; girls expressed dissatisfaction more often than boys did (P = .005). A self-perceived treatment need was reported infrequently by 8% of orthodontically treated and 6% of untreated respondents. In the logistic regression analysis, self-perceived need for orthodontic treatment was the only significant factor explaining dissatisfaction with own dental esthetics. On the applied scales, grades 1 and 2 fulfilled the criteria for satisfactory dental esthetics.
The results suggest that the AC grade 3 could serve as a cutoff value between esthetically acceptable and unacceptable occlusions.
PubMed ID
19413382 View in PubMed
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Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study.

https://arctichealth.org/en/permalink/ahliterature129242
Source
Scand J Gastroenterol. 2012 Jan;47(1):28-35
Publication Type
Article
Date
Jan-2012
Author
David Levarett Buck
Morten Vester-Andersen
Morten Hylander Møller
Author Affiliation
Emergency Department, Holbæk Hospital, Denmark.
Source
Scand J Gastroenterol. 2012 Jan;47(1):28-35
Date
Jan-2012
Language
English
Publication Type
Article
Keywords
APACHE
Adult
Aged
Aged, 80 and over
Area Under Curve
Decision Support Techniques
Denmark - epidemiology
Female
Humans
Male
Middle Aged
Peptic Ulcer Perforation - mortality - surgery
Predictive value of tests
ROC Curve
Severity of Illness Index
Abstract
The aim of the present study was to compare the ability of four clinical prediction rules to predict adverse outcome in perforated peptic ulcer (PPU): the Boey score, the American Society of Anesthesiologists (ASA) score, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, and the sepsis score.
an observational multicenter study.
a total of 117 patients surgically treated for PPU between 1 January 2008 and 31 December 2009 in seven gastrointestinal departments in Denmark were included. Pregnant and breastfeeding women, non-surgically treated patients, patients with malignant ulcers, and patients with perforation of other organs were excluded.
30-day mortality rate.
the ability of four clinical prediction rules to distinguish survivors from non-survivors (discrimination ability) was evaluated by the area under the receiver operating characteristic curve (AUC), positive predictive values (PPVs), negative predictive values (NPVs), and adjusted relative risks.
Median age (range) was 70 years (25-92 years), 51% of the patients were females, and 73% of the patients had at least one co-existing disease. The 30-day mortality proportion was 17% (20/117). The AUCs: the Boey score, 0.63; the sepsis score, 0.69; the ASA score, 0.73; and the APACHE II score, 0.76. Overall, the PPVs of all four prediction rules were low and the NPVs high.
The Boey score, the ASA score, the APACHE II score, and the sepsis score predict mortality poorly in patients with PPU.
PubMed ID
22126610 View in PubMed
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Adjuvant radiotherapy of women with breast cancer - information, support and side-effects.

https://arctichealth.org/en/permalink/ahliterature98769
Source
Eur J Oncol Nurs. 2010 Apr;14(2):147-53
Publication Type
Article
Date
Apr-2010
Author
K. Sjövall
G. Strömbeck
A. Löfgren
P-O Bendahl
B. Gunnars
Author Affiliation
Department of Oncology, Lund University Hospital, S-221 85 Lund, Sweden. katarina.o.sjovall@skane.se
Source
Eur J Oncol Nurs. 2010 Apr;14(2):147-53
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Adult
Aged
Analysis of Variance
Area Under Curve
Breast Neoplasms - drug therapy - psychology - radiotherapy - surgery
Fatigue - etiology
Female
Humans
Linear Models
Mastectomy - adverse effects - methods
Middle Aged
Pain Measurement
Prospective Studies
Questionnaires
Radiotherapy, Adjuvant - adverse effects
Skin Diseases - etiology
Sleep Disorders - etiology
Social Support
Sweden
Translations
Abstract
The aim of this study was to 1) examine the occurrence and burden of side effects over time in the period after post surgical adjuvant radiotherapy in women with breast cancer and 2) explore the women's experiences of given information and need of support to handle side effects. MATERIAL AND METHOD: 171 women with breast cancer receiving post-surgical adjuvant radiotherapy completed a questionnaire on radiotherapy-related side effects (Treatment Toxicity Assessment Tool OTTAT) at four times between the start of radiotherapy and six months after completion. Comparisons were made between women with breast conservative surgery (group A) and women with modified mastectomy (group B), and for having chemotherapy or not (C+ and C-). Questions regarding the experience of delivered information and support were added. RESULTS: Fatigue was the single most prevalent side effect and, together with skin reactions and pain, it also had the highest mean score over the study period and the largest score increase during treatment. The largest increase during the six months was seen for skin reaction, pain, and dyspnoea. The average score for skin reaction was significantly higher in group B than in group A. A majority of the women experienced the given information and support as satisfying and a need for follow-up of the side-effects was expressed. CONCLUSION: Nursing for women with breast cancer receiving adjuvant radiotherapy should focus on preventing and treating side effects, and also include the period post treatment. There is a need for developing evidence based guidelines including guidelines for follow-up.
PubMed ID
19896896 View in PubMed
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Admission neopterin and interleukin 12 concentrations in identifying infections in adult cancer patients.

https://arctichealth.org/en/permalink/ahliterature19891
Source
Cytokine. 2001 Mar 21;13(6):371-4
Publication Type
Article
Date
Mar-21-2001
Author
R. Kallio
H M Surcel
A. Bloigu
H. Syrjälä
Author Affiliation
Department of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland. raija.kallio@oulu.fi
Source
Cytokine. 2001 Mar 21;13(6):371-4
Date
Mar-21-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Area Under Curve
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infection - complications - diagnosis
Interleukin-12 - blood
Male
Middle Aged
Neoplasms - blood - complications
Neopterin - blood
Abstract
Differential diagnosis between infections and neoplastic fever is a common diagnostic problem. The utility of admission serum concentrations of neopterin and interleukin 12 (IL-12) was prospectively evaluated in this respect. The infection group (n=56) had a higher median neopterin value (12.8 nmol/l vs 4.0 nmol/l, P
PubMed ID
11292321 View in PubMed
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Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions.

https://arctichealth.org/en/permalink/ahliterature67631
Source
Clin Pharmacol Ther. 1997 Mar;61(3):331-9
Publication Type
Article
Date
Mar-1997
Author
E A Sotaniemi
A J Arranto
O. Pelkonen
M. Pasanen
Author Affiliation
Department of Internal Medicine, University Hospital of Oulu, Finland.
Source
Clin Pharmacol Ther. 1997 Mar;61(3):331-9
Date
Mar-1997
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aging - metabolism
Analysis of Variance
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Antipyrine - pharmacokinetics
Area Under Curve
Cytochrome P-450 Enzyme System - physiology
Female
Humans
Liver - metabolism
Male
Middle Aged
Smoking - metabolism
Abstract
OBJECTIVES: The effect of aging on drug metabolism in humans has not yet been completely described. METHODS: Two hundred twenty-six patients with equal histopathologic conditions were investigated. The cytochrome P450 contents in the liver biopsy samples, the plasma antipyrine clearance rates after oral administration and, as an independent control of vitality, serum testosterone levels were determined. RESULTS: Cytochrome P450 content in subjects from 20 to 29 years of age was 7.2 +/- 2.6 nmol.gm-1, increased during the fourth decade (+7.2%, p = NS), declined after 40 years (-16%, p
PubMed ID
9091249 View in PubMed
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Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men.

https://arctichealth.org/en/permalink/ahliterature10634
Source
Circulation. 1999 Aug 17;100(7):723-8
Publication Type
Article
Date
Aug-17-1999
Author
S. Boquist
G. Ruotolo
R. Tang
J. Björkegren
M G Bond
U. de Faire
F. Karpe
A. Hamsten
Author Affiliation
Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden.
Source
Circulation. 1999 Aug 17;100(7):723-8
Date
Aug-17-1999
Language
English
Publication Type
Article
Keywords
Alcohol drinking - epidemiology
Apolipoproteins B - blood
Apolipoproteins E - genetics
Area Under Curve
Arteriosclerosis - epidemiology - ultrasonography
Blood pressure
Body constitution
Carotid Artery, Common - ultrasonography - ultrastructure
Carotid Stenosis - epidemiology - ultrasonography
Chylomicrons - blood
Dietary Fats - pharmacokinetics
Eating - physiology
Fasting - blood
Genotype
Homeostasis
Humans
Insulin - blood
Lipids - blood
Lipoproteins - blood
Lipoproteins, LDL Cholesterol - blood
Lipoproteins, VLDL - blood
Male
Middle Aged
Proinsulin - blood
Reference Values
Research Support, Non-U.S. Gov't
Smoking - epidemiology
Sweden - epidemiology
Triglycerides - blood
Tunica Intima - ultrastructure
Abstract
BACKGROUND: Alimentary lipemia has been associated with coronary heart disease and common carotid artery intima-media thickness (IMT). This study was designed to investigate the relations of subclasses of postprandial triglyceride-rich lipoproteins (TRLs) with IMT. METHODS AND RESULTS: Ninety-six healthy 50-year-old men with an apolipoprotein (apo) E3/E3 genotype underwent an oral fat tolerance test and B-mode carotid ultrasound examination. The apo B-48 and apo B-100 contents of each fraction of TRLs were determined as a measure of chylomicron remnant and VLDL particle concentrations. In the fasting state, LDL cholesterol (P
PubMed ID
10449694 View in PubMed
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244 records – page 1 of 25.