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50 records – page 1 of 5.

1999-2000 influenza season: Canadian laboratory diagnoses and strain characterization.

https://arctichealth.org/en/permalink/ahliterature196284
Source
Can Commun Dis Rep. 2000 Nov 15;26(22):185-9
Publication Type
Article
Date
Nov-15-2000
Author
Y. Li
Author Affiliation
Respiratory Viruses Section, National Microbiology Laboratory, Population and Public Health Branch, Health Canada, Winnipeg, Man.
Source
Can Commun Dis Rep. 2000 Nov 15;26(22):185-9
Date
Nov-15-2000
Language
English
French
Publication Type
Article
Keywords
Antiviral Agents - pharmacology - therapeutic use
Canada - epidemiology
Data Collection
Female
Humans
Influenza A virus - drug effects - isolation & purification
Influenza B virus - drug effects - isolation & purification
Influenza, Human - drug therapy - epidemiology - virology
Male
Microbial Sensitivity Tests
Population Surveillance
PubMed ID
11131691 View in PubMed
Less detail

The analysis of structure-anticancer and antiviral activity relationships for macrocyclic pyridinophanes and their analogues on the basis of 4D QSAR models (simplex representation of molecular structure).

https://arctichealth.org/en/permalink/ahliterature18985
Source
Acta Biochim Pol. 2002;49(1):157-68
Publication Type
Article
Date
2002
Author
Victor E Kuz'min
Anatoly G Artemenko
Victor P Lozitsky
Eugene N Muratov
Alla S Fedtchouk
Natalia S Dyachenko
Lidiya N Nosach
Tatiyana L Gridina
Larisa I Shitikova
Liubov M Mudrik
Aleksey K Mescheriakov
Vladislav A Chelombitko
Andrey I Zheltvay
Jean-Jaques Vanden Eynde
Author Affiliation
I.I. Mechnikov Odessa National University, Ukraine. victor@farlep.net
Source
Acta Biochim Pol. 2002;49(1):157-68
Date
2002
Language
English
Publication Type
Article
Keywords
Antineoplastic Agents - pharmacology
Antiviral Agents - pharmacology
Humans
In Vitro
Models, Molecular
Neoplasms - drug therapy
Quantitative Structure-Activity Relationship
Research Support, Non-U.S. Gov't
Tumor Cells, Cultured - drug effects
Abstract
A new 4D-QSAR approach has been considered. For all investigated molecules the 3D structural models have been created and the set of conformers (fourth dimension) have been used. Each conformer is represented as a system of different simplexes (tetratomic fragments of fixed structure, chirality and symmetry). The investigation of influence of molecular structure of macrocyclic pyridinophanes, their analogues and certain other compounds on anticancer and antiviral (anti-influenza, antiherpes and antiadenovirus) activity has been carried out by means of the 4D-QSAR. Statistic characteristics for QSAR of PLS (partial least squares) models are satisfactory (R = 0.92-0.97; CVR = 0.63-0.83). Molecular fragments increasing and decreasing biological activity were defined. This information may be useful for design, and direct synthesis of novel anticancer and antiviral agents.
PubMed ID
12136936 View in PubMed
Less detail

An attempt to predict a possible existence of antiviral and antimicrobial activity.

https://arctichealth.org/en/permalink/ahliterature7388
Source
Med Hypotheses. 2002 May;58(5):429-30
Publication Type
Article
Date
May-2002
Author
G I Danilenko
Author Affiliation
Institute of Organic Chemistry, National Academy of Science, Ukraine. iochkiev@ukrpack.net
Source
Med Hypotheses. 2002 May;58(5):429-30
Date
May-2002
Language
English
Publication Type
Article
Keywords
Animals
Anti-HIV Agents - pharmacology
Anti-Infective Agents - pharmacology
Antibodies, Viral - pharmacology
Antiviral Agents - pharmacology
Binding Sites
Humans
Models, Biological
Molecular Mimicry
Rabies virus - immunology
Abstract
It is known that many pathogenic and toxic agents may attach to binding site of the same endogenic receptor. Such an effect is due to the resemblance between chemical structures in foreign agents. One may imagine the structure which contains binding-site fragments and may compete with the receptor for foreign agents. Then next suggestions are probable: (1)The same substance may interact with some agents with established resemblance; (2) If substance (1) interacts with agents A and B and substance (2) influences agent (2) only then (2) ought to act at agent B as well. In terms 'key-keyhole' this means an existence of the key fitting several keyholes. Application of this conception has given a possibility to predict an anti-HIV and antimicrobial activity of an antirabies immunoglobulin.
PubMed ID
12056882 View in PubMed
Less detail

[Antiphytoviral activity of capsule substances of Cryptococcus albidus yeast]

https://arctichealth.org/en/permalink/ahliterature69023
Source
Mikrobiol Z. 2005 May-Jun;67(3):81-4
Publication Type
Article
Author
O H Kovalenko
A O Barkalova
S S Nahorrna
Source
Mikrobiol Z. 2005 May-Jun;67(3):81-4
Language
Ukrainian
Publication Type
Article
Keywords
Antiviral Agents - pharmacology
Carbohydrates - pharmacology
Cryptococcus - isolation & purification - metabolism - physiology
Cucumis sativus - anatomy & histology
Culture Media - chemistry
Datura - microbiology
English Abstract
Plant Leaves - microbiology
Proteins - pharmacology
Sonication
Tobacco - microbiology
Tobacco Mosaic Virus - drug effects
Zea mays - anatomy & histology
Abstract
The yeast Cryptococcus albidus isolated from the leaves of maize (strain 1003) and cucumbers (strain 1014) produce the capsule substances which can protect the tobacco and datura plants from tobacco mosaic virus. Proteins, carbohydrates and ash elements have been isolated from culture liquids treated by supersound.
PubMed ID
16018209 View in PubMed
Less detail

[Antiviral and phytostimulating properties of the individual components of imanine]

https://arctichealth.org/en/permalink/ahliterature69149
Source
Mikrobiol Zh. 1972 Sep-Oct;34(5):620-4
Publication Type
Article

[A prognostic model of the effect of the antiviral drug Relenza on the epidemic of A(H1N1)/2009 influenza].

https://arctichealth.org/en/permalink/ahliterature128746
Source
Vopr Virusol. 2011 Sep-Oct;56(5):26-30
Publication Type
Article
Author
B V Boev
I F Ershov
Source
Vopr Virusol. 2011 Sep-Oct;56(5):26-30
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Algorithms
Antiviral Agents - pharmacology - therapeutic use
Child
Computer simulation
Disease Outbreaks - statistics & numerical data
Humans
Influenza A Virus, H1N1 Subtype - drug effects
Influenza, Human - drug therapy - epidemiology - prevention & control
Middle Aged
Models, Theoretical
Russia - epidemiology
Zanamivir - pharmacology - therapeutic use
Abstract
The paper gives the results of calculation-theoretical studies estimating the effect of the etiotropic agent Relenza (in preventing influenza in its susceptible patients an in treating patients ill with influenza) on the epidemic of pandemic A(H1N1)/2009 influenza in a large city of Russia. The values of its effect (the number of prevented cases of influenza and that of prevented deaths from its complications) have been calculated on a computer, by applying a modified PSEEI2RF influenza epidemic model (a Russian Baroyan-Rvachev model) with the A(H1N1)/2009 influenza pathogen that dominated in the 2009-2010 season in many countries of the world. Predictive estimates of the action of Relenza on the epidemic of A(H1N1)/2009 influenza have been obtained for 5 scenarios while implementing measures to treat patients with the illness and to prevent its susceptible patients in a large city with a population of one million. In conclusion, there are results of predicting the number of prevented A(H1N1)/2009 influenza cases and damage estimates for 6 cities of Russia due to the massive use of the antiviral drug Relenza.
PubMed ID
22171474 View in PubMed
Less detail

[Characterization of epidemic influenza virus A(H3N2) strains circulating in Russia in the 2003-2004 epidemic season].

https://arctichealth.org/en/permalink/ahliterature170408
Source
Vopr Virusol. 2006 Jan-Feb;51(1):19-23
Publication Type
Article
Author
V T Ivanova
E I Burtseva
A N Slepushkin
M Iu Shchelkanov
Iu V Zagorskaia
E S Shevchenko
R O Rakutina
E G Cherkasov
E I Isaeva
T A Oskerko
E L Feodoritova
D V Maslov
R Z Gatich
Source
Vopr Virusol. 2006 Jan-Feb;51(1):19-23
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Animals
Antibodies, Viral - blood - immunology
Antibody Specificity
Antigens, Viral - immunology
Antiviral Agents - pharmacology
Blood Donors
Cell Line
Child
Child, Preschool
Drug Resistance, Viral
Humans
Influenza A Virus, H1N1 Subtype - immunology
Influenza A Virus, H3N2 Subtype - classification - drug effects - immunology
Influenza, Human - blood - virology
Middle Aged
Rimantadine - pharmacology
Russia
Species Specificity
Abstract
Studies indicated that the epidemic rise in the incidence of influenza was caused by its virus A (H3N2) circulation in Russia in the 2003-2004 season. The Center of Influenza Ecology and Epidemiology investigated 101 epidemic strains isolated the MDCK culture. Antigenic analysis showed that all viruses A(H3N2) were similar to the reference virus A/Fujian/411/02(H3N2) and only 5 strains slightly differed from the latter. Twelve (14%) strains resistant to rimantadine at a concentration of 0.5 mg/ml were identified. Investigation of paired sera from the patients demonstrated a rise of antibodies to the references of influenza virus A(H3N2) in 68.7% of cases and a less increase in those to influenza viruses A(H1N1) and B. The active circulation of A(H3N2) viruses was due not only to changes in their antigenic structure, but also to the low level of antibodies to these viruses, as shown by the analysis of donor sera.
PubMed ID
16515037 View in PubMed
Less detail

[Comparative antiviral activity of the Penicillium funiculosum virus and its RNA]

https://arctichealth.org/en/permalink/ahliterature69141
Source
Mikrobiol Zh. 1974 May-Jun;36(3):341-6
Publication Type
Article

Development of oseltamivir and zanamivir resistance in influenza A(H1N1)pdm09 virus, Denmark, 2014.

https://arctichealth.org/en/permalink/ahliterature282237
Source
Euro Surveill. 2017 Jan 19;22(3)
Publication Type
Article
Date
Jan-19-2017
Author
Ramona Trebbien
Svend Stenvang Pedersen
Kristine Vorborg
Kristina Træholt Franck
Thea Kølsen Fischer
Source
Euro Surveill. 2017 Jan 19;22(3)
Date
Jan-19-2017
Language
English
Publication Type
Article
Keywords
Antiviral Agents - pharmacology - therapeutic use
Denmark
Drug Resistance, Viral - genetics
Genotype
Humans
Immunocompromised Host
Influenza A Virus, H1N1 Subtype - drug effects - genetics - isolation & purification
Influenza, Human - diagnosis - drug therapy - virology
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Middle Aged
Mutation - drug effects
Neuraminidase - genetics
Oseltamivir - pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome
Zanamivir - pharmacology
Abstract
Antiviral treatment of immunocompromised patients with prolonged influenza virus infection can lead to multidrug resistance. This study reveals the selection of antiviral resistance mutations in influenza A(H1N1)pdm09 virus in an immunocompromised patient during a 6-month period. The patient was treated with two courses of oseltamivir (5 days and 2 months, respectively), with the first course starting at symptom onset, and subsequently zanamivir (2 months and 10 days, respectively). Respiratory samples were investigated by Sanger and next generation sequencing (NGS) and, for NGS data, low-frequency-variant-detection analysis was performed. Neuraminidase-inhibition tests were conducted for samples isolated in Madin-Darby canine kidney cells. In a sample collected 15 days after the end of the first treatment with oseltamivir (Day 20 post-symptom onset), oseltamivir resistance was detected (mutation H275Y with 60.3% frequency by NGS). Day 149 when the patient had almost completed the second zanamivir treatment, mixes of the following resistance mutations were detected; H275Y(65.1%), I223R(9.2%), and E119G(89.6%), accompanied by additional mutations, showing a more complex viral population in the long-term treated patient. Two samples obtained on Day 151 from bronchoalveolar lavage (BAL) and nasopharyngeal swab, respectively, showed different mutation profiles, with a higher frequency of antiviral resistance mutations in BAL. The results emphasise the importance of timely antiviral resistance testing both for treatment of individual patients as well as for preventive measures to control the development and transmission of antiviral resistant viruses.
Notes
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PubMed ID
28128091 View in PubMed
Less detail

[Effect of 1-amino adamantane on reproduction of fixed rabies virus in tissue culture]

https://arctichealth.org/en/permalink/ahliterature13566
Source
Mikrobiol Zh. 1968 Jul-Aug;30(4):340-4
Publication Type
Article

50 records – page 1 of 5.