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129 records – page 1 of 13.

Accumulation and depuration of the synthetic antioxidant ethoxyquin in the muscle of Atlantic salmon (Salmo salar L.).

https://arctichealth.org/en/permalink/ahliterature86374
Source
Food Chem Toxicol. 2008 May;46(5):1834-43
Publication Type
Article
Date
May-2008
Author
Bohne Victoria J Berdikova
Lundebye Anne-Katrine
Hamre Kristin
Author Affiliation
National Institute of Nutrition and Seafood Research (NIFES), Nordnes, Bergen, Norway. victoria.bohne@nifes.no
Source
Food Chem Toxicol. 2008 May;46(5):1834-43
Date
May-2008
Language
English
Publication Type
Article
Keywords
Agriculture
Algorithms
Animal Feed - analysis
Animals
Antioxidants - metabolism
Body Weight - drug effects
Data Interpretation, Statistical
Diet
Dose-Response Relationship, Drug
Ethoxyquin - metabolism
Growth - drug effects
Humans
Lipids - analysis
Mice
Muscle, Skeletal - chemistry - metabolism
Norway
Salmo salar - metabolism
Abstract
The biological fate of the fish feed additive, ethoxyquin (EQ) was examined in the muscle of Atlantic salmon during 12 weeks of feeding followed by a 2 weeks depuration period. Parent EQ (1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline), quinone imine (2,6-dihydro-2,2,4-trimethyl-6-quinolone), de-ethylated EQ (6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline) and EQDM (EQ dimer or 1,8'-di(1,2-dihydro-6-ethoxy-2,2,4-trimethyl-quinoline) were found to be the ubiquitous metabolites of dietary EQ, with EQDM as a main metabolite. A rapid decrease in the level of EQ (2.4 days of half-life) was balanced by an increase in EQDM, giving an unchanged net sum following 2 weeks of depuration. The mandatory 14 days depuration period prior to slaughtering of farmed salmon in Norway was not sufficient for complete elimination of EQ-derived residuals. Post depuration, EQDM accounted for 99% of sum of the two compounds in all treatment groups; possible toxicological effects of EQDM are not known. The individual concentrations of EQ and EQDM and their sum are dependent on EQ level in the feed, consequently, their residual concentrations may be controlled. The theoretical amount of EQ and EQDM consumed in one meal of farmed salmon would be under the recommended ADI, provided that the fish were raised on feed with no more than 150 mg EQ/kg feed, which is the EU maximum limit for EQ in fish feed.
PubMed ID
18329775 View in PubMed
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[A correction of lipid peroxidation and antioxidant defense by enterosorption with the use of polysorbates during the combined treatment of the III/IV stage ovarian cancer]

https://arctichealth.org/en/permalink/ahliterature10804
Source
Klin Khir. 1998;(5):30-1
Publication Type
Article
Date
1998
Author
O I Temchenko
I M Klishch
Source
Klin Khir. 1998;(5):30-1
Date
1998
Language
Ukrainian
Publication Type
Article
Keywords
Antineoplastic Agents - therapeutic use
Antioxidants - metabolism
Combined Modality Therapy
English Abstract
Enterosorption - methods
Female
Humans
Lipid Peroxidation - drug effects
Neoplasm Staging
Ovarian Neoplasms - therapy
Polysorbates - pharmacology - therapeutic use
Surface-Active Agents - pharmacology - therapeutic use
Abstract
In 62 patients with ovarial cancer of III-IV stage under the influence of enterosorption using polysorb the contents of primary and intermediate products of peroxidal oxidation of lipids have reduced and the antioxidant system indexes did not change.
PubMed ID
9787568 View in PubMed
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[Activity of enzymatic antioxidant system in the rat tissues under conditions of over- and restricted nutrition]

https://arctichealth.org/en/permalink/ahliterature97370
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Publication Type
Article
Author
Iu V Nikitchenko
V M Dziuba
A S Popovych
V V Bondar
H O Sheremet
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Antioxidants - metabolism
Caloric Restriction
Glutathione Peroxidase - metabolism
Lipid Peroxides - blood - metabolism
Liver - enzymology - metabolism
Male
Overnutrition - blood - enzymology
Oxidation-Reduction
Rats
Rats, Wistar
Thyroid Hormones - blood
Abstract
The state of enzymatic antioxidant system and thyroid status in the rat tissues under early postnatal overnutrition leading to shortening of life-span and calorie-restricted diet extending lifespan have been studied. It was found that the concentration of thyroxine, body weight and content of lipid hydroperoxides in the blood serum and liver post-mitochondrial fraction of rats had been reliably increased. At the same time the concentration of GSH and GSSG, superoxide dismutase, Se-dependent glutathione peroxidase (GP) activities in the liver and GP activity in the blood serum of experimental rats were reduced. The use of calorie-restricted diet for 2 months showed considerable decrease of thyroxine and triiodothyronine concentration, body weight and the content of lipid hydroperoxides in the blood serum of experimental rats compared with control. At the same time GP activity in the liver, Se-dependent GP activity and content of ceruloplasmin in blood of experimental rats were essentially enhanced. The obtained results allow to conclude that from all studied indices the activity of GSH-dependent antioxidant system (especially Se-dependent GP activity) and thyroid status revealed the most sensible changes in response to the used kind of nutrition. Unlike hypocaloric diet overnutrition results in a decrease of Se-dependent GP activity in the liver and blood of rats. That may be the most crucial moment in the maintenance of prooxidant-antioxidant balance of tissues.
PubMed ID
20387664 View in PubMed
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[Activity of glutathione-dependent antioxidant system of the rat liver and blood depending on gamma-irradiation and diet]

https://arctichealth.org/en/permalink/ahliterature89398
Source
Ukr Biokhim Zh. 2008 Nov-Dec;80(6):66-73
Publication Type
Article
Author
Nikitchenko Iu V
Padalko V I
Tkachenko V M
Sheremet H O
Tovstiak V V
Source
Ukr Biokhim Zh. 2008 Nov-Dec;80(6):66-73
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Antioxidants - metabolism
Diet
Dietary Supplements
Gamma Rays
Glutathione Peroxidase - blood - metabolism
Glutathione Transferase - blood - metabolism
Liver - enzymology - metabolism - radiation effects
Male
Microsomes, Liver - enzymology - metabolism - radiation effects
Mitochondria, Liver - enzymology - metabolism - radiation effects
Photinia - chemistry
Plant Extracts - administration & dosage - isolation & purification - therapeutic use
Radiation Injuries, Experimental - blood - metabolism - prevention & control
Rats
Rats, Wistar
Abstract
The role of the glutathione-dependent antioxidant system in the prooxidant-antioxidant balance support was studied in the experiments with Wistar male rat under single gamma-irradiation (8 Gr dose), fed with unbalanced (as to animal proteins and antioxidant vitamins) diet and with addition of Aronia melanocarpa. Single gamma-irradiation of animals led to the decrease of selenium-dependent glutathione-peroxidase activity in the blood plasma and glutathione-S-transferase activity decrease in rat liver mitochondria. Animals which received the unbalanced food allowance under irradiation showed more expressed change of glutathione-dependent antioxidant enzymes activity, namely--proved decrease of glutathione-peroxidase and glutathione-S-transferase activity in liver microsomes and less expressed activation of selenium-dependent glutathione-peroxidase activity in the postmitochondrial fraction of laboratory animals liver. Introduction of the A. melanocarpa food supplement in the unbalanced diet of the laboratory animals which in vitro demonstrated expressed antioxidant and antiradical activity had no effect upon glutathione-peroxidase activity in the investigated tissues. Obtained data concerning significant decrease of the activity of glutathione-dependent antioxidant system and, particularly, of the selenium-dependent glutathione-peroxidase activity under the unbalanced diet condition may be useful in maintenance of prooxidant-antioxidant balance in the tissues of irradiated animals. Allowing for the above stated it is advisable to seek for new food additives which increase activity of the endogenous glutathione-dependent antioxidant enzymes for human tolerance improvement, especially under the unbalanced food allowance condition.
PubMed ID
19351059 View in PubMed
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[Adaptation-compensatory response in adolescents, indigenous people North of Irkutsk region].

https://arctichealth.org/en/permalink/ahliterature257305
Source
Fiziol Cheloveka. 2014 Mar-Apr;40(2):80-6
Publication Type
Article
Author
L I Kolesnikova
M A Darenskaia
L A Grebenkina
E V Osipova
M I Dolgikh
N V Semenova
Source
Fiziol Cheloveka. 2014 Mar-Apr;40(2):80-6
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological
Adolescent
Antioxidants - metabolism
Child
Ethnic Groups
Female
Humans
Lipid Peroxidation - physiology
Male
Siberia
Abstract
A study of pro- and antioxidant status in healthy boys and girls adolescents' representatives Tofalars and Evenks compared to Caucasians newcomers. Revealed activation of the adaptive-compensatory processes in the body young men and women, indigenous peoples of the North as compared to Caucasians alien population, which was reflected statistically significant increase in non-enzymatic components of antioxidant defense system.
PubMed ID
25272710 View in PubMed
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[Age-related changes in blood plasma antioxidant activity in population of the southern Altai].

https://arctichealth.org/en/permalink/ahliterature123935
Source
Zh Evol Biokhim Fiziol. 2012 Mar-Apr;48(2):135-7
Publication Type
Article
Author
E A Chanchaev
R I Aizman
Source
Zh Evol Biokhim Fiziol. 2012 Mar-Apr;48(2):135-7
Language
Russian
Publication Type
Article
Keywords
Adult
Age Factors
Antioxidants - metabolism
Ethnic Groups
Female
Humans
Hydrogen Peroxide - blood
Male
Middle Aged
Russia
Abstract
The blood plasma antioxidant activity was studied in the Russian and Kazakh aborigines of the southern Altai low and high mountains. There was established a decrease of the blood plasma antioxidant activity with age and a relatively low plasma antioxidant activity in the mid-mountain population; in its senior age groups, the gender differences of this parameter were revealed.
PubMed ID
22645974 View in PubMed
Less detail

Aging and the brown Norway rat leydig cell antioxidant defense system.

https://arctichealth.org/en/permalink/ahliterature83080
Source
J Androl. 2006 Mar-Apr;27(2):240-7
Publication Type
Article
Author
Luo Lindi
Chen Haolin
Trush Michael A
Show Matthew D
Anway Matthew D
Zirkin Barry R
Author Affiliation
Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. lluo@jhsph.edu
Source
J Androl. 2006 Mar-Apr;27(2):240-7
Language
English
Publication Type
Article
Keywords
Aging - physiology
Animals
Antioxidants - metabolism
Glutathione Peroxidase - genetics - metabolism
Leydig Cells - enzymology
Male
RNA, Messenger - genetics
Rats
Rats, Inbred BN
Superoxide Dismutase - genetics - metabolism
Testis - growth & development
Transcription, Genetic
Abstract
Previous studies have shown that testosterone production by the Leydig cells of aged Brown Norway rats is reduced from the relatively high levels produced by Leydig cells of young rats and that this reduction is not secondary to decreased serum luteinizing hormone concentration. The free radical theory of aging proposes that imbalance between pro-oxidants and the antioxidant defense system ultimately results in oxidative damage to cellular processes. With this in mind, we hypothesized herein that age-related reductions in steroidogenesis by Brown Norway rat Leydig cells may be associated with the impairment of the antioxidant defense system of these cells. To begin to test this hypothesis, we compared the activities and steady-state mRNA and protein levels of the antioxidant enzymes copper zinc (CuZn) superoxide dismutase (CuZnSOD, SOD1), manganese (Mn) superoxide dismutase (MnSOD, SOD2), and glutathione peroxidase (GPx) and the levels of reduced and oxidized glutathione in Leydig cells isolated from the testes of young (4-month-old) and aged (20-month-old) Brown Norway rats. For some studies, Leydig cells were isolated separately from aged testes that either had regressed because of age-related losses of germ cells or that were nonregressed. SOD (total) and GPx activities were found to decrease significantly with age whether or not the testes were regressed. CuZnSOD and MnSOD mRNA levels decreased with aging, though the magnitude of the decreases were considerably lower than the respective decreases in enzyme activities. GPx mRNA levels also decreased, which is consistent with the decreases seen in enzyme activity. MnSOD protein expression declined with age, and to a lesser extent, CuZnSOD did as well. Reduced and oxidized glutathione also exhibited age-related reductions in cells from both normal and regressed aged testes. The age-related decreases in Leydig cell antioxidant enzyme activities, gene expression, and protein levels and in glutathione were consistent with the hypothesis that the loss of steroidogenic function that accompanies Leydig cell aging may result in part from a decrease in the fidelity of the cellular antioxidant defense system.
PubMed ID
16304208 View in PubMed
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Antioxidant activity of blood plasma in individuals with neoplasms.

https://arctichealth.org/en/permalink/ahliterature18806
Source
Bull Exp Biol Med. 2002 May;133(5):481-3
Publication Type
Article
Date
May-2002
Author
A V Marusin
V B Salyukov
E Yu Bragina
Author Affiliation
Institute of Medical Genetics, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. marussin@img.tsu.ru
Source
Bull Exp Biol Med. 2002 May;133(5):481-3
Date
May-2002
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Aged, 80 and over
Antioxidants - metabolism
Female
Humans
Iron - metabolism
Male
Middle Aged
Neoplasms - blood
Phosphatidylcholines - metabolism
Plasma - metabolism
Sex Factors
Abstract
In 3 groups of patients with neoplasms plasma antioxidant activity was measured by the yield of TBA-reactive products generated in lecithin-Fe(2+) model system. Patients with laryngeal, tongue, oropharyngeal, oral, and laryngopharyngeal tumors showed lower plasma antioxidant activity compared to patients with breast, lung, and bronchial cancer (p
PubMed ID
12420067 View in PubMed
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[Antioxidant activity of blood plasma of mountain Altai's aborigines Russian and Kazakh nationality of low and medium height altitude areas].

https://arctichealth.org/en/permalink/ahliterature123651
Source
Fiziol Cheloveka. 2012 Mar-Apr;38(2):101-6
Publication Type
Article
Author
E A Chanchaeva
O S Kogteva
R I Aizman
Source
Fiziol Cheloveka. 2012 Mar-Apr;38(2):101-6
Language
Russian
Publication Type
Article
Keywords
Adult
Age Factors
Antioxidants - metabolism - physiology
Environment
Ethnic Groups
Female
Humans
Hydrogen Peroxide - blood
Male
Middle Aged
Russia
Abstract
Due to the points about dependence antioxidant activity of organism of human on a nationality, climatic conditions, quality of nutrition are scanty under study a estimate antioxidant activity of blood plasma of Altai's low and medium height altitude aborigines. As a result there has been discovered a dependence of antioxidant activity of blood plasma more upon age and at least geographical and climatic conditions, sex and quality of nutrition.
PubMed ID
22679803 View in PubMed
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[Antioxidant activity of blood plasma of south Altai's indigenous population of low and medium height altitude areas].

https://arctichealth.org/en/permalink/ahliterature101716
Source
Fiziol Cheloveka. 2011 Mar-Apr;37(2):60-5
Publication Type
Article
Author
N A Krivova
E A Chanchaeva
Source
Fiziol Cheloveka. 2011 Mar-Apr;37(2):60-5
Language
Russian
Publication Type
Article
Keywords
Adult
Aging - blood
Altitude
Antioxidants - metabolism
Climate
Data Interpretation, Statistical
Ethnic Groups
Female
Free Radicals - blood
Humans
Male
Middle Aged
Plasma - metabolism
Sex Factors
Siberia
Young Adult
Abstract
Due to the fact that age change theories are still under discussion a study has been conducted on the estimation of antioxidant and antiradical activity of blood plasma. For the experiment was taken a homogeneous group of people which separate populations differ in geographical and climatic parameters of their living conditions. As a result there has been discovered a dependence of Altaians' antioxidant system upon geographical and climatic conditions, and age.
PubMed ID
21542319 View in PubMed
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129 records – page 1 of 13.