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[Administration of essential phospholipids in persons exposed to chemical industrial pollutants].

https://arctichealth.org/en/permalink/ahliterature180414
Source
Ter Arkh. 2004;76(2):63-6
Publication Type
Article
Date
2004
Author
L A Shpagina
S V Bobrov
Source
Ter Arkh. 2004;76(2):63-6
Date
2004
Language
Russian
Publication Type
Article
Keywords
Antioxidants - administration & dosage - therapeutic use
Hazardous Substances - poisoning
Humans
Liver Function Tests
Occupational Diseases - drug therapy - etiology
Occupational Exposure - adverse effects
Phosphatidylcholines - administration & dosage - therapeutic use
Poisoning - drug therapy - etiology
Russia
Treatment Outcome
Abstract
To examine efficacy of the drug essliver-forte in patients with chronic intoxication by a complex of such toxicants as soluble and unsoluble compounds of uranium, lead and mercury.
The examination of bilirubin, synthesis of proteins and enzyme production by the liver, activity of free radical lipid oxidation and antioxidant defence was conducted in 42 persons (mean age 66.4 +/- 4.2 years) occupationally exposed to chemicals (compounds of uranium, lead and mercury) for 12.6 +/- 1.8 years. The patients were divided into two equal groups: patients of group 1 received standard therapy with enterosorbents, cerebral angioprotectors and alpha-tocopherol; patients of group 2 instead of alpha-tocopherol were given essliver-forte (2 capsules twice a day).
Patients of group 2 had significantly less frequent complaints for fatigue, anxiety, dyspnea, sleep disorders; improvement was observed in peripheral blood counts, in concentrations of alpha 2- and gamma-globulins, sulfhydril and catalase activity of erythrocytes; transaminase activity and intensity of saponin hemolysis went down.
Essliver-forte is effective in persons occupationally exposed to chemicals.
PubMed ID
15106419 View in PubMed
Less detail

[Clinical and morphologic efficacy of a complex antioxidant and energy correction therapy of different duration in brain infarction: results of a multicenter randomized trial].

https://arctichealth.org/en/permalink/ahliterature267728
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(8):45-52
Publication Type
Article
Date
2015
Author
S A Rumyantsev?
A L Kovalenko
E V Silin?
V A Stupin
E N Kabaeva
L V Chichanovskaya
M V Nazarov
L A Tsukurova
D V Burenichev
K V Golikov
M V Salnikov
L A Belova
V V Mashin
N K Mazina
E A Zhilina
O Yu Kolotik-Kameneva
M A Sherman
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(8):45-52
Date
2015
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Antioxidants - administration & dosage - therapeutic use
Ascorbic Acid - administration & dosage - therapeutic use
Brain Infarction - drug therapy - pathology - radiography
Drug Combinations
Energy Metabolism
Female
Flavin Mononucleotide - administration & dosage - therapeutic use
Humans
Infusions, Intravenous
Inosine Diphosphate - administration & dosage - therapeutic use
Male
Middle Aged
Niacinamide - administration & dosage - therapeutic use
Russia
Succinates - administration & dosage - therapeutic use
Tomography, X-Ray Computed
Treatment Outcome
Abstract
To compare clinical and morphological results of treatment of ischemic stroke in three groups of patients which differed by the forms and duration of an antioxidant therapy.
A randomized clinical trial was performed in 8 vascular centers of the Russian Federation in 2010-2014. It included 373 patients with ischemic stroke in the carotid territory. Patients were randomized into 3 groups to receive different regimens of antioxidant therapy as an adjunct to standard therapy: control group (ascorbic acid; 132 patients); cytoflavin (20 ml per day for 10 days; 133 patients); cytoflavin (the dose was decreased to 10 ml per day from 11th to 20th day) (108 patients). Patient's condition was assessed in 1, 10 and 21 day by a complex of clinical, laboratory and instrumental methods.
The analysis of CT in 1th and 21th day revealed a significant 1,5-1,7- fold decrease in the cerebral ischemic lesion in both groups treated with cytoflavin with no significant morphologic changes in the ascorbic acid group. The percentage of patients with ischemic lesion, increased during days 1-21, was 2-fold higher in the ascorbic acid group compared to cytoflavin groups. Morphologic changes were correlated with clinical variables and outcome. In patients with =14 points on NIH scale on admission, prolonged 20 day cytoflavin therapy was associated with a more prominent improvement of neurologic, functional and cognitive status compared to 10-day cytoflavin infusion. No differences in clinical variables were observed in patients with mild symptoms (
PubMed ID
26356615 View in PubMed
Less detail

[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].

https://arctichealth.org/en/permalink/ahliterature127505
Source
Eksp Klin Farmakol. 2011;74(11):17-23
Publication Type
Article
Date
2011
Author
I A Volchegorskii
L M Rassokhina
M I Koliadich
M I Alekseev
Source
Eksp Klin Farmakol. 2011;74(11):17-23
Date
2011
Language
Russian
Publication Type
Article
Keywords
Antioxidants - administration & dosage - therapeutic use
Attention - drug effects
Cognition - drug effects
Cognition Disorders - drug therapy - metabolism - physiopathology
Diabetes Complications - drug therapy
Diabetes Mellitus - drug therapy - metabolism - physiopathology
Double-Blind Method
Female
Humans
Hyperglycemia - drug therapy
Hyperlipidemias - drug therapy - metabolism
Hypoglycemic Agents - administration & dosage - therapeutic use
Lipid Peroxidation - drug effects
Male
Middle Aged
Picolines - administration & dosage - therapeutic use
Placebos
Prospective Studies
Psychotropic Drugs - administration & dosage - therapeutic use
Quality of Life
Questionnaires
Russia
Thioctic Acid - administration & dosage - therapeutic use
Abstract
Short-term, prospective placebo-controlled simple blind randomized study of the effects of alpha-lipoic acid and mexidol on the dynamics of affective status disorders, cognitive functions, and quality of life in parallel with changes in carbohydrate metabolism and lipidemia has been conducted in diabetic patients. It is established that two-week administration of alpha-lipoic acid (600 mg once a day, i.v.) and mexidol (300 mg once a day, i.v.) reduced hyperglycemia by 13.00 with simultaneous decrease of depressive "feelings of guilt". In case of mexidol, these effects were accompanied by positive "vitality" dynamics established with SF-36 questionnaire and reflecting improvement in patients' quality of life. Additionally, course administration of alpha-lipoic acid increased attention as studied with Schulte tables. Favorable psychotropic effects of alpha-lipoic acid and mexidol were unrelated to changes in lipidemia and "lipid peroxidation - antioxidant protection" system indicators.
PubMed ID
22288155 View in PubMed
Less detail

Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers.

https://arctichealth.org/en/permalink/ahliterature179406
Source
Am J Epidemiol. 2004 Jul 1;160(1):68-76
Publication Type
Article
Date
Jul-1-2004
Author
Margaret E Wright
Susan T Mayne
Rachael Z Stolzenberg-Solomon
Zhaohai Li
Pirjo Pietinen
Philip R Taylor
Jarmo Virtamo
Demetrius Albanes
Author Affiliation
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA. wrighmar@mail.nih.gov
Source
Am J Epidemiol. 2004 Jul 1;160(1):68-76
Date
Jul-1-2004
Language
English
Publication Type
Article
Keywords
Aged
Antioxidants - administration & dosage - therapeutic use
Cohort Studies
Diet
Double-Blind Method
Finland - epidemiology
Humans
Incidence
Life Style
Lung Neoplasms - epidemiology - etiology - prevention & control
Male
Middle Aged
Questionnaires
Registries
Risk factors
Smoking - adverse effects
alpha-Tocopherol - administration & dosage - therapeutic use
beta Carotene - administration & dosage - therapeutic use
Abstract
In many observational studies, a higher intake of individual antioxidants is inversely associated with lung cancer risk. Data from in vitro and animal experiments suggest that there are biochemical interactions among antioxidant nutrients; therefore, consideration of multiple antioxidants simultaneously may be important in terms of risk estimation. The authors constructed a dietary antioxidant index and evaluated its ability to predict lung cancer risk within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. At baseline (1985-1988), 27,111 Finnish male smokers aged 50-69 years completed a dietary questionnaire that assessed usual frequency of consumption and portion sizes for the previous 12 months. A total of 1,787 incident cases of lung cancer were identified during a follow-up period of up to 14.4 years (1985-1999). Principal components analyses were individually applied to the carotenoid, flavonoid, and vitamin E nutrient groups, and summation of retained principal component scores, plus selenium and vitamin C, yielded the composite antioxidant index. In multivariate proportional hazards models, the relative risks for lung cancer according to increasing quintiles of the antioxidant index were 1.00 (referent), 1.00 (95% confidence interval (CI): 0.87, 1.14), 0.91 (95% CI: 0.79, 1.05), 0.79 (95% CI: 0.68, 0.92), and 0.84 (95% CI: 0.72, 0.98) (p for trend = 0.002). These findings support the hypothesis that a combination of dietary antioxidants reduces lung cancer risk in male smokers.
PubMed ID
15229119 View in PubMed
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Dietary antioxidant capacity and risk for stroke in a prospective cohort study of Swedish men and women.

https://arctichealth.org/en/permalink/ahliterature283619
Source
Nutrition. 2017 Jan;33:234-239
Publication Type
Article
Date
Jan-2017
Author
Luca Colarusso
Mauro Serafini
Ylva Trolle Lagerros
Olof Nyren
Carlo La Vecchia
Marta Rossi
Weimin Ye
Alessandra Tavani
Hans-Olov Adami
Alessandra Grotta
Rino Bellocco
Source
Nutrition. 2017 Jan;33:234-239
Date
Jan-2017
Language
English
Publication Type
Article
Keywords
Adult
Antioxidants - administration & dosage - therapeutic use
Brain Ischemia - epidemiology - ethnology - prevention & control
Cohort Studies
Diet - ethnology
Female
Follow-Up Studies
Humans
Incidence
Intracranial Hemorrhages - epidemiology - ethnology - prevention & control
Male
Middle Aged
Nutrition Surveys
Proportional Hazards Models
Prospective Studies
Registries
Risk factors
Sex Factors
Stroke - epidemiology - ethnology - prevention & control
Sweden - epidemiology
Abstract
Both observational studies and randomized trials have shown that a diet rich in antioxidants can reduce systemic inflammation and oxidative stress, two conditions that, together with obesity and smoking, are established risk factors for stroke. However, the association between antioxidant intake and risk for stroke is poorly understood, particularly when studying possible interaction with sex. We investigated the relationship of nonenzymatic antioxidant capacity (NEAC) on risk for stroke in a large Swedish prospective cohort.
The cohort study included 34 555 men and women from the Swedish National March Cohort. NEAC was assessed using a detailed food frequency questionnaire, collected at baseline. We achieved complete follow-up from enrollment in 1997 through 2010 by record linkage to nationwide registers. We identified 1186 incident cases of a first stroke, of which 860 were ischemic, 201 hemorrhagic, and 125 unspecified. We used multivariable Cox proportional hazards models to estimate adjusted hazard ratios (HR) with 95% confidence intervals (CIs).
Compared with women in the lowest quartile of NEAC, women in the highest quartile had a 27% lower incidence of total stroke (HR, 0.73; 95% CI, 0.53-0.99; Ptrend = 0.03) and 35% lower incidence of ischemic stroke (HR, 0.65; 95% CI, 0.43-0.99; Ptrend = 0.01). Among men, the relationship between NEAC and risk for stroke was not statistically significant and all HRs were close to unity.
Findings from the present study suggest that dietary antioxidant capacity from different foods and beverages is inversely associated with risk for stroke, more specifically ischemic stroke, in women.
PubMed ID
27667181 View in PubMed
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Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans.

https://arctichealth.org/en/permalink/ahliterature53777
Source
Atherosclerosis. 2002 Mar;161(1):199-207
Publication Type
Article
Date
Mar-2002
Author
Asaf A Qureshi
Saeed A Sami
Winston A Salser
Farooq A Khan
Author Affiliation
Advanced Medical Research, 8251 Raymond Road, Madison, WI 53719, USA. nqureshi@mhub.facstaff.wisc.edu
Source
Atherosclerosis. 2002 Mar;161(1):199-207
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Adult
Antioxidants - administration & dosage - therapeutic use
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Cholesterol - blood
Coronary Disease - prevention & control
Dose-Response Relationship, Drug
Female
Heat
Humans
Hypercholesterolemia - diet therapy - drug therapy
Lipoproteins, HDL Cholesterol - blood
Lipoproteins, LDL Cholesterol - blood
Male
Middle Aged
Oryza sativa
Plant Extracts - administration & dosage - therapeutic use
Research Support, Non-U.S. Gov't
Tocotrienols - administration & dosage - therapeutic use
Triglycerides - blood
Abstract
Tocotrienols are effective in lowering serum total and LDL-cholesterol levels by inhibiting the hepatic enzymic activity of beta-hydroxy-beta-methylglutaryl coenzymeA (HMG-CoA) reductase through the post-transcriptional mechanism. alpha-Tocopherol, however, has an opposite effect (induces) on this enzyme activity. Since tocotrienols are also converted to tocopherols in vivo, it is necessary not to exceed a certain dose, as this would be counter-productive. The present study demonstrates the effects of various doses of a tocotrienol-rich fraction (TRF25) of stabilized and heated rice bran in hypercholesterolemic human subjects on serum lipid parameters. Ninety (18/group) hypercholesterolemic human subjects participated in this study, which comprised three phases of 35 days each. The subjects were initially placed on the American Heart Association (AHA) Step-1 diet and the effects noted. They were then administered 25, 50, 100, and 200 mg/day of TRF25 while on the restricted (AHA) diet. The results show that a dose of 100 mg/day of TRF25 produce maximum decreases of 20, 25, 14 (P
PubMed ID
11882333 View in PubMed
Less detail

[Fluimucyl-antibiotic IT: ability of antioxidant therapy for patients with acute attack of infectious chronic obstructive lung disease]

https://arctichealth.org/en/permalink/ahliterature82247
Source
Lik Sprava. 2006 Jan-Sep;(1-2):65-81
Publication Type
Article
Author
Vysotiuk L.
Hromova A.
Source
Lik Sprava. 2006 Jan-Sep;(1-2):65-81
Language
Ukrainian
Publication Type
Article
Keywords
Acetylcysteine - administration & dosage - therapeutic use
Acute Disease
Anti-Bacterial Agents - administration & dosage - therapeutic use
Antioxidants - administration & dosage - therapeutic use
Drug Combinations
Humans
Lipid Peroxidation - drug effects
Male
Middle Aged
Oxidative Stress - drug effects
Pulmonary Disease, Chronic Obstructive - drug therapy - metabolism - microbiology - physiopathology
Respiration - drug effects
Thiamphenicol - administration & dosage - therapeutic use
Treatment Outcome
Abstract
The article presents current views on the role of acid-dependent reactions in the development of daptative and compensative processes of human being. The authors outline oxidative stress as the most important part in the pathogenesis of broncho-pulmonary system diseases. The authors underline in the article the role of non-invasive methods to detect oxidative stress derivates to assess the state of Lipid Peroxidation -AOZ system, carry out differential diagnostics of broncho-obstructive syndrome and monitor the efficacy of anti-inflammatory therapy. The article presents the data on antioxidative systems protecting human body. Complex interconnections between the system generating free-radical compounds and the system utilizing these compound are described in the article. The authors focused on literature data concerning influence of Fluimucyl (N-acetylcysteine) on oxidant-antioxidant system in patients with chronic obstructive lung diseases. The article presents experience results on Fluimucyl-antibiotic IT use in 25 patients with acute attack of stage II and III infectious chronic obstructive lung disease. These results show that Fluimucyl use reduces disease clinical symptoms at the acute stage, normalizes oxidative blood activity (against serum ceruloplasmin level), has positive influence on external respiration indices and eradicates infectious agents causing exacerbation of chronic obstructive lung disease. The study results confirm that combined Fluimucyl-antibiotic IT is a pathogenetic and antioxidative treatment for patients with moderate and severe exacerbation of chronic obstructive lung disease.
PubMed ID
16689098 View in PubMed
Less detail

Oral hydrogen water prevents chronic allograft nephropathy in rats.

https://arctichealth.org/en/permalink/ahliterature98754
Source
Kidney Int. 2010 Jan;77(2):101-9
Publication Type
Article
Date
Jan-2010
Author
Jon S Cardinal
Jianghua Zhan
Yinna Wang
Ryujiro Sugimoto
Allan Tsung
Kenneth R McCurry
Timothy R Billiar
Atsunori Nakao
Author Affiliation
Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA.
Source
Kidney Int. 2010 Jan;77(2):101-9
Date
Jan-2010
Language
English
Publication Type
Article
Keywords
Administration, Oral
Animals
Antioxidants - administration & dosage - therapeutic use
Biological Markers - metabolism
Graft Survival - drug effects
Hydrogen - administration & dosage - therapeutic use
Inflammation - metabolism
Kidney Function Tests
Kidney Transplantation - adverse effects
Male
Rats
Rats, Inbred Lew
Renal Insufficiency, Chronic - etiology - metabolism - prevention & control
Signal Transduction - drug effects
Transplantation, Homologous
Weight Gain - drug effects
Abstract
Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway recipients that had undergone bilateral nephrectomy. Molecular hydrogen was dissolved in water and recipients were given HW from day 0 until day 150. Rats that were treated with regular water (RW) gradually developed proteinuria and their creatinine clearance declined, ultimately leading to graft failure secondary to CAN. In contrast, treatment with HW improved allograft function, slowed the progression of CAN, reduced oxidant injury and inflammatory mediator production, and improved overall survival. Inflammatory signaling pathways, such as mitogen-activated protein kinases, were less activated in renal allografts from HW-treated rats as compared with RW-treated rats. Hence, oral HW is an effective antioxidant and antiinflammatory agent that prevented CAN, improved survival of rat renal allografts, and may be of therapeutic value in the setting of transplantation.
Notes
RefSource: Kidney Int. 2010 Jan;77(2):85-7
PubMed ID
19907413 View in PubMed
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8 records – page 1 of 1.