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22 records – page 1 of 3.

Distribution of the blood groups of the Norwegian lapps.

https://arctichealth.org/en/permalink/ahliterature43650
Source
Am J Phys Anthropol. 1972 Mar;36(2):257-66
Publication Type
Article
Date
Mar-1972

Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.

https://arctichealth.org/en/permalink/ahliterature172833
Source
J Neuroimmunol. 2005 Dec 30;170(1-2):122-33
Publication Type
Article
Date
Dec-30-2005
Author
Hilde Monica F Riise Stensland
Janna Saarela
Denis O Bronnikov
Maija Parkkonen
Anne J Jokiaho
Aarno Palotie
Pentti J Tienari
Marja-Liisa Sumelahti
Irina Elovaara
Keijo Koivisto
Tuula Pirttilä
Mauri Reunanen
Eric Sobel
Leena Peltonen
Author Affiliation
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Source
J Neuroimmunol. 2005 Dec 30;170(1-2):122-33
Date
Dec-30-2005
Language
English
Publication Type
Article
Keywords
Chromosome Mapping
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 5
Finland
Genetic Linkage
Genetic Predisposition to Disease - genetics
HLA-DR Antigens - classification - genetics
Haplotypes
Humans
Linkage Disequilibrium
Lod Score
Microsatellite Repeats
Multiple Sclerosis - genetics
Abstract
Linkage analyses have identified four major MS susceptibility loci in Finns. Here we have fine mapped the region on chromosome 5p in 28 Finnish MS families. Marker D5S416 provided the highest pairwise LOD score, and multipoint and haplotype analyses restrict the critical region to about 5.3 Mb on 5p15 between markers D5S1987 and D5S416. Ascertaining for HLA type and geographical origin indicated that families with and without the HLA DR15 risk haplotype, as well as families within and outside an internal high-risk region, contributed to the linkage to 5p, implying the general significance for this locus in Finnish MS families.
PubMed ID
16169605 View in PubMed
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[Heterogeneity of hepatitis B virus and diagnostic potential of modern test systems for the detection of HBsAg].

https://arctichealth.org/en/permalink/ahliterature125897
Source
Zh Mikrobiol Epidemiol Immunobiol. 2012 Jan-Feb;(1):68-75
Publication Type
Article
Author
S N Kuzin
E E Zabotina
N N Zabelin
E N Kudriavtseva
E I Samokhvalov
O V Borisova
T A Manina
E V Lisitsina
L E Kuzina
N A Malyshev
V F Lavrov
Source
Zh Mikrobiol Epidemiol Immunobiol. 2012 Jan-Feb;(1):68-75
Language
Russian
Publication Type
Article
Keywords
Adult
Amino Acid Substitution - immunology
DNA, Viral - analysis - biosynthesis
Female
Genetic Heterogeneity
Genotype
Hepatitis B Antibodies - analysis - immunology
Hepatitis B Surface Antigens - classification - genetics - immunology
Hepatitis B virus - classification - genetics - immunology
Hepatitis B, Chronic - diagnosis - immunology
Humans
Immunoassay
Male
Middle Aged
Mutation
Open Reading Frames - immunology
Promoter Regions, Genetic - immunology
Protein Precursors - classification - genetics - immunology
Protein Structure, Tertiary
Russia
Sensitivity and specificity
Abstract
Study heterogeneity ofhepatitis B virus in adult patients with chronic hepatitis B and determination of diagnostic potential of modern test systems with the detection of HBsAg with amino acid substitutions in the main hydrophilic region (MHR).
In 27 hepatitis B virus samples isolated from patients with chronic hepatitis B virus infection living in Vladimir, nucleotide sequence ofgenome region corresponding to preS1/preS2/S genes was determined.
In all of the 27 isolates genotype D virus presented by 3 subgenotypes D1, D2, D3 was detected in 18%, 26% and 56% respectively. Based on the distribution of nucleotide substitutions in the compared functional regions of hepatitis B virus (virus entry into the cell coding site (2875 - 2991 n.b.), pre-S2/S promoter region (2994 - 3171 n.b.), 5'-end pre-S2 and S-genes sequences (3172 - 154 n.b. and 155-455 n.b.), MHR (455 - 635 n.b.) and 3'-end S-gene sequence (636 - 835 n.b.), substitutions are mostly concentrated in the promoter region of the S2/S-genes (30.8%). HBsAg serotypes were determined in 24 of 27 cases by using the predicted amino acid sequence, and in 17 cases HBsAg belonged to ayw2 (71%) serotype and in 7 cases - to ayw3 serotype (29%). Amino acid substitutions G145A, M133I, S132T localized in the main hydrophilic region and P217L, S207N, V184A localized in the C-end of the protein C that are connected with diagnostic and vaccine escape were identified in 5 isolates.
Diagnostic potential of test systems with the detection of HBsAg with known amino acid sequence of the MHR region were studied. Approximately equal potential of 6 test systems to detect HBsAg with amino acid substitutions G145A, M133I and S132T localized in the MHR region were shown.
PubMed ID
22442974 View in PubMed
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HLA alleles and IDDM in children in Hungary: a comparison with Finland.

https://arctichealth.org/en/permalink/ahliterature195080
Source
Hum Immunol. 2001 Apr;62(4):391-8
Publication Type
Article
Date
Apr-2001
Author
R. Hermann
C H Mijovic
M. Rayner
N. Croft
M A Kelly
D. Jenkins
G. Soltész
A H Barnett
Author Affiliation
Department of Paediatrics, University Medical School of Pécs, Hungary.
Source
Hum Immunol. 2001 Apr;62(4):391-8
Date
Apr-2001
Language
English
Publication Type
Article
Keywords
Alleles
Child
Diabetes Mellitus, Type 1 - epidemiology - genetics - immunology
Female
Finland - epidemiology
Gene Frequency
Genotype
HLA-DQ Antigens - classification - genetics
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens - classification - genetics
HLA-DRB1 Chains
Haplotypes
Humans
Hungary - epidemiology
Incidence
Male
Risk factors
Abstract
It has been postulated that variation in the distribution of human leukocyte antigen (HLA)-encoded susceptibility alleles for insulin-dependent diabetes mellitus (IDDM) is the genetic basis for variation in the incidence of the disease between populations. The aim of this study was to characterize HLA-encoded susceptibility to IDDM in Hungary and to identify whether HLA-DRB1/DQ-encoded susceptibility could account for the five times lower incidence of disease in Hungary compared with Finland. The haplotypes DRB1*03-DQA1*05-DQB1*02 (DRB1*03-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DRB1*04-DQ8) were significantly associated with disease in both populations. Three genotypes incorporating either or both of these haplotypes accounted for over 70% of the diabetic population in both races. The combined background frequency and the degree of risk as measured by odds ratios of these HLA-DRB1-DQ genotypes were not significantly different in the two countries. Comparison of the DRB1*0401-DQ8 haplotype between the two races suggested a role for HLA-B alleles in susceptibility. These data indicate that the susceptibility associated with high risk DRB1-DQ genotypes alone is insufficient to account for the fivefold variation in incidence of IDDM between Hungary and Finland. Other genetic and/or environmental influences must be involved.
PubMed ID
11295472 View in PubMed
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HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis.

https://arctichealth.org/en/permalink/ahliterature14263
Source
Tissue Antigens. 1997 Feb;49(2):116-23
Publication Type
Article
Date
Feb-1997
Author
S. Gonzalez-Roces
M V Alvarez
S. Gonzalez
A. Dieye
H. Makni
D G Woodfield
L. Housan
V. Konenkov
M C Abbadi
N. Grunnet
E. Coto
C. López-Larrea
Author Affiliation
Department of Immunology, Hospital Central de Asturias, Oviedo, Spain.
Source
Tissue Antigens. 1997 Feb;49(2):116-23
Date
Feb-1997
Language
English
Publication Type
Article
Keywords
Alleles
Disease Susceptibility
HLA-B27 Antigen - classification - genetics
Humans
Phylogeny
Polymorphism, Genetic
Population
Research Support, Non-U.S. Gov't
Spondylitis, Ankylosing - genetics - immunology
World Health
Abstract
HLA-B27 is strongly associated to ankylosing spondylitis (AS) and represents a family of eleven B27 alleles (B*2701-11). Our aim was to analyze the distribution of B27 subtypes by PCR/SSOP and genomic sequencing in a large group of populations (n = 17). 711 B27-positive samples from Caucasoid, Asian, African, Amerindian and Polynesian populations were selected to ascertain transracial gene mapping of the B27 subtypes. 476 of these were AS patients, chosen to investigate the contribution of B27 alleles to AS susceptibility. Some significant new findings have arisen from this study: 1) B*2705 was the predominant subtype in circumpolar and subarctic areas. B*2702 was found to be practically restricted to Caucasian populations, showing a higher frequency in Middle-East (Jews) and North Africa (Arabs/Berbers) groups. 2) B*2703 appears associated with AS in Western Africans. This is of remarkable interest since it was suggested that B*2703 would be negatively disease-associated. 3) Although B*2706 appears negatively associated with AS in Thais, we identified two patients from northern China carrying it. This may be a reflection of a disease heterogeneity and could indicate that more than one pathogenic agent can be involved in AS. B*2709 has been recently described as negatively associated with AS in Sardinians. The molecular changes His114Asp (B*2706) and Asp116His (B*2709) could modify the genetic susceptibility to AS.
Notes
Erratum In: Tissue Antigens 1997 Sep;50(3):315
PubMed ID
9062966 View in PubMed
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HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations.

https://arctichealth.org/en/permalink/ahliterature33306
Source
Tissue Antigens. 1999 May;53(5):459-69
Publication Type
Article
Date
May-1999
Author
A. Spurkland
S. Saarinen
K M Boberg
S. Mitchell
U. Broome
L. Caballeria
E. Ciusani
R. Chapman
G. Ercilla
O. Fausa
I. Knutsen
A. Pares
F. Rosina
O. Olerup
E. Thorsby
E. Schrumpf
Author Affiliation
Institute of Immunology, National Hospital, Oslo, Norway.
Source
Tissue Antigens. 1999 May;53(5):459-69
Date
May-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Cholangitis, Sclerosing - genetics - immunology - physiopathology
Europe
Female
Genotype
HLA-DQ Antigens - classification - genetics
HLA-DR Antigens - classification - genetics
Haplotypes
Histocompatibility testing
Humans
Male
Middle Aged
Research Support, Non-U.S. Gov't
Abstract
The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR=3.0, P
PubMed ID
10372541 View in PubMed
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HLA-DRB1 in eight Finnish monozygotic twin pairs concordant for rheumatoid arthritis.

https://arctichealth.org/en/permalink/ahliterature209178
Source
Tissue Antigens. 1997 Mar;49(3 Pt 1):277-9
Publication Type
Article
Date
Mar-1997
Author
N. de Vries
H. Tijssen
P. Jarvinen
K. Aho
L B van de Putte
Author Affiliation
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Source
Tissue Antigens. 1997 Mar;49(3 Pt 1):277-9
Date
Mar-1997
Language
English
Publication Type
Article
Keywords
Arthritis, Rheumatoid - genetics - immunology
Case-Control Studies
Cohort Studies
Female
Finland
HLA-DR Antigens - classification - genetics
HLA-DRB1 Chains
Humans
Male
Twins, Monozygotic - genetics
Abstract
This study presents the results of HLA-DRB1 typing of the eight monozygotic twin pairs with both members affected by rheumatoid arthritis (RA), sampled in the nationwide Finnish twin cohort. The shared epitope, associated with RA in case-control studies, was present in all eight twin pairs, being significantly more frequent than among RA patients in a recent Dutch case-control study. Furthermore, 4 out of 8 twin pairs were homozygous for the shared epitope, while in 73 Dutch healthy controls encoding the shared epitope only 13 (18%) were homozygous: this suggests a gene dose effect in RA susceptibility. Combining these results with data from other sources may help to clarify the contribution of HLA alleles in the genetic predisposition to RA.
PubMed ID
9098938 View in PubMed
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[Human histocompatibility antigens (HL-A-antigens). Genetic studies and identification of "new" HL-A-antigens]

https://arctichealth.org/en/permalink/ahliterature44144
Source
Nord Med. 1970 Feb 12;83(7):193-7
Publication Type
Article
Date
Feb-12-1970

22 records – page 1 of 3.