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Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men.

https://arctichealth.org/en/permalink/ahliterature8997
Source
J Natl Cancer Inst. 2006 Mar 15;98(6):407-13
Publication Type
Article
Date
Mar-15-2006
Author
Susanna C Larsson
Niclas Håkansson
Edward Giovannucci
Alicja Wolk
Author Affiliation
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se
Source
J Natl Cancer Inst. 2006 Mar 15;98(6):407-13
Date
Mar-15-2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol Drinking - adverse effects
Anticarcinogenic Agents - administration & dosage - metabolism
Dietary Supplements
Female
Folic Acid - administration & dosage - metabolism
Food Habits
Fruit
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Pancreatic Neoplasms - epidemiology - etiology - prevention & control
Proportional Hazards Models
Prospective Studies
Questionnaires
Research Support, Non-U.S. Gov't
Risk factors
Smoking - adverse effects
Sweden - epidemiology
Treatment Outcome
Vegetables
Abstract
BACKGROUND: Epidemiologic evidence supports an association between high folate intake and reduced risk of some cancers, in particular colorectal cancer. However, epidemiologic data concerning the relationship between folate and pancreatic cancer risk are sparse. We examined the association between folate intake and risk of pancreatic cancer in a population-based prospective study of Swedish women and men. METHODS: We prospectively followed 81,922 women and men in the Swedish Mammography Cohort and the Cohort of Swedish Men who were cancer-free and completed a 96-item food-frequency questionnaire in 1997. Cox proportional hazards models were used to estimate multivariable rate ratios (RRs) with 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS: A total of 135 incident pancreatic cancer cases were diagnosed during a mean follow-up of 6.8 years. In multivariable analyses controlling for age, smoking, fruit and vegetable consumption, and other potential confounders, dietary and total folate intakes were statistically significantly inversely associated with risk of pancreatic cancer. The multivariable rate ratios of pancreatic cancer for those in the highest category of folate intake (> or = 350 microg/day) compared with the lowest category of intake ( or = 300 microg/day compared with 0 microg/day of supplemental folic acid, multivariable RR = 1.02; 95% CI = 0.56 to 1.88). The sex- and age-standardized incidence rates of pancreatic cancer per 100,000 person-years were 41 for the lowest and 18 for the highest category of dietary folate intake. CONCLUSION: Our results suggest that increased intake of folate from food sources, but not from supplements, may be associated with a reduced risk of pancreatic cancer.
PubMed ID
16537833 View in PubMed
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