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The 1996 Albert Lasker Medical Research Awards. Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines.

https://arctichealth.org/en/permalink/ahliterature34605
Source
JAMA. 1996 Oct 9;276(14):1181-5
Publication Type
Article
Date
Oct-9-1996
Author
J B Robbins
R. Schneerson
P. Anderson
D H Smith
Author Affiliation
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2720, USA.
Source
JAMA. 1996 Oct 9;276(14):1181-5
Date
Oct-9-1996
Language
English
Publication Type
Article
Keywords
Animals
Antibody formation
Awards and Prizes
Bacterial Capsules - immunology
Bacterial Vaccines - immunology
Clinical Medicine - history
Communicable disease control
Haemophilus Infections - prevention & control
Haemophilus Vaccines - immunology
Haemophilus influenzae - immunology
History, 20th Century
Humans
Immunogenetics
Meningitis, Haemophilus - prevention & control
Polysaccharides, Bacterial - immunology
United States
Vaccines, Conjugate - immunology
Abstract
The development of Haemophilus influenzae type b (Hib) conjugate vaccines has led to the virtual elimination of systemic infections caused by that pathogen, has provided insights into the pathogenesis of and immunity to other capsulated bacteria, and has contributed to the development of new vaccines. Meningitis, a common and serious infection of children, and other infections caused by Hib have been virtually eliminated in countries that have achieved widespread vaccination with Hib conjugates, including the United States, Canada, the United Kingdom, Iceland, Scandinavia, France, and Germany. Hib conjugates have also been shown to be highly effective in developing countries. The principles derived from the use of these vaccines, along with studies of other capsulated pathogens, should allow the rapid inclusion of new polysaccharide-based conjugates into routine vaccination schedules of infants, and should help to realize further reductions in serious systemic infectious diseases.
PubMed ID
8827975 View in PubMed
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[A calendar of prophylactic inoculations in wide practical use]

https://arctichealth.org/en/permalink/ahliterature38630
Source
Zh Mikrobiol Epidemiol Immunobiol. 1988 Jan;(1):37-41
Publication Type
Article
Date
Jan-1988
Author
L M Chudnaia
A B Shekhter
L S Krasiuk
V G Oksiiuk
B N Fastovskaia
Source
Zh Mikrobiol Epidemiol Immunobiol. 1988 Jan;(1):37-41
Date
Jan-1988
Language
Russian
Publication Type
Article
Keywords
Antibody formation
Child
Child, Preschool
Comparative Study
Diphtheria Toxoid - immunology
Diphtheria-Tetanus-Pertussis Vaccine
Drug Combinations - immunology
English Abstract
Humans
Immunization Schedule
Immunization, Secondary
Infant
Measles Vaccine - immunology
Mumps Vaccine - immunology
Pertussis Vaccine - immunology
Poliovirus Vaccine, Inactivated - immunology
Rural Population
Tetanus Toxoid - immunology
Time Factors
Ukraine
Urban Population
Vaccination
Abstract
The validity of immunizations, made in due time in children aged up to 7 years in accordance with the approved immunization schedule, is analyzed in this work. The content of antibodies to diphtheria, tetanus and poliomyelitis antigens in children immunized in accordance with the old and new schedules has been studied. This study has revealed that the injection of adsorbed DPT vaccine to children aged 3-4 months induces fully valid immune response to all antigens under study. The level of measles and parotitis antibodies after the injections of measles and parotitis vaccines, introduced separately and simultaneously, has been measured. The simultaneous administration of these preparations did not decrease the levels of immunity to parotitis and measles.
PubMed ID
3259058 View in PubMed
Less detail
Source
Wien Med Wochenschr. 1991;141(12):270-2
Publication Type
Article
Date
1991
Author
G. Wiedermann
F. Ambrosch
H. Vanura
Author Affiliation
Institut für Spezifische Prophylaxe und Tropenmedizin, Universität Wien.
Source
Wien Med Wochenschr. 1991;141(12):270-2
Date
1991
Language
German
Publication Type
Article
Keywords
Antibody Formation - immunology
Antigens, Bacterial - administration & dosage - immunology
Bordetella pertussis - immunology
English Abstract
Humans
Pertussis Vaccine - administration & dosage - immunology
Toxoids - administration & dosage - immunology
Vaccines, Inactivated - administration & dosage - immunology
Whooping Cough - immunology - prevention & control
Abstract
Acellular pertussis vaccines contain antigen components of B. pertussis, usually lymphocytosis promoting factor (LPF) which is also called pertussis-toxin (PT) or pertussigen, filamentous hemagglutinin (FH) and, eventually, agglutinogens 2 and 3. Acellular vaccines are being used in Japan since 1981. Several Phase II studies have been performed and showed a better tolerability than whole cell vaccines and antibody responses of at least equal magnitude. In some of these studies good protection rates were observed. The latter were not satisfactory in a Phase III study in Sweden. This study, however, might cause some criticism in as much as only 2 vaccine doses were given and a control group with whole cell vaccine was missing. Moreover, the significance of bacterial infections in vaccinated children is doubtful, similar observations have not been made in other trials nor in Japan since introduction of the vaccine in 1981. Preliminary results of our own study with a newly developed acellular vaccine which has been permitted by the Austrian Drug Commission have shown good tolerability.
PubMed ID
1949820 View in PubMed
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Activation of the immune system and systemic immune-complex deposits in Brown Norway rats with dental amalgam restorations.

https://arctichealth.org/en/permalink/ahliterature72544
Source
J Dent Res. 1998 Jun;77(6):1415-25
Publication Type
Article
Date
Jun-1998
Author
P. Hultman
U. Lindh
P. Hörsted-Bindslev
Author Affiliation
Department of Health and Environment, Linköping University, Sweden.
Source
J Dent Res. 1998 Jun;77(6):1415-25
Date
Jun-1998
Language
English
Publication Type
Article
Keywords
Analysis of Variance
Animals
Antibody Formation - drug effects
Antigen-Antibody Complex - analysis - blood
Autoimmune Diseases - chemically induced
Autoimmunity
Body Burden
Comparative Study
Copper - analysis
Dental Amalgam - toxicity
Dinitrobenzenes
Female
Immune Complex Diseases - chemically induced
Immunoglobulin E - blood
Laminin
Lymphocyte Activation - drug effects
Mercury - analysis - blood - pharmacokinetics
Rats
Rats, Inbred BN
Rats, Inbred Lew
Research Support, Non-U.S. Gov't
Silver - analysis
Spectrum Analysis, Mass
Statistics, nonparametric
Tissue Distribution
Abstract
Dental amalgam restorations are a significant source of mercury exposure in the human population, but their potential to cause systemic health effects is highly disputed. We examined effects on the immune system by giving genetically mercury-susceptible Brown Norway (BN) rats and mercury-resistant Lewis (LE) rats silver amalgam restorations in 4 molars of the upper jaw, causing a body burden similar to that described in human amalgam-bearers (from 250 to 375 mg amalgam/kg body weight). BN rats with amalgam restorations, compared with control rats given composite resinous restorations, developed a rapid activation of the immune system, with a maximum 12-fold increase of the plasma IgE concentration after 3 wks (p 0.05). After 12 wks, BN rats with amalgam restorations showed significantly increased (p spleen > cerebrum occipital lobe > cerebellum > liver > thymus, and the tissue silver concentration was significantly (p
PubMed ID
9649170 View in PubMed
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[Age-related characteristics of the immune status in children of the first year of life in the Amur region]

https://arctichealth.org/en/permalink/ahliterature37329
Source
Pediatriia. 1991;(6):109-10
Publication Type
Article
Date
1991

[A new approach to the therapy of pyoderma in servicemen: the use of the actoprotector bemitil].

https://arctichealth.org/en/permalink/ahliterature204985
Source
Voen Med Zh. 1998 May;319(5):50-4, 96
Publication Type
Article
Date
May-1998
Author
A V Samtsov
G N Tarasenko
A V Smirnov
Source
Voen Med Zh. 1998 May;319(5):50-4, 96
Date
May-1998
Language
Russian
Publication Type
Article
Keywords
Adjuvants, Immunologic - therapeutic use
Adult
Antibody Formation - drug effects
Benzimidazoles - therapeutic use
Chronic Disease
Drug Evaluation
Humans
Immunity, Cellular - drug effects
Military Personnel
Ointments
Pyoderma - drug therapy - immunology
Recurrence
Russia
Tablets
Abstract
At 51 men at the age from 20 till 30, sick with pyodermatitis, the clinical-immunological aspects and efficiency of-actoprotector, capable to support motor activity and human performance in the extreme environments. Bemitil has appeared more effective in comparison with conventional therapy: by general and combined application the parameters of immunity have been normalized statistically authentically, and at outside application-the places of damage were cleared faster, disappeared painfulness, hyperemia, edema, terms of staying in the hospital were reduced. The clinical recovery was in 86.3 +/- 4.8% of the patients, while effectiveness from conventional means was 62.1 +/- 6.8%.
PubMed ID
9680838 View in PubMed
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An influenza B epidemic within a remote Alaska community. Serologic, epidemiologic, and clinical observations.

https://arctichealth.org/en/permalink/ahliterature7074
Source
JAMA. 1970 Oct 19;214(3):507-12
Publication Type
Article
Date
Oct-19-1970
Author
P S Clark
E T Feltz
B. List-Young
D G Ritter
G R Noble
Source
JAMA. 1970 Oct 19;214(3):507-12
Date
Oct-19-1970
Language
English
Geographic Location
U.S.
Publication Type
Article
Keywords
Acute Disease
Adolescent
Adult
Age Factors
Alaska
Antibody formation
Child
Child, Preschool
Disease Outbreaks
Female
Hemagglutination inhibition tests
Humans
Infant
Influenza Vaccines - administration & dosage - isolation & purification
Influenza, Human - blood - complications - diagnosis - epidemiology - immunology - prevention & control
Male
Middle Aged
Sex Factors
Abstract
During January 1969 an epidmic of influenza B was documented in Klawock, Alaska, a remote insular community 80 miles west of Ketchikan. One person died and 149 others developed an acute respiratory disease characterized by fever, cough, headache, and coryza. A fourfold or greater rise in hemagglutination-inhibiting (HI) antibody titer to influenza B developed in 26 persons, and influenza B virus was isolated from 5 patients. Reciprocal HI testing of the Alaska strain (B/Alaska/4-69) did not disclose a significant antigenic difference from the vaccine strain (B/Massachusetts/3-66). However, 36 of the 46 persons who had been vaccinated during the preceding 3 to 12 months developed clinical influenza, and the attack rate within this group did not differ significantly from the attack rate among the unvaccinated population.
PubMed ID
5469025 View in PubMed
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[Antibodies of a varying physicochemical nature in whooping cough infection].

https://arctichealth.org/en/permalink/ahliterature252250
Source
Zh Mikrobiol Epidemiol Immunobiol. 1975 May;(5):143-4
Publication Type
Article
Date
May-1975

335 records – page 1 of 34.