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185 records – page 1 of 19.

5-aminosalicylic acid dependency in Crohn's disease: a Danish Crohn Colitis Database study.

https://arctichealth.org/en/permalink/ahliterature138932
Source
J Crohns Colitis. 2010 Nov;4(5):575-81
Publication Type
Article
Date
Nov-2010
Author
Dana Duricova
Natalia Pedersen
Margarita Elkjaer
Jens K Slott Jensen
Pia Munkholm
Author Affiliation
Clinical and Research Center for Inflammatory Bowel Disease, ISCARE a.s. and Charles University in Prague, Czech Republic. dana.duricova@seznam.cz
Source
J Crohns Colitis. 2010 Nov;4(5):575-81
Date
Nov-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Crohn Disease - drug therapy
Denmark
Drug Utilization
Female
Hospitals, University
Humans
Male
Mesalamine - therapeutic use
Middle Aged
Phenotype
Retrospective Studies
Sex Factors
Time Factors
Treatment Outcome
Young Adult
Abstract
The role of 5-aminosalicylic acid (5-ASA) in Crohn's disease is unclear. The outcome of the first course of 5-ASA monotherapy with emphasis on 5-ASA dependency was retrospectively assessed in consecutive cohort of 537 Crohn's disease patients diagnosed 1953-2007.
Following outcome definitions were used: Immediate outcome (30 days after 5-ASA start) defined as complete/partial response (total regression/improvement of symptoms) and no response (no regression of symptoms with a need of corticosteroids, immunomodulator or surgery). Long-term outcome defined as prolonged response (still in complete/partial response 1 year after induction of response); 5-ASA dependency (relapse on stable/reduced dose of 5-ASA requiring dose escalation to regain response or relapse =1 year after 5-ASA cessation regaining response after 5-ASA re-introduction).
One hundred sixty-five (31%) patients had monotherapy with 5-ASA. In 50% 5-ASA monotherapy was initiated =1 year after diagnosis (range 0-49 years). Complete/partial response was obtained in 75% and no response in 25% of patients. Thirty-six percent had prolonged response, 23% developed 5-ASA dependency and 38% were non-responders in long-term outcome. Female gender had higher probability to develop prolonged response or 5-ASA dependency (OR 2.89, 95%CI: 1.08-7.75, p=0.04). The median duration (range) of 5-ASA monotherapy was 34 months (1-304) in prolonged responders, 63 (6-336) in 5-ASA dependent and 2 (0-10) in non-responders.
A selected phenotype of Crohn's disease patients may profit from 5-ASA. Fifty-nine percent of patients obtained long-term benefit with 23% becoming 5-ASA dependent. Prospective studies are warranted to assess the role of 5-ASA in Crohn's disease.
PubMed ID
21122562 View in PubMed
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Acute pain management services have progressed, albeit insufficiently in Canadian academic hospitals.

https://arctichealth.org/en/permalink/ahliterature181204
Source
Can J Anaesth. 2004 Mar;51(3):231-5
Publication Type
Article
Date
Mar-2004
Author
David H Goldstein
Elizabeth G VanDenKerkhof
William C Blaine
Author Affiliation
Department of Anesthesiology, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. goldsted@kgh.kari.net.
Source
Can J Anaesth. 2004 Mar;51(3):231-5
Date
Mar-2004
Language
English
Publication Type
Article
Keywords
Acute Disease
Anesthesiology - education
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biomedical research
Canada
Humans
Pain, Postoperative - drug therapy
Abstract
Acute pain management services (APMS) evolved in response to the desire for improved management of postoperative pain. The management of postoperative pain received formal support from international organizations over the past decade and by 1993 half of the Canadian university-affiliated teaching hospitals had implemented an APMS. The purpose of this survey was to describe APMSs in Canadian academic institutions, with specific emphasis on postoperative analgesics, new analgesic methods, training and research.
Between June 2000 and January 2001, 62 Canadian hospitals affiliated with the 16 Canadian university anesthesiology departments were sent a postal questionnaire.
Fifty of the 62 respondents returned a completed questionnaire representing a response rate of 81%. Eighty percent of the hospitals surveyed had at least 200 beds, 90% (45) had implemented an APMS. Anesthesiology was primarily responsible in all 45 hospitals with an APMS. The results presented are based on the 45 centres with an APMS.
Since the early 1990s the percent of Canadian academic hospitals with an APMS has increased from 53% to 92%. These figures are comparable to the United States. Greater collaboration from nursing and pharmacy, mandatory training for medical and nursing students and residents, and a standardized approach to continuous quality improvement remain necessary.
PubMed ID
15010404 View in PubMed
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Acute sarcoid arthritis: a favourable outcome? A retrospective survey of 49 patients with review of the literature.

https://arctichealth.org/en/permalink/ahliterature14315
Source
Scand J Rheumatol. 1996;25(2):70-3
Publication Type
Article
Date
1996
Author
J T Gran
E. Bøhmer
Author Affiliation
Department of Rheumatology, Central Hospital of Aust Agder, Arendal, Norway.
Source
Scand J Rheumatol. 1996;25(2):70-3
Date
1996
Language
English
Publication Type
Article
Keywords
Acute Disease
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis - complications - drug therapy - etiology
Female
Humans
Male
Middle Aged
Multicenter Studies
Retrospective Studies
Sarcoidosis - complications
Time Factors
Treatment Outcome
Abstract
Forty-nine patients, 30 males and 19 females with acute sarcoid arthritis admitted to three different hospitals in Norway were studied retrospectively. All patients had peripheral arthritis and hilar adenopathy, and 87.8% also presented with erythema nodosum (EN). Mean duration of arthritis was 3.7 months (0.5-12 months), but in 26% of the cases, duration of the inflammatory joint disease exceeded three months. Radiological bony erosions were not seen. Two patients had recurrence of acute sarcoid arthritis, 14 months and 10 years after the initial episode, respectively. Two other patients developed chronic myalgia and fibromyalgia. Four patients, one female and three males, developed chronic pulmonal sarcoidosis. Of these, two patients had simultaneous onset of acute sarcoid arthritis and parenchymal disease while two patients developed chronic lung disease three months after onset of acute sarcoid arthritis. We thus tentatively suggest that although acute sarcoid arthritis is usually a self-limiting joint disease, recurrences may occasionally occur and some cases develop chronic sarcoidosis of the lungs.
PubMed ID
8614769 View in PubMed
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Acute sarcoid arthritis: occurrence, seasonal onset, clinical features and outcome.

https://arctichealth.org/en/permalink/ahliterature14350
Source
Br J Rheumatol. 1995 Jan;34(1):45-50
Publication Type
Article
Date
Jan-1995
Author
A. Glennås
T K Kvien
K. Melby
O K Refvem
O. Andrup
B. Karstensen
J E Thoen
Author Affiliation
Oslo City Department of Rheumatology, Norwegian Lutheran Hospital.
Source
Br J Rheumatol. 1995 Jan;34(1):45-50
Date
Jan-1995
Language
English
Publication Type
Article
Keywords
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis, Reactive - complications - drug therapy
Erythema Nodosum - etiology
Female
Follow-Up Studies
Humans
Lung Diseases - etiology
Male
Middle Aged
Norway - epidemiology
Prospective Studies
Research Support, Non-U.S. Gov't
Sarcoidosis - complications - drug therapy - epidemiology
Seasons
Treatment Outcome
Abstract
In a 2-yr prospective follow-up study of patients presenting clinically with possible reactive arthritis (ReA), 17 (9%) of the patients turned out to have acute sarcoid arthritis (SA). The number of new cases of SA per year was 2.9/100,000 persons in the city of Oslo between 18 and 60 yr of age. The onset of SA clustered in the spring. All the SA patients presented with bilateral ankle joint involvement and bilateral hilar lymphadenopathy, and ten (59%) presented with the triad of erythema nodosum, arthritis and lung involvement. A prospective follow-up after 104 weeks showed complete remission of arthritis in all 17 cases of SA. The total duration of arthritis [median (range)] was 11 (2-107) weeks. Erythema nodosum was mild and transient in all cases. At week 104, the lung and hilar manifestations had resolved. We conclude that the outcome of SA appeared favourable. Bilateral ankle joint involvement, erythema nodosum and bilateral hilar lymphadenopathy found at the routine chest X-ray examination are important clues for the diagnosis of SA.
PubMed ID
7881838 View in PubMed
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Source
Can Fam Physician. 2007 Nov;53(11):1961-2
Publication Type
Article
Date
Nov-2007
Author
Graham J Worrall
Author Affiliation
Dr William H. Newhook Memorial Health Centre, Whitbourne, NL. gworrall@mun.ca
Source
Can Fam Physician. 2007 Nov;53(11):1961-2
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Adult
Age Distribution
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Child
Child, Preschool
Family Practice - methods
Female
Humans
Incidence
Male
Newfoundland and Labrador - epidemiology
Pharyngitis - drug therapy - epidemiology - microbiology
Risk assessment
Sex Distribution
Streptococcal Infections - diagnosis - drug therapy - epidemiology
Streptococcus agalactiae - drug effects - isolation & purification
Treatment Outcome
Notes
Cites: Ann Intern Med. 2001 Mar 20;134(6):506-811255529
Cites: Cochrane Database Syst Rev. 2006;(4):CD00002317054126
Cites: CMAJ. 1998 Jan 13;158(1):75-839475915
Cites: Clin Infect Dis. 2002 Jul 15;35(2):113-2512087516
PubMed ID
18000276 View in PubMed
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Adherence to medical treatment in relation to pregnancy, birth outcome & breastfeeding behavior among women with Crohn's disease.

https://arctichealth.org/en/permalink/ahliterature280216
Source
Dan Med J. 2016 Jul;63(7)
Publication Type
Article
Date
Jul-2016
Author
Mette Julsgaard
Source
Dan Med J. 2016 Jul;63(7)
Date
Jul-2016
Language
English
Publication Type
Article
Keywords
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Birth weight
Breast Feeding - psychology
Crohn Disease - drug therapy - epidemiology
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Infant, Newborn
Male
Patient compliance
Pilot Projects
Population Surveillance
Pregnancy
Pregnancy Complications - drug therapy - epidemiology
Pregnancy outcome
Prevalence
Retrospective Studies
Abstract
Crohn's disease (CD) is common among women of fertile age, and it often requires maintenance medical treatment. Adherence to medical treatment among women with CD prior to, during, and after pregnancy has, however, never been examined. Although CD women have increased risk of adverse pregnancy outcomes, little is known about predictors for these outcomes in women with CD. In addition, the impact of breastfeeding on disease activity remains controversial.
The aims of this PhD thesis were to determine adherence to treatment and to investigate predictors for and prevalence rates of non-adherence to maintenance medical treatment among women with CD prior to, during, and after pregnancy; to assess pregnancy outcomes among women with CD, taking medical treatment, smoking status, and disease activity into account; to assess breastfeeding rates and the impact of breastfeeding on the risk of relapse.
We conducted a population-based prevalence study including 154 women with CD who had given birth within a six-year period. We combined questionnaire data, data from medical records, and medical register data.
Among 105 (80%) respondents, more than half reported taking medication with an overall high adherence rate of 69.8%. Counselling, previous pregnancy, and planned pregnancy seemed to decrease the likelihood of non-adherence, whereas smoking seemed to predict non-adherence prior to pregnancy, although our sample size prevented any firm conclusions. During pregnancy, the vast majority (95%) of CD women were in remission. The children's birth weight did not differ in relation to maternal medical treatment, but mean birth weight in children of smokers in medical treatment was 274 g lower than that of children of non-smokers in medical treatment. In our relatively small study CD women in medical treatment were not at increased risk of adverse pregnancy outcomes compared with untreated women with CD. In total, 87.6% of CD women were breastfeeding, and rates did not vary by medical treatment. Smoking and non-adherence seemed to predict relapse in CD during the postpartum period, whereas breastfeeding seemed protective against relapse.  
Although we generally had low statistical precision this thesis suggests that counselling regarding medical treatment may be an important factor for medical adherence among CD women of fertile age. In addition CD women in medical treatment did not seem at increased risk of adverse pregnancy outcome, but smoking predicted lower birth weight. Breastfeeding did not seem to increase the risk of relapse in CD.
PubMed ID
27399984 View in PubMed
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Adherence to vascular protection drugs in diabetic patients in Quebec: a population-based analysis.

https://arctichealth.org/en/permalink/ahliterature144306
Source
Diab Vasc Dis Res. 2010 Apr;7(2):167-71
Publication Type
Article
Date
Apr-2010
Author
Shabnam Asghari
Josiane Courteau
Catherine Drouin
Jean-Pierre Grégoire
André C Carpentier
Mariane Pâquet
Alain Vanasse
Author Affiliation
PRIMUS Group, Centre de recherche clinique Etienne-Le Bel, CHUS, Sherbrooke (QC), Canada.
Source
Diab Vasc Dis Res. 2010 Apr;7(2):167-71
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Aged
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin - therapeutic use
Diabetic Angiopathies - prevention & control
Female
Humans
Male
Medication Adherence - statistics & numerical data
Middle Aged
Multivariate Analysis
Quebec
Retrospective Studies
Abstract
The purpose of this study was to assess adherence to vascular protection drugs in diabetic patients using a cohort of diabetic patients aged >or=30 years, covered by the public drug insurance in the province of Quebec, excluding gestational diabetes and patients who were hopitalized or died during the 1-year follow-up. Drug adherence was measured using the medication possession ratio. Multivariate analyses, including logit and multinomial logit were used. Of the 170,381 diabetics (mean age: 62 +/- 14 years), 18% and 32% were regular users of ASA and ACEIs/ARBs, respectively. Regular use increased with age (p
PubMed ID
20382781 View in PubMed
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Administrative claims data analysis of nurse practitioner prescribing for older adults.

https://arctichealth.org/en/permalink/ahliterature149161
Source
J Adv Nurs. 2009 Oct;65(10):2077-87
Publication Type
Article
Date
Oct-2009
Author
Andrea L Murphy
Ruth Martin-Misener
Charmaine Cooke
Ingrid Sketris
Author Affiliation
School of Nursing, Dalhousie University, Halifax, Nova Scotia, Canada. andrea.murphy@dal.ca
Source
J Adv Nurs. 2009 Oct;65(10):2077-87
Date
Oct-2009
Language
English
Publication Type
Article
Keywords
Aged
Anti-Infective Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Drug Prescriptions - economics - nursing - statistics & numerical data
Female
Health Services Research
Health Services for the Aged
Humans
Insurance, Pharmaceutical Services - statistics & numerical data
Male
Nova Scotia - epidemiology
Nurse Practitioners - statistics & numerical data
Nurse's Practice Patterns - statistics & numerical data - trends
Pharmacoepidemiology
Retrospective Studies
Rural Population
Abstract
This paper is a report of a study to identify the patterns of prescribing by primary health care nurse practitioners for a cohort of older adults.
The older adult population is known to receive complex pharmacotherapy. Monitoring prescribing to older adults can inform quality improvement initiatives. In comparison to other countries, research examining nurse practitioner prescribing in Canada is limited. Nurse practitioner prescribing for older adults is relatively unexplored in the international literature. Although commonly used to study physician prescribing, few studies have used claims data from drug insurance programmes to investigate nurse practitioner prescribing.
Drug claims for prescriptions written by nurse practitioners from fiscal years 2004/05 to 2006/07 for beneficiaries of the Nova Scotia Seniors' Pharmacare programme were analysed. Data were retrieved and analysed in May 2008. Prescribing was described for each drug using the World Health Organization Anatomical Therapeutic Chemical code classification system by usage and costs for each fiscal year.
Antimicrobials and non-steroidal anti-inflammatory drugs consistently represented the top ranked groups for prescription volume and cost. Over the three fiscal years, antimicrobial prescription rates declined relative to rates of other groups of medications. Prescription volume per nurse doubled and cost per prescription increased by approximately 20%.
Prescription claims data can be used to characterize the prescribing trends of nurse practitioners. Research linking patient characteristics, including diagnoses, to prescriptions is needed to assess prescribing quality. Some potential areas of improvement were identified with antimicrobial and non-steroidal antiinflammatory selection.
PubMed ID
19674174 View in PubMed
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Adoption of celecoxib and rofecoxib: a nationwide database study.

https://arctichealth.org/en/permalink/ahliterature175412
Source
J Clin Pharm Ther. 2005 Apr;30(2):145-52
Publication Type
Article
Date
Apr-2005
Author
A. Helin-Salmivaara
R. Huupponen
A. Virtanen
T. Klaukka
Author Affiliation
Centre for Pharmacotherapy Development, Helsinki, Finland. arja.helin-salmivaara@rohto.fi
Source
J Clin Pharm Ther. 2005 Apr;30(2):145-52
Date
Apr-2005
Language
English
Publication Type
Article
Keywords
Age Factors
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Child
Databases, Factual - statistics & numerical data - trends
Drug Utilization Review - methods
Finland - epidemiology
Humans
Insurance, Pharmaceutical Services - trends - utilization
Lactones - therapeutic use
Medicine - statistics & numerical data
Physician's Practice Patterns - statistics & numerical data - trends
Product Surveillance, Postmarketing - economics - methods
Pyrazoles - therapeutic use
Retrospective Studies
Sex Factors
Specialization
Sulfonamides - therapeutic use
Sulfones - therapeutic use
Time Factors
Abstract
Cyclooxygenase 2-selective non-steroidal anti-inflammatory drugs (NSAIDs, coxibs) are recommended primarily for patients at high risk of gastrointestinal bleeding, most of them being elderly. Our objective was to describe and analyse patient- and physician-related factors affecting the adoption of celecoxib and rofecoxib 2 years after their launch in Finland.
Retrospective analysis of the nationwide Prescription Register. Physicians who had issued at least 200 reimbursed prescriptions in 2002 (n = 12 033, 80% of working-age Finnish physicians) were involved in the analysis.
Excluding patients with rheumatoid arthritis (RA), almost one-fifth (18%) of NSAIDs prescriptions were for coxibs. In patients with RA the share was 25%. The share of coxib prescriptions of all NSAIDs increased with age of the patient. Over one half (58%) of coxib prescriptions were issued for patients under 65 years of age. Specialists in physical and rehabilitation medicine were the fastest adopters of coxibs: one-third of their NSAID prescriptions in 2002 were for coxibs. Primary care physicians were the most conservative both in adopting and favouring coxibs.
Coxibs have gained the status of standard prescription NSAIDs within a few years. Their use should be restricted to patients who could benefit most from the use. Routine prescribing of expensive new drugs increases the drug bill without additional health gain.
PubMed ID
15811167 View in PubMed
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After patients are diagnosed with knee osteoarthritis, what do they do?

https://arctichealth.org/en/permalink/ahliterature144212
Source
Arthritis Care Res (Hoboken). 2010 Apr;62(4):510-5
Publication Type
Article
Date
Apr-2010
Author
Kelly A Grindrod
Carlo A Marra
Lindsey Colley
Jolanda Cibere
Ross T Tsuyuki
John M Esdaile
Louise Gastonguay
Jacek Kopec
Author Affiliation
University of British Columbia, Vancouver, British Columbia, Canada.
Source
Arthritis Care Res (Hoboken). 2010 Apr;62(4):510-5
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
British Columbia
Chondroitin - therapeutic use
Dietary Supplements
Exercise Therapy
Female
Follow-Up Studies
Glucosamine - therapeutic use
Health Surveys
Humans
Male
Middle Aged
Orthotic Devices - utilization
Osteoarthritis, Knee - drug therapy - rehabilitation
Pharmacies
Quality of Life
Risk Reduction Behavior
Self Care
Severity of Illness Index
Abstract
To learn more about the health services and products that patients use after receiving a diagnosis of knee osteoarthritis (OA), as well as the trajectory of their health-related quality of life (HRQOL).
Using a simple screening survey, community pharmacists identified 194 participants with previously undiagnosed knee OA. Of these participants, 190 were confirmed to have OA on further investigation. At baseline and 1, 3, and 6 months after diagnosis, a survey was administered to assess health services, product use, and HRQOL, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Medical Outcomes Study Short Form 36 (SF-36) health survey, the Paper Adaptive Test (PAT-5D-QOL), and the Health Utilities Index Mark 3.
With a mean age of 63 years, participants were mostly women, white, and overweight. By 6 months, more than 90% of the participants had visited their family physician to discuss their OA, and more than 50% of participants took either prescription or nonprescription analgesics. In addition, three-quarters of the participants started exercising, one-third initiated activity aids, and one-third had started natural medicine products. At 6 months compared with baseline, significant improvements were seen in the SF-36 physical component summary (P = 0.001) and bodily pain domain scores (P = 0.02), the PAT-5D-QOL overall, pain, and usual daily activities scores (P
PubMed ID
20391506 View in PubMed
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185 records – page 1 of 19.