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High serum total cholesterol is a long-term cause of osteoporotic fracture.

https://arctichealth.org/en/permalink/ahliterature141003
Source
Osteoporos Int. 2011 May;22(5):1615-20
Publication Type
Article
Date
May-2011
Author
P. Trimpou
A. Odén
T. Simonsson
L. Wilhelmsen
K. Landin-Wilhelmsen
Author Affiliation
Section for Endocrinology, Institution of Medicine, Sahlgrenska University Hospital at Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden. pinelopi.trimpou@vgregion.se
Source
Osteoporos Int. 2011 May;22(5):1615-20
Date
May-2011
Language
English
Publication Type
Article
Keywords
Adult
Anthropometry - methods
Cholesterol - blood
Coffee - adverse effects
Epidemiologic Methods
Female
Humans
Life Style
Male
Middle Aged
Motor Activity
Osteoporotic Fractures - blood - epidemiology - etiology
Recurrence
Smoking - adverse effects - epidemiology
Sweden - epidemiology
Abstract
Risk factors for osteoporotic fractures were evaluated in 1,396 men and women for a period of 20 years. Serum total cholesterol was found to be an independent osteoporotic fracture risk factor whose predictive power improves with time.
The purpose of this study was to evaluate long-term risk factors for osteoporotic fracture.
A population random sample of men and women aged 25-64 years (the Gothenburg WHO MONICA project, N?=?1,396, 53% women) was studied prospectively. The 1985 baseline examination recorded physical activity at work and during leisure time, psychological stress, smoking habits, coffee consumption, BMI, waist/hip ratio, blood pressure, total, HDL and LDL cholesterol, triglycerides, and fibrinogen. Osteoporotic fractures over a period of 20 years were retrieved from the Gothenburg hospital registers. Poisson regression was used to analyze the predictive power for osteoporotic fracture of each risk factor.
A total number of 258 osteoporotic fractures occurred in 143 participants (10.2%). As expected, we found that previous fracture, smoking, coffee consumption, and lower BMI each increase the risk for osteoporotic fracture independently of age and sex. More unexpectedly, we found that the gradient of risk of serum total cholesterol to predict osteoporotic fracture significantly increases over time (p?=?0.0377).
Serum total cholesterol is an independent osteoporotic fracture risk factor whose predictive power improves with time. High serum total cholesterol is a long-term cause of osteoporotic fracture.
PubMed ID
20821192 View in PubMed
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Obesity, smoking and secular trends in cardiovascular risk factors in middle-aged women: data from population studies in Göteborg from 1980 to 2003.

https://arctichealth.org/en/permalink/ahliterature139163
Source
J Intern Med. 2010 Dec;268(6):594-603
Publication Type
Article
Date
Dec-2010
Author
S. Johansson
L. Wilhelmsen
C. Welin
H. Eriksson
L. Welin
A. Rosengren
Author Affiliation
Department of Emergency and Cardiovascular Medicine, Sahlgrenska University Hospital/Östra, Göteborg, Sweden. saga.johansson@astrazeneca.com
Source
J Intern Med. 2010 Dec;268(6):594-603
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Anthropometry - methods
Blood Pressure - physiology
Body mass index
Cardiovascular Diseases - etiology
Cross-Sectional Studies
Female
Humans
Hypertension - complications - epidemiology
Lipids - blood
Middle Aged
Motor Activity - physiology
Obesity - complications - epidemiology
Risk factors
Smoking - adverse effects - epidemiology - trends
Stress, Psychological - complications - epidemiology
Sweden - epidemiology
Abstract
To study the trends in cardiovascular risk factors in middle-aged city-dwelling Swedish women from 1980 to 2003.
Using cross-sectional population-based surveys, five random population samples of a total of 1915 women aged between 45 and 54 years, participating in the BEDA study in 1980, WHO MONICA studies in 1985, 1990 and 1995, and a study of 50-year-old women in 2003 were measured for the following parameters: anthropometry, serum cholesterol and triglyceride levels, smoking habits, blood pressure, physical activity and stress.
Over almost 25 years, middle-aged women gained on average 4.4 kg in weight, with a net increase in body mass index (BMI) from 24.7 to 25.6 kg m?². The proportion of participants classified as obese (=30 kg m?²) increased by 50% from 10.4% to 15.1%. Women who were smokers in 2003 did not have lower BMI values than nonsmokers. Mean serum cholesterol concentrations decreased markedly, whereas smoking habits did not significantly change. The prevalence of hypertension decreased by 8%, whereas that of diabetes remained stable at around 2%. Optimal risk factor status - no smoking, normotension and serum cholesterol
PubMed ID
21091809 View in PubMed
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Teenage girls and elderly women living in northern Europe have low winter vitamin D status.

https://arctichealth.org/en/permalink/ahliterature29902
Source
Eur J Clin Nutr. 2005 Apr;59(4):533-41
Publication Type
Article
Date
Apr-2005
Author
R. Andersen
C. Mølgaard
L T Skovgaard
C. Brot
K D Cashman
E. Chabros
J. Charzewska
A. Flynn
J. Jakobsen
M. Kärkkäinen
M. Kiely
C. Lamberg-Allardt
O. Moreiras
A M Natri
M. O'brien
M. Rogalska-Niedzwiedz
L. Ovesen
Author Affiliation
Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark. ria@dfvf.dk
Source
Eur J Clin Nutr. 2005 Apr;59(4):533-41
Date
Apr-2005
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Analysis of Variance
Anthropometry - methods
Calcium - administration & dosage
Child
Chromatography, High Pressure Liquid - methods
Cross-Sectional Studies
Europe - epidemiology
Female
Humans
Nutrition Surveys
Nutritional Status - physiology
Research Support, Non-U.S. Gov't
Seasons
Smoking
Vitamin D - administration & dosage - blood
Vitamin D Deficiency - epidemiology
Abstract
OBJECTIVE: To determine the vitamin D status (serum 25-hydroxyvitamin D; S-25OHD) in adolescent girls and elderly community-dwelling women living in four countries of northern Europe and to explain differences in S-25OHD concentrations between and within the countries. DESIGN: A cross-sectional observational study conducted in a standardised way during February-March. S-25OHD was analysed by high-performance liquid chromatography. Vitamin D and calcium intake was calculated using a standardised food composition database. SETTING: Denmark, Finland, Ireland, and Poland. SUBJECTS: A total of 199 girls (mean (s.d.) age 12.6 (0.5) y) and 221 women (mean (s.d.) age 71.8 (1.4) y). RESULTS: The median (inter quartiles) concentration of S-25OHD was 29.4 (20.3, 38.3) nmol/l for the girls and 40.7 (28.0, 54.2) nmol/l for the women. S-25OHD below 25 nmol/l was found in 37% of the girls and 17% of the women, and S-25OHD below 50 nmol/l was found in 92% of the girls and 37% of the women. Positive significant determinants for S-25OHD in girls were use of vitamin D supplements, and in women sun habits, dietary vitamin D intake, use of vitamin D and calcium supplements. Body mass index and smoking were negative determinants in women. For women predictors could explain the differences between countries (P(country) = 0.09, R(2) = 0.39), but for girls the difference remained significant even after including predictors (P(country) = 0.03, R(2) = 0.15). CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623).
PubMed ID
15714215 View in PubMed
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[The features of the relationship of the indices of physical and sexual development of teenagers of the city of Chelyabinsk--the industrial center of South Ural].

https://arctichealth.org/en/permalink/ahliterature263729
Source
Gig Sanit. 2014 Jul-Aug;(4):75-8
Publication Type
Article
Author
A N Uzunova
D A Lopatina
S Yu Petrunina
A R Sharapov
E Kh Kharrasova
Source
Gig Sanit. 2014 Jul-Aug;(4):75-8
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adolescent Development
Anthropometry - methods
Body mass index
Child
Child Development
Female
Humans
Male
Russia
Sexual Development
Student Health Services
Students - statistics & numerical data
Urban Population - trends
Abstract
There was made a determination of the correlation relationships (CR) between indices of physical and sexual development (SD) of 1997 adolescents aged from 11 years 6 months to 17 years 5 months 29 days residing in the industrial center of the Southern Urals characterized by high levels of air pollution (API 7-13). Benzo(a)pyrene and formaldehyde contribute the greatest part to air pollution. The level of SD, time of appearance of secondary sexual characteristics was revealed to be interrelated with the pace of physical development of adolescents, regardless of the gender Children with an accelerated pace of physical development (macrosomatotype) are characterized by advancing sexual development and the earlier appearance of secondary sexual characteristics. Slow pace of physical development (microsomatotype) is characterized by SD retardation and the later appearance of secondary sexual characteristics. The degree of intensity of secondary sexual characteristics and such anthropometric indices as height, body mass are interrelated and have age and gender differences: the maximal CR for these indices is typical for boys aged from 13 to 16 years as for girls--of 13 and 14 years old.
PubMed ID
25842503 View in PubMed
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