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Alveolar hydatid disease. A review of clinical features of 33 indigenous cases of Echinococcus multilocularis infection in Alaskan Eskimos.

https://arctichealth.org/en/permalink/ahliterature4252
Source
American Journal of Tropical Medicine and Hygiene. 1980 Nov;29(6):1340-55
Publication Type
Article
Date
Nov-1980
Author
J F Wilson
R L Rausch
Source
American Journal of Tropical Medicine and Hygiene. 1980 Nov;29(6):1340-55
Date
Nov-1980
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adolescent
Adult
Aged
Alaska
Alveolar hydatid disease
Child
Diagnosis, Differential
Echinococcosis, Hepatic - diagnosis - pathology - surgery
Echinococcus multilocularis
Echinococcosis, Pulmonary - diagnosis - surgery
Female
Humans
Inuits
Liver - pathology
Male
Mebendazole
Middle Aged
Research Support, U.S. Gov't, P.H.S.
Zoonosis
Abstract
The clinical features of 33 cases of alveolar hydatid disease (AHD) in Alaskan Eskimos and a review of the surgical experience with this disease are presented. Among untreated patients, progression of the disease to a fatal outcome was observed in 70%. The primary hepatic lesion resembles cancer, and errors in diagnosis by both the surgeon and pathologist are common. Although surgical resection of the entire primary hepatic lesion offers the only proven curative treatment, only 26% of those explored were resectable. All seven patients resected for cure are alive 6-27 years post-operatively (average survival, 14.7 years). A 5-year experience with continuous mebendazole therapy in the management of five nonresectable cases of AHD indicates that a favorable effect of this drug is being observed. It now appears that Echinococcus infections are no longer the sole province of the surgeon. Although the role of medical therapy is not yet clearly defined, it must be considered in the management of all cases of AHD. The first reported locally-acquired case of AHD in the conterminous United States, and the widespread occurrence and expanding range of E. multilocularis in the north-central United States and south-central Canada, point to the increasing public health importance of alveolar hydatid disease.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2086.
PubMed ID
7446824 View in PubMed
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Alveolar hydatid disease of the liver: rationale and technics of surgical treatment.

https://arctichealth.org/en/permalink/ahliterature2623
Source
Annals of Surgery. 157(4):548-559.
Publication Type
Article
Date
1963
  1 website  
Author
West, J.T.
Hillman, F.J.
Rausch, R.L.
Author Affiliation
U.S. Indian Health Service
Source
Annals of Surgery. 157(4):548-559.
Date
1963
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Point Hope
Kotzebue
Savoonga
Gambell
Nome
Alveolar hydatid disease
Echinococcus multilocularis
Zoonosis
Surgery
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2084.
Cited in: Fortuine, Robert. 1968. The Health of the Eskimos: a bibliography 1857-1967. Dartmouth College Libraries. Citation number 936.
Online Resources
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An ELISA test for diagnosis and screening of Echinococcus multilocularis in a high-risk Inupiat Eskimo population.

https://arctichealth.org/en/permalink/ahliterature1387
Source
Pages 691-692 in H. Linderholm et al., eds. Circumpolar Health 87. Proceedings of the Seventh International Congress on Circumpolar Health, UmeÃ?Â¥, Sweden, 1987. Arctic Medical Research. 1988;47 Supp 1.
Publication Type
Article
Date
1988
ELISA test with semi-purified EM antigen (EM2l and the standard IHA. The EM2 test was more sensitive and specific. All 21 patients with Alveolar Hydatid Disease were positive on EM2 at diagnosis, compared to 86% on IHA. In addition, EM2 was positive earlier than IHA and showed good clinical
  1 document  
Author
Lanier, A.P.
Author Affiliation
U.S. Centers for Disease Control
Source
Pages 691-692 in H. Linderholm et al., eds. Circumpolar Health 87. Proceedings of the Seventh International Congress on Circumpolar Health, UmeÃ?Â¥, Sweden, 1987. Arctic Medical Research. 1988;47 Supp 1.
Date
1988
Language
English
Geographic Location
U.S.
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
University of Alaska Anchorage
Keywords
Alveolar hydatid disease
Echinococcus multilocularis
ELISA test
Zoonosis
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2063.
Documents
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Biotic interrelationships of helminth parasitism.

https://arctichealth.org/en/permalink/ahliterature2024
Source
Pages 18-24 in U.S. Public Health Service. Public health problems in Alaska. Reprint 3100. Also Public Health Reports. 66(29):928-934.
Publication Type
Article
Date
1951
  1 document  
Author
Rausch, R.
Author Affiliation
Arctic Health Research Center
Source
Pages 18-24 in U.S. Public Health Service. Public health problems in Alaska. Reprint 3100. Also Public Health Reports. 66(29):928-934.
Date
1951
Language
English
Geographic Location
U.S.
Publication Type
Article
File Size
848175
Physical Holding
Alaska Medical Library
Keywords
Trichinosis
Diphyllobothrium spp.
Alveolar hydatid disease
Zoonosis
Alaska
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2053.
Cited in: Fortuine, Robert. 1968. The Health of the Eskimos: a bibliography 1857-1967. Dartmouth College Libraries. Citation number 846.
Paper presented at the first comprehensive Alaskan Science Conference held in Washington, D. C., November 9 to 11, 1950, under the auspices of the National Academy of Science- National Research Council.
Documents
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Changes in the Alaskan Eskimo relation of man to dog and their effect on two human diseases.

https://arctichealth.org/en/permalink/ahliterature1408
Source
Arctic Anthropology. 17(1):2-26.
Publication Type
Article
Date
1980
Author
Lantis, M.
Author Affiliation
University of Kentucky
Source
Arctic Anthropology. 17(1):2-26.
Date
1980
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Zoonosis
Echinococcus granulosus
Echinococcus multilocularis
Alveolar hydatid disease
Cystic hydatid disease
Transmission
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2064.
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A clinical trial of mebendazole in the treatment of alveolar hydatid disease.

https://arctichealth.org/en/permalink/ahliterature2668
Source
American Review of Respiratory Disease. 1978 Oct: 118(4):747-757.
Publication Type
Article
Date
1978
Author
Wilson, J.F.
Davidson, M.
Rausch, R.L.
Author Affiliation
U.S. Indian Health Service
Source
American Review of Respiratory Disease. 1978 Oct: 118(4):747-757.
Date
1978
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Alveolar hydatid disease
Echinococcus multilocularis
Zoonosis
Administration, Oral
Adult
Aged
Benzimidazoles - therapeutic use
Drug Evaluation
Echinococcosis, Hepatic - drug therapy - immunology - radiography
Echinococcosis, Pulmonary - drug therapy - immunology - radiography
Female
Humans
Immunoglobulin E - analysis
Inuits
Liver Abscess - surgery
Male
Mebendazole - administration & dosage - adverse effects - therapeutic use
Middle Aged
Suction
Abstract
In July 1974, mebendazole was reported to be effective against the larval stage of Echinococcus granulosus in experimentally infected mice. A clinical trial of mebendazole was initiated in December 1974 in 4 patients with far advanced, nonresectable lesions caused by Echinococcus multilocularis. A daily dose of 40 mg of the drug per kg of body weight was administered to the 4 patients for more than 3 years. No evidence of toxicity or adverse reactions has been observed. Detectable plasma mebendazole concentrations were achieved with high-dose mebendazole therapy. Serum concentrations of IgE increased and decreased early in therapy. There was no evidence that the larval cestode was killed. The metastatic lesions appeared to be stabilized or diminished, and over-all clinical results were encouraging. Progressively enlarging thoracic metastases in 2 patients regressed during therapy, and symptomatic improvement was observed in all 4 patients. Mebendazole, a highly effective antihelmintic in enteric infections, is poorly absorbed by the gastrointestinal tract. Resulting low serum concentrations limit treatment of the massive, scirrhous lesions characteristic of E. multilocularis infections. Nevertheless, encouraging clinical responses observed with mebendazole therapy suggest that a more soluble form of this or a related drug might prove highly effective in the medical management of hydatid disease in humans.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2087.
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Comparison of serologic tests for the diagnosis and follow-up of alveolar hydatid disease.

https://arctichealth.org/en/permalink/ahliterature38749
Source
American Journal of Tropical Medicine and Hygiene. 1987 Nov;37(3):609-15
Publication Type
Article
Date
Nov-1987
Author
A P Lanier
D E Trujillo
P M Schantz
J F Wilson
B. Gottstein
B J McMahon
Author Affiliation
Arctic Investigations Laboratory, Centers for Disease Control, Anchorage, Alaska 99501.
Source
American Journal of Tropical Medicine and Hygiene. 1987 Nov;37(3):609-15
Date
Nov-1987
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adult
Aged
Alveolar hydatid disease
Animals
Antibodies
Antigens, Helminth - analysis
Child
Comparative Study
Echinococcosis, Pulmonary - blood - diagnosis - immunology
Echinococcus multilocularis - immunology
ELISA test
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Male
Parasitic Diseases - blood - diagnosis
Research Support, Non-U.S. Gov't
Abstract
Alveolar hydatid disease is a serious and often fatal condition caused by infection with the metacestode form of Echinococcus multilocularis. Sera of 21 patients with histologically confirmed disease were tested by an enzyme-linked immunosorbent assay (ELISA) using a semi-purified E. multilocularis antigen fraction (Em2) and by indirect hemagglutination (IHA) and double diffusion (DD5) tests using antigens prepared from E. granulosus cyst fluid. At diagnosis, sera from all 21 patients were positive by Em2 ELISA, 18 (86%) by IHA, and 5 (24%) by DD5. Em2 ELISA detected an antibody response earlier than IHA in 4 of 9 patients from whom sera were available before diagnosis. Following complete surgical resection, Em2 ELISA converted from positive to negative in serum of 2 of 3 patients, while IHA results did not change. Following incomplete resection, 14 of 15 patients tested remained positive by Em2 ELISA, while 12 remained positive by IHA. Of sera from 361 healthy persons from regions free of E. multilocularis, none were positive by Em2 ELISA, while 8% were positive by IHA. Of sera from 59 patients with non-echinococcal parasitic infections, none were positive by Em2 ELISA, while 31% were positive by IHA. Thus, in comparison with tests using E. granulosus antigens, Em2 ELISA appears to be more sensitive and specific for diagnosing AHD, useful on follow-up of resected patients, and positive earlier in the course of disease.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2062.
PubMed ID
3688314 View in PubMed
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Current status of alveolar hydatid disease in northern regions.

https://arctichealth.org/en/permalink/ahliterature2044
Source
Pages 245-247 in R. Fortuine, ed. Circumpolar Health 84. Proceedings of the International Symposium on Circumpolar Health, 6th, Anchorage, 13-18 May, 1984. University of Washington Press, Seattle.
Publication Type
Article
Date
1985
Circumpolar Health 84:245-24? THE CURRENT STATUS OF ALVEOLAR HYDATID DISEASE IN NORTHERN REGIONS ROBERT L. RAUSCH and JOSEPH F. WILSON The genus Echinocoeaus, in the family Taeniidae, includes four species of very sma 11 tapeworms that occur as adults in carnivores. The life cycles of
  1 document  
Author
Rausch, R.L.
Wilson, J.F.
Author Affiliation
University of Washington
Source
Pages 245-247 in R. Fortuine, ed. Circumpolar Health 84. Proceedings of the International Symposium on Circumpolar Health, 6th, Anchorage, 13-18 May, 1984. University of Washington Press, Seattle.
Date
1985
Language
English
Geographic Location
U.S.
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
Alaska Medical Library
Keywords
Alveolar hydatid disease
Echinococcus multilocularis
Mebendazole
Surgery
Zoonosis
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2078.
Documents
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Current status of animal-borne diseases among the Eskimos.

https://arctichealth.org/en/permalink/ahliterature832
Source
Canadian Journal of Comparative Medicine and Veterinary Science. 1961 Jul; 25(7):185-189.
Publication Type
Article
Date
1961
Author
Fortuine, R.
Source
Canadian Journal of Comparative Medicine and Veterinary Science. 1961 Jul; 25(7):185-189.
Date
1961
Language
English
Geographic Location
Multi-National
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Trichinosis
Zoonosis
Brucellosis
Fish tapeworm
Cystic hydatid disease
Alveolar hydatid disease
Rabies
Tularemia
Psittacosis
Humans
Animals
Parasites
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 1679.
Cited in: Fortuine, Robert. 1968. The Health of the Eskimos: a bibliography 1857-1967. Dartmouth College Libraries. Citation number 836.
PubMed ID
17649313 View in PubMed
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Echinococcus multilocularis infection.

https://arctichealth.org/en/permalink/ahliterature2025
Source
Pages 597-610 in Proceedings of the 6th International Congress on Tropical Medicine and Malaria, Sept. 5-13. Vol. 2.
Publication Type
Article
Date
1958
Author
Rausch, R.
Author Affiliation
Arctic Health Research Center
Source
Pages 597-610 in Proceedings of the 6th International Congress on Tropical Medicine and Malaria, Sept. 5-13. Vol. 2.
Date
1958
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Alveolar hydatid disease
Echinococcus multilocularis
Zoonosis
Abstract
Rausch discusses the controversy on the identification of Echinococcus granulosus and E. multilocularis, summarizes the information available on the host relationships and geographical distribution of E. multilocularis and gives an account of alveolar hydatid disease in man. In conclusion he emphasizes that further research is required on the epidemiology of alveolar hydatid so that preventive measures can be developed in order to produce an anthelmintic effective against the adult cestode in cats and dogs and in order to develop techniques for diagnosing the disease in man in its early stages.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2072.
Cited in: Fortuine, Robert. 1968. The Health of the Eskimos: a bibliography 1857-1967. Dartmouth College Libraries. Citation number 921.
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26 records – page 1 of 3.