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Involvement of alpha-4 integrins in allergic airway responses and mast cell degranulation in vivo.

https://arctichealth.org/en/permalink/ahliterature57560
Source
Am J Respir Crit Care Med. 1998 Oct;158(4):1127-33
Publication Type
Article
Date
Oct-1998
Author
M. Hojo
K. Maghni
T B Issekutz
J G Martin
Author Affiliation
Meakins-Christie Laboratories, McGill University, Montreal, Quebec; and the Izaak Walton Killam Children's Hospital, Grace Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
Source
Am J Respir Crit Care Med. 1998 Oct;158(4):1127-33
Date
Oct-1998
Language
English
Publication Type
Article
Keywords
Adjuvants, Immunologic - administration & dosage
Airway Resistance - immunology
Allergens - administration & dosage - immunology
Animals
Anti-Allergic Agents - immunology
Antibodies, Monoclonal - therapeutic use
Antigens, CD - immunology
Antigens, CD29 - immunology
Bile - chemistry
Bronchoalveolar Lavage Fluid - chemistry
Cell Adhesion Molecules - immunology
Cell Degranulation - immunology
Histamine - analysis
Immunization
Integrin alpha4
Integrin alpha4beta1
Integrins - immunology
Leukotriene E4 - analogs & derivatives - analysis
Male
Mast Cells - immunology
Ovalbumin - administration & dosage - immunology
Rats
Rats, Inbred BN
Receptors, Lymphocyte Homing - immunology
Receptors, Very Late Antigen - immunology
Research Support, Non-U.S. Gov't
Respiratory Hypersensitivity - immunology
Serine Endopeptidases - analysis
Virulence Factors, Bordetella - administration & dosage
Abstract
Antibodies against integrins have been shown to inhibit allergic airway responses. The purpose of this study was to test the hypothesis that the beta1 integrin, very late antigen-4 (VLA-4), is involved in mast cell activation triggered by allergen exposure in sensitized animals. To do this we studied Brown Norway rats that were sensitized to ovalbumin (OA; 1 mg subcutaneously) using Bordetella pertussis as an adjuvant. Two weeks later rats were challenged with OA, pulmonary resistance (RL) was determined, and the concentrations of histamine and tryptase in bronchoalveolar lavage fluid and N-acetyl-leukotriene (LT)E4 in bile were measured. Pretreatment with a monoclonal antibody against VLA-4 (TA-2) attenuated the early response after OA challenge (342.9 +/- 24.4% baseline RL versus 153.3 +/- 19.4%; p
PubMed ID
9769271 View in PubMed
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