Skip header and navigation

Refine By

45 records – page 1 of 5.

Accumulation of perfluorooctane sulfonate in marine mammals.

https://arctichealth.org/en/permalink/ahliterature6747
Source
Environ Sci Technol. 2001 Apr 15;35(8):1593-8
Publication Type
Article
Date
Apr-15-2001
Author
K. Kannan
J. Koistinen
K. Beckmen
T. Evans
J F Gorzelany
K J Hansen
P D Jones
E. Helle
M. Nyman
J P Giesy
Author Affiliation
National Food Safety and Toxicology Center, Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA. kuruntha@msu.edu
Source
Environ Sci Technol. 2001 Apr 15;35(8):1593-8
Date
Apr-15-2001
Language
English
Publication Type
Article
Keywords
Alkanesulfonic Acids - blood - pharmacokinetics
Animals
Carnivora
Dolphins
Female
Fluorocarbons - blood - pharmacokinetics
Geography
Liver - chemistry
Male
Research Support, Non-U.S. Gov't
Seals, Earless
Seawater
Species Specificity
Whales
Abstract
Perfluorooctane sulfonate (PFOS) is a perfluorinated molecule that has recently been identified in the sera of nonindustrially exposed humans. In this study, 247 tissue samples from 15 species of marine mammals collected from Florida, California, and Alaskan coastal waters; and northern Baltic Sea; the Arctic (Spitsbergen); and Sable Island in Canada were analyzed for PFOS. PFOS was detected in liver and blood of marine mammals from most locations including those from Arctic waters. The greatest concentrations of PFOS found in liver and blood were 1520 ng/g wet wt in a bottlenose dolphin from Sarasota Bay, FL, and 475 ng/mL in a ringed seal from the northern Baltic Sea (Bothnian Sea), respectively. No age-dependent increase in PFOS concentrations in marine mammals was observed in the samples analyzed. The occurrence of PFOS in marine mammals from the Arctic waters suggests widespread global distribution of PFOS including remote locations.
PubMed ID
11329707 View in PubMed
Less detail

Adiposity and glycemic control in children exposed to perfluorinated compounds.

https://arctichealth.org/en/permalink/ahliterature104801
Source
J Clin Endocrinol Metab. 2014 Apr;99(4):E608-14
Publication Type
Article
Date
Apr-2014
Author
Clara Amalie G Timmermann
Laura I Rossing
Anders Grøntved
Mathias Ried-Larsen
Christine Dalgård
Lars B Andersen
Philippe Grandjean
Flemming Nielsen
Kira D Svendsen
Thomas Scheike
Tina K Jensen
Author Affiliation
Department of Environmental Medicine, Institute of Public Health (C.A.G.T., L.I.R., C.D., P.G., F.N., T.K.J.), and Institute of Sports Science and Clinical Biomechanics (A.G., M.R.-L., L.B.A.), University of Southern Denmark, 5000 Odense C, Denmark; and Department of Biostatistics (K.D.S., T.S.), University of Copenhagen, 1353 Copenhagen, Denmark.
Source
J Clin Endocrinol Metab. 2014 Apr;99(4):E608-14
Date
Apr-2014
Language
English
Publication Type
Article
Keywords
Adiposity - drug effects - physiology
Alkanesulfonic Acids - blood
Blood Glucose - drug effects - metabolism
Body mass index
Caprylates - blood
Child
Denmark - epidemiology
Environmental Exposure - analysis - statistics & numerical data
Environmental Pollutants - blood - toxicity
Female
Fluorocarbons - blood - toxicity
Humans
Insulin Resistance
Male
Obesity - blood - epidemiology
Skinfold thickness
Abstract
Our objective was to explore whether childhood exposure to perfluorinated and polyfluorinated compounds (PFCs), widely used stain- and grease-repellent chemicals, is associated with adiposity and markers of glycemic control.
Body mass index, skinfold thickness, waist circumference, leptin, adiponectin, insulin, glucose, and triglyceride concentrations were assessed in 8- to 10-year-old children in 1997 in a subset of the European Youth Heart Study, Danish component. Plasma PFC concentrations were available from 499 children. Linear regression models were performed to determine the association between PFC exposure and indicators of adiposity and markers of glycemic control.
There was no association between PFC exposures and adiposity or markers of glycemic control in normal-weight children. Among overweight children, an increase of 10 ng perfluorooctane sulfonic acid/mL plasma was associated with 16.2% (95% confidence interval [CI], 5.2%-28.3%) higher insulin concentration, 12.0% (95% CI, 2.4%-22.4%) higher ß-cell activity, 17.6% (95% CI, 5.8%-30.8%) higher insulin resistance, and 8.6% (95% CI, 1.2%-16.5%) higher triglyceride concentrations, and an increase of 10 ng perfluorooctanoic acid/mL plasma was associated with 71.6% (95% CI, 2.4%-187.5%) higher insulin concentration, 67.5% (95% CI, 5.5%-166.0%) higher ß-cell function, 73.9% (95% CI, 0.2%-202.0%) higher insulin resistance, and 76.2% (95% CI, 22.8%-153.0%) higher triglyceride concentrations.
Increased PFC exposure in overweight 8- to 10-year-old children was associated with higher insulin and triglyceride concentrations. Chance findings may explain some of our results, and due to the cross-sectional design, reverse causation cannot be excluded. The findings therefore need to be confirmed in longitudinal studies.
PubMed ID
24606078 View in PubMed
Less detail

Association between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive.

https://arctichealth.org/en/permalink/ahliterature127981
Source
Hum Reprod. 2012 Mar;27(3):873-80
Publication Type
Article
Date
Mar-2012
Author
Sonja Vestergaard
Flemming Nielsen
Anne-Maria Andersson
Niels Henrik Hjøllund
Philippe Grandjean
Helle Raun Andersen
Tina Kold Jensen
Author Affiliation
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, J.B. Winsloews Vej 17A, DK-5000 Odense C, Denmark. svestergaard@health.sdu.dk
Source
Hum Reprod. 2012 Mar;27(3):873-80
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Alkanesulfonic Acids - blood - pharmacology
Cohort Studies
Denmark
Female
Fertility - drug effects
Fluorocarbons - blood - pharmacology
Food Contamination
Humans
Male
Maternal Exposure
Odds Ratio
Pregnancy
Time Factors
Abstract
Perfluorinated chemicals (PFCs) have been widely used and have emerged as important food contaminants. A recent study on pregnant women suggested that PFC exposure was associated with a longer time to pregnancy (TTP). We examined the association between serum concentrations of PFCs in females and TTP in 222 Danish first-time pregnancy planners during the years 1992-1995.
The couples were enrolled in the study when discontinuing birth control and followed for six menstrual cycles or until a clinically recognized pregnancy occurred. Fecundability ratio (FR) was calculated using discrete-time survival models. In addition, odds ratio (OR) for TTP >6 cycles was calculated.
OR for TTP >6 cycles for those with PFC concentrations above the median were 0.96 [95% confidence interval (CI): 0.54-1.64] for perfluorooctane sulfonic acid (PFOS), the major PFC, compared with those below the median. FRs for those with PFOS concentrations above the median were 1.05 (95% CI: 0.74-1.48) compared with those below the median. Other PFCs showed the same lack of association with TTP. The results were not affected by adjustment for covariates. PFOS and perfluorooctanoic acid concentrations were similar to those observed in a previous Danish study.
These findings suggest that exposure to PFCs affects TTP only to a small extent, if at all.
PubMed ID
22246448 View in PubMed
Less detail

Association between plasma PFOA and PFOS levels and total cholesterol in a middle-aged Danish population.

https://arctichealth.org/en/permalink/ahliterature116030
Source
PLoS One. 2013;8(2):e56969
Publication Type
Article
Date
2013
Author
Kirsten T Eriksen
Ole Raaschou-Nielsen
Joseph K McLaughlin
Loren Lipworth
Anne Tjønneland
Kim Overvad
Mette Sørensen
Author Affiliation
Danish Cancer Society Research Center, Copenhagen, Denmark. kirsthor@cancer.dk
Source
PLoS One. 2013;8(2):e56969
Date
2013
Language
English
Publication Type
Article
Keywords
Aged
Alkanesulfonic Acids - blood
Caprylates - blood
Cholesterol - blood
Cross-Sectional Studies
Denmark - epidemiology
Environmental Exposure
Female
Fluorocarbons - blood
Humans
Male
Middle Aged
Population Surveillance
Abstract
Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are used in a variety of consumer products and have been detected worldwide in human blood. Recent studies mainly of highly exposed populations have indicated that PFOA and PFOS may affect serum cholesterol levels, but the magnitude of the effect may be inconsistent across exposure levels. The aim of the present cross-sectional study was to investigate the association between plasma PFOA and PFOS and total cholesterol in a general, middle-aged Danish population. The study population comprised 753 individuals (663 men and 90 women), 50-65 years of age, nested within a Danish cohort of 57,053 participants. Blood samples were taken from all cohort members at enrolment (1993-1997) and stored in a biobank at -150°C. Plasma levels of PFOA and PFOS and serum levels of total cholesterol were measured. The associations between plasma PFOA and PFOS levels and total cholesterol levels were analysed by generalized linear models, both crude and adjusted for potential confounders. We observed statistically significant positive associations between both perfluorinated compounds and total cholesterol, e.g. a 4.4 [95% CI ?=? 1.1-7.8] higher concentration of total cholesterol (mg/dL) per interquartile range of PFOA plasma level. Sex and prevalent diabetes appeared to modify the association between PFOA and PFOS, respectively, and cholesterol. In conclusion, this study indicated positive associations between plasma PFOA and PFOS levels and total cholesterol in a middle-aged Danish population, although whether the observed pattern of results reflects a causal association is unclear.
Notes
Cites: Drug Chem Toxicol. 2000 Nov;23(4):603-2011071397
Cites: Environ Sci Technol. 2011 Oct 1;45(19):8137-4320939531
Cites: Crit Rev Toxicol. 2004 Jul-Aug;34(4):351-8415328768
Cites: Environ Sci Technol. 2004 Sep 1;38(17):4489-9515461154
Cites: Mol Pharmacol. 1998 Jan;53(1):14-229443928
Cites: Chemosphere. 2006 Apr;63(3):490-616213555
Cites: Environ Sci Technol. 2006 Apr 1;40(7):2128-3416646443
Cites: J Occup Environ Med. 2006 Aug;48(8):771-916902369
Cites: Int J Hyg Environ Health. 2006 Nov;209(6):489-9616872899
Cites: Environ Health Perspect. 2006 Nov;114(11):1776-8217107867
Cites: Environ Res. 2007 Feb;103(2):176-8416893538
Cites: J Occup Environ Med. 2007 Aug;49(8):872-917693785
Cites: Scand J Public Health. 2007;35(4):432-4117786808
Cites: Environ Health Perspect. 2007 Sep;115(9):1298-30517805419
Cites: Toxicol Sci. 2007 Oct;99(2):366-9417519394
Cites: Int Arch Occup Environ Health. 2007 Nov;81(2):231-4617605032
Cites: J Occup Environ Med. 2007 Oct;49(10):1086-9618000414
Cites: J Occup Environ Med. 2009 Mar;51(3):364-7219225424
Cites: J Natl Cancer Inst. 2009 Apr 15;101(8):605-919351918
Cites: Am J Epidemiol. 2009 Nov 15;170(10):1268-7819846564
Cites: Environ Health Perspect. 2010 Feb;118(2):197-20220123614
Cites: Environ Health Perspect. 2010 Aug;118(8):1100-820423814
Cites: Environ Res. 2010 Oct;110(7):710-720696425
Cites: Arch Pediatr Adolesc Med. 2010 Sep;164(9):860-920819969
Cites: J Occup Environ Med. 2003 Mar;45(3):260-7012661183
PubMed ID
23441227 View in PubMed
Less detail

Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men.

https://arctichealth.org/en/permalink/ahliterature116786
Source
Environ Health Perspect. 2013 Apr;121(4):453-8, 458e1-5
Publication Type
Article
Date
Apr-2013
Author
Anne Vested
Cecilia Høst Ramlau-Hansen
Sjurdur Frodi Olsen
Jens Peter Bonde
Susanne Lund Kristensen
Thorhallur Ingi Halldorsson
Georg Becher
Line Småstuen Haug
Emil Hagen Ernst
Gunnar Toft
Author Affiliation
Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. anneveed@rm.dk
Source
Environ Health Perspect. 2013 Apr;121(4):453-8, 458e1-5
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Alkanesulfonic Acids - blood
Caprylates - blood
Chromatography, Liquid
Cohort Studies
Denmark - epidemiology
Endocrine Disruptors - blood
Environmental Exposure
Female
Fluorocarbons - blood
Gonadal Steroid Hormones - blood
Humans
Linear Models
Luminescent Measurements
Male
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology
Prospective Studies
Semen - drug effects - physiology
Semen Analysis
Sperm Count
Tandem Mass Spectrometry
Testis - anatomy & histology - drug effects
Young Adult
Abstract
Perfluorinated alkyl acids (PFAAs), persistent chemicals with unique water-, dirt-, and oil-repellent properties, are suspected of having endocrine-disrupting activity. The PFAA compounds perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are found globally in humans; because they readily cross the placental barrier, in utero exposure may be a cause for concern.
We investigated whether in utero exposure to PFOA and PFOS affects semen quality, testicular volume, and reproductive hormone levels.
We recruited 169 male offspring (19-21 years of age) from a pregnancy cohort established in Aarhus, Denmark, in 1988-1989, corresponding to 37.6% of the eligible sons. Each man provided a semen sample and a blood sample. Semen samples were analyzed for sperm concentration, total sperm count, motility, and morphology, and blood samples were used to measure reproductive hormones. As a proxy for in utero exposure, PFOA and PFOS were measured in maternal blood samples from pregnancy week 30.
Multivariable linear regression analysis suggested that in utero exposure to PFOA was associated with lower adjusted sperm concentration (ptrend = 0.01) and total sperm count (ptrend = 0.001) and with higher adjusted levels of luteinizing hormone (ptrend = 0.03) and follicle-stimulating hormone (ptrend = 0.01). PFOS did not appear to be associated with any of the outcomes assessed, before or after adjustment.
The results suggest that in utero exposure to PFOA may affect adult human male semen quality and reproductive hormone levels.
Notes
Cites: Environ Sci Technol. 2004 Sep 1;38(17):4489-9515461154
Cites: Environ Health Perspect. 2004 Aug;112(11):1204-715289168
Cites: J Endocrinol. 1989 Mar;120(3):517-232494289
Cites: Hum Reprod. 1990 Jul;5(5):586-922394790
Cites: Br J Nutr. 1995 Mar;73(3):387-957766562
Cites: Br J Nutr. 1995 Mar;73(3):397-4047766563
Cites: Occup Environ Med. 1996 Aug;53(8):511-98983461
Cites: J Occup Environ Med. 2006 Aug;48(8):759-7016902368
Cites: J Agric Food Chem. 2006 Oct 18;54(21):8385-917032055
Cites: Reprod Biomed Online. 2007 Feb;14(2):159-6517298717
Cites: J Agric Food Chem. 2007 Apr 18;55(8):3203-1017381114
Cites: Fertil Steril. 2007 Jun;87(6):1480-217296192
Cites: Environ Health Perspect. 2007 Sep;115(9):1298-30517805419
Cites: Toxicol Sci. 2007 Oct;99(2):366-9417519394
Cites: Environ Health Perspect. 2007 Nov;115(11):1677-8218008003
Cites: J Clin Invest. 2008 Apr;118(4):1479-9018340380
Cites: J Chromatogr A. 2009 Jan 16;1216(3):385-9319026423
Cites: Fertil Steril. 2009 May;91(5):1812-918423454
Cites: Environ Health Perspect. 2009 Jun;117(6):923-719590684
Cites: Environ Health. 2009;8:3719689815
Cites: Toxicology. 2010 Apr 30;271(1-2):64-7220223269
Cites: Epidemiology. 2010 Nov;21(6):779-8520805751
Cites: Environ Int. 2011 May;37(4):687-9321334069
Cites: Biol Reprod. 2011 May;84(5):1016-2321209418
Cites: Environ Health Perspect. 2011 May;119(5):713-821262597
Cites: Asian J Androl. 2011 May;13(3):453-821516117
Cites: Environ Sci Technol. 2011 Oct 1;45(19):7999-800521332198
Cites: JAMA. 2012 Jan 25;307(4):391-722274686
Cites: Int J Hyg Environ Health. 2012 Feb;215(2):216-921937271
Cites: Reprod Toxicol. 2012 Jul;33(4):419-2721736937
Cites: Environ Sci Technol. 2012 Jun 5;46(11):6330-822554481
Cites: Hum Reprod. 2012 Aug;27(8):2532-4022647447
Cites: BJU Int. 2012 Aug;110(4):568-7222177092
Cites: Environ Sci Technol. 2001 Apr 1;35(7):1339-4211348064
Cites: Reproduction. 2003 Jun;125(6):769-8412773099
Cites: Toxicology. 2004 Mar 1;196(1-2):95-11615036760
Cites: Br Med Bull. 1979 May;35(2):187-92387166
PubMed ID
23360585 View in PubMed
Less detail

Attention deficit/hyperactivity disorder and childhood autism in association with prenatal exposure to perfluoroalkyl substances: a nested case-control study in the Danish National Birth Cohort.

https://arctichealth.org/en/permalink/ahliterature269614
Source
Environ Health Perspect. 2015 Apr;123(4):367-73
Publication Type
Article
Date
Apr-2015
Author
Zeyan Liew
Beate Ritz
Ondine S von Ehrenstein
Bodil Hammer Bech
Ellen Aagaard Nohr
Chunyuan Fei
Rossana Bossi
Tine Brink Henriksen
Eva Cecilie Bonefeld-Jørgensen
Jørn Olsen
Source
Environ Health Perspect. 2015 Apr;123(4):367-73
Date
Apr-2015
Language
English
Publication Type
Article
Keywords
Adult
Alkanesulfonic Acids - blood - toxicity
Attention Deficit Disorder with Hyperactivity - epidemiology - etiology
Autistic Disorder - epidemiology - etiology
Caprylates - blood - toxicity
Case-Control Studies
Child
Cohort Studies
Denmark - epidemiology
Environmental Pollutants - toxicity
Female
Fluorocarbons - blood - toxicity
Humans
Male
Maternal Exposure - adverse effects
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology - etiology
Abstract
Perfluoroalkyl substances (PFASs) are persistent pollutants found to be endocrine disruptive and neurotoxic in animals. Positive correlations between PFASs and neurobehavioral problems in children were reported in cross-sectional data, but findings from prospective studies are limited.
We investigated whether prenatal exposure to PFASs is associated with attention deficit/hyperactivity disorder (ADHD) or childhood autism in children.
Among 83,389 mother-child pairs enrolled in the Danish National Birth Cohort during 1996-2002, we identified 890 ADHD cases and 301 childhood autism cases from the Danish National Hospital Registry and the Danish Psychiatric Central Registry. From this cohort, we randomly selected 220 cases each of ADHD and autism, and we also randomly selected 550 controls frequency matched by child's sex. Sixteen PFASs were measured in maternal plasma collected in early or mid-pregnancy. We calculated risk ratios (RRs) using generalized linear models, taking into account sampling weights.
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were detected in all samples; four other PFASs were quantified in = 90% of the samples. We did not find consistent evidence of associations between mother's PFAS plasma levels and ADHD [per natural log nanograms per milliliter increase: PFOS RR = 0.87 (95% CI: 0.74, 1.02); PFOA RR = 0.98 (95% CI: 0.82, 1.16)] or autism [per natural log nanograms per milliliter increase: PFOS RR = 0.92 (95% CI: 0.69, 1.22); PFOA RR = 0.98 (95% CI: 0.73, 1.31)]. We found positive as well as negative associations between higher PFAS quartiles and ADHD in models that simultaneously adjusted for all PFASs, but these estimates were imprecise.
In this study we found no consistent evidence to suggest that prenatal PFAS exposure increases the risk of ADHD or childhood autism in children.
Notes
Cites: Environ Sci Technol. 2011 Oct 1;45(19):8151-921682250
Cites: J Autism Dev Disord. 2010 Feb;40(2):139-4819728067
Cites: Acta Paediatr. 2012 Aug;101(8):811-822458970
Cites: Environ Health Perspect. 2010 Dec;118(12):1762-720551004
Cites: Environ Health Perspect. 2011 Apr;119(4):573-821062688
Cites: Integr Environ Assess Manag. 2011 Oct;7(4):513-4121793199
Cites: Environ Sci Technol. 2011 Oct 1;45(19):8037-4521469664
Cites: Environ Sci Technol. 2011 Oct 1;45(19):7974-8421630688
Cites: Environ Sci Technol. 2012 Aug 21;46(16):9071-922770559
Cites: Int J Occup Med Environ Health. 2012 Sep;25(4):330-5523086631
Cites: J Hazard Mater. 2013 Jan 15;244-245:637-4423177245
Cites: Environ Health Perspect. 2013 Feb;121(2):231-623151773
Cites: Toxicology. 2013 Feb 8;304:185-9123287389
Cites: Epidemiology. 2013 Jul;24(4):590-923680941
Cites: Environ Sci Pollut Res Int. 2013 Nov;20(11):8045-5623539207
Cites: Environ Sci Pollut Res Int. 2013 Nov;20(11):8031-4423764977
Cites: Int J Epidemiol. 2014 Apr;43(2):443-6424518932
Cites: Environ Health Perspect. 2014 May;122(5):529-3424577800
Cites: Environ Health Perspect. 2014 May;122(5):513-2024622245
Cites: Epidemiology. 2014 Jul;25(4):505-1224807698
Cites: Am J Epidemiol. 2014 Sep 15;180(6):574-8125139206
Cites: Environ Health Perspect. 2000 Jun;108 Suppl 3:433-810852841
Cites: Scand J Public Health. 2001 Dec;29(4):300-711775787
Cites: Toxicol Sci. 2003 Aug;74(2):382-9212773772
Cites: Acta Psychiatr Scand Suppl. 1993;370:27-328452052
Cites: J Abnorm Child Psychol. 1996 Oct;24(5):555-698956084
Cites: Dan Med Bull. 1999 Jun;46(3):263-810421985
Cites: Environ Health Perspect. 2004 Dec;112(17):1691-615579415
Cites: Toxicology. 2005 Nov 5;215(1-2):149-6916129535
Cites: J Neuropathol Exp Neurol. 2005 Nov;64(11):925-3516254487
Cites: Am J Epidemiol. 2005 Nov 15;162(10):983-9016207803
Cites: Environ Sci Technol. 2006 Jun 1;40(11):3463-7316786681
Cites: Environ Res. 2007 Feb;103(2):176-8416893538
Cites: Nord J Psychiatry. 2007;61(1):71-817365792
Cites: Environ Sci Technol. 2007 Apr 1;41(7):2237-4217438769
Cites: Am J Psychiatry. 2007 Jun;164(6):942-817541055
Cites: Toxicol Sci. 2007 Aug;98(2):571-8117488742
Cites: Environ Health Perspect. 2007 Sep;115(9):1298-30517805419
Cites: Toxicol Sci. 2007 Oct;99(2):366-9417519394
Cites: Environ Health Perspect. 2007 Nov;115(11):1677-8218008003
Cites: Neurotoxicology. 2008 Jan;29(1):160-918063051
Cites: Pediatrics. 2008 Feb;121(2):e358-6518245408
Cites: Environ Health Perspect. 2008 Jun;116(6):716-2218560525
Cites: Epidemiology. 2009 Jan;20(1):84-9019234401
Cites: Toxicol Sci. 2009 Apr;108(2):412-819211617
Cites: Hum Reprod. 2009 May;24(5):1200-519176540
Cites: Reprod Toxicol. 2009 Jun;27(3-4):319-3019162172
Cites: Environ Health Perspect. 2011 Oct;119(10):1466-7121665566
PubMed ID
25616253 View in PubMed
Less detail

Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?

https://arctichealth.org/en/permalink/ahliterature296906
Source
Environ Health. 2018 02 01; 17(1):11
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Date
02-01-2018
Author
Xindi C Hu
Clifton Dassuncao
Xianming Zhang
Philippe Grandjean
Pál Weihe
Glenys M Webster
Flemming Nielsen
Elsie M Sunderland
Author Affiliation
Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA. xhu@mail.harvard.edu.
Source
Environ Health. 2018 02 01; 17(1):11
Date
02-01-2018
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Keywords
Adolescent
Adult
Aged
Alkanesulfonic Acids - blood
Child
Denmark
Environmental Exposure
Environmental monitoring
Environmental pollutants - blood
Female
Fluorocarbons - blood
Humans
Male
Middle Aged
Nutrition Surveys
Prospective Studies
United States
Young Adult
Abstract
Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects.
We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases.
Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure sources in two North American populations, suggesting generalizability of results from the Faroese population.
We conclude that PFAS homologue profiles in serum provide valuable information on major exposure sources. It is essential to compare samples collected at similar time periods and to correct for demographic groups that are highly affected by differences in physiological processes (e.g., pregnancy). Information on PFAS homologue profiles is crucial for attributing adverse health effects to the proper mixtures or individual PFASs.
PubMed ID
29391068 View in PubMed
Less detail

Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women.

https://arctichealth.org/en/permalink/ahliterature116233
Source
Environ Int. 2013 Apr;54:74-84
Publication Type
Article
Date
Apr-2013
Author
A L Brantsæter
K W Whitworth
T A Ydersbond
L S Haug
M. Haugen
H K Knutsen
C. Thomsen
H M Meltzer
G. Becher
A. Sabaredzovic
J A Hoppin
M. Eggesbø
M P Longnecker
Author Affiliation
Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403 Oslo, Norway. Anne.Lise.Brantsaeter@fhi.no
Source
Environ Int. 2013 Apr;54:74-84
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Adult
Alkanesulfonic Acids - blood
Cohort Studies
Diet - statistics & numerical data
Environmental pollutants - blood
Female
Fluorocarbons - blood
Humans
Maternal Exposure - statistics & numerical data
Norway
Pregnancy
Abstract
Perfluoroalkyl substances (PFASs) are widespread pollutants that have been associated with adverse health effects although not on a consistent basis. Diet has been considered the main source of exposure. The aim of the present study was to identify determinants of four plasma PFASs in pregnant Norwegian women.
This study is based in the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Our sample included 487 women who enrolled in MoBa from 2003 to 2004. A questionnaire regarding sociodemographic, medical, and reproductive history was completed at 17 weeks of gestation and a dietary questionnaire was completed at 22 weeks of gestation. Maternal plasma samples were obtained around 17 weeks of gestation. Plasma concentrations of four PFASs (perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA)) were examined in relation to demographic, lifestyle, dietary, and pregnancy-related covariates. Predictors were identified by optimizing multiple linear regression models using Akaike's information criterion (AIC).
Parity was the determinant with the largest influence on plasma PFAS concentrations, with r(2) between 0.09 and 0.32 in simple regression models. In optimal multivariate models, when compared to nulliparous women, parous women had 46%, 70%, 19%, and 62% lower concentrations of PFOS, PFOA, PFHxS, and PFNA respectively (p
Notes
Cites: J Obstet Gynaecol Br Commonw. 1973 Dec;80(12):1067-744761381
Cites: Environ Int. 2012 Nov 15;49:120-723018201
Cites: Scand J Clin Lab Invest. 1992 Sep;52(5):387-921514017
Cites: Am J Clin Nutr. 1997 Apr;65(4 Suppl):1220S-1228S; discussion 1229S-1231S9094926
Cites: J Clin Invest. 1958 Dec;37(12):1764-7413611044
Cites: Toxicology. 2006 Oct 3;227(1-2):156-6416978759
Cites: Int J Epidemiol. 2006 Oct;35(5):1146-5016926217
Cites: Environ Health Perspect. 2007 Feb;115(2):226-3017384769
Cites: Environ Health Perspect. 2007 Sep;115(9):1298-30517805419
Cites: Environ Health Perspect. 2007 Nov;115(11):1670-618008002
Cites: Environ Health Perspect. 2007 Nov;115(11):1677-8218008003
Cites: J Toxicol Environ Health A. 2013;76(1):25-5723151209
Cites: Arch Intern Med. 2012 Oct 8;172(18):1397-40322945282
Cites: Int J Hyg Environ Health. 2013 Nov;216(6):633-4022999890
Cites: Chemosphere. 2010 Aug;80(10):1137-4320599247
Cites: Environ Toxicol Chem. 2003 Nov;22(11):2639-4914587903
Cites: J Occup Health. 2004 Mar;46(2):141-715090689
Cites: Matern Child Nutr. 2008 Jan;4(1):14-2718171404
Cites: Matern Child Nutr. 2008 Jan;4(1):28-4318171405
Cites: Risk Anal. 2008 Apr;28(2):251-6918419647
Cites: Food Chem Toxicol. 2008 Aug;46(8):2808-1418599176
Cites: Environ Health Perspect. 2008 Oct;116(10):1391-518941583
Cites: Neuro Endocrinol Lett. 2008 Oct;29(5):599-60818987583
Cites: J Chromatogr A. 2009 Jan 16;1216(3):385-9319026423
Cites: Environ Sci Technol. 2008 Dec 1;42(23):8971-719192827
Cites: BMC Mol Biol. 2009;10:1619239717
Cites: Hum Reprod. 2009 May;24(5):1200-519176540
Cites: Environ Sci Technol. 2009 Mar 15;43(6):2131-619368225
Cites: Environ Sci Technol. 2009 Apr 1;43(7):2641-719452929
Cites: Paediatr Perinat Epidemiol. 2009 Nov;23(6):597-60819840297
Cites: Public Health Nutr. 2010 Jan;13(1):54-6219490733
Cites: Environ Health Perspect. 2010 Feb;118(2):222-820123620
Cites: Scand J Work Environ Health. 2010 Sep;36(5):413-2120200757
Cites: Rev Environ Contam Toxicol. 2010;208:161-7720811864
Cites: Rev Environ Contam Toxicol. 2010;208:179-21520811865
Cites: Environ Health Perspect. 2010 May;118(5):686-9220089479
Cites: Environ Health Perspect. 2010 Jun;118(6):796-80220146964
Cites: Environ Sci Technol. 2010 Jul 1;44(13):5225-3220527765
Cites: Environ Int. 2010 Oct;36(7):772-820579735
Cites: Environ Sci Technol. 2010 Sep 15;44(18):7123-920722423
Cites: Environ Sci Technol. 2010 Dec 15;44(24):9550-621090747
Cites: Environ Int. 2011 May;37(4):687-9321334069
Cites: Environ Int. 2011 Oct;37(7):1206-1221620474
Cites: Environ Sci Technol. 2011 Oct 1;45(19):8137-4320939531
Cites: Environ Sci Technol. 2011 Oct 1;45(19):7991-821417377
Cites: Br J Nutr. 2012 Feb;107(3):436-4421767447
Cites: Environ Int. 2012 Apr;40:187-9521864910
Cites: Epidemiology. 2012 Mar;23(2):257-6322081060
Cites: Hum Reprod. 2012 Mar;27(3):873-8022246448
Cites: Int J Hyg Environ Health. 2012 Feb;215(2):216-921937271
Cites: Environ Health Perspect. 2012 May;120(5):668-7322306490
Cites: Chemosphere. 2012 Aug;88(7):779-8322542201
Cites: Am J Epidemiol. 2012 Jun 15;175(12):1209-1622517810
Cites: Chemosphere. 2012 Aug;88(8):980-722483730
Cites: Environ Sci Technol. 2012 Aug 21;46(16):9071-922770559
Cites: Environ Health Perspect. 2012 Oct;120(10):1432-722935244
Cites: Br J Obstet Gynaecol. 1981 Jan;88(1):1-97459285
PubMed ID
23419425 View in PubMed
Less detail

Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada).

https://arctichealth.org/en/permalink/ahliterature149165
Source
Environ Sci Technol. 2009 Jul 1;43(13):5130-6
Publication Type
Article
Date
Jul-1-2009
Author
Renée Dallaire
Pierre Ayotte
Daria Pereg
Serge Déry
Pierre Dumas
Eric Langlois
Eric Dewailly
Author Affiliation
Public Health Research Unit, Centre hospitalier universitaire de Québec-CHUL, Québec, Québec, Canada.
Source
Environ Sci Technol. 2009 Jul 1;43(13):5130-6
Date
Jul-1-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Alkanesulfonic Acids - blood
Animals
Bromine Compounds - blood
Canada
Environmental Exposure
Environmental Monitoring - methods
Female
Fishes
Fluorocarbons - blood
Halogenation
Humans
Inuits
Male
Middle Aged
Abstract
Perfluorooctanesulfonate (PFOS) and brominated organic compounds (BOCs) have been found in biota and humans worldwide with levels of BOCs being the highest in North America. PFOS and BOC exposure of remote populations that consume species of a marine food web for their subsistence has seldom been investigated. In 2004, we determined the concentrations of these contaminants in 883 Nunavik Inuit adults from the Canadian Arctic and investigated the demographic and dietary factors associated with them. Demographic and dietary information were collected by questionnaires. Multiple linear regressions were conducted to investigate predictors of exposure to those contaminants. Polychlorinated biphenyl (PCB) congener 153 concentrations are presented for comparative purposes. PFOS and PCB 153 were detected in all samples, with plasma concentrations several times higher than BOCs. The consumption of fish and marine mammals appears to be an important contributor to PFOS exposure among Nunavik Inuit. While PBDE 153 also appears as a persistent PBDE congener, exposure to PBDE 47 seems to be more recent in this population. Adoption of a westernized lifestyle seems to be related to an increased exposure to PBDE 47, but specific sources remain to be elucidated. In conclusion, we found that the remote geographical location and traditional lifestyle of the Nunavik Inuit population do not protect them against exposure to emerging POPs, particularly PFOS.
PubMed ID
19673318 View in PubMed
Less detail

Determinants of plasma PFOA and PFOS levels among 652 Danish men.

https://arctichealth.org/en/permalink/ahliterature140125
Source
Environ Sci Technol. 2011 Oct 1;45(19):8137-43
Publication Type
Article
Date
Oct-1-2011
Author
Kirsten T Eriksen
Mette Sørensen
Joseph K McLaughlin
Anne Tjønneland
Kim Overvad
Ole Raaschou-Nielsen
Author Affiliation
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. kirsthor@cancer.dk
Source
Environ Sci Technol. 2011 Oct 1;45(19):8137-43
Date
Oct-1-2011
Language
English
Publication Type
Article
Keywords
Aged
Alkanesulfonic Acids - blood
Caprylates - blood
Denmark
Environmental monitoring
Female
Fluorocarbons - blood
Humans
Male
Middle Aged
Abstract
Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are used in a variety of industrial and consumer products and have been detected worldwide in human blood. The sources for human exposure are not well described, but dietary intake is suggested as an important source. In this study of 652 Danish men from the Diet, Cancer and Health cohort, we examined intake of 10 major dietary groups, tap water drinks, alcohol consumption, cooking method, geographical area, age, smoking status, and BMI as potential determinants of PFOA and PFOS plasma levels. Living in the Aarhus area was associated with higher PFOA and PFOS plasma levels compared with living in the Copenhagen area, and never smokers had higher levels than current smokers. Frying as compared with other cooking methods was a determinant of PFOA and PFOS levels. BMI and alcohol consumption were inversely associated with both compounds. Among the dietary groups, only intake of eggs was significantly positively associated with PFOS plasma levels. In future studies, PFOA and PFOS levels in air, dust and water samples should be measured to elucidate further the sources of exposure; exposure through diet needs to be studied in greater detail. Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation.
PubMed ID
20939531 View in PubMed
Less detail

45 records – page 1 of 5.