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121 records – page 1 of 13.

25-Hydroxycholecaliferol and fractures of the proximal.

https://arctichealth.org/en/permalink/ahliterature252013
Source
Lancet. 1975 Aug 16;2(7929):300-2
Publication Type
Article
Date
Aug-16-1975
Author
B. Lund
O H Sorensen
A B Christensen
Source
Lancet. 1975 Aug 16;2(7929):300-2
Date
Aug-16-1975
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Alkaline Phosphatase - blood
Calcium - blood
Clinical Trials as Topic
Denmark
Femoral Fractures - blood - epidemiology - etiology
Great Britain
Humans
Hydroxycholecalciferols - blood - metabolism
Kidney - metabolism
Middle Aged
Osteomalacia - blood - complications - etiology
Phosphorus - blood
Seasons
Vitamin D - administration & dosage
Abstract
Plasma 25-hydroxycholecalciferol (25-H.C.C.) has been measured in 67 consective cases of fracture of the proximal femur. The values found in these patients were not different from values found in these patients were not different from those in control groups at the same time of the year. Plasma 25-H.C.C. was not correlated to plasma calcium or phosphorus, the Ca times P product, or the alkaline phosphatase. X-rays showed Looser zones in only 1 patient, in whom the lowest plasma 25-H.C.C. was found. Osteomalacia is not uncommon among elderly people in Denmark, but it is more likely to depend on a decline in the renal efficiency to convert 25-H.C.C. to 1,25-dihydroxycholecalciferol than a low dietary intake of vitamin D.
PubMed ID
50509 View in PubMed
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25-Hydroxyvitamin D concentrations in maternal and cord blood at delivery and in maternal blood during lactation in Finland.

https://arctichealth.org/en/permalink/ahliterature240391
Source
Hum Nutr Clin Nutr. 1984 Jul;38(4):261-8
Publication Type
Article
Date
Jul-1984
Author
C. Lamberg-Allardt
M. Larjosto
E. Schultz
Source
Hum Nutr Clin Nutr. 1984 Jul;38(4):261-8
Date
Jul-1984
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alkaline Phosphatase - blood
Calcifediol - blood
Calcium - blood
Cholecalciferol - administration & dosage
Female
Fetal Blood - metabolism
Finland
Food Habits
Humans
Infant, Newborn
Lactation
Maternal-Fetal Exchange
Nutritional Requirements
Pregnancy
Seasons
Vitamin D Deficiency - blood
Abstract
The 25-hydroxyvitamin D concentration (25-OHD) in maternal and cord blood of 192 mothers was determined at delivery from June to the end of November. Ninety-nine mothers had received a daily supplementation of 12.5 micrograms of vitamin D during pregnancy and this group had a significantly higher 25-OHD concentration both in maternal and in cord blood than in the corresponding non-supplemented group. A daily supplement of 2.5 micrograms of vitamin D was given to 63 of the mothers during lactation. Of these mothers 44 were still lactating after 6 months. The dietary vitamin D intake of 31 mothers was calculated. We found a significant correlation between the maternal serum 25-OHD concentration 16-18 weeks after delivery and the total vitamin D intake. The intake (5.5 micrograms/d, including supplementation) was lower than that recommended for lactating mothers which is 10 micrograms/d (Food and Nutrition Board, 1980).
PubMed ID
6088438 View in PubMed
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25-hydroxyvitamin D levels among healthy children in Alaska.

https://arctichealth.org/en/permalink/ahliterature4777
Source
J Pediatr. 2003 Oct;143(4):434-7
Publication Type
Article
Date
Oct-2003
Author
Bradford D Gessner
Julia Plotnik
Pam T Muth
Author Affiliation
Alaska Division of Public Health, PO Box 240249, 3601 C Street, Anchorage, AK 99524, USA. Brad_Gessner@health.state.ak.us
Source
J Pediatr. 2003 Oct;143(4):434-7
Date
Oct-2003
Language
English
Publication Type
Article
Keywords
Alaska - epidemiology
Alkaline Phosphatase - blood
Breast Feeding
Female
Humans
Infant
Infant, Newborn
Male
Population Surveillance
Prospective Studies
Risk factors
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - epidemiology
Abstract
OBJECTIVE: To determine vitamin D levels among children 6 to 23 months old receiving services from Women, Infants, and Children (WIC) programs in Alaska.Study design During 2001 and 2002, we recruited 133 children receiving services at seven WIC clinics, administered a risk factor questionnaire, and collected blood. RESULTS: Fifteen (11%) and 26 (20%) children, respectively, had vitamin D levels or =25 ng/mL. Among 41 still breast-feeding children, 14 (34%) took supplemental vitamins, and six (18%) were reported to have received vitamins every day. CONCLUSIONS: Vitamin D deficiency is prevalent in Alaska. Breast-feeding in the absence of adequate vitamin D supplementation is the greatest risk factor.
Notes
Comment In: J Pediatr. 2003 Oct;143(4):422-314571210
PubMed ID
14571215 View in PubMed
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25-Hydroxyvitamin D levels during breast-feeding with or without maternal or infantile supplementation of vitamin D.

https://arctichealth.org/en/permalink/ahliterature238975
Source
J Pediatr Gastroenterol Nutr. 1985 Apr;4(2):220-6
Publication Type
Article
Date
Apr-1985
Author
M. Ala-Houhala
Source
J Pediatr Gastroenterol Nutr. 1985 Apr;4(2):220-6
Date
Apr-1985
Language
English
Publication Type
Article
Keywords
Adult
Alkaline Phosphatase - blood
Breast Feeding
Calcium - blood
Female
Finland
Humans
Hydroxycholecalciferols - blood
Infant
Magnesium - blood
Phosphorus - blood
Pilot Projects
Rickets - prevention & control
Risk
Seasons
Sunlight
Vitamin D - therapeutic use
Abstract
Serum 25-hydroxyvitamin D (25-OHD), calcium, phosphorus, magnesium, and alkaline phosphatase levels of breast-fed infants and their mothers were studied by following 100 healthy term mother-infant pairs with different supplementation protocols of vitamin D. A pilot study in winter revealed that six of eight breast-fed infants without vitamin D supplementation had serum 25-OHD levels below the risk limit for rickets (5 ng/ml) at the age of 8 weeks. In the main study in winter groups, it was found that the 25-OHD levels were low (5.6 +/- 3.7 ng/ml) at the age of 8 weeks in the unsupplemented breast-fed infants, whose mothers were given vitamin D supplementation of 1,000 IU/day during lactation (group I), compared with the levels of those infants receiving either 400 (18.0 +/- 8.4 ng/ml, group II) or 1,000 IU (22.8 +/- 11.2 ng/ml, group III) vitamin D (group I vs. group II or III, p less than 0.001; group II vs. group III, NS). In group I 10 of 18 infants had serum 25-OHD levels less than 5 ng/ml compared with none of the infants in groups II and III. Yet the infants with 25-OHD levels less than 5 ng/ml showed no signs of clinical or biochemical rickets at the age of 8 or 20 weeks. In summer at delivery the maternal 25-OHD levels were good, but decreased thereafter. Also in summer groups, the infantile 25-OHD concentrations decreased; however, because the levels at delivery were high, they stayed in the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
3989622 View in PubMed
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Aberrant circulating levels of purinergic signaling markers are associated with several key aspects of peripheral atherosclerosis and thrombosis.

https://arctichealth.org/en/permalink/ahliterature263533
Source
Circ Res. 2015 Mar 27;116(7):1206-15
Publication Type
Article
Date
Mar-27-2015
Author
Juho Jalkanen
Gennady G Yegutkin
Maija Hollmén
Kristiina Aalto
Tuomas Kiviniemi
Veikko Salomaa
Sirpa Jalkanen
Harri Hakovirta
Source
Circ Res. 2015 Mar 27;116(7):1206-15
Date
Mar-27-2015
Language
English
Publication Type
Article
Keywords
5'-Nucleotidase - blood
Adenosine Diphosphate - blood
Adenosine Triphosphate - blood
Adult
Age Factors
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Anoxia - blood
Antigens, CD - blood
Apyrase - blood
Artifacts
Atherosclerosis - blood - epidemiology
Biological Markers
Chronic Disease
Comorbidity
Disease Progression
Drug Utilization
Female
Finland - epidemiology
GPI-Linked Proteins - blood
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypertension - blood - drug therapy - epidemiology
Male
Middle Aged
Models, Cardiovascular
Peripheral Arterial Disease - blood - epidemiology
Purinergic P2Y Receptor Antagonists - therapeutic use
Risk factors
Second Messenger Systems
Smoking - adverse effects - blood - epidemiology
Thrombophilia - blood - epidemiology - etiology
Abstract
Purinergic signaling plays an important role in inflammation and vascular integrity, but little is known about purinergic mechanisms during the pathogenesis of atherosclerosis in humans.
The objective of this study is to study markers of purinergic signaling in a cohort of patients with peripheral artery disease.
Plasma ATP and ADP levels and serum nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/CD39) and ecto-5'-nucleotidase/CD73 activities were measured in 226 patients with stable peripheral artery disease admitted for nonurgent invasive imaging and treatment. The major findings were that ATP, ADP, and CD73 values were higher in atherosclerotic patients than in controls without clinically evident peripheral artery disease (P
PubMed ID
25645301 View in PubMed
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Activity of lysosomal enzymes in the bile and serum of mice with intrahepatic cholestasis.

https://arctichealth.org/en/permalink/ahliterature90427
Source
Bull Exp Biol Med. 2008 May;145(5):560-3
Publication Type
Article
Date
May-2008
Author
Korolenko T A
Savchenko N G
Yuz'ko Ju V
Alexeenko T V
Sorochinskaya N V
Author Affiliation
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. t.a.korolenko@iph.ma.nsc.ru
Source
Bull Exp Biol Med. 2008 May;145(5):560-3
Date
May-2008
Language
English
Publication Type
Article
Keywords
1-Naphthylisothiocyanate - toxicity
Alkaline Phosphatase - blood - metabolism
Animals
Bile - enzymology
Cholestasis, Intrahepatic - blood - chemically induced - enzymology
Cholesterol - biosynthesis - blood
Hexosaminidases - blood - metabolism
Lysosomes - enzymology
Male
Mice
Mice, Inbred CBA
Polyethylene Glycols - toxicity
beta-Galactosidase - blood - metabolism
beta-N-Acetylhexosaminidases - blood - metabolism
gamma-Glutamyltransferase - blood - metabolism
Abstract
Lysosomal enzyme activity in the bile and blood serum was compared in mice with experimental intrahepatic cholestasis induced by alpha-naphthyl isothiocyanate and Triton WR 1339. Triton WR 1339 increases the synthesis of cholesterol (fatty acid precursor) in liver cells. The development of intrahepatic cholestasis was confirmed by the increase in activities of alkaline phosphatase and gamma-glutamyltransferase in blood serum. Administration of Triton WR 1339 in a dose of 100 mg/100 g was followed by a 10-fold increase in beta-galactosidase activity (hepatocyte lysosomal enzyme) in the bile, but not in the serum of mice. beta-Galactosidase activity significantly increased in the bile, but decreased in the serum of mice after treatment with a-naphthyl isothiocyanate in a dose of 200 mg/kg. Our results indicate that intrahepatic cholestasis is manifested in increased secretion of lysosomal glycosidases into the bile. Bile components can aggravate damage to liver cells by affecting the processes of hepatocyte apoptosis and necrosis.
PubMed ID
19145281 View in PubMed
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[Activity of phosphomonoesterases of blood cells in persons subjected to dust in the industrial environment].

https://arctichealth.org/en/permalink/ahliterature250473
Source
Lab Delo. 1977;(8):464-7
Publication Type
Article
Date
1977

[Age-related and geographic characteristics of cytochemical indicators of the lymphocytes in healthy children, newcomers to the Baikal-Amur Railway construction area and natives]

https://arctichealth.org/en/permalink/ahliterature40810
Source
Pediatriia. 1981;(8):41-3
Publication Type
Article
Date
1981

Aggressive breast cancer leads to discrepant serum levels of the type I procollagen propeptides PINP and PICP.

https://arctichealth.org/en/permalink/ahliterature21862
Source
Cancer Res. 1997 Dec 15;57(24):5517-20
Publication Type
Article
Date
Dec-15-1997
Author
A. Jukkola
R. Tähtelä
E. Thölix
K. Vuorinen
G. Blanco
L. Risteli
J. Risteli
Author Affiliation
Department of Oncology, University of Oulu, Finland.
Source
Cancer Res. 1997 Dec 15;57(24):5517-20
Date
Dec-15-1997
Language
English
Publication Type
Article
Keywords
Alkaline Phosphatase - blood
Bone Neoplasms - blood - secondary
Breast Neoplasms - blood - pathology
Collagen - metabolism
Cross-Sectional Studies
Disease Progression
Female
Humans
Peptide Fragments - blood
Procollagen - blood
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Abstract
The propeptides PICP and PINP are derived from the synthesis of type I collagen, a major matrix protein of bone and soft tissues. The aim of this cross-sectional study was to investigate their value as indicators of the aggressivity of breast cancer. Serum PINP, PICP, and total alkaline phosphatase were determined from 89 breast cancer patients. Forty had major bone and/or soft tissue metastases with an aggressive disease course: the progressive disease (PD) group. Forty-nine had either none or minor bone and/or soft tissue metastases with a stable clinical course: the stable disease group (SD). The mean value of PINP in the PD group was 7.2 times higher than that in the SD group (276 +/- 79 microg/l versus 38 +/- 3 microg/l, respectively; P = 0.005), whereas PICP mean value was only 1.7 times higher in the PD group (174 +/- 20 microg/l versus 100 +/- 5 microg/l; P = 0.001). The ratio of PICP to PINP was 1.02 +/- 0.07 in the PD group and 3.07 +/- 0.18 in the SD group (P
PubMed ID
9407961 View in PubMed
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[Alimentary and oxygen deprivation as the modulator of the bone tissue physiological remodelling rate in young rats]

https://arctichealth.org/en/permalink/ahliterature86619
Source
Fiziol Zh. 2008;54(1):85-93
Publication Type
Article
Date
2008
Author
Litovka I H
Source
Fiziol Zh. 2008;54(1):85-93
Date
2008
Language
Ukrainian
Publication Type
Article
Keywords
Alkaline Phosphatase - blood - metabolism
Animals
Anoxia - metabolism - physiopathology
Body Weight - physiology
Bone Remodeling - physiology
Bone and Bones - metabolism
Caloric Restriction
Electrophoresis, Agar Gel
Gene Expression - physiology
Glycosaminoglycans - blood
Insulin-Like Growth Factor I - genetics
Liver - metabolism
Male
Melatonin - blood
Polymerase Chain Reaction
Rats
Rats, Wistar
Abstract
Influencing of 28-days alimentary deprivation and intermittent hypoxia to 3 months Wistar male rats (n = 30) bone tissue physiological remodelling is studied. We investigated 3 groups of animals, I group was control, II--food limitation mode (-40% in relation to the normal ration) and III--animals, which breathed hypoxic gas mixture with 13% O2 in nitrogen (HGM) during 4 hours in the intermittent mode (10 min of deoxygenation and 10 min of reoxygenation). It is showed significant increasing of melatonin and glicozaminoglikans levels in the rats II and III gr. serum. Activity of alkaline phosphatase in the bone tissue of III gr. rats increased and in the bone tissue and serum of II gr. rats for 1.2 and 1.4 time accordingly. We registered significant increasing of serum acid phosphatase activity in animals, which have breathed hypoxic gas mixture. The IGF-I gene expression level did not change practically in both experimental groups. We conclude, that alimentary deprivation and intermittent hypoxia have positive effects on the physiological remodelling of bone tissue.
PubMed ID
18416190 View in PubMed
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121 records – page 1 of 13.