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Depression of tuberculin sensitivity following measles vaccination

https://arctichealth.org/en/permalink/ahliterature3402
Source
American Review of Respiratory Disease. 1964 Oct;90(4):607-611
Publication Type
Article
Date
Oct-1964
Author
Brody, JA
McAlister, R
Author Affiliation
Arctic Health Research Center
Source
American Review of Respiratory Disease. 1964 Oct;90(4):607-611
Date
Oct-1964
Language
English
Geographic Location
U.S.
Publication Type
Article
Keywords
Alaska
Alaskan Indians
Aleuts
Allergy and immunology
Eskimos
gamma-Globulins
Killed vaccine
Live vaccine
Measles Vaccine
Tuberculin Test
Abstract
The tuberculin reaction is frequently depressed following natural measles infection. Evidence also indicates that measles infection may aggravate a preexisting tuberculous condition. In a recent study, Mellman and Wetton described a temporary depression of the tuberculin reaction in children following vaccination with live attenuated measles virus vaccine. These writers stated that the depression occurred in measles-immune as well as in measles-susceptible persons but could be prevented by administering gamma-globulin simultaneously with the measles vaccine. Starr and Berkovich noted a depression in tuberculin sensitivity following the administration of live measles vaccine and gamma globulin, but stated that this occurred only in those susceptible to measles.Tuberculosis and measles are diseases of particular concern among Alaskan Indians, Aleuts, and Eskimos. Accordingly, at the Arctic Health Research Center in Anchorage, studies were initiated to confirm the above-cited observations and to extend the investigation to include the effect of killed measles virus vaccine on the tuberculin reaction. As will be seen, the data are somewhat at variance with those previously reported.
Notes
Cited in: Fortuine, Robert. 1968. The Health of the Eskimos: a bibliography 1857-1967. Dartmouth College Libraries. Citation number 569.
PubMed ID
14221673 View in PubMed
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