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Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder.

https://arctichealth.org/en/permalink/ahliterature299458
Source
Behav Genet. 2019 01; 49(1):11-23
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Date
01-2019
Author
Tom Rosenström
Nikolai Olavi Czajkowski
Eivind Ystrom
Robert F Krueger
Steven H Aggen
Nathan A Gillespie
Espen Eilertsen
Ted Reichborn-Kjennerud
Fartein Ask Torvik
Author Affiliation
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway. tom.rosenstrom@helsinki.fi.
Source
Behav Genet. 2019 01; 49(1):11-23
Date
01-2019
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Keywords
Adult
Adverse Childhood Experiences
Alcoholism - etiology - genetics
Biometry
Child
Diagnostic and Statistical Manual of Mental Disorders
Diseases in Twins
Female
Gene-Environment Interaction
Humans
Life Change Events
Male
Models, Statistical
Norway
Personality
Personality Disorders - complications - genetics
Phenotype
Risk factors
Twins - genetics - psychology
Abstract
A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD). Unlike conventional statistical mediation models, this biometric mediation model can detect unobserved confounding. Using a sample of 1410 pairs of Norwegian twins, we investigated specific hypotheses that DSM-IV personality-disorder (PD) traits mediate effects of childhood stressful life events (SLEs) on AUD, and that adulthood SLEs mediate effects of PDs on AUD. Models including borderline PD traits indicated unobserved confounding in phenotypic path coefficients, whereas models including antisocial and impulsive traits did not. More than half of the observed effects of childhood SLEs on adulthood AUD were mediated by adulthood antisocial and impulsive traits. Effects of PD traits on AUD 5?10 years later were direct rather than mediated by adulthood SLEs. The results and the general approach contribute to triangulation of developmental origins for complex behavioral disorders.
PubMed ID
30536213 View in PubMed
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Inheritance of alcohol abuse. Cross-fostering analysis of adopted men.

https://arctichealth.org/en/permalink/ahliterature12975
Source
Arch Gen Psychiatry. 1981 Aug;38(8):861-8
Publication Type
Article
Date
Aug-1981
Author
C R Cloninger
M. Bohman
S. Sigvardsson
Source
Arch Gen Psychiatry. 1981 Aug;38(8):861-8
Date
Aug-1981
Language
English
Publication Type
Article
Keywords
Adoption
Adult
Alcoholism - etiology - genetics
Environment
Humans
Male
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Risk
Sweden
Abstract
The inheritance of alcoholism was studied in 862 Swedish men adopted by nonrelatives at an early age. Both the congenital and postnatal backgrounds of the adoptees modify their risk for alcohol abuse. We distinguish two forms of alcoholism that have distinct genetic and environmental causes and differ in their association with criminality, severity of alcohol abuse, and the frequency of expression in biological mothers. Postnatal milieu determines the frequency and severity of expression of the common type of susceptibility in both men and women. In contrast, the less common type is highly heritable in men but is seldom expressed in mothers of affected men.
PubMed ID
7259422 View in PubMed
Less detail