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Blood pressure level and risk of major cardiovascular events and all-cause of mortality in patients with type 2 diabetes and renal impairment: an observational study from the Swedish National Diabetes Register.

https://arctichealth.org/en/permalink/ahliterature270847
Source
Diabetologia. 2015 Jun;58(6):1203-11
Publication Type
Article
Date
Jun-2015

A high mean-HbA1c value 3-15?months after diagnosis of type 1 diabetes in childhood is related to metabolic control, macroalbuminuria, and retinopathy in early adulthood--a pilot study using two nation-wide population based quality registries.

https://arctichealth.org/en/permalink/ahliterature260889
Source
Pediatr Diabetes. 2014 May;15(3):229-35
Publication Type
Article
Date
May-2014
Author
Ulf Samuelsson
Isabelle Steineck
Soffia Gubbjornsdottir
Source
Pediatr Diabetes. 2014 May;15(3):229-35
Date
May-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Albuminuria - complications - physiopathology - prevention & control
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 - blood - complications - physiopathology - therapy
Diabetic Nephropathies - complications - physiopathology - prevention & control
Diabetic Retinopathy - complications - physiopathology - prevention & control
Disease Progression
Female
Follow-Up Studies
Health Knowledge, Attitudes, Practice
Hemoglobin A, Glycosylated - analysis
Humans
Hyperglycemia - prevention & control
Male
Pilot Projects
Registries
Risk factors
Severity of Illness Index
Sex Factors
Sweden - epidemiology
Young Adult
Abstract
Intensive treatment of patients with type 1 diabetes delays the onset of long-term complications.
On the basis of the information from two nation-wide quality registers, we investigated to which extent HbA1c values 3-15?months after diagnosis in childhood are related to metabolic control, albuminuria, and retinopathy in early adulthood.
In Sweden, physicians register all children and adolescents with type 1 diabetes mellitus in the Swedish Pediatric Quality Registry. After 18?yr of age, people with diabetes are followed by the Swedish National Diabetes Register. We identified 1543 children and adolescents with a mean age of 13.9?yr at diagnosis and a mean duration of type 1 diabetes mellitus of 7.1?yr.
Children and adolescents with poor metabolic control (mean HbA1c = 70?mmol/mol (8.6 %)) adjacent to diagnosis had a significantly higher mean HbA1c value years later as adults than did patients with a good metabolic control [
PubMed ID
24119008 View in PubMed
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Microalbuminuria and risk factors in type 1 and type 2 diabetic patients.

https://arctichealth.org/en/permalink/ahliterature47112
Source
Diabetes Res Clin Pract. 2005 Mar;67(3):258-66
Publication Type
Article
Date
Mar-2005
Author
J. Cederholm
B. Eliasson
P M Nilsson
L. Weiss
S. Gudbjörnsdottir
Author Affiliation
Family Medicine and Epidemiology Section, Department of Public Health and Caring Sciences, Dag Hammarskjolds vag 14B, University Hospital, Uppsala SE-75185, Sweden. jan.cederholm@pubcare.uu.se
Source
Diabetes Res Clin Pract. 2005 Mar;67(3):258-66
Date
Mar-2005
Language
English
Publication Type
Article
Keywords
Adult
Albuminuria - complications
Blood pressure
Body mass index
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - epidemiology - urine
Diabetes Mellitus, Type 2 - epidemiology - urine
Diabetic Nephropathies - epidemiology
Female
Hemoglobin A, Glycosylated - analysis
Humans
Hypertension - epidemiology
Male
Middle Aged
Registries
Regression Analysis
Research Support, Non-U.S. Gov't
Risk factors
Smoking - epidemiology
Sweden - epidemiology
Abstract
A prospective study of normoalbuminuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 microg/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbuminuria was independently associated with HbA(1c), diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbuminuria achieved treatment targets of HbA(1c)
PubMed ID
15713359 View in PubMed
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Microalbuminuria and short-term prognosis in patients undergoing cardiac surgery.

https://arctichealth.org/en/permalink/ahliterature95203
Source
Interact Cardiovasc Thorac Surg. 2009 Sep;9(3):484-90
Publication Type
Article
Date
Sep-2009
Author
Mikkelsen Martin Majlund
Andersen Niels Holmark
Christensen Thomas Decker
Hansen Troels Krarup
Eiskjaer Hans
Mogensen Carl Erik
Hjortdal Vibeke Elisabeth
Johnsen Søren Paaske
Author Affiliation
Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark. majlund@ki.au.dk
Source
Interact Cardiovasc Thorac Surg. 2009 Sep;9(3):484-90
Date
Sep-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Albumins - metabolism
Albuminuria - complications - mortality - urine
Atrial Fibrillation - etiology
Biological Markers - urine
Cardiac Surgical Procedures - adverse effects - mortality
Creatine - urine
Denmark - epidemiology
Female
Follow-Up Studies
Heart Diseases - complications - mortality - surgery
Humans
Intensive Care
Kaplan-Meiers Estimate
Length of Stay
Male
Middle Aged
Myocardial Infarction - etiology
Odds Ratio
Prospective Studies
Registries
Renal Insufficiency - etiology
Reoperation
Risk assessment
Risk factors
Sepsis - etiology
Stroke - etiology
Surgical Procedures, Elective
Surgical Wound Infection - etiology
Time Factors
Treatment Outcome
Young Adult
Abstract
OBJECTIVES: To examine if preoperative microalbuminuria (MA) is associated with in increased risk of adverse outcomes in patients undergoing elective cardiothoracic surgery, and if adding information on MA could improve the accuracy of the additive EuroSCORE. METHODS: In a follow-up study we included 962 patients undergoing elective cardiothoracic surgery from 1 April 2005 to 30 September 2007 at our department. MA (urine albumin/creatinine ratio between 2.5-25 mg/mmol) was assessed in a morning spot-urine sample. We used population-based medical registries for 30-day follow-up and compared the length of stay and adverse outcomes including (i) all-cause death, myocardial infarction, stroke, or atrial fibrillation, (ii) surgical reintervention, renal insufficiency, sternal wound infection, or septicaemia among patients with and without MA. RESULTS: MA was found in 180 (18.7%) patients. The risk of both combined outcomes (adjusted odds ratios (ORs): 1.00 (95% confidence interval (CI): 0.77-1.30) and 1.18 (95% CI: 0.79-1.75), respectively) and most individual outcomes did not differ between the micro- and normoalbuminuric patients. The patients with MA and an additive EuroSCORE of 5 had a significantly prolonged median length of intensive care unit (ICU) stay (0.15 days [95% CI: 0.04-0.26]) and total hospital stay (0.5 days [95% CI: 0.04-0.96]). Patients with MA had a higher risk of postoperative septicaemia (OR: 12.1 [95% CI: 3.2-45.9]). Area under receiver operating characteristics curves of the EuroSCORE with regard to 30-day mortality was 0.86 both with and without MA. CONCLUSIONS: Preoperative MA in patients undergoing elective cardiothoracic surgery was not associated with most early adverse outcomes. However, risk of septicaemia was higher and patients with MA also had a marginally longer length of ICU and hospital stay. Information on preoperative MA did not improve the accuracy of the additive EuroSCORE.
PubMed ID
19549646 View in PubMed
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Risk factors for atrial fibrillation in type 2 diabetes: report from the Swedish National Diabetes Register (NDR).

https://arctichealth.org/en/permalink/ahliterature273926
Source
Diabetologia. 2015 Oct;58(10):2259-68
Publication Type
Article
Date
Oct-2015
Author
Björn Zethelius
Soffia Gudbjörnsdottir
Björn Eliasson
Katarina Eeg-Olofsson
Ann-Marie Svensson
Jan Cederholm
Source
Diabetologia. 2015 Oct;58(10):2259-68
Date
Oct-2015
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Albuminuria - complications - physiopathology
Atrial Fibrillation - etiology - physiopathology
Blood Pressure - physiology
Diabetes Mellitus, Type 2 - complications - physiopathology
Female
Humans
Hypertension - complications - physiopathology
Male
Middle Aged
Registries
Risk factors
Sex Factors
Sweden
Abstract
Atrial fibrillation (AF) is more frequent in patients with diabetes than in the general population. However, characteristics contributing to AF risk in diabetes remain speculative.
Observational study of 83,162 patients with type 2 diabetes, aged 30-79 years, with no baseline AF, 17% had history of cardiovascular disease (CVD) and 3.3% history of congestive heart failure (CHF), followed up for development of AF during mean 6.8 years from 2005-2007 to 2012. A subgroup of 67,780 patients without history of CVD or CHF was also analysed.
Using Cox regression, cardiovascular risk factors associated with risk for AF were updated mean BMI (HR 1.31 per 5 kg/m(2)) or obesity (HR 1.51), updated mean systolic BP (SBP; HR 1.13 per 10 mmHg) or hypertension (HR 1.71), and cumulative microalbuminuria (HR 1.21), p?
PubMed ID
26088442 View in PubMed
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Risk of coronary artery disease and stroke according to sex and presence of diabetic nephropathy in type 1 diabetes.

https://arctichealth.org/en/permalink/ahliterature300347
Source
Diabetes Obes Metab. 2018 12; 20(12):2759-2767
Publication Type
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Date
12-2018
Author
Valma Harjutsalo
Merlin C Thomas
Carol Forsblom
Per-Henrik Groop
Author Affiliation
Folkhälsan Institute of Genetics, Folkhälsan Research Centre, Helsinki, Finland.
Source
Diabetes Obes Metab. 2018 12; 20(12):2759-2767
Date
12-2018
Language
English
Publication Type
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Adult
Age of Onset
Albuminuria - complications - epidemiology
Child
Coronary Artery Disease - epidemiology - etiology
Diabetes Mellitus, Type 1 - blood - complications - physiopathology
Diabetic Nephropathies - blood - complications - physiopathology
Female
Finland - epidemiology
Glomerular Filtration Rate
Humans
Incidence
Kidney - physiopathology
Male
Prospective Studies
Registries
Risk factors
Serum Albumin - analysis
Sex Factors
Stroke - epidemiology - etiology
Young Adult
Abstract
To determine the effect of different stages of diabetic nephropathy (DN) and sex on the excess and absolute morbidity of coronary artery disease (CAD) and stroke in people with type 1 diabetes (T1D) in order to distinguish different cardiovascular disease (CVD) risk profiles in people with T1D.
The study included 4410 people with T1D from the Finnish Diabetic Nephropathy Study (FinnDiane), divided by DN status, and a control population of 12?434 people without diabetes. CVD events were identified from the Finnish nationwide health registries. Cumulative incidences for CAD and stroke were calculated and standardized incidence ratios (SIRs) were estimated between participants with T1D and the control group, stratified by DN status and sex.
There were 487 incident CADs and 290 strokes at the end of 2014 (median follow-up 12.9 years). The cumulative incidence rates of CAD and stroke were similar in men and women within different nephropathy groups. The SIR for CAD was 7.5 (95% confidence interval [CI] 6.9-8.2), 17.2 (95% CI 14.9-19.5) in women and 5.3 (95% CI 4.7-5.9) in men. The women-to-men ratio of SIR increased by nephropathy group: 3.3, 3.7, 5.3 and 6.8 in the normo-, micro- and macroalbuminuria and end-stage renal disease (ESRD) groups, respectively. The SIR for stroke was 5.0 (95% CI 4.3-5.5), similar in men and women. The women-to-men ratio of SIR for stroke was 0.8, 1.3, 1.6 and 1.7, in the normo-, micro- and macroalbuminuria and ESRD groups, respectively. The SIR in participants with normoalbuminuria and an estimated glomerular filtration rate?=90?mL/min/1.73?m2 was 3.5 (95% CI 2.5-4.5) for CAD and 1.6 (95% CI 1.0-2.3) for stroke.
Although the excess CVD risk is several-fold greater in women compared to men, the absolute CVD risk in men and women was equal when nephropathy was taken into account. Even participants with normoalbuminuria and normal kidney function were found to have an excess CVD risk compared with the control group without diabetes.
PubMed ID
29962015 View in PubMed
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Trends in blood pressure control in patients with type 2 diabetes: data from the Swedish National Diabetes Register (NDR).

https://arctichealth.org/en/permalink/ahliterature133697
Source
Blood Press. 2011 Dec;20(6):348-54
Publication Type
Article
Date
Dec-2011
Author
Peter M Nilsson
Jan Cederholm
Bj Rn Zethelius
Bj Rn Eliasson
Katarina Eeg-Olofsson
Soffia Gudbj Rnsdottir
Author Affiliation
Department of Clinical Sciences, Lund University, University Hospital, Malm, Sweden. Peter.Nilsson@med.lu.se
Source
Blood Press. 2011 Dec;20(6):348-54
Date
Dec-2011
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Albuminuria - complications - drug therapy - epidemiology - physiopathology
Antihypertensive Agents - administration & dosage
Blood pressure
Body mass index
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - complications - drug therapy - epidemiology - physiopathology
Female
Follow-Up Studies
Humans
Hypertension - complications - drug therapy - epidemiology - physiopathology
Male
Middle Aged
Obesity - complications - drug therapy - epidemiology - physiopathology
Prevalence
Registries
Risk factors
Smoking - epidemiology - physiopathology
Sweden - epidemiology
Abstract
We assessed blood pressure (BP) trends in patients with type 2 diabetes from a national diabetes register using three cross-sectional samples (aged 30?85 years) in 2005, 2007 and 2009, and in patients from 2005 followed individually until 2009. The prevalence of hypertension was 87% among all 180 369 patients in 2009, although lower in subgroups with ages 30?39, 40?49 and 50?59 years: 40%, 60% and 77%. In the three cross-sectional surveys, mean BP decreased (141/77?136/76 mmHg), uncontrolled BP? 140/90 mmHg decreased (58?46%), and antihypertensive drug treatment (AHT) increased (73?81%). Comparatively in 79 185 patients followed individually for 5 years, mean BP decreased (141/77?137/75 mmHg), uncontrolled BP ?140/90 mmHg decreased (58?47%) and AHT increased (73?82%). Independent predictors of BP decrease were BMI decrease (stronger) and increase in AHT. AHT occurred among 81% of all patients in 2009. In 57 645 patients on AHT followed individually, mean BP decreased (143/77?138/75 mmHg) and uncontrolled BP ?140/90 mmHg decreased (63?50%). Among 5164 patients with nephropathy on AHT followed individually, BP
PubMed ID
21675827 View in PubMed
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7 records – page 1 of 1.