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Accelerated immunosenescence in preindustrial twin mothers.

https://arctichealth.org/en/permalink/ahliterature178937
Source
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12391-6
Publication Type
Article
Date
Aug-17-2004
Author
Samuli Helle
Virpi Lummaa
Jukka Jokela
Author Affiliation
Section of Ecology, Department of Biology, University of Turku, FIN-20014, Turku, Finland. samuli.helle@utu.fi
Source
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12391-6
Date
Aug-17-2004
Language
English
Publication Type
Article
Keywords
Aged
Aging - immunology
Female
Finland - epidemiology
History, 18th Century
History, 19th Century
Humans
Industry - history
Infection - immunology - mortality
Longevity - immunology
Models, Immunological
Pregnancy
Pregnancy, Multiple - immunology
Reproduction - immunology
Time Factors
Tuberculosis, Pulmonary - immunology - mortality
Abstract
Life-history theory predicts a tradeoff between reproductive effort and lifespan. It has been suggested that this tradeoff is a result of reproductive costs accelerating senescence of the immune system, leading to earlier death. Longevity costs of reproduction are suggested for some human populations, but whether high reproductive effort leads to impaired immune function is unknown. We examined how reproductive effort affected postreproductive survival and the probability of dying of an infectious disease in women born in preindustrial Finland between 1702 and 1859. We found that mothers delivering twins had reduced postreproductive survival after age 65. This effect arose because mothers of twins had a higher probability of succumbing to an infectious disease (mainly tuberculosis) than mothers delivering singletons. The risk among mothers of twins of dying of an infectious disease was further elevated if mothers had started reproducing early. In contrast, neither female postreproductive survival nor the risk of succumbing to an infectious disease was influenced by the total number of offspring produced. Our results provide evidence of a long-term survival cost of twinning in humans and indicate that the mechanism mediating this cost might have been accelerated immunosenescence.
Notes
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PubMed ID
15295101 View in PubMed
Less detail

Age-related change in anti-carbohydrate antibody levels.

https://arctichealth.org/en/permalink/ahliterature12367
Source
Am J Epidemiol. 1989 Jan;129(1):89-96
Publication Type
Article
Date
Jan-1989
Author
G. Nordenstam
B. Andersson
C. Bengtsson
D. Briles
G. Scott
A. Svanborg
C. Svanborg Edén
Author Affiliation
Department of Clinical Immunology, Göteborg University, Sweden.
Source
Am J Epidemiol. 1989 Jan;129(1):89-96
Date
Jan-1989
Language
English
Publication Type
Article
Keywords
ABO Blood-Group System - immunology
Adult
Aged
Aged, 80 and over
Aging - immunology
Antibodies - analysis
Choline - analogs & derivatives
Female
Humans
Immunoglobulin M - metabolism
Isoantibodies - analysis
Longitudinal Studies
Male
Middle Aged
Phosphorylcholine - immunology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
It has been proposed that immunity declines with age. Most evidence for this hypothesis has been obtained from cross-sectional samples of unrelated populations that differ in age, antigen exposure, and morbidity. In the present study, the authors used serum samples collected repeatedly from the same persons in longitudinal studies. Two representative samples of the population in G?teborg, Sweden were obtained; the first was studied at ages 38, 50, and 62 years, and the second at ages 70, 75, 79, and 81 years, respectively. The phosphorylcholine determinant of pneumococcal teichoic acid and the B blood group determinant were selected as model polysaccharide antigens. The results demonstrate a consistent decline in individual antibody levels in the decades before age 70 years but not later. Antibodies to phosphorylcholine and blood group B were highly parallel, suggesting that the decline was a general phenomenon for antibodies to polysaccharide antigens.
PubMed ID
2910075 View in PubMed
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Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study.

https://arctichealth.org/en/permalink/ahliterature217452
Source
Exp Gerontol. 1994 Sep-Oct;29(5):531-41
Publication Type
Article
Author
A. Wikby
B. Johansson
F. Ferguson
J. Olsson
Author Affiliation
Department of Natural Science and Biomedicine, University College of Health Sciences, Jönköping, Sweden.
Source
Exp Gerontol. 1994 Sep-Oct;29(5):531-41
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Aging - immunology
Humans
Leukocyte Count
Longitudinal Studies
Lymphocyte Activation
Lymphocyte Subsets
Middle Aged
Sweden
Abstract
This study used a longitudinal design to examine age-related changes in a well-defined sample of Swedish people ranging from 86 to 92 years of age at baseline. The longitudinal design encompassed three measurement occasions with 1 year intermeasurement intervals. The results were analyzed by multivariate analyses of variance (MANOVA), which is useful for comparing individuals over time. Healthy middle-aged subjects (39 years SD +/- 5.8) served as controls. The proliferative responses to Concanavalin A (Con A), a T-cell mitogen, indicated significant lower levels in responses of the old when the two groups were compared. The MANOVA revealed no significant change in mitogen responses over measurement occasions in the old sample as compared with the young. However, when cell types and lymphocyte subpopulations were examined, significant differences were found between the two age groups in many of these parameters and for some (lymphocyte percentages and numbers, CD3 numbers) the MANOVA indicated significant decreases over the measurement occasions in the very old. The results also consistently indicated significant intraindividual correlations in cell types, lymphocyte subpopulations, and mitogen responses over time.
PubMed ID
7828662 View in PubMed
Less detail

[Age-related characteristics of the melatonin-producing epiphyseal function in CBA mice immunized by T-dependent antigen]

https://arctichealth.org/en/permalink/ahliterature57367
Source
Fiziol Zh. 2005;51(4):45-50
Publication Type
Article
Date
2005
Author
I F Labunets'
Source
Fiziol Zh. 2005;51(4):45-50
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Aging - immunology - metabolism
Animals
Antigens - immunology
Corticosterone - metabolism
English Abstract
Female
Immunization
Melatonin - metabolism
Mice
Mice, Inbred CBA
Pineal Gland - immunology - metabolism
T-Lymphocytes - immunology
Thymic Factor, Circulating - metabolism
Time Factors
Abstract
It was investigated both melatonin blood level in the adult and old CBA-mice after immunization by sheep erythrocytes and the link between thymus and adrenal glands function in the old immunizated mice with high melatonin content in the pineal gland. It has been revealed that in the adult mice blood melatonin level was influenced by the phase changes in dynamic of immunization, namely raised significantly in 20 min with following suppression after 3 hrs and rehabilitation up to normal in 4 days. In the old mice fluctuations of melatonin level were impaired and characterized by gradually decrease in dynamics of immunization. The increase of melatonin content in pineal gland by administration of epithalamine improved the dynamics of fluctuations of thymic hormone and corticosterone level in the immunizated old mice.
PubMed ID
16201149 View in PubMed
Less detail

[Age-related characteristics of the thymus and adrenal cortex function in CBA mice immunized by T-dependent antigen]

https://arctichealth.org/en/permalink/ahliterature57377
Source
Fiziol Zh. 2005;51(1):77-83
Publication Type
Article
Date
2005
Author
I F Labunets'
Source
Fiziol Zh. 2005;51(1):77-83
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Adrenal Glands - immunology
Aging - immunology
Animals
Antigens - immunology
Corticosterone - blood - immunology
English Abstract
Erythrocytes - immunology
Immunization
Mice
Mice, Inbred CBA
T-Lymphocytes - immunology
Thymic Factor, Circulating - immunology
Thymus Gland - immunology
Thymus Hormones - pharmacology
Abstract
The thymic serum factor (FTS) titer and corticosterone level in blood of adult and old CBA mice after immunization by T-dependent antigen was investigated. It has been revealed that in adult mice these indices influenced by phase changes in dynamics of immunization whereas in old mice fluctuations of FFS and corticosterone levels were monotonous. In both adult and old mice the correlation exists between thymic hormone and corticosterone. The increasing of thymic function by thymaline administration did not improve the dynamics of FTS titer and corticosterone level in immunized old mice.
PubMed ID
15801203 View in PubMed
Less detail

Age-related susceptibility to experimental autoimmune myasthenia gravis: immunological and electrophysiological aspects.

https://arctichealth.org/en/permalink/ahliterature57596
Source
Muscle Nerve. 1997 Sep;20(9):1091-101
Publication Type
Article
Date
Sep-1997
Author
A C Hoedemaekers
J J Verschuuren
F. Spaans
Y F Graus
S. Riemersma
P J van Breda Vriesman
M H De Baets
Author Affiliation
Department of Immunology, Maastricht University, The Netherlands.
Source
Muscle Nerve. 1997 Sep;20(9):1091-101
Date
Sep-1997
Language
English
Publication Type
Article
Keywords
Aging - immunology - physiology
Animals
Antibodies - immunology
Chronic Disease
Disease Susceptibility
Electrophysiology
Female
Immunization
Myasthenia Gravis - immunology - physiopathology
Neuromuscular Junction - physiopathology
Osmolar Concentration
Rats
Rats, Inbred BN
Rats, Inbred Lew
Receptors, Cholinergic - immunology - metabolism
Research Support, Non-U.S. Gov't
Synaptic Transmission
Abstract
Susceptibility to experimental autoimmune myasthenia gravis (EAMG) was found to decrease with aging in both Lewis and Brown Norway (BN) rats. In this study, the difference in susceptibility between young and aged Lewis and BN rats was used to analyze factors determining the clinical severity of EAMG. The incidence and severity of muscular weakness did not correlate with acetylcholine receptor (AChR) loss nor with the ability of antibodies to interfere with AChR function. Aged rats showed significantly lower anti-rat AChR antibody titers than young rats and developed less severe or no clinical signs of disease. In individual young or aged rats, however, no significant correlation was found between the clinical signs of disease and anti-rat AChR titer. Neuromuscular transmission was found to change with aging as measured by single-fiber electromyography (SFEMG). In aged BN rats, increased jitter and blockings were found even before EAMG induction. Despite this disturbed neuromuscular transmission, these aged BN rats were clinically resistant against induction of EAMG. The results of this study indicate that the age-related susceptibility to EAMG is influenced by factors determined by the immune attack as well as mechanisms at the level of the neuromuscular junction.
PubMed ID
9270663 View in PubMed
Less detail

Age specific prevalence of antibodies against Chlamydia pneumoniae in Iceland.

https://arctichealth.org/en/permalink/ahliterature35988
Source
Scand J Infect Dis. 1994;26(4):393-7
Publication Type
Article
Date
1994
Author
S. Einarsson
H K Sigurdsson
S D Magnusdottir
H. Erlendsdottir
H. Briem
S. Gudmundsson
Author Affiliation
University of Iceland Medical School, Reykjavik.
Source
Scand J Infect Dis. 1994;26(4):393-7
Date
1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Aging - immunology
Antibodies, Bacterial - analysis
Child
Child, Preschool
Chlamydia Infections - epidemiology - immunology
Chlamydophila pneumoniae - immunology
Female
Humans
Iceland - epidemiology
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infant
Infant, Newborn
Male
Middle Aged
Prevalence
Respiratory Tract Infections - epidemiology - microbiology
Abstract
Chlamydia pneumoniae is a newly recognized common cause of respiratory tract infections. The aim of this study was to examine its prevalence in Iceland. The study was based on 1020 serum samples from individuals 0-99 years old. The samples were divided into 10-year age groups. IgG and IgM antibodies were determined with microimmunofluorescence assay. An IgG titer > or = 32 and IgM titer > or = 16 were considered positive. The prevalence of positive IgG titer in the study population was 53 +/- 16% (mean +/- SD, age group range 14-66%). Neither seasonal nor gender-based difference in IgG antibody prevalence was demonstrated. It was lowest in the youngest group, 0-9 years old (p
PubMed ID
7984969 View in PubMed
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Ambient air quality and asthma: a northern perspective.

https://arctichealth.org/en/permalink/ahliterature210219
Source
J Investig Allergol Clin Immunol. 1997 Jan-Feb;7(1):7-13
Publication Type
Article
Author
T L Guidotti
Author Affiliation
Department of Public Health Sciences, University of Alberta Faculty of Medicine, Edmonton, Canada.
Source
J Investig Allergol Clin Immunol. 1997 Jan-Feb;7(1):7-13
Language
English
Publication Type
Article
Keywords
Aging - immunology
Air - standards
Air Pollution - adverse effects - prevention & control
Allergens - adverse effects
Asthma - etiology - immunology - prevention & control
Canada
Humans
Irritants - adverse effects
Ozone - adverse effects
Risk factors
Abstract
An important part of the new thinking about asthma is control of preventable risk factors, air pollution among them. The epidemiological evidence that ground-level ozone, in particular, is an important risk factor for provoking asthmatic attacks is strong. however, the evidence that it increases the prevalence of asthma overall, or mortality from asthma at levels frequently encountered in the developed world is lacking. The mechanism of airway response to ozone may be complex, involving modification of the atopic response to an antigen, rather than simple inflammation. Likewise, there may be many complexities in assessing the mechanism of association between exposure to air pollution and airways exposure, including susceptibility states, comorbidity from respiratory disorders, tolerance, and the attack rate for common viral infections. Some jurisdictions have proposed to use the frequency of asthmatic episodes as a means to set air pollution standards. The current state of the art, for many of these same reasons, does not support this. Progress will require mechanistic as well as population based research and broader thinking in the analysis of available data. Two hypotheses that especially require critical testing are age-dependent sensitization as a risk factor for asthma, and gradient-threshold response to irritant exposures.
PubMed ID
9093927 View in PubMed
Less detail

[An epidemiological assessment of the protection against measles by population age groups in the Russian Federation].

https://arctichealth.org/en/permalink/ahliterature220816
Source
Zh Mikrobiol Epidemiol Immunobiol. 1993 Jul-Aug;(4):56-62
Publication Type
Article
Author
Iu P Rykushin
Source
Zh Mikrobiol Epidemiol Immunobiol. 1993 Jul-Aug;(4):56-62
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aging - immunology
Child
Child, Preschool
Humans
Immunization, Secondary
Infant
Measles - epidemiology - immunology
Measles Vaccine - immunology
Risk factors
Russia - epidemiology
USSR - epidemiology
Abstract
The population of the Russian Federation has been divided into 5 groups according to their immunity to measles; the epidemiological importance of this division for the prognosis of measles morbidity for the next decade has been substantiated. As revealed in this study, children under 6 years and born in 1966-1978 who have received only one immunization are least protected from measles and make up the main socio-epidemiological nucleus of the population which will determine the level of measles morbidity in the next decade. The conclusion has been made on the necessity of mass immunization (revaccination) of high school and college students and groups of servicemen not later than 1995 in order to eliminate measles by the year of 2000.
PubMed ID
8067116 View in PubMed
Less detail

An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.

https://arctichealth.org/en/permalink/ahliterature70665
Source
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65
Publication Type
Article
Date
May-2005
Author
Anders Wikby
Frederick Ferguson
Rosalyn Forsey
Julie Thompson
Jan Strindhall
Sture Löfgren
Bengt-Olof Nilsson
Jan Ernerudh
Graham Pawelec
Boo Johansson
Author Affiliation
Department of Natural Science and Biomedicine, School of Health sciences, Jönköping University, Sweden.
Source
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65
Date
May-2005
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aging - immunology
Analysis of Variance
Antigens, CD - immunology
CD4-CD8 Ratio
Cognition Disorders - immunology - mortality
Cohort Studies
Comparative Study
Female
Geriatric Assessment
Health Status Indicators
Humans
Immunocompromised Host
Interleukin-2 - genetics - immunology
Interleukin-6 - genetics - immunology
Life expectancy
Longevity
Longitudinal Studies
Male
Phenotype
Probability
Research Support, Non-U.S. Gov't
Risk assessment
Statistics, nonparametric
Survival Rate
Sweden
Abstract
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86-94 years). Immune system measurements consisted of determinations of T-cell subsets, plasma interleukin 6 and cytomegalovirus and Epstein-Barr virus serology. Interleukin 2 responsiveness to concanavalin A, using data from the previous OCTO (octogenarians) immune study, hereafter OCTO immune, was also examined. Cognitive status was rated using a battery of neuropsychological tests. Logistic regression indicated that the IRP and cognitive impairment together predicted 58% of observed deaths. IRP was associated with late differentiated CD8+CD28-CD27- cells (p
PubMed ID
15972602 View in PubMed
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54 records – page 1 of 6.