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Source
Acta Obstet Gynecol Scand. 2004 Feb;83(2):124-5
Publication Type
Article
Date
Feb-2004
Author
Charlotte Wilken-Jensen
Source
Acta Obstet Gynecol Scand. 2004 Feb;83(2):124-5
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Africa - ethnology
Bias (epidemiology)
Circumcision, Female
Female
Health Surveys
Humans
Sweden - epidemiology
PubMed ID
14756726 View in PubMed
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How to deal with female circumcision as a health issue in the Nordic countries.

https://arctichealth.org/en/permalink/ahliterature71300
Source
Acta Obstet Gynecol Scand. 2003 Aug;82(8):683-6
Publication Type
Article
Date
Aug-2003
Author
Birgitta Essén
Charlotte Wilken-Jensen
Author Affiliation
Department of Obstetrics and Gynecology, Lund University, University Hospital MAS, Malmö, Sweden. birgitta.essen@obst.mas.lu.se
Source
Acta Obstet Gynecol Scand. 2003 Aug;82(8):683-6
Date
Aug-2003
Language
English
Publication Type
Article
Keywords
Africa - ethnology
Circumcision, Female - adverse effects
Female
Humans
Scandinavia
Women's health
PubMed ID
12848638 View in PubMed
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Long terminal repeat promoter/enhancer activity of different subtypes of HIV type 1.

https://arctichealth.org/en/permalink/ahliterature7575
Source
AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1293-303
Publication Type
Article
Date
Sep-20-1999
Author
M H Naghavi
S. Schwartz
A. Sönnerborg
A. Vahlne
Author Affiliation
Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Huddinge/Stockholm, Sweden. muna@lab01.hs.sll.se
Source
AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1293-303
Date
Sep-20-1999
Language
English
Publication Type
Article
Keywords
Adult
Africa - ethnology
Base Sequence
Binding Sites
Chloramphenicol O-Acetyltransferase
Enzyme-Linked Immunosorbent Assay
Female
HIV Core Protein p24 - metabolism
HIV Enhancer - genetics
HIV Infections - ethnology - genetics
HIV Long Terminal Repeat - genetics
HIV-1 - genetics
Hela Cells
Humans
Male
Middle Aged
Molecular Sequence Data
NF-kappa B - metabolism
Polymerase Chain Reaction
Promoter Regions (Genetics) - genetics
Research Support, Non-U.S. Gov't
Sequence Alignment
Sweden - ethnology
Transfection
Abstract
Transcription of the HIV-1 provirus genome is regulated by a complex interplay between viral regulatory proteins and cellular transcription factors that interact with the viral long terminal repeat (LTR) region of HIV-1. However, several cellular transcription factors have been identified that can interact with the HIV-1 LTR; the significance of all of these factors is not clearly understood. In this study we have characterized the LTR region of different subtypes of HIV-1 with regard to nucleotide sequence and promoter activity. The LTR regions of HIV-1 from peripheral blood mononuclear cells of 29 infected individuals originating from 10 different geographical regions were sequenced and further analyzed for promoter/enhancer activity in transient transfection of HeLa cells, in the context of a reporter gene and in the context of the complete virus genome. We found several subtype-specific LTR sequences of the various HIV-1 strains, such as an insertion that created a potential third NF-kappaB site in the LTR of the subtype C strains. The USF-binding site in the NRE also contained subtype-specific sequences. Interestingly, the promoter/enhancer activities of the subtype C LTRs were higher than the activities of the other subtypes analyzed here (subtypes A, B, D, E, and G), suggesting that the potential third NF-kappaB site may confer higher LTR activity or that the subtype C NRE may be less potent. Thus, our data suggest that genetic diversity of the LTR may result in HIV-1 subtypes with different replicative properties.
PubMed ID
10505678 View in PubMed
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