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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites.

https://arctichealth.org/en/permalink/ahliterature95137
Source
Lancet. 2009 Oct 3;374(9696):1179-85
Publication Type
Article
Date
Oct-3-2009
Author
Sorg O.
Zennegg M.
Schmid P.
Fedosyuk R.
Valikhnovskyi R.
Gaide O.
Kniazevych V.
Saurat J-H
Author Affiliation
Dermato-Toxicology, Swiss Centre for Applied Human Toxicology, and Department of Dermatology, University Hospital, Geneva, Switzerland.
Source
Lancet. 2009 Oct 3;374(9696):1179-85
Date
Oct-3-2009
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Biopsy
Drug Residues - analysis - metabolism
Fatal Outcome
Feces - chemistry
Forensic Medicine - methods
Half-Life
Homicide
Humans
Male
Middle Aged
Politics
Substance Abuse Detection - methods
Sweat - chemistry
Tetrachlorodibenzodioxin - analysis - chemistry - metabolism - poisoning
Time Factors
Ukraine
Abstract
BACKGROUND: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a long half-life of 5-10 years in human beings as a result of its high lipophilicity, and little or no metabolism. We monitored TCDD, its form, distribution, and elimination in Victor Yushchenko after he presented with severe poisoning. METHODS: In late December, 2004, a patient presented with TCDD poisoning; the levels in his blood serum (108000 pg/g lipid weight) were more than 50 000-fold greater than those in the general population. We identified TCDD and its metabolites, and monitored their levels for 3 years using gas chromatography and high-resolution mass spectrometry in samples of blood serum, adipose tissue, faeces, skin, urine, and sweat, after they were extracted and cleaned with different organic solvents. FINDINGS: The amount of unmodified TCDD in the samples that were analysed accounted for about 60% of TCDD eliminated from the body during the same period. Two TCDD metabolites-2,3,7-trichloro-8-hydroxydibenzo-p-dioxin and 1,3,7,8-tetrachloro-2-hydroxydibenzo-p-dioxin-were identified in the faeces, blood serum, and urine. The faeces contained the highest concentration of TCDD metabolites, and were the main route of elimination. Altogether, the different routes of elimination of TCDD and its metabolites accounted for 98% of the loss of the toxin from the body. The half-life of TCDD in our patient was 15.4 months. INTERPRETATION: This case of poisoning with TCDD suggests that the design of methods for routine assessment of TCDD metabolites in human beings should be a main aim of TCDD research in the metabolomic era. FUNDING: University of Geneva Dermatology Fund, and Swiss Centre for Applied Human Toxicology.
Notes
Comment In: Lancet. 2009 Oct 3;374(9696):1131-219660808
PubMed ID
19660807 View in PubMed
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Accumulation features and temporal trends of PCDDs, PCDFs and PCBs in Baikal seals (Pusa sibirica).

https://arctichealth.org/en/permalink/ahliterature90631
Source
Environ Pollut. 2009 Mar;157(3):737-47
Publication Type
Article
Date
Mar-2009
Author
Imaeda Daisuke
Kunisue Tatsuya
Ochi Yoko
Iwata Hisato
Tsydenova Oyuna
Takahashi Shin
Amano Masao
Petrov Evgeny A
Batoev Valeriy B
Tanabe Shinsuke
Author Affiliation
Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Source
Environ Pollut. 2009 Mar;157(3):737-47
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry - metabolism
Animals
Body Burden
Ecotoxicology - methods
Environmental Pollutants - analysis - pharmacokinetics
Female
Fresh Water
Male
Polychlorinated Biphenyls - analysis - pharmacokinetics
Seals, Earless - metabolism
Siberia
Tetrachlorodibenzodioxin - analogs & derivatives - analysis - pharmacokinetics
Time Factors
Abstract
This study investigated the accumulation features and temporal trends of PCDD/Fs, dioxin-like PCBs (DL-PCBs) and non-dioxin-like PCBs (NDL-PCBs) in the blubber of Baikal seals collected in 1992 and 2005. DL-PCBs (480-3600ng/g) and NDL-PCBs (980-35,000ng/g) were dominant contaminants. Concentrations of PCDDs and PCBs in males were significantly higher than in females. In males, age-dependent accumulation was observed for PCDDs, mono-ortho PCBs and NDL-PCBs. PCDFs and non-ortho PCBs showed no such trends, implying that exposure of seals to these contaminants has been decreasing in recent years. No decreasing temporal trend was observed for PCDDs, mono-ortho PCBs and NDL-PCBs, suggesting that Baikal seals are still exposed to PCDDs and PCBs. TEQs of PCDDs and mono-ortho PCBs in seals collected in 2005 accounted for 62-77% of total TEQs. The TEQ levels in 40% of the specimens exceeded the threshold level for immunosuppression observed in harbor seals (209pg/g).
PubMed ID
19110354 View in PubMed
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Adipose organochlorine concentrations and risk of breast cancer among postmenopausal Danish women.

https://arctichealth.org/en/permalink/ahliterature17245
Source
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):67-74
Publication Type
Article
Date
Jan-2005
Author
Ole Raaschou-Nielsen
Marian Pavuk
Alain Leblanc
Pierre Dumas
Jean Philippe Weber
Anja Olsen
Anne Tjønneland
Kim Overvad
Jørgen H Olsen
Author Affiliation
Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, 2100 Copenhagen, Denmark. ole@cancer.dk
Source
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):67-74
Date
Jan-2005
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Breast Neoplasms - epidemiology
Case-Control Studies
Denmark - epidemiology
Female
Humans
Hydrocarbons, Chlorinated - analysis
Logistic Models
Middle Aged
Pesticide Residues - analysis
Polychlorinated biphenyls - analysis
Postmenopause
Prospective Studies
Questionnaires
Research Support, Non-U.S. Gov't
Risk factors
Abstract
OBJECTIVE: Exposure to environmental organochlorines has been examined as a potential risk factor for human breast cancer with mixed results. Our purpose was to examine associations between organochlorines and the development of breast cancer in a large prospective study using stored adipose tissue. METHODS: We conducted a nested case-control study of 409 postmenopausal women who developed breast cancer and 409 controls selected from the 29,875 women enrolled in the Danish Diet, Cancer, and Health cohort between 1993 and 1997. We measured concentrations of 14 pesticides and 18 polychlorinated biphenyls in adipose tissue, collected upon enrollment, and estimated relative risk (RR) of breast cancer using conditional logistic regression. RESULTS: The results showed no higher risk of breast cancer among women with higher levels of any pesticides or polychlorinated biphenyls; the RR associated with the upper quartile of 1,1-dichloro-2, 2-bis(p-chlorophenyl)ethylene concentration was 0.7 [95% confidence interval (95% CI), 0.5-1.2] contrasting the lower quartile, and for the sum of polychlorinated biphenyls the similar risk was 1.1 (95% CI, 0.7-1.7). We observed a pattern of substantially lower risk of estrogen receptor-negative breast cancer in association with higher levels of most of the pesticides and polychlorinated biphenyls; the RR for the higher quartile of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene was 0.1 (95% CI, 0.0-0.5) and for the sum of polychlorinated biphenyls it was 0.3 (95% CI, 0.1-0.9). CONCLUSION: The results do not support that higher organochlorine body levels increase the risk of breast cancer in postmenopausal women. The interpretation of the inverse association for estrogen receptor-negative breast cancer is currently unclear.
PubMed ID
15668478 View in PubMed
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Adipose tissue fatty acids and insulin sensitivity in elderly men.

https://arctichealth.org/en/permalink/ahliterature98176
Source
Diabetologia. 2010 May;53(5):850-7
Publication Type
Article
Date
May-2010
Author
D. Iggman
J. Arnlöv
B. Vessby
T. Cederholm
P. Sjögren
U. Risérus
Author Affiliation
Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Source
Diabetologia. 2010 May;53(5):850-7
Date
May-2010
Language
English
Geographic Location
Sweden
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Aged
Chromatography, Gas
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - etiology
Dietary Fats - adverse effects
Docosahexaenoic Acids - analysis
Eicosapentaenoic Acid - analysis
Fatty Acids, Unsaturated - analysis
Glucose Clamp Technique
Health Surveys
Humans
Insulin Resistance
Longitudinal Studies
Male
Palmitic Acid - analysis
Questionnaires
Regression Analysis
Sweden
Abstract
AIMS/HYPOTHESIS: Dietary fatty acids may affect insulin sensitivity. Adipose tissue fatty acid composition partly reflects long-term dietary intake, but data from large studies regarding relationships with insulin sensitivity are lacking. We aimed to determine the association between adipose tissue fatty acids and insulin sensitivity in elderly Swedish men. METHODS: In a cross-sectional analysis of the community-based Uppsala Longitudinal Study of Adult Men (n = 795, mean age 71 years), adipose tissue biopsies were obtained and fatty acid composition was determined by gas-liquid chromatography. Insulin sensitivity was measured directly by a euglycaemic clamp. RESULTS: Palmitic acid (16:0), the major saturated fatty acid (SFA) in the diet and in adipose tissue, was negatively correlated with insulin sensitivity (r = -0.14), as were 16:1 n-7 (r = -0.15), 20:3 n-6 (r = -0.31), 20:4 n-6 (r = -0.38), 22:4 n-6 (r = -0.37) and 22:5 n-3 (r = -0.24; p
Notes
RefSource: Diabetologia. 2010 May;53(5):799-801
PubMed ID
20127308 View in PubMed
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Adipose tissue fatty acids in men from two populations with different cardiovascular risk: the LiVicordia study.

https://arctichealth.org/en/permalink/ahliterature54224
Source
Scand J Clin Lab Invest. 1999 May;59(3):227-32
Publication Type
Article
Date
May-1999
Author
A. Kaminskas
B. Ziedén
B. Elving
M. Kristenson
A. Abaravicius
B. Bergdahl
A G Olsson
Z. Kucinskiene
Author Affiliation
Department of Physiology and Biochemistry, Faculty of Medicine, Vilnius, Lithuania.
Source
Scand J Clin Lab Invest. 1999 May;59(3):227-32
Date
May-1999
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Body mass index
Comparative Study
Coronary Disease - epidemiology - metabolism
Diet, Atherogenic
Dietary Fats - analysis
Fatty Acids - analysis
Fatty Acids, Unsaturated - analysis
Humans
Lipid Peroxidation - physiology
Lipoproteins, LDL - metabolism
Lithuania - epidemiology
Male
Middle Aged
Myristic Acid - analysis
Research Support, Non-U.S. Gov't
Risk factors
Sweden - epidemiology
alpha-Linolenic Acid - analysis
Abstract
The LiVicordia study was set up to investigate possible causes for coronary heart disease mortality in middle-aged Lithuanian men being four times higher than in Swedish men. In a previous part of this study we found lower total and low density lipoprotein (LDL) cholesterol in the Lithuanian men in spite of them having a higher fat intake than in the Swedish men. Their LDL was also more susceptible to oxidation in vitro than was that of the Swedish men. Fat quality can influence LDL oxidation. In order to obtain data on long-term fat quality intake we measured the fatty acid composition of abdominal wall adipose tissue by gas chromatography in men aged 50 years from Vilnius, Lithuania (n=50) and Linköping, Sweden (n=50). Men from Vilnius had a significantly higher percentage of adipose tissue long chain polyunsaturated fatty acids (PUFA) (20:4n6, 20:5n3, 22:5n5, 22:6n3) and lower percentage of saturated fatty acids, especially myristic acid (14:0), 3.4+/-0.7 versus 4.6+/-0.8, p
PubMed ID
10400167 View in PubMed
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Age and seasonal variability of polybrominated diphenyl ethers in free-ranging East Greenland polar bears (Ursus maritimus).

https://arctichealth.org/en/permalink/ahliterature80128
Source
Environ Pollut. 2007 Mar;146(1):166-73
Publication Type
Article
Date
Mar-2007
Author
Dietz Rune
Rigét Frank F
Sonne Christian
Letcher Robert J
Backus Sean
Born Erik W
Kirkegaard Maja
Muir Derek C G
Author Affiliation
Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark. rdi@dmu.dk
Source
Environ Pollut. 2007 Mar;146(1):166-73
Date
Mar-2007
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Aging - physiology
Animals
Body Burden
Environmental Exposure
Environmental Pollutants - analysis
Female
Flame Retardants - analysis
Food chain
Greenland
Male
Polybrominated Biphenyls - analysis
Seasons
Ursidae - physiology
Abstract
Polybrominated diphenyl ethers (PBDEs) were analysed in adipose tissue from 92 East Greenland polar bears (Ursus maritimus) sampled during 1999-2001. Mean SigmaPBDE concentrations were 70 ng/g lipid weight (lw) (range: 22-192 ng/g lw) and showed no relationship with age or sex. Of the 32 analysed PBDE congeners; BDE47, BDE153, BDE99 and BDE100 dominated, and comprised 99.6% of the SigmaPBDE concentration. The SigmaPBDE concentration had a highly significant correlation with SigmaPCB, SigmaCHL, dieldrin, HCB and SigmaHCH concentrations. We found a seasonal pattern of median SigmaPBDE concentration with 1.2 to 1.8 times higher concentrations in March to July than the rest of the year. The seasonal variation also provides a clue to the seasonal exposure, bio-availability, toxic exposure and degradation. We suggest that future geographical PBDE data comparisons may not need corrections for sex or age, but such data sets should be corrected for seasonal variability, using the presented correctional trigonometric regression.
PubMed ID
17055135 View in PubMed
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Are body mass index, waist circumference and waist-to-hip ratio associated with leptin in 90-year-old people?

https://arctichealth.org/en/permalink/ahliterature116009
Source
Eur J Clin Nutr. 2013 Apr;67(4):420-2
Publication Type
Article
Date
Apr-2013
Author
I. Lisko
K. Tiainen
S. Stenholm
T. Luukkaala
M. Hurme
T. Lehtimäki
A. Hervonen
M. Jylhä
Author Affiliation
Gerontology Research Center and School of Health Sciences, University of Tampere, Tampere, Finland. inna.lisko@uta.fi
Source
Eur J Clin Nutr. 2013 Apr;67(4):420-2
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Aged, 80 and over
Body Composition
Body mass index
Female
Finland
Humans
Leptin - blood
Male
Prospective Studies
Waist Circumference
Waist-Hip Ratio
Abstract
Data on how body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are associated with body fat in the oldest-old people are scarce. The purpose of this study was to examine if BMI, WC or WHR are associated with leptin, a biological surrogate measure of body fat in 90-year-old people. The data comes from the Vitality 90+ Study, a prospective population-based study of people living in Tampere, Finland. BMI, WC, WHR and plasma concentration of leptin were available for 160 women and 54 men aged 90 years. BMI and WC had a strong significant positive association with leptin both in women and in men, but WHR was associated with leptin only in men. In conclusion, based on the circulating level of leptin, BMI and WC, and WHR in men, reflect body fat in 90-year-old people, but WHR seems to be a poor indicator of body fat in 90-year-old women.
PubMed ID
23443829 View in PubMed
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Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study.

https://arctichealth.org/en/permalink/ahliterature272722
Source
Environ Health. 2015;14:78
Publication Type
Article
Date
2015
Author
Jaakko J Koskenniemi
Helena E Virtanen
Hannu Kiviranta
Ida N Damgaard
Jaakko Matomäki
Jørgen M Thorup
Timo Hurme
Niels E Skakkebaek
Katharina M Main
Jorma Toppari
Source
Environ Health. 2015;14:78
Date
2015
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Benzofurans - toxicity
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Cryptorchidism - chemically induced - epidemiology
Denmark - epidemiology
Dioxins - toxicity
Environmental Pollutants - toxicity
Female
Finland - epidemiology
Halogenated Diphenyl Ethers - toxicity
Humans
Incidence
Infant
Infant, Newborn
Male
Polychlorinated Biphenyls - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology
Abstract
Congenital cryptorchidism, i.e. failure of the testicular descent to the bottom of the scrotum, is a common birth defect. The evidence from epidemiological, wildlife, and animal studies suggests that exposure to mixtures of endocrine disrupting chemicals during fetal development may play a role in its pathogenesis. We aimed to assess the association between cryptorchidism and prenatal exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), and polybrominated diphenyl ethers (PBDEs).
We conducted a case-control study consisting of 44 cryptorchid cases, and 38 controls operated for inguinal hernia, umbilical hernia, or hydrocele at the Turku University Hospital or Rigshospitalet, Copenhagen in 2002-2006. During the operation a subcutaneous adipose tissue biopsy was taken. Samples were analysed for 37 PCBs, 17 PCDD/Fs and 14 PBDEs by gas chromatography-high-resolution mass spectrometry. Chemical concentrations were adjusted for postnatal variation introduced by differences in duration of breastfeeding, age at the operation, and country of origin with a multiple linear regression. Association between adjusted and unadjusted chemical concentrations and the risk of cryptorchidism were analysed with logistic regression to get an estimate for odds ratio (OR) of cryptorchidism per multiplication of chemical concentrations with ca. 2.71 (Napier's constant).
Total-TEq i.e. the WHO-recommended 2,3,7,8-TCDD equivalent quantity of 17 dioxins and 12 dioxin-like PCBs and sum of PCDD/Fs were positively associated with cryptorchidism [OR 3.21 (95% CI 1.29-9.09), OR 3.69 (95% CI 1.45-10.9), respectively], when adjusting for country of origin, the duration the child was breastfed, and age at operation. The association between the sum of PCBs and cryptorchidism was close to significant [OR 1.92 (95% CI 0.98-4.01)], whereas the association between the sum of PBDEs and cryptorchidism was not [OR 0.86 (95% CI 0.47-1.54)]. There were no associations between unadjusted chemical concentrations and the risk of cryptorchidism.
Prenatal exposure to PCDD/Fs and PCDD/F-like PCBs may be associated with increased risk for cryptorchidism. Our finding does not exclude the possibility of an association between the exposure to PBDEs and cryptorchidism.
Notes
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PubMed ID
26403566 View in PubMed
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Association between trans fatty acid intake and cardiovascular risk factors in Europe: the TRANSFAIR study.

https://arctichealth.org/en/permalink/ahliterature61814
Source
Eur J Clin Nutr. 2000 Feb;54(2):126-35
Publication Type
Article
Date
Feb-2000
Author
L P van de Vijver
A F Kardinaal
C. Couet
A. Aro
A. Kafatos
L. Steingrimsdottir
J A Amorim Cruz
O. Moreiras
W. Becker
J M van Amelsvoort
S. Vidal-Jessel
I. Salminen
J. Moschandreas
N. Sigfússon
I. Martins
A. Carbajal
A. Ytterfors
G. Poppel
Author Affiliation
Department of Consumer Research and Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands. VandeVijver@Voeding.TNO.NL
Source
Eur J Clin Nutr. 2000 Feb;54(2):126-35
Date
Feb-2000
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Aged
Cardiovascular Diseases - etiology
Cholesterol - blood
Cross-Sectional Studies
Diet Records
Dietary Fats - administration & dosage
Energy intake
Europe
Fatty Acids - administration & dosage - analysis
Female
Humans
Isomerism
Linear Models
Lipids - blood
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Male
Middle Aged
Research Support, Non-U.S. Gov't
Risk factors
Abstract
BACKGROUND: High intakes of trans fatty acids (TFA) have been found to exert an undesirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. OBJECTIVES: Investigation of the association between TFA intake and serum lipids. DESIGN: Cross-sectional study in eight European countries (Finland, France, Greece, Iceland, The Netherlands, Portugal, Spain, Sweden) among 327 men and 299 women (50-65 y). Using a dietary history method, food consumption was assessed and TFA intake was calculated with recent figures on TFA levels of foods, collected in the TRANSFAIR study. RESULTS: Mean (+/-s.d.) TFA intake was 2.40+/-1.53 g/day for men and 1.98+/-1.49 g/day for women (0.87+/-0.48% and 0. 95+/-0.55% of energy, respectively), with the highest consumption in Iceland and the lowest in the Mediterranean countries. No associations were found between total TFA intake and LDL, HDL or LDL/HDL ratio after adjustment for cardiovascular risk factors. Additional adjustment for other fatty acid clusters resulted in a significant inverse trend between total TFA intake and total cholesterol (Ptrend
PubMed ID
10694783 View in PubMed
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Association of Adipose Tissue Fatty Acids With Cardiovascular and All-Cause Mortality in Elderly Men.

https://arctichealth.org/en/permalink/ahliterature295101
Source
JAMA Cardiol. 2016 10 01; 1(7):745-753
Publication Type
Journal Article
Date
10-01-2016
Author
David Iggman
Johan Ärnlöv
Tommy Cederholm
Ulf Risérus
Author Affiliation
Unit for Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden2Center for Clinical Research Dalarna, Falun, Sweden.
Source
JAMA Cardiol. 2016 10 01; 1(7):745-753
Date
10-01-2016
Language
English
Publication Type
Journal Article
Keywords
Adipose Tissue - chemistry
Aged
Aged, 80 and over
Cardiovascular Diseases - mortality
Cause of Death
Cohort Studies
Fatty Acids - analysis
Fatty Acids, Unsaturated - analysis
Humans
Male
Middle Aged
Sweden
Abstract
The major polyunsaturated fatty acids in adipose tissue objectively reflect long-term dietary intake, and may provide more reliable information than would self-reported intake. Whether adipose tissue fatty acids predict cardiovascular and all-cause mortality needs investigation.
To investigate associations between adipose tissue fatty acids and cardiovascular and overall mortality in a cohort of elderly men.
We hypothesized that polyunsaturated fatty acids reflecting dietary intake, are inversely associated with cardiovascular and all-cause mortality. In the Swedish cohort study Uppsala Longitudinal Cohort of Adult Men, buttock fatty acid composition was analyzed by gas-liquid chromatography in 1992 to 1993 and 2008. The study participants were followed during 11?311 person-years, between 1991 and 2011 (median follow-up, 14.8 years). In this community-based study that took place from 1970 to 1973, all men born in 1920 to 1924 in Uppsala, Sweden, were invited and 2322 (82%) were included (at age 50 years). At the reinvestigation at age 71 years, 1221 (73%) of the 1681 invited men participated. Adipose tissue biopsy specimens were taken in a subsample of 853 men. There was no loss to follow-up.
Adipose tissue proportions of 4 polyunsaturated fatty acids that were considered to mainly reflect dietary intake (linoleic acid, 18:2n-6; a-linolenic acid, 18:3n-3; eicosapentaenoic acid, 20:5n-3; and docosahexaenoic acid, 22:6n-3) comprised primary analyses, and all other available fatty acids were secondary analyses.
Hazard ratios (HRs) for cardiovascular and all-cause mortality using Cox proportional hazards regression analyses, performed in 2015.
Among the 853 Swedish men, there were 605 deaths, of which 251 were cardiovascular deaths. After adjusting for risk factors, none of the 4 primary fatty acids were associated with cardiovascular mortality (HR, 0.92-1.05 for each standard deviation increase; P?=?.27). Linoleic acid was inversely associated with all-cause mortality (HR,?0.90; 95% CI, 0.82-0.98; P?=?.02) and directly associated with intake (P?
PubMed ID
27541681 View in PubMed
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107 records – page 1 of 11.