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Aberrant circulating levels of purinergic signaling markers are associated with several key aspects of peripheral atherosclerosis and thrombosis.

https://arctichealth.org/en/permalink/ahliterature263533
Source
Circ Res. 2015 Mar 27;116(7):1206-15
Publication Type
Article
Date
Mar-27-2015
Author
Juho Jalkanen
Gennady G Yegutkin
Maija Hollmén
Kristiina Aalto
Tuomas Kiviniemi
Veikko Salomaa
Sirpa Jalkanen
Harri Hakovirta
Source
Circ Res. 2015 Mar 27;116(7):1206-15
Date
Mar-27-2015
Language
English
Publication Type
Article
Keywords
5'-Nucleotidase - blood
Adenosine Diphosphate - blood
Adenosine Triphosphate - blood
Adult
Age Factors
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Anoxia - blood
Antigens, CD - blood
Apyrase - blood
Artifacts
Atherosclerosis - blood - epidemiology
Biological Markers
Chronic Disease
Comorbidity
Disease Progression
Drug Utilization
Female
Finland - epidemiology
GPI-Linked Proteins - blood
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypertension - blood - drug therapy - epidemiology
Male
Middle Aged
Models, Cardiovascular
Peripheral Arterial Disease - blood - epidemiology
Purinergic P2Y Receptor Antagonists - therapeutic use
Risk factors
Second Messenger Systems
Smoking - adverse effects - blood - epidemiology
Thrombophilia - blood - epidemiology - etiology
Abstract
Purinergic signaling plays an important role in inflammation and vascular integrity, but little is known about purinergic mechanisms during the pathogenesis of atherosclerosis in humans.
The objective of this study is to study markers of purinergic signaling in a cohort of patients with peripheral artery disease.
Plasma ATP and ADP levels and serum nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/CD39) and ecto-5'-nucleotidase/CD73 activities were measured in 226 patients with stable peripheral artery disease admitted for nonurgent invasive imaging and treatment. The major findings were that ATP, ADP, and CD73 values were higher in atherosclerotic patients than in controls without clinically evident peripheral artery disease (P
PubMed ID
25645301 View in PubMed
Less detail

Effect of chronic altitude hypoxia on hematologic and glycolytic parameters.

https://arctichealth.org/en/permalink/ahliterature243223
Source
Am J Physiol. 1982 May;242(5):R447-51
Publication Type
Article
Date
May-1982
Author
J. Clench
R E Ferrell
W J Schull
Source
Am J Physiol. 1982 May;242(5):R447-51
Date
May-1982
Language
English
Publication Type
Article
Keywords
2,3-Diphosphoglycerate
Adaptation, Physiological
Adenosine Triphosphate - blood
Adolescent
Adult
Aged
Altitude Sickness - blood - metabolism
Anoxia - blood
Child
Diphosphoglyceric Acids - blood
Erythrocyte Indices
Female
Glycolysis
Hematocrit
Hemoglobins - analysis
Humans
Male
Middle Aged
Time Factors
Abstract
The physiological effect of chronic exposure to altitude hypoxia on the glycolytic intermediates, adenosine triphosphate and 2,3-diphosphoglyceric acid, and the hematologic parameters, hemoglobin, hematocrit, and mean cell hemoglobin concentration, has been examined in an indigenous population, the Aymara, of the Departamento de Arica, Chile. This population normally resides at three altitudes: the coast (0-500 m), the sierra (2,500-3,500 m), and the altiplano (above 4,200 m). After isolation of altitude from other environmental factors (age, sex, body build, ethnicity, smoking, and residential permanence), an increase in 2,3-diphosphoglycerate and a decrease in adenosine triphosphate was observed. Both hemoglobin and hematocrit increased as expected, but mean cell hemoglobin concentration declined. It is proposed that a decline in the activity of a single enzyme, pyruvate kinase, can account for these observed changes and suggests a pivotal role for pyruvate kinase in the physiological adaptation to altitude hypoxia.
PubMed ID
7081469 View in PubMed
Less detail

[Influence of conditions of artificial hibernation on energy metabolism indices in rats]

https://arctichealth.org/en/permalink/ahliterature82575
Source
Ukr Biokhim Zh. 2005 May-Jun;77(3):131-5
Publication Type
Article
Author
Mel'nychuk S D
Vykhovanets' V I
Source
Ukr Biokhim Zh. 2005 May-Jun;77(3):131-5
Language
Ukrainian
Publication Type
Article
Keywords
Adenine Nucleotides - blood - metabolism
Adenosine Diphosphate - blood - metabolism
Adenosine Monophosphate - blood - metabolism
Adenosine Triphosphate - blood - metabolism
Animals
Cyclic AMP - blood - metabolism
Energy Metabolism
Hypothermia, Induced
Liver - metabolism
Male
Rats
Time Factors
Abstract
Influence of the conditions of artificial hibernation on the content of ATP, ADP, AMP, cAMF in the blood and liver of rats is studied. It is established, that the entering and stay of animals in the conditions of artificial hibernation is accompanied by a decrease of the content of ADP and P(l). The animal coming out of the condition of artificial hibernation is accompanied by an increase of the content of ATP and cAMP and achievement in twenty-four hours of the level of monitoring values.
PubMed ID
16566140 View in PubMed
Less detail

[Phosphorus compounds in the blood of children with glomerulonephritis]

https://arctichealth.org/en/permalink/ahliterature43077
Source
Pediatr Akus Ginekol. 1974 Mar-Apr;(2):12-4
Publication Type
Article

[Several indices of macroerg metabolism and blood sulfhydryl group levels in children with glomerulonephritis and pyelonephritis]

https://arctichealth.org/en/permalink/ahliterature42222
Source
Pediatr Akus Ginekol. 1976 Sep-Oct;(5):8-10
Publication Type
Article

[The ATP content of the neutrophils and whole blood in the inhabitants of regions in the Altai Territory subjected to nuclear testing exposure].

https://arctichealth.org/en/permalink/ahliterature210204
Source
Radiats Biol Radioecol. 1997 Jan-Feb;37(1):13-9
Publication Type
Article
Author
V G Frundzhian
N A Romanova
E I Dement'eva
L Iu Brovko
N N Ugarova
K N Novikov
V I Brusovanik
V O Kobialko
N A Meshkov
Source
Radiats Biol Radioecol. 1997 Jan-Feb;37(1):13-9
Language
Russian
Publication Type
Article
Keywords
Adenosine Triphosphate - blood - radiation effects
Animals
Erythrocytes - drug effects - radiation effects
Female
Gamma Rays
Humans
Male
Neutrophils - drug effects - radiation effects
Nuclear Warfare
Radioactive Fallout - adverse effects
Rats
Rats, Wistar
Rural Population
Siberia
Time Factors
Xenobiotics - pharmacology
Abstract
The bioluminescent method was used in the studies of the influence of ionizing irradiation and/or xenobiotics on the content of ATP in RBC and neutrophils of rats, and in whole blood and neutrophils of 80 examined women of Altai Region exposed to ionizing radiation during a series of nuclear tests in Semipalatinsk in 1949-1965. Deviations from the normal ATP content were measured with due to account of the natural variability of a given metabolite. For rats, deviations from the content of ATP in erythrocytes were short-term, those in neutrophils were long-term. For people, a statistically significant increase in the content of ATP in neutrophils as compared to the control was observed. A non-linear correlation between the content of ATP in neutrophils and the calculated dose of radiation was observed. An increase in the ATP content in whole blood, with regard to the control, was not statistically significant for all groups of examined persons.
PubMed ID
9102122 View in PubMed
Less detail

[The blood energy system in pneumonia in children of the 1-4 years of age group]

https://arctichealth.org/en/permalink/ahliterature43768
Source
Pediatr Akus Ginekol. 1972 Jan-Feb;1:11-3
Publication Type
Article

8 records – page 1 of 1.