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Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study.

https://arctichealth.org/en/permalink/ahliterature297760
Source
Eur J Epidemiol. 2018 01; 33(1):67-77
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
01-2018
Author
Yi-Qian Sun
Arnulf Langhammer
Chunsen Wu
Frank Skorpen
Yue Chen
Tom Ivar Lund Nilsen
Pål Richard Romundstad
Xiao-Mei Mai
Author Affiliation
Department of Clinical and Molecular Medicine (IKOM), NTNU, Norwegian University of Science and Technology, Trondheim, Norway. yi-qian.sun@ntnu.no.
Source
Eur J Epidemiol. 2018 01; 33(1):67-77
Date
01-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adenocarcinoma - blood - epidemiology - pathology
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Incidence
Lung Neoplasms - blood - epidemiology - pathology
Male
Middle Aged
Norway - epidemiology
Prospective Studies
Vitamin D - analogs & derivatives - blood
Abstract
Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of serum 25(OH)D levels with incidence of lung cancer overall and different histologic types. We performed a population-based prospective case-cohort study including 696 incident lung cancer cases and 5804 individuals in a subcohort who participated in the second survey of the Nord-Trøndelag Health Study in Norway. Cox proportional hazards regression models counting for the case-cohort design were used to estimate hazard ratios (HRs) with 95% confidence interval (CIs) for lung cancer overall or histologic types in relation to serum 25(OH)D levels. Compared with the fourth season-specific quartile of 25(OH)D (median 68.0 nmol/L), lower 25(OH)D levels were not associated with the incidence of overall, small or squamous cell lung cancer. However, the risk of adenocarcinoma was lower in the second and third quartiles (median 39.9 and 51.5 nmol/L) compared with the fourth quartile, with HRs of 0.63 (95% CI 0.41-0.98) and 0.58 (0.38-0.88), respectively. The associations of lower levels of 25(OH)D with a reduced risk of adenocarcinoma were only observed in the overweight/obese subjects [HRs for second and third quartiles: 0.40 (0.22-0.72) and 0.50 (0.27-0.92)] but not in the normal weight subjects [HRs: 0.95 (0.52-1.75) and 0.60 (0.32-1.10)]. Serum 25(OH)D levels were not associated with the risk of lung cancer in general. The observation that lower 25(OH)D levels were associated with a lower risk of adenocarcinoma should be interpreted with caution.
PubMed ID
29080012 View in PubMed
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