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Predictors of symptomatic HIV-associated neurocognitive disorders in universal health care.

https://arctichealth.org/en/permalink/ahliterature120519
Source
HIV Med. 2013 Feb;14(2):99-107
Publication Type
Article
Date
Feb-2013
Author
J A McCombe
P. Vivithanaporn
M J Gill
C. Power
Author Affiliation
Department of Medicine, University of Alberta, Edmonton, AB, Canada. jmccombe@ualberta.ca
Source
HIV Med. 2013 Feb;14(2):99-107
Date
Feb-2013
Language
English
Publication Type
Article
Keywords
AIDS Dementia Complex - epidemiology - etiology - physiopathology
Acquired Immunodeficiency Syndrome - complications - epidemiology - physiopathology
Adolescent
Adult
Aged
Aged, 80 and over
Anti-HIV Agents - therapeutic use
CD4 Lymphocyte Count
Canada - epidemiology
Cognition Disorders - epidemiology - etiology - physiopathology
Cohort Studies
Female
HIV Infections
HIV Seropositivity - complications - epidemiology - physiopathology
Hepatitis C
Humans
Logistic Models
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Predictive value of tests
Risk factors
Viral Load
Abstract
The aim of the study was to determine the risk factors predictive of symptomatic HIV-associated neurocognitive disorders (sHAND) among HIV-infected patients receiving active medical care.
Baseline demographic and clinical characteristics were analysed in patients with sHAND (HIV-associated dementia and minor neurocognitive disorder) in a population-based longitudinal cohort of HIV-infected patients with access to universal health care, including combination antiretroviral therapy (cART) from 1999 to 2008. Variables evaluated for their association with sHAND included age and ethnicity, survival duration with HIV-1 infection, vascular disease risk factors, and laboratory indices such as blood CD4 T-cell count at its nadir and at cART initiation, using both univariable and multivariable logistic regression models.
A total of 1320 patients were investigated, including the patients diagnosed with sHAND (n = 90) during the study period. In univariable analyses, increased age, increased length of survival with HIV, low nadir CD4 and CD8 T-cell counts, high baseline viral load (> 1,000,000 HIV-1 RNA copies/mL), and African origin were predictive of a diagnosis of sHAND (P
PubMed ID
22994556 View in PubMed
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