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Chloracne caused by ingestion of olive oil contaminated with PCDDs and PCDFs.

https://arctichealth.org/en/permalink/ahliterature37044
Source
Hum Exp Toxicol. 1991 Sep;10(5):311-22
Publication Type
Article
Date
Sep-1991
Author
A. Rodriguez-Pichardo
F. Camacho
C. Rappe
M. Hansson
A G Smith
J B Greig
Author Affiliation
Departmento de Dermatologia, Universidad de Sevilla, Spain.
Source
Hum Exp Toxicol. 1991 Sep;10(5):311-22
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Acne Vulgaris - chemically induced
Adult
Animals
Benzofurans - poisoning
Chickens
Child
Child, Preschool
Female
Food contamination - analysis
Humans
Infant, Newborn
Male
Mice
Plant Oils - analysis
Polymers - poisoning
Spain
Tetrachlorodibenzodioxin - analogs & derivatives - poisoning
Abstract
1. All members of a Spanish family (father, mother and six children) developed chloracne. 2. The causative agent was found to be the family's stock of olive oil, which had become contaminated with polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), pentachlorophenol, and hexachlorobenzene. 3. The more highly chlorinated PCDDs, in particular octachlorodibenzo-p-dioxin, were the predominant congeners in the oil. 4. Three members of the family exhibited either an overt or a sub-clinical disturbance of kidney function. The father also had a chronic respiratory problem. These changes could not be unequivocally attributed to the PCDDs. 5. Experimental toxicity of the oil was limited to the development of an hepatic porphyria in mice. 6. A serum sample, taken 5 years after consumption of the oil ceased, contained high levels of the PCDDs and PCDFs. Extrapolation back to ingested dose was used to validate dosage estimates. 7. The use of toxicity equivalence factors (TEFs) provided estimates of cumulative dosage to produce chloracne as 0.13-0.31 micrograms 2378-TCDD kg-1 (using EPA TEFs) or 6.7-16 micrograms 2378-TCDD kg-1 (using Nordic/NATO TEFs). 8. This is the first incident in which human toxicity is related primarily to ingestion of PCDDs and for which estimates of dosage can be made.
PubMed ID
1683543 View in PubMed
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Severe acne as a side effect of propranolol and nadolol in a migraineur.

https://arctichealth.org/en/permalink/ahliterature10252
Source
Headache. 1999 Nov-Dec;39(10):758-60
Publication Type
Article
Author
Z H Bajwa
N. Sami
C. Flory
Author Affiliation
Department of Anesthesia and Neurology, Arnold Pain Center, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
Source
Headache. 1999 Nov-Dec;39(10):758-60
Language
English
Publication Type
Article
Keywords
Acne Vulgaris - chemically induced
Adrenergic beta-Antagonists - adverse effects
Adult
Female
Humans
Migraine Disorders - drug therapy
Nadolol - adverse effects
Propranolol - adverse effects
Abstract
Beta-blockers have proven effective in the treatment of migraine. Dermatologic side effects are extremely rare. We report a patient with migraine who developed an acnelike dermatitis with two different beta-blockers with complete resolution of the acne upon discontinuation of each drug.
PubMed ID
11279953 View in PubMed
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