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The ABCA4 2588G>C Stargardt mutation: single origin and increasing frequency from South-West to North-East Europe.

https://arctichealth.org/en/permalink/ahliterature50771
Source
Eur J Hum Genet. 2002 Mar;10(3):197-203
Publication Type
Article
Date
Mar-2002
Author
Alessandra Maugeri
Kris Flothmann
Nadine Hemmrich
Sofie Ingvast
Paula Jorge
Eva Paloma
Reshma Patel
Jean-Michel Rozet
Jaana Tammur
Francesco Testa
Susana Balcells
Alan C Bird
Han G Brunner
Carel B Hoyng
Andres Metspalu
Francesca Simonelli
Rando Allikmets
Shomi S Bhattacharya
Michele D'Urso
Roser Gonzàlez-Duarte
Josseline Kaplan
Gerard J te Meerman
Rosário Santos
Marianne Schwartz
Guy Van Camp
Claes Wadelius
Bernhard H F Weber
Frans P M Cremers
Author Affiliation
Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands. a.maugeri@antrg.azn.nl
Source
Eur J Hum Genet. 2002 Mar;10(3):197-203
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Alleles
Base Sequence
Europe
Gene Frequency
Heterozygote
Humans
Molecular Sequence Data
Mutation
Point Mutation
Research Support, Non-U.S. Gov't
United States
Abstract
Inherited retinal dystrophies represent the most important cause of vision impairment in adolescence, affecting approximately 1 out of 3000 individuals. Mutations of the photoreceptor-specific gene ABCA4 (ABCR) are a common cause of retinal dystrophy. A number of mutations have been repeatedly reported for this gene, notably the 2588G>C mutation which is frequent in both patients and controls. Here we ascertained the frequency of the 2588G>C mutation in a total of 2343 unrelated random control individuals from 11 European countries and 241 control individuals from the US, as well as in 614 patients with STGD both from Europe and the US. We found an overall carrier frequency of 1 out of 54 in Europe, compared with 1 out of 121 in the US, confirming that the 2588G>C ABCA4 mutation is one of the most frequent autosomal recessive mutations in the European population. Carrier frequencies show an increasing gradient in Europe from South-West to North-East. The lowest carrier frequency, 0 out of 199 (0%), was found in Portugal; the highest, 11 out of 197 (5.5%), was found in Sweden. Haplotype analysis in 16 families segregating the 2588G>C mutation showed four intragenic polymorphisms invariably present in all 16 disease chromosomes and sharing of the same allele for several markers flanking the ABCA4 locus in most of the disease chromosomes. These results indicate a single origin of the 2588G>C mutation which, to our best estimate, occurred between 2400 and 3000 years ago.
PubMed ID
11973624 View in PubMed
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ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

https://arctichealth.org/en/permalink/ahliterature150732
Source
Clin Pharmacol Ther. 2009 Aug;86(2):197-203
Publication Type
Article
Date
Aug-2009
Author
J E Keskitalo
O. Zolk
M F Fromm
K J Kurkinen
P J Neuvonen
M. Niemi
Author Affiliation
Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Source
Clin Pharmacol Ther. 2009 Aug;86(2):197-203
Date
Aug-2009
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Adult
Anticholesteremic Agents - pharmacokinetics
Area Under Curve
Cross-Over Studies
Drug Resistance, Multiple
European Continental Ancestry Group - genetics
Female
Finland
Fluorobenzenes - administration & dosage - blood - pharmacokinetics - urine
Genotype
Heptanoic Acids - administration & dosage - blood - pharmacokinetics - urine
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Linear Models
Male
Neoplasm Proteins - genetics
Polymorphism, Single Nucleotide
Pyrimidines - administration & dosage - blood - pharmacokinetics - urine
Pyrroles - administration & dosage - blood - pharmacokinetics - urine
Reference Values
Sulfonamides - administration & dosage - blood - pharmacokinetics - urine
Abstract
The ABCG2 c.421C>A single-nucleotide polymorphism (SNP) was determined in 660 healthy Finnish volunteers, of whom 32 participated in a pharmacokinetic crossover study involving the administration of 20 mg atorvastatin and rosuvastatin. The frequency of the c.421A variant allele was 9.5% (95% confidence interval 8.1-11.3%). Subjects with the c.421AA genotype (n = 4) had a 72% larger mean area under the plasma atorvastatin concentration-time curve from time 0 to infinity (AUC(0-infinity)) than individuals with the c.421CC genotype had (n = 16; P = 0.049). In participants with the c.421AA genotype, the rosuvastatin AUC(0-infinity) was 100% greater than in those with c.421CA (n = 12) and 144% greater than in those with the c.421CC genotype. Also, those with the c.421AA genotype showed peak plasma rosuvastatin concentrations 108% higher than those in the c.421CA genotype group and 131% higher than those in the c.421CC genotype group (P
PubMed ID
19474787 View in PubMed
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Adrenoleukodystrophy in Norway: high rate of de novo mutations and age-dependent penetrance.

https://arctichealth.org/en/permalink/ahliterature116231
Source
Pediatr Neurol. 2013 Mar;48(3):212-9
Publication Type
Article
Date
Mar-2013
Author
Morten A Horn
Lars Retterstøl
Michael Abdelnoor
Ola H Skjeldal
Chantal M E Tallaksen
Author Affiliation
Department of Neurology, Oslo University Hospital, Oslo, Norway. morten.andreas.horn@ous-hf.no
Source
Pediatr Neurol. 2013 Mar;48(3):212-9
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Adolescent
Adrenoleukodystrophy - epidemiology - genetics
Adult
Age Factors
Cross-Sectional Studies
Female
Humans
Incidence
Male
Middle Aged
Mutation
Norway - epidemiology
Penetrance
Phenotype
Prevalence
Retrospective Studies
Survival Rate
Abstract
To investigate X-linked adrenoleukodystrophy in an unselected population, we performed a population based, cross-sectional prevalence study, supplemented by a retrospective study of deceased subjects. Sixty-three subjects (34 males, 29 females) belonging to 22 kindreds were included. Thirty-nine subjects (13 males, 26 females) were alive, and 24 (21 males, 3 females) were deceased on the prevalence day. The point prevalence of X-linked adrenoleukodystrophy in Norway on July 1, 2011, was 0.8 per 100,000 inhabitants. The incidence at birth in the period 1956-1995 was 1.6 per 100,000 inhabitants. An age-dependent penetrance was observed among males and females, with more severe phenotypes appearing with rising age. Only 5% of deceased males had not developed cerebral leukodystrophy. No female older than 50 years was neurologically intact. Sixteen mutations in the ABCD1 gene were identified. De novo mutations were found in 19% of probands. The frequency of X-linked adrenoleukodystrophy was lower in Norway than reported in the literature. A more severe natural course than previously reported was observed, indicating a need for better follow-up of both male and female patients. Given the high rate of de novo mutations, identification programs such as newborn screening may be required to offer timely treatment to all patients.
PubMed ID
23419472 View in PubMed
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Adrenomyeloneuropathy: report of a new mutation in a French Canadian female.

https://arctichealth.org/en/permalink/ahliterature173849
Source
Can J Neurol Sci. 2005 May;32(2):261-3
Publication Type
Article
Date
May-2005
Author
Annie Dionne
Denis Brunet
Alexander McCampbell
Nicolas Dupré
Author Affiliation
Départment des Sciences Neurologiques, CHAUQ-Hôpital Enfant-Jésus, McGill University, QC, Canada.
Source
Can J Neurol Sci. 2005 May;32(2):261-3
Date
May-2005
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Adrenoleukodystrophy - genetics - metabolism - physiopathology
Amino Acid Sequence - genetics
Amino Acid Substitution - genetics
Chromosomes, Human, X - genetics
DNA Mutational Analysis
Diagnosis, Differential
Exons - genetics
Family Health
Female
Genetic Testing
Humans
Middle Aged
Mutation, Missense - genetics
Pedigree
Phenotype
Quebec - ethnology
Sex Factors
Abstract
X-linked adrenoleukodystrophy is a peroxisomial disorder caused by mutations in the ABCD1 gene. Adrenomyeloneuropathy is the second most frequent phenotype (25-46%) of this disease and classically presents in adulthood with spastic paraparesis. Female heterozygotes can be symptomatic, but they are frequently misdiagnosed as having multiple sclerosis.
We report a novel missense mutation in the ABCD1 gene in a 47-year-old French-Canadian female with spastic paraparesis and no confirmed family history of X-linked adrenoleukodystrophy. The mutation is located on exon 1 and causes the amino acid substitution of a valine for an alanine in a region of the protein highly conserved between mouse and man.
Adrenomyeloneuropathy must be considered in the differential diagnosis of spastic paraparesis in men or women. This is an initial report of an ABCD1 gene mutation in the French-Canadian population, which should lead to the recognition of other cases in the future.
PubMed ID
16018167 View in PubMed
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Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes.

https://arctichealth.org/en/permalink/ahliterature190837
Source
Hum Immunol. 2002 Jan;63(1):61-70
Publication Type
Article
Date
Jan-2002
Author
Alfred Penfornis
Eva Tuomilehto-Wolf
Denise L Faustman
Graham A Hitman
Author Affiliation
Immunobiology Laboratory, Massachusetts General Hospital-East and Harvard Medical School, Charlestown 02129, USA.
Source
Hum Immunol. 2002 Jan;63(1):61-70
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Alleles
Base Sequence
Case-Control Studies
DNA Primers - genetics
Diabetes Mellitus, Type 1 - genetics
Female
Finland
Gene Frequency
Genes, MHC Class II
Genotype
Humans
Linkage Disequilibrium
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Abstract
Type I diabetes mellitus is an immune-mediated disease that is known to be associated and linked with genes in the human leukocyte antigen (HLA) region on chromome 6. Functionally, HLA class I antigen presentation may be deranged in type I diabetes. The TAP1 and TAP2 transporters, which mediate the translocation of antigenic peptides into the endoplasmic reticulum and whose genes are located in the HLA class II region, are potential candidates for conferrring predisposition to type I diabetes. Five known coding region variants (codons 379, 565, 651, 665, and 687) as well as three new polymorphisms of TAP2, one silent (codon 604) and two intronic (nucleotide positions 49,270 and 49,471), were typed in a cohort of 146 well-characterized Finnish individuals with type I diabetes and 90 control subjects. Absolute linkage disequilibrium was apparent for the polymorphisms at codons 604, 665, and 687 as well as the two downstream intronic polymorphisms in a 613-bp region of the 3' portion of TAP2; the polymorphism at codon 651, which is also present within this region, was excluded from this linkage. The codon 651 polymorphism defines the allele TAP2F, the frequency of which in HLA-DR4+ diabetic subjects was 5.4 times that in DR4+ controls (27 vs. 5%, p = 0.002, p(c) = 0.01). These data are consistent with the existence of susceptibility haplotypes for type I diabetes in the Finnish population consisting of DRB1*04 (*0401 and *0404), DQ8, and TAP2F.
PubMed ID
11916171 View in PubMed
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Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis originating from endodontic infections in Finland and Lithuania.

https://arctichealth.org/en/permalink/ahliterature169666
Source
Oral Microbiol Immunol. 2006 Jun;21(3):164-8
Publication Type
Article
Date
Jun-2006
Author
A H Reynaud Af Geijersstam
M J Ellington
M. Warner
N. Woodford
M. Haapasalo
Author Affiliation
Department of Endodontics, Institute of Clinical Odontology, Oslo, Norway. annehr@odont.uio.no
Source
Oral Microbiol Immunol. 2006 Jun;21(3):164-8
Date
Jun-2006
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Anti-Bacterial Agents - pharmacology
Base Sequence
DNA Mutational Analysis
Dental Pulp Cavity - microbiology
Drug Resistance, Multiple, Bacterial - genetics
Electrophoresis, Gel, Pulsed-Field
Enterococcus faecalis - drug effects - genetics
Finland - epidemiology
Genes, Bacterial
Gram-Positive Bacterial Infections - epidemiology - microbiology
Humans
Latvia - epidemiology
Microbial Sensitivity Tests
Molecular Epidemiology
Molecular Sequence Data
Periapical Periodontitis - epidemiology - microbiology
Virginiamycin - analogs & derivatives - pharmacology
Abstract
Enterococcus faecalis strains with multiple antibiotic resistances can cause infections that are difficult to treat. The microbial flora in treatment-resistant apical periodontitis is dominated by E. faecalis, and is a potential source of infections at other sites.
Sensitivities to a range of antibiotics were determined for 59 endodontic E. faecalis isolates from Finland and Lithuania. The DNA sequence of the gene responsible for the species' intrinsic quinupristin-dalfopristin resistance, lsa, was determined from two isolates with diminished resistance. Four pairs of isolates from the same root canal were typed by pulsed-field gel electrophoresis.
A high prevalence of resistance to rifampicin was found, whereas all isolates were susceptible or showed intermediate susceptibility to penicillin and ampicillin and four isolates were unusually susceptible to cefotaxime. No vancomycin or high-level gentamicin resistance was detected. Nine of 59 isolates were susceptible to quinupristin-dalfopristin. A fully quinupristin-dalfopristin-susceptible isolate also susceptible to clindamycin produced a truncated Lsa polypeptide, and an isolate with borderline quinupristin-dalfopristin-susceptibility had mutations proximal to the predicted ribosomal binding site. Pulsed-field gel electrophoresis showed that the same root canal could harbor two different strains of E. faecalis during the course of the same infection.
Despite the differing antibiotic usage in Finland and Lithuania, E. faecalis from endodontic infections in these countries showed similar susceptibility patterns with levels of resistance considered typical for the species, and decreased resistance to clindamycin and quinupristin-dalfopristin as well as lesions in the lsa gene which were similar to those described in other clinical isolates.
PubMed ID
16626373 View in PubMed
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Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis.

https://arctichealth.org/en/permalink/ahliterature151250
Source
Arthritis Rheum. 2009 May;60(5):1317-23
Publication Type
Article
Date
May-2009
Author
W P Maksymowych
R D Inman
D D Gladman
J P Reeve
A. Pope
P. Rahman
Author Affiliation
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. walter.maksymowych@ualberta.ca
Source
Arthritis Rheum. 2009 May;60(5):1317-23
Date
May-2009
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Aminopeptidases - genetics
Canada
European Continental Ancestry Group
Genetic Predisposition to Disease - genetics
Haplotypes
Humans
Multienzyme Complexes - genetics
Polymorphism, Single Nucleotide
Proteasome Endopeptidase Complex
Spondylitis, Ankylosing - genetics
Abstract
Alterations in antigen processing have been proposed to play a significant role in the pathogenesis of ankylosing spondylitis (AS). A non-major histocompatibility complex gene encoding an endoplasmic reticulum aminopeptidase, ERAP1, has been implicated recently. This study assessed 13 coding single-nucleotide polymorphisms (SNPs) from 5 genes involved in antigen processing (ERAP1, TAP1, TAP2, LMP2, and LMP7) in 3 Canadian cohorts of patients with AS, to address the possibility of gene interactions in disease susceptibility.
The study involved 992 AS cases and 1,437 controls from 3 centers (472 cases and 451 controls from Alberta, 138 cases and 392 controls from Newfoundland, and 382 cases and 594 controls from Toronto). Most of the patients with AS and healthy, unrelated controls were Caucasians of northern European descent. Single-marker and haplotype associations were determined using an allelic likelihood ratio test in UNPHASED, version 3.0.12, and the WHAP program, respectively. P values for significance of haplotype associations were calculated using a permutation test.
A specific ERAP1 haplotype, rs27044/10050860/30187-CCT, was strongly associated with increased risk of AS in all 3 case-control cohorts (pooled odds ratio [OR] 1.81, 95% confidence interval [95% CI] 1.46-2.24; P=7x10(-8)), while a second specific ERAP1 haplotype, rs30187/26618/26653-CTG, reduced the disease risk (pooled OR 0.77, 95% CI 0.67-0.88; P=9x10(-5)). Significant associations were also noted for 3 ERAP1 SNP variants (rs10050860, rs30187, and rs26653), although no significant haplotype interaction between ERAP1 and TAP/LMP loci was evident.
These data indicate that an AS disease locus may reside on a specific ERAP1 haplotype, and its effect is not multiplicative with contributions from TAP and LMP genes.
PubMed ID
19404951 View in PubMed
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Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease.

https://arctichealth.org/en/permalink/ahliterature86329
Source
JAMA. 2008 Jun 4;299(21):2524-32
Publication Type
Article
Date
Jun-4-2008
Author
Frikke-Schmidt Ruth
Nordestgaard Børge G
Stene Maria C A
Sethi Amar A
Remaley Alan T
Schnohr Peter
Grande Peer
Tybjaerg-Hansen Anne
Author Affiliation
Department of Clinical Biochemistry, Rigshospitalet, Herlev Hospital.
Source
JAMA. 2008 Jun 4;299(21):2524-32
Date
Jun-4-2008
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Aged
Cholesterol, HDL - blood
Denmark
European Continental Ancestry Group - genetics
Female
Genotype
Humans
Loss of Heterozygosity
Male
Middle Aged
Mutation
Myocardial Ischemia - blood - epidemiology - genetics
Risk factors
Abstract
CONTEXT: Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear. OBJECTIVE: To determine whether genetically reduced HDL cholesterol due to heterozygosity for 4 loss-of-function mutations in ABCA1 cause increased risk of ischemic heart disease (IHD). DESIGN, SETTING, AND PARTICIPANTS: Three studies of white individuals from Copenhagen, Denmark, were used: the Copenhagen City Heart Study (CCHS), a 31-year prospective general population study (n = 9022; 28 heterozygotes); the Copenhagen General Population Study (CGPS), a cross-sectional general population study (n = 31,241; 76 heterozygotes); and the Copenhagen Ischemic Heart Disease Study (CIHDS), a case-control study (n = 16,623; 44 heterozygotes). End points in all 3 studies were recorded during the period of January 1, 1976, through July 9, 2007. MAIN OUTCOME MEASURES: Levels of HDL cholesterol in the general population, cellular cholesterol efflux, and the association between IHD and HDL cholesterol and genotype. RESULTS: Heterozygotes vs noncarriers for 4 ABCA1 mutations (P1065S, G1216V, N1800H, R2144X) had HDL cholesterol levels of 41 mg/dL (interquartile range, 31-50 mg/dL) vs 58 mg/dL (interquartile range, 46-73 mg/dL), corresponding to a reduction in HDL cholesterol of 17 mg/dL (P
PubMed ID
18523221 View in PubMed
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Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

https://arctichealth.org/en/permalink/ahliterature172935
Source
Neurosci Lett. 2006 Jan 2;391(3):142-6
Publication Type
Article
Date
Jan-2-2006
Author
Nobuto Shibata
Toshitaka Kawarai
Joseph H Lee
Hye-Seung Lee
Eri Shibata
Christine Sato
Yan Liang
Rajan Duara
Richard P Mayeux
Peter H St George-Hyslop
Ekaterina Rogaeva
Author Affiliation
Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ont., Canada M5S 3H2.
Source
Neurosci Lett. 2006 Jan 2;391(3):142-6
Date
Jan-2-2006
Language
English
Publication Type
Article
Keywords
ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters - genetics
Aged
Alzheimer Disease - genetics - metabolism
Caribbean Region - epidemiology
Cholesterol - metabolism
Female
Florida - epidemiology
Genetic Predisposition to Disease - epidemiology - genetics
Hispanic Americans - statistics & numerical data
Humans
Male
Ontario - epidemiology
Phenotype
Prevalence
Risk Assessment - methods
Risk factors
Statistics as Topic
Steroid Hydroxylases - genetics
Abstract
Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). Case-control of North American Caucasians and AD families of Caribbean Hispanic origin were examined. Although excellent biological candidates, the case-control dataset did not support the hypothesis that these three genes were associated with susceptibility to AD. Similarly, no association was found in the Caribbean Hispanic families for CH25H. However, we did observe a possible interaction between ABCA1 and APOE in the Hispanics.
PubMed ID
16157450 View in PubMed
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ATP-binding cassette transporter A1 locus is not a major determinant of HDL-C levels in a population at high risk for coronary heart disease.

https://arctichealth.org/en/permalink/ahliterature53618
Source
Atherosclerosis. 2003 Feb;166(2):285-90
Publication Type
Article
Date
Feb-2003
Author
Sakari Kakko
Jani Kelloniemi
Peter von Rohr
Ina Hoeschele
Minna Tamminen
Margaret E Brousseau
Y Antero Kesäniemi
Markku J Savolainen
Author Affiliation
Department of Internal Medicine and Biocenter Oulu, University of Oulu, P.O. BOX 5000, 90014, Oulu, Finland. sakari.kakko@oulu.fi
Source
Atherosclerosis. 2003 Feb;166(2):285-90
Date
Feb-2003
Language
English
Publication Type
Article
Keywords
ATP-Binding Cassette Transporters - genetics
Adult
Analysis of Variance
Case-Control Studies
Comparative Study
Coronary Disease - epidemiology - genetics
Female
Finland - epidemiology
Genetic Predisposition to Disease
Genotype
Humans
Incidence
Lipoproteins, HDL Cholesterol - analysis - metabolism
Male
Middle Aged
Mutation
Phenotype
Probability
Research Support, Non-U.S. Gov't
Risk assessment
Sampling Studies
Sensitivity and specificity
Abstract
ATP-binding cassette transporter A1 (ABCA1) transports cellular cholesterol to lipid-poor apolipoproteins. Mutations in the ABCA1 gene are linked to rare phenotypes, familial hypoalphalipoproteinemia (FHA) and Tangier disease (TD), characterized by markedly decreased plasma high-density lipoprotein cholesterol (HDL-C) levels. The aim was to test if the ABCA1 locus is a major locus regulating HDL-C levels in the homogenous Finnish population with a high prevalence of coronary heart disease (CHD). Firstly, the ABCA1 locus was tested for linkage to HDL-C levels in 35 families with premature CHD and low HDL-C levels. Secondly, 62 men with low HDL-C levels and CHD were screened for the five mutations known to cause FHA. Thirdly, polymorphisms of the ABCA1 gene were tested for an association with HDL-C levels in a population sample of 515 subjects. The ABCA1 locus was not linked to HDL-C levels in the CHD families, and no carriers of the FHA mutations were found. The AA596 genotype was associated with higher HDL-C levels compared with the GG and GA genotypes in the women, but not in the men. The G596A genotypes explained 4% and the A2589G genotypes 3% of the variation in plasma HDL-C levels in women. The data suggest that the ABCA1 locus is of minor importance in the regulation of HDL-C in Finns.
Notes
Comment In: Atherosclerosis. 2003 Oct;170(2):34914612218
PubMed ID
12535741 View in PubMed
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52 records – page 1 of 6.