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Adjuvant chemotherapy for non-small-cell lung cancer in the elderly: a population-based study in Ontario, Canada.

https://arctichealth.org/en/permalink/ahliterature124994
Source
J Clin Oncol. 2012 May 20;30(15):1813-21
Publication Type
Article
Website
Date
May-20-2012
Author
Sinead Cuffe
Christopher M Booth
Yingwei Peng
Gail E Darling
Gavin Li
Weidong Kong
William J Mackillop
Frances A Shepherd
Author Affiliation
Princess Margaret Hospital, University Health Network, Toronto, Canada. sinead.cuffe@uhn.on.ca
Source
J Clin Oncol. 2012 May 20;30(15):1813-21
Date
May-20-2012
Language
English
Publication Type
Article
Website
Keywords
Age Factors
Aged
Aged, 80 and over
Antineoplastic Agents - adverse effects - therapeutic use
Carcinoma, Non-Small-Cell Lung - mortality - pathology - therapy
Chemotherapy, Adjuvant
Chi-Square Distribution
Electronic Health Records
Female
Hospitalization
Humans
Kaplan-Meier Estimate
Logistic Models
Lung Neoplasms - mortality - pathology - therapy
Male
Medical Record Linkage
Multivariate Analysis
Odds Ratio
Ontario
Physician's Practice Patterns - statistics & numerical data
Pneumonectomy - adverse effects - mortality
Registries
Retrospective Studies
Time Factors
Treatment Outcome
Abstract
Non-small-cell lung cancer (NSCLC) is predominantly a disease of the elderly. Retrospective analyses of the National Cancer Institute of Canada Clinical Trials Group JBR.10 trial and the Lung Adjuvant Cisplatin Evaluation (LACE) meta-analysis suggest that the elderly benefit from adjuvant chemotherapy. However, the elderly were under-represented in these studies, raising concerns regarding the reproducibility of the study results in clinical practice.
By using the Ontario Cancer Registry, we identified 6,304 patients with NSCLC who were treated with surgical resection from 2001 to 2006. Registry data were linked to electronic treatment records. Uptake of chemotherapy was compared across age groups: younger than 70, 70 to 74, 75 to 79, and = 80 years. As a proxy of survival benefit from chemotherapy, we compared survival of patients diagnosed from 2004 to 2006 with survival of those diagnosed from 2001 to 2003. Hospitalization rates within 6 to 24 weeks of surgery served as a proxy of severe chemotherapy-related toxicity.
In all, 2,763 (43.8%) of 6,304 surgical patients were elderly (age = 70 years). Uptake of adjuvant chemotherapy in the elderly increased from 3.3% (2001 to 2003) to 16.2% (2004 to 2006). Among evaluable elderly patients, 70% received cisplatin and 28% received carboplatin-based regimens. Requirements for dose adjustments or drug substitutions were similar across age groups. Hospitalization rates within 6 to 24 weeks of surgery were similar across age groups (28.0% for patients age
PubMed ID
22529258 View in PubMed
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Alaska Area Health Education Centers (AHEC)

https://arctichealth.org/en/permalink/ahliterature288378
Publication Type
Website
  2 websites  
Author Affiliation
University of Alaska Anchorage
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
One Health
Northern communities
Public Health
Area Health Education Centers
Alaska
Primary Health Care
Health Occupations
Health Personnel
Rural Population
Quality of Health Care
Abstract
The Alaska Area Health Education Centers (AHEC) program began at the University of Alaska Anchorage (UAA) in 2005. AHECs are academic and community-based partnerships engaged in primary care workforce engagement, training and recruiting, and retaining activities to improve the distribution, diversity, supply and quality of health care personnel. The Alaska AHEC program office (at UAA) contracts with five regional Centers to implement educational activities involving health professions and to expose students to primary care delivery in rural and/or underserved settings. In addition, AHECs work closely with state and local workforce investment boards to identify and address health care needs and shortages.
The Alaska Center for Rural Health (ACRH) was created in 1987 by rural health care providers, educators, and administrators. Our mission is to help strengthen systems to deliver comprehensive and culturally relevant health care to rural Alaskans.
Online Resources
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Alaska Community Action on Toxics (ACAT)

https://arctichealth.org/en/permalink/ahliterature288381
Publication Type
Website
  1 website  
Author Affiliation
Alaska Community Action On Toxics
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
One Health
Northern communities
Witnesses to Change
Alaska
Environmental pollution
Environment
Abstract
ACAT is an environmental group based in Alaska that encourages a community based approach to determining exposure, sources and solutions to environmental contaminants.
Online Resources
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Alaska Environmental Health Association (AEHA)

https://arctichealth.org/en/permalink/ahliterature288383
Publication Type
Website
  1 website  
Author Affiliation
Alaska Environmental Health Association
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
One Health
Northern communities
Public Health
Environmental health
Health Personnel
Environment
Abstract
AEHA is a professional group of sanitarians and environmental health professionals who work to control those factors of the environment that result or may result in harmful effects to the health and well-being of all Alaskans.
Online Resources
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Publication Type
Website
  1 website  
Author Affiliation
Alaska Forum on the Environment
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
What’s New
Conferences & Symposiums
Hazardous Waste
Alaska
Environment
Environmental Pollution
Abstract
The Alaska Forum, Inc., was initially formed as an organization to support an annual educational event, the Alaska Forum on the Environment. This widely recognized event began in 1990 as the Alaska Federal Facility Environmental Roundtable as an annual conference focused on contaminants, hazardous waste cleanup, hazardous materials management, pollution prevention, etc. at federal facilities.
Online Resources
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Alaska Marine Conservation Council (AMCC)

https://arctichealth.org/en/permalink/ahliterature288385
Publication Type
Website
  1 website  
Author Affiliation
Alaska Marine Conservation Council (AMCC)
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
One Health
Changing Ecosystem
Marine biodiversity & Sustainability
Oceans and Seas
Natural resources
Climate change
Abstract
AMCC works with scientists, subsistence harvesters, fishermen, and natural resource managers to understand the effects of warming oceans and ocean acidification.
Online Resources
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Publication Type
Website
  1 website  
Author Affiliation
University of Alaska Anchorage
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
Governments and Organizations
United States
Library Services
Libraries
Medical
Abstract
A unit of the Consortium Library at the University of Alaska Anchorage that provides fee-based medical library services throughout the state.
Online Resources
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Publication Type
Website
  1 website  
Author Affiliation
Alaska Native Health Board (ANHB)
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
One Health
Northern communities
Public Health
Alaska Natives
Spiritualism
Inuits
Abstract
Promotes the spiritual, physical, mental, social, and cultural well-being and pride of Alaska Native people.
Online Resources
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Alaska Native Tribal Health Consortium

https://arctichealth.org/en/permalink/ahliterature288390
Publication Type
Website
  1 website  
Author Affiliation
Alaska Native Tribal Health Consortium (ANTHC)
Language
English
Geographic Location
U.S.
Publication Type
Website
Digital File Format
Web site (.html, .htm)
Keywords
One Health
Northern communities
Public Health
Alaska
Alaska Natives
Health services
Health education
Abstract
The Alaska Native Tribal Health Consortium is a non-profit health organization owned and managed by Alaska Native tribal governments and their regional health organizations.
Online Resources
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Source
Juneau, AK: Section of Women’s, Children’s and Family Health, Division of Public Health, Alaska Department of Health and Social Services, 2012
Publication Type
Website
Date
2012
  1 website  
Author
Whistler, BJ
Source
Juneau, AK: Section of Women’s, Children’s and Family Health, Division of Public Health, Alaska Department of Health and Social Services, 2012
Date
2012
Geographic Location
U.S.
Publication Type
Website
Keywords
Dental public health
Online Resources
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131 records – page 1 of 14.