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Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF.

https://arctichealth.org/en/permalink/ahliterature200378
Source
Hum Reprod. 1999 Nov;14(11):2762-9
Publication Type
Article
Date
Nov-1999
Author
A. Strandell
A. Lindhard
U. Waldenström
J. Thorburn
P O Janson
L. Hamberger
Author Affiliation
Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden.
Source
Hum Reprod. 1999 Nov;14(11):2762-9
Date
Nov-1999
Language
English
Publication Type
Article
Keywords
Adult
Embryo Transfer
Fallopian Tube Diseases - complications - surgery
Female
Fertilization in Vitro
Humans
Laparoscopy
Pregnancy
Pregnancy outcome
Prospective Studies
Retrospective Studies
Scandinavia
Treatment Failure
Abstract
Many retrospective studies have shown that hydrosalpinx is associated with poor in-vitro fertilization (IVF) outcome. The mechanism of the actual cause is not yet fully understood. A clinical practice of performing salpingectomy before IVF has developed, without any evidence from prospective trials. The aim of the present prospective randomized trial was to test if a salpingectomy prior to IVF was effective in terms of increased pregnancy rates. Patients with hydrosalpinx were randomized to either a laparoscopic salpingectomy or no intervention before IVF. A total of 204 patients was available for an intention-to-treat analysis and 192 actually started IVF. Clinical pregnancy rates per included patient were 36.6% in the salpingectomy group and 23.9% in the non-intervention group (not significant, P = 0.067) and the ensuing delivery rates were 28.6% and 16.3% (P = 0.045). The corresponding delivery rates per transfer cycle were 29.5% versus 17. 5% (not significant, P = 0.083). A subgroup analysis revealed significant differences in favour of salpingectomy, in implantation rates in patients with bilateral hydrosalpinges (25.6% versus 12.3%, P = 0.038) and in clinical pregnancy rates (45.7% versus 22.5%, P = 0.029) and delivery rates (40.0% versus 17.5%, P = 0.038) in patients with ultrasound visible hydrosalpinges. The delivery rate was increased 3.5-fold in patients with bilateral hydrosalpinges visible on ultrasound (P = 0.019).
Notes
Comment In: Hum Reprod. 2000 Oct;15(10):2072-411006175
PubMed ID
10548619 View in PubMed
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[Is early discharge after labor possible from the point of view of medical risk?]

https://arctichealth.org/en/permalink/ahliterature60374
Source
Lakartidningen. 1983 Nov 9;80(45):4286-9
Publication Type
Article
Date
Nov-9-1983