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Common variants in human CRC genes as low-risk alleles.

https://arctichealth.org/en/permalink/ahliterature98081
Source
Eur J Cancer. 2010 Apr;46(6):1041-8
Publication Type
Article
Date
Apr-2010
Author
Simone Picelli
Pawel Zajac
Xiao-Lei Zhou
David Edler
Claes Lenander
Johan Dalén
Fredrik Hjern
Nils Lundqvist
Ulrik Lindforss
Lars Påhlman
Kennet Smedh
Anders Törnqvist
Jörn Holm
Martin Janson
Magnus Andersson
Susanne Ekelund
Louise Olsson
Joakim Lundeberg
Annika Lindblom
Author Affiliation
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Source
Eur J Cancer. 2010 Apr;46(6):1041-8
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Alleles
Case-Control Studies
Colorectal Neoplasms - epidemiology - genetics
Female
Genetic Predisposition to Disease - epidemiology - genetics
Genome-Wide Association Study
Genotype
Germ-Line Mutation - genetics
Humans
Male
Middle Aged
Penetrance
Polymorphism, Genetic
Risk factors
Sweden - epidemiology
Young Adult
Abstract
The genetic susceptibility to colorectal cancer (CRC) has been estimated to be around 35% and yet high-penetrance germline mutations found so far explain less than 5% of all cases. Much of the remaining variations could be due to the co-inheritance of multiple low penetrant variants. The identification of all the susceptibility alleles could have public health relevance in the near future. To test the hypothesis that what are considered polymorphisms in human CRC genes could constitute low-risk alleles, we selected eight common SNPs for a pilot association study in 1785 cases and 1722 controls. One SNP, rs3219489:G>C (MUTYH Q324H) seemed to confer an increased risk of rectal cancer in homozygous status (OR=1.52; CI=1.06-2.17). When the analysis was restricted to our 'super-controls', healthy individuals with no family history for cancer, also rs1799977:A>G (MLH1 I219V) was associated with an increased risk in both colon and rectum patients with an odds ratio of 1.28 (CI=1.02-1.60) and 1.34 (CI=1.05-1.72), respectively (under the dominant model); while 2 SNPs, rs1800932:A>G (MSH6 P92P) and rs459552:T>A (APC D1822V) seemed to confer a protective effect. The latter, in particular showed an odds ratio of 0.76 (CI=0.60-0.97) among colon patients and 0.73 (CI=0.56-0.95) among rectal patients. In conclusion, our study suggests that common variants in human CRC genes could constitute low-risk alleles.
PubMed ID
20149637 View in PubMed
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The effects of short-course preoperative irradiation on local recurrence rate and survival in rectal cancer: a population-based nationwide study.

https://arctichealth.org/en/permalink/ahliterature134697
Source
Dis Colon Rectum. 2011 Jun;54(6):672-80
Publication Type
Article
Date
Jun-2011
Author
Marit Tiefenthal
Per J Nilsson
Robert Johansson
Bengt Glimelius
Lars Påhlman
Author Affiliation
Department of Surgery, Ersta Hospital, Stockholm, Sweden. marit.tiefenthal@erstadiakoni.se
Source
Dis Colon Rectum. 2011 Jun;54(6):672-80
Date
Jun-2011
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local - prevention & control
Neoplasm Staging
Preoperative Care
Proportional Hazards Models
Rectal Neoplasms - mortality - pathology - radiotherapy - surgery
Registries
Retrospective Studies
Risk factors
Survival Analysis
Sweden - epidemiology
Treatment Outcome
Abstract
Preoperative irradiation with 5 × 5 Gy in randomized trials reduces local recurrence rate and may improve survival in patients with resectable rectal cancer.
The aim of this study was to determine whether the same favorable effects could be observed in a population-based study.
This study was conducted via a retrospective analysis of prospectively collected data from the Swedish Rectal Cancer Registry.
This study examined population-based data from Sweden.
All newly diagnosed rectal cancers in Sweden are reported to the Swedish Rectal Cancer Registry.
Between 1995 and 2001, 6878 patients (stages I-III) were operated on with an anterior resection, an abdominoperineal resection, or a Hartmann's procedure. Short-course irradiation was given to 41% of patients preoperatively. To reduce bias, patients operated on with a Hartmann procedure or older than 75 years were excluded when 5-year survival was analyzed (n = 3466). Tumors were analyzed according to height (0-5 cm, 6-10 cm, 11-15 cm).
Five-year cumulative local recurrence and survival rates.
The 5-year cumulative local recurrence rate was 6.3% (95% CI 5.4-7.4) for patients receiving preoperative irradiation and 12.1% (95% CI 10.8-13.5) for patients not receiving preoperative irradiation. Multivariate analyses indicated the risk of local recurrence was 50% lower for patients receiving preoperative irradiation compared with patients not receiving irradiation (hazard ratio = 0.50; 95% CI 0.40-0.62). Among patients younger than 76 years and operated on with an anterior resection or abdominoperineal resection, the 5-year cumulative survival rate was 0.70 (95% CI 0.69-0.72). Disease-free and overall survivals were higher in irradiated patients, and the difference was statistically significant in low tumors.
In this population-based analysis, the favorable effect of preoperative short-course irradiation on local recurrence rates, seen in randomized trials, was confirmed for the entire Swedish population irrespective of tumor height and stage. Data also suggested an effect on 5-year survival, especially in patients with low tumors (0-5 cm).
PubMed ID
21552050 View in PubMed
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The inter-observer reliability is very low at clinical examination of parastomal hernia.

https://arctichealth.org/en/permalink/ahliterature141002
Source
Int J Colorectal Dis. 2011 Jan;26(1):89-95
Publication Type
Article
Date
Jan-2011
Author
Ambatchew Gurmu
Peter Matthiessen
Sven Nilsson
Lars Påhlman
Jörgen Rutegård
Ulf Gunnarsson
Author Affiliation
Department of Surgical Gastroenterology, CLINTEC, Karolinska Institutet, Stockholm, Sweden. ambatchew.gurmu@karolinska.se
Source
Int J Colorectal Dis. 2011 Jan;26(1):89-95
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Body mass index
Colostomy - adverse effects
Hernia - epidemiology - etiology - radiography
Herniorrhaphy
Humans
Observer Variation
Questionnaires
Sweden - epidemiology
Tomography, X-Ray Computed
Abstract
Parastomal hernia in patients with a permanent colostomy is common. The aim of this study was to evaluate the reliability of the diagnosis based on clinical examination and to compare this examination with the result of a specially designed questionnaire and computerised tomography (CT) scan.
Forty-one patients operated upon with an abdominoperineal resection due to rectal cancer at three hospitals between 1996 and 2002 were included. At minimum of 4 years after the operation, they underwent clinical examination by two or three independent surgeons, answered a colostomy questionnaire and were offered a CT scan of the abdominal wall.
At Hospital I, 17 patients were examined by three surgeons, with inter-observer kappa values between 0.35 and 0.64. At Hospital II, 13 patients were examined by three surgeons, the kappa values ranged between 0.29 and 0.43. At Hospital III, 11 patients were examined by two surgeons, with kappa value of 0.73. The kappa value between CT scan and the colostomy questionnaire was 0.45.
The inter-observer reliability was low, indicating that parastomal hernia is difficult to diagnose by patient history and clinical examination. Some herniae may not be detected by CT scan, and the correlation to patient-reported complaints is low. A more sensitive radiological method to detect parastomal hernia is needed.
PubMed ID
20821218 View in PubMed
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Lymph nodes, tumor deposits, and TNM: are we getting better?

https://arctichealth.org/en/permalink/ahliterature134661
Source
J Clin Oncol. 2011 Jun 20;29(18):2487-92
Publication Type
Article
Date
Jun-20-2011
Author
Iris D Nagtegaal
Tibor Tot
David G Jayne
Phil McShane
Anders Nihlberg
Helen C Marshall
Lars Påhlman
Julia M Brown
Pierre J Guillou
Philip Quirke
Author Affiliation
Department of Pathology 824, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. i.nagtegaal@pathol.umcn.nl
Source
J Clin Oncol. 2011 Jun 20;29(18):2487-92
Date
Jun-20-2011
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - mortality - pathology - secondary
Aged
Aged, 80 and over
Colorectal Neoplasms - mortality - pathology
Disease-Free Survival
Great Britain - epidemiology
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Middle Aged
Multicenter Studies as Topic - statistics & numerical data
Neoplasm Invasiveness
Neoplasm Staging - methods - trends
Prognosis
Randomized Controlled Trials as Topic - statistics & numerical data
Reproducibility of Results
Sweden - epidemiology
Tumor Burden
Abstract
New editions of the TNM staging system for colorectal cancer have been subject to extensive criticism. In the current study, we evaluate each edition of TNM and analyze stage migration caused by the different versions.
Two independent test populations were used: participants derived from a randomized surgical trial from the United Kingdom (n = 455) and patients from a population-based series from Sweden (n = 505). All slides from these patient cases were reviewed with special attention for the presence of tumor deposits. Tumor deposits were classified according to the fifth, sixth, and seventh editions of TNM and correlated with prognosis.
Every change in edition of TNM led to a stage migration of between 33% and 64% in patients with tumor deposits. Reproducibility was best in the fifth edition of TNM. The prognostic value of the seventh edition was best only when all tumor deposits irrespective of size or contour were included as lymph nodes. The prognostic value of the fifth edition was better than that of the sixth.
We demonstrate there is a place for tumor deposits in the staging of patients with colorectal cancer. However, many questions remain about their definition and the reproducibility and use of this category in special situations, such as after neoadjuvant treatment. These should be the subject of additional research before use as a factor in TNM staging. This work demonstrates the necessity of testing modifications before their introduction.
Notes
Comment In: Strahlenther Onkol. 2012 Feb;188(2):191-222231635
PubMed ID
21555695 View in PubMed
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A population-based comparison of the survival of patients with colorectal cancer in England, Norway and Sweden between 1996 and 2004.

https://arctichealth.org/en/permalink/ahliterature137234
Source
Gut. 2011 Aug;60(8):1087-93
Publication Type
Article
Date
Aug-2011
Author
Eva J A Morris
Fredrik Sandin
Paul C Lambert
Freddie Bray
Asa Klint
Karen Linklater
David Robinson
Lars Påhlman
Lars Holmberg
Henrik Møller
Author Affiliation
Cancer Epidemiology Group, Centre for Epidemiology & Biostatistics, University of Leeds, NYCRIS, St James's University Hospital, Leeds, UK. eva.morris@nycris.leedsth.nhs.uk
Source
Gut. 2011 Aug;60(8):1087-93
Date
Aug-2011
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Colorectal Neoplasms - diagnosis - mortality
England - epidemiology
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Middle Aged
Norway - epidemiology
Population Surveillance - methods
Retrospective Studies
Survival Analysis
Survival Rate - trends
Sweden - epidemiology
Time Factors
Young Adult
Abstract
To examine differences in the relative survival and excess death rates of patients with colorectal cancer in Norway, Sweden and England.
All individuals diagnosed with colorectal cancer (ICD10 (International Classification of Diseases, 10th revision) C18-C20) between 1996 and 2004 in England, Norway and Sweden were included in this population-based study of patients with colorectal cancer. The main outcome measures were 5-year cumulative relative period of survival and excess death rates stratified by age and period of follow-up.
The survival of English patients with colorectal cancer was significantly lower than was observed in both Norway and Sweden. Five-year age-standardised colon cancer relative survival was 51.1% (95% CI 50.1% to 52.0%) in England compared with 57.9% (95% CI 55.2% to 60.5%) in Norway and 59.9% (95% CI 57.7% to 62.0%) in Sweden. Five-year rectal cancer survival was 52.3% (95% CI 51.1% to 53.5%) in England compared with 60.7% (95% CI 57.0% to 64.2%) and 59.8% (95% CI 56.9% to 62.6%) in Norway and Sweden, respectively. The lower survival for colon cancer in England was primarily due to a high number of excess deaths among older patients in the first 3 months after diagnosis. In patients with rectal cancer, excess deaths remained elevated until 2 years of follow-up. If the lower excess death rate in Norway applied in the English population, then 890 (13.6%) and 654 (16.8%) of the excess deaths in the colon and rectal cancer populations, respectively, could have been prevented at 5 years follow-up. Most of these avoidable deaths occurred shortly after diagnosis.
There was significant variation in survival between the countries, with the English population experiencing a poorer outcome, primarily due to a relatively higher number of excess deaths in older patients in the short term after diagnosis. It seems likely, therefore, that in England a greater proportion of the population present with more rapidly fatal disease (especially in the older age groups) than in Norway or Sweden.
PubMed ID
21303917 View in PubMed
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Prevalence of fecal carriage of antibiotic-resistant bacteria in patients with acute surgical abdominal infections.

https://arctichealth.org/en/permalink/ahliterature143131
Source
Scand J Gastroenterol. 2010 Oct;45(10):1203-10
Publication Type
Article
Date
Oct-2010
Author
Abbas Chabok
Maria Tärnberg
Kenneth Smedh
Lars Påhlman
Lennart E Nilsson
Christian Lindberg
Håkan Hanberger
Author Affiliation
Department of Surgery, Uppsala University, Central Hospital, Västerås, Sweden. abbas.chabok@ltv.se
Source
Scand J Gastroenterol. 2010 Oct;45(10):1203-10
Date
Oct-2010
Language
English
Publication Type
Article
Keywords
Abdomen, Acute - surgery
Abdominal Abscess - microbiology - surgery
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Bacteria, Aerobic - drug effects - isolation & purification
Bacteria, Anaerobic - drug effects - isolation & purification
Bacterial Infections - epidemiology - microbiology
Drug Resistance, Multiple, Bacterial
Feces - microbiology
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Prevalence
Prospective Studies
Sampling Studies
Surgicenters
Sweden - epidemiology
Abstract
Antibiotic resistance is increasing worldwide. The aims of the current study were to determine the fecal carriage of antibiotic-resistant bacteria and antibiotic treatment in surgical patients admitted to hospital due to acute intra-abdominal infections.
Eight Swedish surgical units participated in this prospective multicenter investigation. Rectal swabs were obtained on admission to hospital. Cultures were performed on chromogenic agar and antibiotic susceptibility testing was performed using the disk diffusion method. Extended-spectrum beta-lactamase (ESBL)-phenotype was confirmed by Etest.
Rectal samples were obtained and analyzed from 208 patients with intra-abdominal surgical infections. Surgery was performed in 134 patients (65%). Cephalosporins were the most frequently used empirical antibiotic therapy. The highest rates of resistance among Enterobacteriaceae were detected for ampicillin (54%), tetracycline (26%), cefuroxime (26%) and trimethoprim-sulfamethoxazole (20%). The prevalence of decreased susceptibility (I + R) for the other antibiotics tested was for ciprofloxacin 20%, piperacillin-tazobactam 17%, cefotaxime 14%, ertapenem 12%, gentamicin 3% and imipenem 0%. ESBL-producing Enterobacteriaceae were found in samples from 10 patients (5%). Three patients had five E. coli isolates producing AmpC enzymes.
This study shows a high rate of resistance among Enterobacteriaceae against antibiotics which are commonly used in Sweden and should have implications for the future choice of antibiotics for surgical patients.
PubMed ID
20521871 View in PubMed
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6 records – page 1 of 1.