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A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness.

https://arctichealth.org/en/permalink/ahliterature70572
Source
BMJ. 2005 Sep 17;331(7517):602
Publication Type
Article
Date
Sep-17-2005
Author
Lone Petersen
Pia Jeppesen
Anne Thorup
Maj-Britt Abel
Johan Øhlenschlaeger
Torben Østergaard Christensen
Gertrud Krarup
Per Jørgensen
Merete Nordentoft
Author Affiliation
Bispebjerg Hospital, Department of Psychiatry, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
Source
BMJ. 2005 Sep 17;331(7517):602
Date
Sep-17-2005
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Assertiveness
Community Mental Health Services - utilization
Female
Follow-Up Studies
Humans
Interpersonal Relations
Male
Middle Aged
Observer Variation
Patient compliance
Patient satisfaction
Psychotic Disorders - therapy
Research Support, Non-U.S. Gov't
Schizophrenia - therapy
Treatment Outcome
Abstract
OBJECTIVES: To evaluate the effects of integrated treatment for patients with a first episode of psychotic illness. DESIGN: Randomised clinical trial. SETTING: Copenhagen Hospital Corporation and Psychiatric Hospital Aarhus, Denmark. PARTICIPANTS: 547 patients with first episode of schizophrenia spectrum disorder. INTERVENTIONS: Integrated treatment and standard treatment. The integrated treatment lasted for two years and consisted of assertive community treatment with programmes for family involvement and social skills training. Standard treatment offered contact with a community mental health centre. MAIN OUTCOME MEASURES: Psychotic and negative symptoms (each scored from 0 to a maximum of 5) at one and two years' follow-up. RESULTS: At one year's follow-up, psychotic symptoms changed favourably to a mean of 1.09 (standard deviation 1.27) with an estimated mean difference between groups of -0.31 (95% confidence interval -0.55 to -0.07, P = 0.02) in favour of integrated treatment. Negative symptoms changed favourably with an estimated difference between groups of -0.36 (-0.54 to -0.17, P
Notes
Comment In: BMJ. 2005 Sep 17;331(7517):586-716166109
Erratum In: BMJ. 2005 Nov 5;331(7524):1065
PubMed ID
16141449 View in PubMed
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