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Air pollution and disability days in Toronto: results from the national population health survey.

https://arctichealth.org/en/permalink/ahliterature189023
Source
Environ Res. 2002 Jul;89(3):210-9
Publication Type
Article
Date
Jul-2002
Author
David M Stieb
Marc Smith-Doiron
Jeffrey R Brook
Richard T Burnett
Tom Dann
Alexandre Mamedov
Yue Chen
Author Affiliation
Healthy Environments and Consumer Safety Branch, Health Canada.
Source
Environ Res. 2002 Jul;89(3):210-9
Date
Jul-2002
Language
English
Publication Type
Article
Keywords
Air Pollutants - adverse effects
Disabled persons - statistics & numerical data
Environmental Exposure
Health Surveys
Humans
Ontario - epidemiology
Particle Size
Seasons
Temperature
Urban Population
Abstract
The influence of air pollution on disability days in Toronto during the period 1994-1999 was examined using data from Canada's National Population Health Survey. A model of disability days (the sum of days spent in bed and days when the respondent cut down on usual activities) during the 2 weeks prior to the interview was constructed by sequentially examining the influence of time period, personal characteristics, weather, and air pollution. After adjusting for these other factors, only the effects of carbon monoxide and particulate matter of median diameter less than 2.5 microm (PM2.5) were statistically significant (respectively, 30.8% (95% CI 1.2-69.0) and 21.9% (95% CI 3.8-43.0) increase in disability days for a change in concentration equal to the interquartile range of the 2-week average pollutant concentration). PM2.5 was more strongly associated with disability days in the warm season. Results of multipollutant models were difficult to interpret in that effect sizes appeared to be influenced by covariation among pollutants. With the exception of warm season results for PM2.5, findings were not sensitive to alternative analytical approaches. While these results are suggestive of significant effects of the urban air pollution mix at relatively low ambient concentrations, the precise contribution of individual pollutants could not be determined.
PubMed ID
12176005 View in PubMed
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Air quality risk assessment and management.

https://arctichealth.org/en/permalink/ahliterature159796
Source
J Toxicol Environ Health A. 2008;71(1):24-39
Publication Type
Article
Date
2008
Author
Yue Chen
Lorraine Craig
Daniel Krewski
Author Affiliation
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Source
J Toxicol Environ Health A. 2008;71(1):24-39
Date
2008
Language
English
Publication Type
Article
Keywords
Air Pollutants - standards - toxicity
Air Pollution - adverse effects - legislation & jurisprudence - prevention & control
Canada
Europe
Hospitalization - statistics & numerical data
Humans
Mortality
Risk assessment
United States
Abstract
This article provides (1) a synthesis of the literature on the linkages between air pollution and human health, (2) an overview of quality management approaches in Canada, the United States, and the European Union (EU), and (3) future directions for air quality research. Numerous studies examining short-term effects of air pollution show significant associations between ambient levels of particulate matter (PM) and other air pollutants and increases in premature mortality and hospitalizations for cardiovascular and respiratory illnesses. Several well-designed epidemiological studies confirmed the adverse long-term effects of PM on both mortality and morbidity. Epidemiological studies also document significant associations between ozone (O3), sulfur (SO2), and nitrogen oxides (NO(x)) and adverse health outcomes; however, the effects of gaseous pollutants are less well documented. Subpopulations that are more susceptible to air pollution include children, the elderly, those with cardiorespiratory disease, and socioeconomically deprived individuals. Canada-wide standards for ambient air concentrations of PM2.5 and O3 were set in 2000, providing air quality targets to be achieved by 2010. In the United States, the Clean Air Act provides the framework for the establishment and review of National Ambient Air Quality Standards for criteria air pollutants and the establishment of emissions standards for hazardous air pollutants. The 1996 European Union's enactment of the Framework Directive for Air Quality established the process for setting Europe-wide limit values for a series of pollutants. The Clean Air for Europe program was established by the European Union to review existing limit values, emission ceilings, and abatement protocols, as set out in the current legislation. These initiatives serve as the legislative framework for air quality management in North America and Europe.
PubMed ID
18080890 View in PubMed
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Alcohol drinking and renal cell carcinoma in Canadian men and women.

https://arctichealth.org/en/permalink/ahliterature157674
Source
Cancer Detect Prev. 2008;32(1):7-14
Publication Type
Article
Date
2008
Author
Jinfu Hu
Yue Chen
Yang Mao
Marie Desmeules
Les Mery
Author Affiliation
Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, 120 Colonnade Road, AL 6701A, Ottawa, Ontario, Canada. Jinfu_Hu@phac-aspc.gc.ca
Source
Cancer Detect Prev. 2008;32(1):7-14
Date
2008
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol drinking - epidemiology
Canada - epidemiology
Carcinoma, Renal Cell - epidemiology
Case-Control Studies
Female
Humans
Kidney Neoplasms - epidemiology
Male
Middle Aged
Odds Ratio
Questionnaires
Risk factors
Abstract
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cell carcinoma (RCC), but sex-specific results are inconsistent. The present study examines the association between alcohol intake and the risk of RCC among men and women.
Mailed questionnaires were completed by 1138 newly diagnosed, histologically confirmed RCC cases and 5039 population controls between 1994 and 1997 in eight Canadian provinces. A food frequency questionnaire provided data on eating habits and alcohol consumption 2 years before data collection. Other information included socio-economic status, lifestyle habits, alcohol use, and diet. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived through unconditional logistic regression.
Total alcohol intake was inversely associated with RCC in men and in women; the OR for the highest intake group (> or =22.3 g/day among men and > or =7.9 g/day among women) versus the non-drinkers was 0.7 (95% CI, 0.5-0.9) for both sexes. Analysis of menopausal status produced ORs for the highest intake group versus the non-drinkers of 1.2 (95% CI, 0.7-2.1) among premenopausal women and 0.6 (95% CI, 0.4-0.9) among postmenopausal women. Smoking and obesity were not important effect modifiers.
Moderate alcohol consumption may be associated with a decreased risk of RCC in men and in women (mainly postmenopausal women).
PubMed ID
18420355 View in PubMed
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Association between air pollution and multiple respiratory hospitalizations among the elderly in Vancouver, Canada.

https://arctichealth.org/en/permalink/ahliterature167576
Source
Inhal Toxicol. 2006 Dec;18(13):1005-11
Publication Type
Article
Date
Dec-2006
Author
Karen Y Fung
Shahedul Khan
Daniel Krewski
Yue Chen
Author Affiliation
Department of Mathematics and Statistics, University of Windsor, Windsor, Ontario, Canada. kfung@uwindsor.ca
Source
Inhal Toxicol. 2006 Dec;18(13):1005-11
Date
Dec-2006
Language
English
Publication Type
Article
Keywords
Aged
Air Pollutants - toxicity
British Columbia
Carbon Monoxide - toxicity
Environmental pollution
Humans
Inhalation Exposure
Models, Statistical
Nitrogen Dioxide - toxicity
Particle Size
Patient Readmission - statistics & numerical data
Respiratory Tract Diseases - etiology
Retrospective Studies
Sulfur Dioxide - standards - toxicity
Weather
Abstract
Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using a new method proposed by (Dewanji and Moolgavkar 2000, 2002) for recurrent events, and compared it with some traditional methods. In particular, we assessed the impact of ambient gaseous (SO2, NO2, CO, and O3) and particulate pollutants (PM10, PM2.5, and PM10-2.5) as well as the coefficient of haze (CoH) on recurrent respiratory hospital admissions. Using the new procedure, significant associations were found between admissions and 3-day, 5-day, and 7-day moving averages of the ambient SO2 concentrations, with the strongest association observed at the 7-day lag (RR = 1.044, 95% CI: 1.018-1.070). We also found PM10-2.5 for 3-day and 5-day lag to be significant, with the strongest association at 5-day lag (RR = 1.020, 95% CI: 1.001-1.039). No significant associations with admission were found with current day exposure.
PubMed ID
16966300 View in PubMed
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The association between allergy and diabetes in the Canadian population: implications for the Th1-Th2 hypothesis.

https://arctichealth.org/en/permalink/ahliterature172954
Source
Eur J Epidemiol. 2005;20(8):713-7
Publication Type
Article
Date
2005
Author
Robert Dales
Yue Chen
Mei Lin
Jacob Karsh
Author Affiliation
Department of Medicine, Ottawa Health Research Institute, Canada. rdales@ohri.ca
Source
Eur J Epidemiol. 2005;20(8):713-7
Date
2005
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Canada - epidemiology
Child
Diabetes Mellitus, Type 1 - epidemiology - immunology
Female
Humans
Hypersensitivity - epidemiology - immunology
Logistic Models
Male
Middle Aged
Prevalence
Risk factors
Th1 Cells - immunology
Th2 Cells - immunology
Abstract
T-lymphocytes may preferentially differentiate towards a Th1 subtype, which is thought to be involved in the autoimmune aspects of diabetes, or a Th2 subtype, which is thought to mediate allergic disease. The activation of one subtype is thought to inhibit the other. To determine if diabetes is less common among those with allergic disease, consistent with the postulated TH1/Th2 paradigm, we used data from the 2000-2001 Canadian Community Health Survey of those at least 12 years of age from 125,159 households. Diabetes requiring insulin was reported in 1% whether or not allergies were reported. The crude odds ratio between diabetes and allergies for the entire population was 1.06 (95% confidence interval (CI): 0.90, 1.24). Adjusted for household size, number of bedrooms, immigrant status, income adequacy, educational level, smoking status, alcohol drinking status, regular exercise, and age, there was a positive association between allergy and diabetes with an odds ratio of 1.25 (95% CI: 1.06, 1.49). These results do not provide evidence for the existence of the Th1/Th2 paradigm as a determinant of disease patterns in the general population.
PubMed ID
16151885 View in PubMed
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The association between allergy and rheumatoid arthritis in the Canadian population.

https://arctichealth.org/en/permalink/ahliterature172823
Source
Eur J Epidemiol. 2005;20(9):783-7
Publication Type
Article
Date
2005
Author
Jacob Karsh
Yue Chen
Mei Lin
Robert Dales
Author Affiliation
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Source
Eur J Epidemiol. 2005;20(9):783-7
Date
2005
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Arthritis, Rheumatoid - epidemiology - immunology
Canada - epidemiology
Child
Female
Humans
Hypersensitivity - epidemiology - immunology
Logistic Models
Male
Middle Aged
Prevalence
Abstract
Antagonism between Th1 and Th2 lymphocyte mediated responses has been proposed to explain the observed 20th Century population increase in Th2 mediated allergic disease and reciprocal decrease in infectious disease, which stimulates a Th1 mediated response.
To determine if Th1/Th2 antagonism would be consistent with associations between non-infectious diseases, we tested the hypothesis that the population prevalence of Th2 mediated allergies is inversely related to the prevalence of Th1 mediated rheumatoid arthritis.
The analysis was based on data from the Canadian Community Health Survey conducted by Statistics Canada in 2000-2001 of those at least 12 years of age from 125,129 households. Each subject was asked if he or she had certain chronic health conditions that had been diagnosed by a health professional. Logistic regression models were used to evaluate the association between rheumatoid arthritis and allergies with consideration of other important variables.
Allergy history was positively related to the prevalence of rheumatoid arthritis both in women (adjusted odds ratio (OR): 1.57, 95% CI: 1.43, 1.73) and in men (adjusted OR: 1.55, 95% CI: 1.36, 1.77).
The reported population prevalences of allergies and rheumatoid arthritis were positively associated and not explained by Th1/Th2 anatagonism suggesting that this mechanism may only be applicable to the association between an infectious and an immunologic disease. Mechanisms accounting for positive associations between immunologic diseases deserve further study.
PubMed ID
16170662 View in PubMed
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Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada.

https://arctichealth.org/en/permalink/ahliterature183028
Source
Environ Health Perspect. 2003 Nov;111(14):1773-8
Publication Type
Article
Date
Nov-2003
Author
Shiliang Liu
Daniel Krewski
Yuanli Shi
Yue Chen
Richard T Burnett
Author Affiliation
McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, and Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Sliu@uottawa.ca
Source
Environ Health Perspect. 2003 Nov;111(14):1773-8
Date
Nov-2003
Language
English
Publication Type
Article
Keywords
Adult
Air Pollutants - adverse effects
British Columbia - epidemiology
Epidemiologic Studies
Female
Fetal Growth Retardation - epidemiology - etiology
Humans
Infant, Low Birth Weight
Infant, Newborn
Obstetric labor, premature
Pregnancy
Pregnancy Complications - epidemiology - etiology
Pregnancy outcome
Abstract
The association between ambient air pollution and adverse health effects, such as emergency room visits, hospitalizations, and mortality from respiratory and cardiovascular diseases, has been studied extensively in many countries, including Canada. Recently, studies conducted in China, the Czech Republic, and the United States have related ambient air pollution to adverse pregnancy outcomes. In this study, we examined association between preterm birth, low birth weight, and intrauterine growth retardation (IUGR) among singleton live births and ambient concentrations of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone in Vancouver, Canada, for 1985-1998. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for such effects. Low birth weight was associated with exposure to SO2 during the first month of pregnancy (OR = 1.11, 95% CI, 1.01-1.22, for a 5.0 ppb increase). Preterm birth was associated with exposure to SO2 (OR = 1.09, 95% CI, 1.01-1.19, for a 5.0 ppb increase) and to CO (OR = 1.08, 95% CI, 1.01-1.15, for a 1.0 ppm increase) during the last month of pregnancy. IUGR was associated with exposure to SO2 (OR = 1.07, 95% CI, 1.01-1.13, for a 5.0 ppb increase), to NO2 (OR = 1.05, 95% CI, 1.01-1.10, for a 10.0 ppb increase), and to CO (OR = 1.06, 95% CI, 1.01-1.10, for a 1.0 ppm increase) during the first month of pregnancy. In conclusion, relatively low concentrations of gaseous air pollutants are associated with adverse effects on birth outcomes in populations experiencing diverse air pollution profiles.
Notes
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Comment In: Environ Health Perspect. 2004 Oct;112(14):A792; author reply A792-415471710
PubMed ID
14594630 View in PubMed
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The association between home and vehicle environmental tobacco smoke (ETS) and chronic bronchitis in a Canadian population: the Canadian Community Health Survey, 2005.

https://arctichealth.org/en/permalink/ahliterature154691
Source
Inhal Toxicol. 2009 Feb;21(3):244-9
Publication Type
Article
Date
Feb-2009
Author
Jessica Evans
Yue Chen
Author Affiliation
Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada. jevan048@uottawa.ca
Source
Inhal Toxicol. 2009 Feb;21(3):244-9
Date
Feb-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Air Pollution, Indoor - adverse effects
Bronchitis, Chronic - diagnosis - epidemiology
Canada
Child
Disease Susceptibility - epidemiology
European Continental Ancestry Group - statistics & numerical data
Female
Humans
Hypersensitivity - epidemiology
Male
Middle Aged
Motor Vehicles
Odds Ratio
Population Surveillance
Public Health
Questionnaires
Regression Analysis
Smoking - epidemiology
Tobacco Smoke Pollution - adverse effects
Young Adult
Abstract
This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS exposure in the home and vehicle was 9.0% and 8.4% respectively. The prevalence of self-reported doctor diagnosed chronic bronchitis was 1.5%. When considered separately, home and vehicle ETS were both significantly associated with chronic bronchitis in children and adolescents aged 12-19 years, with adjusted odds ratios of 2.30 (95% CI 1.46-3.63) and 2.25 (95% CI 1.42-3.58), respectively. Neither home, nor vehicle ETS exposure was significantly associated with chronic bronchitis in age groups greater than 19 years. When home and vehicle ETS exposure were considered together, and sex, age, allergies, asthma, marital status, level of education, and race where controlled for, home ETS exposure was not a significant predictor of chronic bronchitis (P = 0.296), while vehicle ETS was. The correlation between exposure variables was fair, with a kappa coefficient of 0.40 (P
PubMed ID
18923950 View in PubMed
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Association between lifetime stress and obesity in Canadians.

https://arctichealth.org/en/permalink/ahliterature121054
Source
Prev Med. 2012 Nov;55(5):464-7
Publication Type
Article
Date
Nov-2012
Author
Yue Chen
Lingjia Qian
Author Affiliation
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. ychen@uottawa.ca
Source
Prev Med. 2012 Nov;55(5):464-7
Date
Nov-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Body mass index
Canada - epidemiology
Comorbidity
Female
Health Surveys
Humans
Logistic Models
Male
Middle Aged
Obesity - epidemiology
Prevalence
Risk factors
Sex Distribution
Stress, Psychological - epidemiology
Abstract
Obesity has been linked to stress, but there is lack of strong evidence from general populations.
The analysis was based on data from 112,716 Canadians aged 18 years or more who participated in a national survey conducted in 2007-2008. A questionnaire covered the information on self-perceived lifetime stress, height, and weight. Logistic regression analysis was used to determine the association between chronic stress and obesity.
The crude prevalence of obesity was 18.1% for men and 16.0% for women. A small proportion (3.7%) of the participants reported being extremely stressed most days in their lives and 19.1% reported being quite a bit stressed, and the proportions of stress were slightly higher in women than in men. Overall, those who reported being extremely stressed (adjusted OR: 1.23, 95% CI: 1.13, 1.35) or those who reported being quite a bit stressed (adjusted OR: 1.08, 95% CI: 1.02, 1.15) had an increased risk of obesity compared with who were not at all stressed. The adjusted odds ratio was 1.44 (95% CI: 1.13, 1.35) for women who were extremely stressed compared with women who were not at all stressed.
Lifetime stress was associated with an increased risk of obesity especially in women.
PubMed ID
22944151 View in PubMed
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Association between maternal exposure to ambient air pollutants during pregnancy and fetal growth restriction.

https://arctichealth.org/en/permalink/ahliterature169079
Source
J Expo Sci Environ Epidemiol. 2007 Aug;17(5):426-32
Publication Type
Article
Date
Aug-2007
Author
Shiliang Liu
Daniel Krewski
Yuanli Shi
Yue Chen
Richard T Burnett
Author Affiliation
McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, 1 Stewart Street, Ontario, Canada. Sliu@uottawa.ca
Source
J Expo Sci Environ Epidemiol. 2007 Aug;17(5):426-32
Date
Aug-2007
Language
English
Publication Type
Article
Keywords
Air Pollutants - metabolism - toxicity
Air Pollution - adverse effects
Canada
Carbon Monoxide - metabolism - toxicity
Female
Fetal Growth Retardation - chemically induced - pathology
Humans
Infant, Newborn
Maternal Exposure - adverse effects
Nitrogen Dioxide - metabolism - toxicity
Ozone - metabolism - toxicity
Particle Size
Pregnancy
Pregnancy Trimester, First - drug effects - metabolism
Risk assessment
Sulfur Dioxide - metabolism - toxicity
Time Factors
Urban health
Abstract
Previous research demonstrated consistent associations between ambient air pollution and emergency room visits, hospitalizations, and mortality. Effect of air pollution on perinatal outcomes has recently drawn more attention. We examined the association between intrauterine growth restriction (IUGR) among singleton term live births and sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), ozone (O3), and fine particles (PM2.5) present in ambient air in the Canadian cities of Calgary, Edmonton, and Montreal for the period 1985-2000. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for IUGR, based on average daily levels of individual pollutants over each month and trimester of pregnancy after adjustment for maternal age, parity, infant gender, season, and city of residence. A 1 ppm increase in CO was associated with an increased risk of IUGR in the first (OR=1.18; 95% CI 1.14-1.23), second (OR=1.15; 95% CI 1.10-1.19) and third (OR=1.19; 95% CI 1.14-1.24) trimesters of pregnancy, respectively. A 20 ppb increase in NO2 (OR=1.16; 95% CI 1.09-1.24; OR=1.14; 95% CI 1.06--1.21; and OR=1.16; 95% CI 1.09-1.24 in the first, second, and third trimesters) and a 10 mug/m3 increase in PM2.5 (OR=1.07; 95% CI 1.03-1.10; OR=1.06; 95% CI 1.03-1.10; and OR=1.06; 95% CI 1.03-1.10) were also associated with an increased risk of IUGR. Consistent results were found when ORs were calculated by month rather than trimester of pregnancy. Our findings add to the emerging body of evidence that exposure to relatively low levels of ambient air pollutants in urban areas during pregnancy is associated with adverse effects on fetal growth.
PubMed ID
16736056 View in PubMed
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72 records – page 1 of 8.