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Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study.

https://arctichealth.org/en/permalink/ahliterature297760
Source
Eur J Epidemiol. 2018 01; 33(1):67-77
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
01-2018
Author
Yi-Qian Sun
Arnulf Langhammer
Chunsen Wu
Frank Skorpen
Yue Chen
Tom Ivar Lund Nilsen
Pål Richard Romundstad
Xiao-Mei Mai
Author Affiliation
Department of Clinical and Molecular Medicine (IKOM), NTNU, Norwegian University of Science and Technology, Trondheim, Norway. yi-qian.sun@ntnu.no.
Source
Eur J Epidemiol. 2018 01; 33(1):67-77
Date
01-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adenocarcinoma - blood - epidemiology - pathology
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Incidence
Lung Neoplasms - blood - epidemiology - pathology
Male
Middle Aged
Norway - epidemiology
Prospective Studies
Vitamin D - analogs & derivatives - blood
Abstract
Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of serum 25(OH)D levels with incidence of lung cancer overall and different histologic types. We performed a population-based prospective case-cohort study including 696 incident lung cancer cases and 5804 individuals in a subcohort who participated in the second survey of the Nord-Trøndelag Health Study in Norway. Cox proportional hazards regression models counting for the case-cohort design were used to estimate hazard ratios (HRs) with 95% confidence interval (CIs) for lung cancer overall or histologic types in relation to serum 25(OH)D levels. Compared with the fourth season-specific quartile of 25(OH)D (median 68.0 nmol/L), lower 25(OH)D levels were not associated with the incidence of overall, small or squamous cell lung cancer. However, the risk of adenocarcinoma was lower in the second and third quartiles (median 39.9 and 51.5 nmol/L) compared with the fourth quartile, with HRs of 0.63 (95% CI 0.41-0.98) and 0.58 (0.38-0.88), respectively. The associations of lower levels of 25(OH)D with a reduced risk of adenocarcinoma were only observed in the overweight/obese subjects [HRs for second and third quartiles: 0.40 (0.22-0.72) and 0.50 (0.27-0.92)] but not in the normal weight subjects [HRs: 0.95 (0.52-1.75) and 0.60 (0.32-1.10)]. Serum 25(OH)D levels were not associated with the risk of lung cancer in general. The observation that lower 25(OH)D levels were associated with a lower risk of adenocarcinoma should be interpreted with caution.
PubMed ID
29080012 View in PubMed
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Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study.

https://arctichealth.org/en/permalink/ahliterature297954
Source
Eur Respir J. 2017 10; 50(4):
Publication Type
Letter
Research Support, Non-U.S. Gov't
Date
10-2017

Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway.

https://arctichealth.org/en/permalink/ahliterature292500
Source
BMJ Open. 2017 Jul 03; 7(6):e017256
Publication Type
Journal Article
Date
Jul-03-2017
Author
Yi-Qian Sun
Arnulf Langhammer
Frank Skorpen
Yue Chen
Xiao-Mei Mai
Author Affiliation
Department of Laboratory Medicine, Children's and Women's Health (LBK), Trondheim, Norway.
Source
BMJ Open. 2017 Jul 03; 7(6):e017256
Date
Jul-03-2017
Language
English
Publication Type
Journal Article
Keywords
Adult
Aged
Chronic Disease - epidemiology
Female
Humans
Male
Middle Aged
Mortality
Norway - epidemiology
Proportional Hazards Models
Prospective Studies
Registries
Risk factors
Vitamin D - analogs & derivatives - blood
Young Adult
Abstract
To investigate the association of vitamin D status with all-cause mortality in a Norwegian population and the potential influences of existing chronic diseases on the association.
A population-based prospective cohort study.
Nord-Trøndelag County, Norway.
A random sample (n=6613) of adults aged 20 years or older in a cohort.
Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in blood samples collected at baseline (n=6377). Mortality was ascertained from the Norwegian National Registry. Cox regression models were applied to estimate the HRs with 95% CIs for all-cause mortality in association with serum 25(OH)D levels after adjustment for a wide spectrum of confounding factors as well as chronic diseases at baseline.
The median follow-up time was 18.5 years, during which 1539 subjects died. The HRs for all-cause mortality associated with the first quartile level of 25(OH)D (
Notes
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PubMed ID
28674149 View in PubMed
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