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15 years after Chernobyl: new evidence of thyroid cancer.

https://arctichealth.org/en/permalink/ahliterature19395
Source
Lancet. 2001 Dec 8;358(9297):1965-6
Publication Type
Article
Date
Dec-8-2001
Author
Y. Shibata
S. Yamashita
V B Masyakin
G D Panasyuk
S. Nagataki
Source
Lancet. 2001 Dec 8;358(9297):1965-6
Date
Dec-8-2001
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Byelarus - epidemiology
Child
Female
Humans
Male
Mass Screening
Neoplasms, Radiation-Induced - epidemiology
Nuclear Reactors
Population Surveillance
Radioactive fallout
Research Support, Non-U.S. Gov't
Thyroid Neoplasms - epidemiology - etiology
Ukraine - epidemiology
Abstract
The Chernobyl nuclear power plant accident happened on April 26, 1986. We investigated the cause of the striking increase in frequency of thyroid cancer in children who lived within a 150 km radius of Chernobyl and who were born before and after the accident. No thyroid cancer was seen in 9472 children born in 1987-89, whereas one and 31 thyroid cancers were recorded in 2409 children born April 27, 1986, to Dec 31, 1986, and 9720 born Jan 1, 1983, to April 26, 1986, respectively. Short-lived radioactive fallout caused by the Chernobyl accident probably induced thyroid cancer in children living near Chernobyl.
PubMed ID
11747925 View in PubMed
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137Cs concentration among children in areas contaminated with radioactive fallout from the Chernobyl accident: Mogilev and Gomel oblasts, Belarus.

https://arctichealth.org/en/permalink/ahliterature35663
Source
Health Phys. 1994 Sep;67(3):272-5
Publication Type
Article
Date
Sep-1994
Author
M. Hoshi
Y. Shibata
S. Okajima
T. Takatsuji
S. Yamashita
H. Namba
N. Yokoyama
M. Izumi
S. Nagataki
K. Fujimura
Author Affiliation
Research Institute for Nuclear Medicine and Biology, Hiroshima University, Japan.
Source
Health Phys. 1994 Sep;67(3):272-5
Date
Sep-1994
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Cesium Radioisotopes - analysis
Child
Child, Preschool
Environmental Exposure
Female
Humans
Male
Nuclear Reactors
Research Support, Non-U.S. Gov't
Ukraine
Whole-Body Counting
Abstract
The level of radiation exposure in children in Belarus caused by the Chernobyl accident was investigated on the basis of whole body 137Cs count. The subjects were 10,062 children (4,762 boys and 5,300 girls) in Mogilev and Gomel, Belarus, who received Chernobyl Sasakawa Health and Medical Cooperation Project health examinations from May 1991 to December 1992 and who were 5-16 y old at the time of examination. The median whole body 137Cs count per body weight varied from 21-48 Bq kg-1 and from 28-126 Bq kg-1 in Mogilev oblast and Gomel oblast, respectively. (The "oblast" is the largest administrative district constituting the country. Belarus consists of 6 oblasts). Corresponding annual effective dose equivalents were all less than the public dose limit of 1 mSv y-1, but the observed levels in the children were considerably higher than the average level of 2.3 Bq kg-1 reported in the past for the former Soviet Union.
Notes
Comment In: Health Phys. 1995 May;68(5):733-57730075
PubMed ID
8056594 View in PubMed
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Childhood thyroid diseases around Chernobyl evaluated by ultrasound examination and fine needle aspiration cytology.

https://arctichealth.org/en/permalink/ahliterature23054
Source
Thyroid. 1995 Oct;5(5):365-8
Publication Type
Article
Date
Oct-1995
Author
M. Ito
S. Yamashita
K. Ashizawa
H. Namba
M. Hoshi
Y. Shibata
I. Sekine
S. Nagataki
I. Shigematsu
Author Affiliation
Department of Pathology, Nagasaki University School of Medicine, Japan.
Source
Thyroid. 1995 Oct;5(5):365-8
Date
Oct-1995
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adenocarcinoma, Follicular - pathology - ultrasonography
Adolescent
Adult
Biopsy, Needle
Byelarus
Carcinoma, Papillary - pathology - ultrasonography
Child
Chronic Disease
Female
Goiter - pathology - ultrasonography
Humans
Male
Research Support, Non-U.S. Gov't
Russia
Thyroid Diseases - etiology - pathology - ultrasonography
Thyroid Neoplasms - etiology - pathology - ultrasonography
Thyroiditis - pathology - ultrasonography
Ukraine
Abstract
Screening by ultrasound examination and fine-needle aspiration cytological biopsy (FNA) was conducted in five regions in Belarus, Ukraine, and Russia to investigate the prevalence of childhood thyroid diseases around Chernobyl. Gomel, Zhitomir, Kiev, and the western area of Bryansk are the administrative regions where severe radioactive contamination occurred. The subjects from Mogilev, where contamination was relatively low, served as controls. Among 55,054 subjects (26,406 boys and 28,648 girls), the prevalence of ultrasonographic thyroid abnormalities such as nodule, cyst, and abnormal echogenity was significantly higher in the regions with severe contamination than in Mogilev. Of the 1,396 children showing echographic thyroid abnormalities 197 were selected for FNA, and a sample was successfully obtained for diagnosis from 171 (51 boys and 120 girls) of the 197 subjects. The aspirate was insufficient for diagnosis in the remaining 26 subjects. Thyroid cancer was encountered in four children (2.3%) from the contaminated regions, two children being from Gomel. The other thyroid diseases were follicular neoplasm, 6.4%; adenomatous goiter, 18.7%; chronic thyroiditis, 31.0%; and cyst, 24.0%, suggesting that a major cause of thyroid nodularity is nonneoplastic changes, mainly chronic thyroiditis and cysts. These results will serve as an important data base for further analyses and suggest that childhood thyroid diseases, including both neoplasms and immunological disorders, are consequences of radioactive fallout.
PubMed ID
8563473 View in PubMed
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Evaluation of a telemedicine system for supporting thyroid disease diagnosis.

https://arctichealth.org/en/permalink/ahliterature19509
Source
Medinfo. 2001;10(Pt 1):866-9
Publication Type
Article
Date
2001
Author
K. Yokota
N. Takamura
Y. Shibata
S. Yamashita
M. Mine
M. Tomonaga
Author Affiliation
Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, 852-8523, Japan. kyokota@net2.nagasaki-u.ac.jp
Source
Medinfo. 2001;10(Pt 1):866-9
Date
2001
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Byelarus
Databases, Factual
Humans
International Cooperation
Japan
Medical Records Systems, Computerized
Power Plants
Remote Consultation
Spacecraft
Telemedicine - instrumentation
Thyroid Diseases - diagnosis - etiology
Ukraine
Abstract
A telemedicine system connecting Japan and Belarus via a communication satellite and the international ISDN has been in use since February, 1999. Two relational databases, which are essentially the same, are set respectively at Nagasaki University School of Medicine and Gomel Regional Specialized Dispensary in Belarus for management of patients' data and for research including epidemiologic studies. The thyroid ultrasonographic images, microscopic images of cytological findings and other information on patients are sent from Gomel to Nagasaki once a week with diagnoses and comments by physicians at Gomel Regional Specialized Dispensary for cases whom they found difficult to diagnose. Thyroid specialists at Nagasaki University School of Medicine correct the diagnoses, if necessary, on the basis of information from Gomel and send their comments and instructions to Gomel for improving diagnosis skills of physicians at Gomel. The findings of 330 cases have been sent from Gomel to Nagasaki by September, 2000 since the commencement of the system in February, 1999. Of the 329 cases, thyroid diagnosis was made at Gomel for 261 cases in whom two or more diagnoses were made for 35 cases. As of the end of October, 2000, the Gomel diagnoses have been reviewed for 217 cases and the remaining 112 cases are under review at Gomel. The diagnoses made at Gomel and Nagasaki were in agreement for 110 (50.7%) of 217 cases. Thyroid cancer was diagnosed in 8 cases in whom 6 had been diagnosed at Gomel while the other 2 were diagnosed anew at Nagasaki. The usefulness of the system for improving thyroid diagnosis in Belarus was indicated.
PubMed ID
11604859 View in PubMed
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Histopathological characteristics of childhood thyroid cancer in Gomel, Belarus.

https://arctichealth.org/en/permalink/ahliterature22804
Source
Int J Cancer. 1996 Jan 3;65(1):29-33
Publication Type
Article
Date
Jan-3-1996
Author
M. Ito
S. Yamashita
K. Ashizawa
T. Hara
H. Namba
M. Hoshi
Y. Shibata
I. Sekine
L. Kotova
G. Panasyuk
E P Demidchick
S. Nagataki
Author Affiliation
Department of Pathology, Nagasaki University School of Medicine, Japan.
Source
Int J Cancer. 1996 Jan 3;65(1):29-33
Date
Jan-3-1996
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Byelarus
Cesium Radioisotopes - analysis
Child
Child, Preschool
Environmental Pollutants - adverse effects
Female
Humans
Male
Neoplasms, Radiation-Induced - pathology
Nuclear Reactors
Power Plants
Research Support, Non-U.S. Gov't
Thyroid Neoplasms - pathology
Ukraine
Abstract
We reviewed histopathologically 19 cases of childhood thyroid cancer occurring between 1991 and 1994 among 14,396 screening subjects in Gomel, Republic of Belarus, the region most severely radio-contaminated by the Chernobyl nuclear power plant accident in 1986. The patients were 13 girls and 6 boys with a mean age of 10.6 years. The mean age at the time of the accident was 3.2 years. Mean tumor diameter was 16 mm, and all cases were papillary carcinoma with various amounts of solid component. Psammoma bodies and stromal fibrosis were encountered to some extent in almost all cases. The tumors were highly prone to local invasion and regional lymph-node metastasis. No morphological evidence for radiation-induced cancer was obtained in these cases. 137Cs levels were relatively high in the patients' bodies and in the soil at the places of domicile. However, there was no dose-response relationship between cancer prevalence and radioactivity. These facts suggest that the incidence of aggressive pediatric thyroid cancer is extremely high in Gomel, where most of the children were exposed to a low level of radioactivity over a long time after the accident. At present, however, no definite conclusion can be drawn on the relationship between cancer occurrence and radioactive contamination.
PubMed ID
8543392 View in PubMed
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Prevalence of goiter and urinary iodine excretion levels in children around Chernobyl.

https://arctichealth.org/en/permalink/ahliterature34140
Source
J Clin Endocrinol Metab. 1997 Oct;82(10):3430-3
Publication Type
Article
Date
Oct-1997
Author
K. Ashizawa
Y. Shibata
S. Yamashita
H. Namba
M. Hoshi
N. Yokoyama
M. Izumi
S. Nagataki
Author Affiliation
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Source
J Clin Endocrinol Metab. 1997 Oct;82(10):3430-3
Date
Oct-1997
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Child
Child, Preschool
Female
Geography
Goiter - epidemiology
Humans
Iodine - urine
Male
Osmolar Concentration
Power Plants
Prevalence
Research Support, Non-U.S. Gov't
Thyroid Gland - pathology
Ukraine
Abstract
The prevalence of goiter among children living in areas affected by the Chernobyl accident was investigated by analysis of data on approximately 120,000 children examined at five medical diagnostic centers in Belarus, Russia, and the Ukraine. Examinations of thyroid gland were conducted with an arch-automatic ultrasonographic instrument at the five centers under the same protocol. The diagnosis of goiter was established when the thyroid volume exceeded a limit calculated from age, height, and body weight of a child. A considerable variation by region was noted in the prevalence of goiter. Highest in the Kiev region, the prevalence in the five regions was 54% in Kiev, 38% in the Zhitomir regions of the Ukraine, 18% in Gomel, 22% in the Mogilev regions of Belarus, and 41% in the Bryansk region of Russia. Urinary iodine content was measured in approximately 5700 children, and an endemic iodine deficient zone was confirmed in the Bryansk, Kiev, and Zhitomir regions. A significant negative correlation was observed between the prevalence of goiter and the median level of urinary iodine content (Spearman's rank correlation coefficient was -0.35, P = 0.025).
PubMed ID
9329381 View in PubMed
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Purification and properties of a bacteriocin of Staphylococcus epidermidis isolated from dental plaque.

https://arctichealth.org/en/permalink/ahliterature203503
Source
Oral Microbiol Immunol. 1998 Dec;13(6):387-9
Publication Type
Article
Date
Dec-1998
Author
T. Nakamura
K. Hirai
Y. Shibata
S. Fujimura
Author Affiliation
Department of Oral Microbiology, Matsumoto Dental University School of Dentistry, NAGANO-Ken, Japan.
Source
Oral Microbiol Immunol. 1998 Dec;13(6):387-9
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Bacterial Proteins - chemistry - isolation & purification - pharmacology
Bacteriocins - chemistry - isolation & purification - pharmacology
Dental Plaque - microbiology
Ecosystem
Humans
Microbial Sensitivity Tests
Staphylococcus - drug effects
Staphylococcus epidermidis - chemistry - isolation & purification - physiology
Streptococcus - drug effects
Abstract
An extracellular bacteriocin of Staphylococcus epidermidis isolated from dental plaque was purified and characterized. Its molecular mass was 3500 Da and pI was 10.5. This bacteriocin inhibited the growth of Staphylococcus aureus, Streptococcus salivarius, and Streptococcus mitis, but Streptococcus mutans, Streptococcus sanguis and other oral indigenous bacterial species examined were not inhibited. The mode of inhibition was found to be bacteriostatic.
PubMed ID
9872117 View in PubMed
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Radiocesium in children residing in the western districts of the Bryansk Oblast from 1991-1996.

https://arctichealth.org/en/permalink/ahliterature197785
Source
Health Phys. 2000 Aug;79(2):182-6
Publication Type
Article
Date
Aug-2000
Author
M. Hoshi
Y O Konstantinov
T Y Evdeeva
A I Kovalev
A S Aksenov
N V Koulikova
H. Sato
T. Takatsui
J. Takada
S. Endo
Y. Shibata
S. Yamashita
Author Affiliation
Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
Source
Health Phys. 2000 Aug;79(2):182-6
Date
Aug-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Age Distribution
Body Burden
Body Weight
Cesium Radioisotopes - analysis
Child
Child, Preschool
Environmental Exposure - analysis
Environmental Monitoring - statistics & numerical data
Female
Food chain
Food contamination, radioactive
Food Habits
Humans
Male
Radioactive Hazard Release
Radioactive Pollutants - analysis
Radiometry
Russia
Seasons
Whole-Body Counting
Abstract
Measurements of 137Cs body burden were carried out in 1991-1996 for children residing in the western part of Bryansk Oblast (Russia) where area contamination with 137Cs following the Chernobyl accident varied from 0.03-3.7 MBq m(-2). The mean and median values of 137Cs specific activity (SA) in the bodies of children 5-15 y old for the whole period of surveillance averaged for 26,029 measurements was 85 Bq kg(-1) and 49 Bq kg(-1), respectively. Mean values in different places of residence varied from 30-342 Bq kg(-1) for the settlements where the number of examinees was not less than 50. There is a moderately strong relationship between mean SA in the settlement and the level of area contamination with 137Cs. A strong seasonal effect on 137Cs body burden was found. The ratio of average SA values is 1:1.75 for spring to autumn 1992-1995 in the settlement where the largest number of children was examined. This effect might be attributed to a seasonal change in diet. Based on questionnaire information on individual consumption of locally produced foods, the descending rank of contribution of food items to 137Cs intake by children was found to be: meat-mushrooms-milk-vegetables. Assuming that the dose distribution would follow the distribution of SA values, internal doses to the whole body from ingested 137Cs were assessed. The mean value of annual internal dose averaged for the whole set of measurements is 0.21 mSv, and the median of the individual dose distribution is 0.12 mSv y(-1) For 2% of the total sample the annual dose exceeded 1 mSv, with the highest individual dose being 9 mSv in 1994 for a 7-y-old girl.
PubMed ID
10910388 View in PubMed
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11 records – page 1 of 2.