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Twin studies used to prove that the comorbidity of major depressive disorder with IBS is NOT influenced by heredity.

https://arctichealth.org/en/permalink/ahliterature84569
Source
Am J Gastroenterol. 2007 Oct;102(10):2230-1
Publication Type
Article
Date
Oct-2007
Author
Whitehead William E
Source
Am J Gastroenterol. 2007 Oct;102(10):2230-1
Date
Oct-2007
Language
English
Publication Type
Article
Keywords
Depressive Disorder, Major - complications - epidemiology - genetics
Humans
Irritable Bowel Syndrome - epidemiology - genetics - psychology
Reproducibility of Results
Research Design
Sweden - epidemiology
Twin Studies as Topic
Twins, Dizygotic
Twins, Monozygotic
Abstract
Twin studies have traditionally been used to assess the heritability of diseases such as irritable bowel syndrome (IBS) by comparing concordance rates in monozygotic twins (identical genetic endowment) to dizygotic twins (half of genes shared). Wojczynski et al. used twins in a novel way-they studied monozygotic twins who were discordant for IBS (but who shared identical genes) to show that the comorbidity of IBS with major depressive disorder could NOT be due to genetic influences. This paradigm provides the most rigorous method for separating genetic from environmental influences and should be adopted by other researchers. However, the authors' conclusion that major depressive disorder and IBS are part of the same pathophysiological process is questioned on the basis of (a) incomplete co-occurrence of IBS and major depressive disorder (13-45% co-occurrence) and (b) lack of specificity-the authors show that chronic widespread pain (related to fibromyalgia) and chronic fatigue are also strongly associated with IBS. This study provides precise, generalizable estimates from a large population-based study for the comorbidity of IBS with major depressive disorder, chronic widespread pain, and chronic fatigue.
Notes
Comment On: Am J Gastroenterol. 2007 Oct;102(10):2220-917897337
PubMed ID
17897338 View in PubMed
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