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Association of Epstein-Barr virus with nasopharyngeal carcinoma in Alaskan native patients: serum antibodies and tissue EBNA and DNA.

https://arctichealth.org/en/permalink/ahliterature4247
Source
Int J Cancer. 1981 Sep 15;28(3):301-5
Publication Type
Article
Date
Sep-15-1981
Author
A P Lanier
G W Bornkamm
W. Henle
G. Henle
T R Bender
M L Talbot
P H Dohan
Source
Int J Cancer. 1981 Sep 15;28(3):301-5
Date
Sep-15-1981
Language
English
Geographic Location
U.S.
Publication Type
Article
Keywords
Alaska
Antibodies, Viral - analysis
Antigens, Viral - analysis
Asian Continental Ancestry Group
DNA, Viral - analysis
Epstein-Barr Virus Nuclear Antigens
Herpesvirus 4, Human - immunology
Humans
Nasopharyngeal Neoplasms - immunology - microbiology
Nucleic Acid Hybridization
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Salivary Gland Neoplasms - analysis
Abstract
Biopsy specimens from Alaskan Native patients with nasopharyngeal carcinoma (NPC) and from other patients seen on the otolaryngology service were tested for Epstein-Barr virus-specific DNA and nuclear antigen (EBNA). Serum samples from both groups were tested for various EBV-related antibodies. EBV DNA and EBNA results were in agreement in 29 of 31 tissue specimens tested by the two methods. Ten of 11 biopsies containing NPC cells were positive for EBV DNA. Two NPC patients had biopsies that showed only atypical epithelium but were also positive for EBV DNA or EBNA. The other tissue specimens were negative except for biopsies from two patients: one with a parotid gland lymphoepithelial lesion; another with undifferentiated carcinoma of salivary gland origin.
PubMed ID
6274814 View in PubMed
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Epstein-Barr virus and malignant lymphoepithelial lesions of the salivary gland.

https://arctichealth.org/en/permalink/ahliterature4137
Source
Arctic Med Res. 1991 Apr;50(2):55-61
Publication Type
Article
Date
Apr-1991
Author
A P Lanier
S R Clift
G. Bornkamm
W. Henle
H. Goepfert
N. Raab-Traub
Author Affiliation
Center for Infectious Diseases, Center for Disease Control, Anchorage, Alaska.
Source
Arctic Med Res. 1991 Apr;50(2):55-61
Date
Apr-1991
Language
English
Publication Type
Article
Keywords
Adolescent
Aged
Antigens, Viral - analysis
Carcinoma - microbiology
DNA, Viral - analysis
Epstein-Barr Virus Nuclear Antigens
Female
Herpesvirus 4, Human - genetics - isolation & purification
Humans
Male
Middle Aged
Research Support, U.S. Gov't, P.H.S.
Salivary Gland Neoplasms - microbiology
Abstract
This report describes the results of histopathologic and virologic studies in six patients with undifferentiated carcinoma (malignant lymphoepithelial lesions) of the salivary glands. Epstein-Barr virus (EBV) was detected in tumors from all six patients by DNA hybridization, while adjacent non-tumorous salivary gland tissue was negative for EBV in two patients tested for DNA and in three patients tested for Epstein-Barr nuclear antigen (EBNA). These findings add more evidence that these unusual salivary gland tumors are EBV-associated, and that EBV is specific to the tumor.
PubMed ID
1646614 View in PubMed
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Epstein-Barr virus DNA in tumour tissue from Native Alaskan patients with nasopharyngeal carcinoma.

https://arctichealth.org/en/permalink/ahliterature4266
Source
Lancet. 1978 Nov 18;2(8099):1095
Publication Type
Article
Date
Nov-18-1978
Author
A. Lanier
T. Bender
M. Talbot
S. Clift
C. Tschopp
P. Dohan
G. Bornkamm
W. Henle
Source
Lancet. 1978 Nov 18;2(8099):1095
Date
Nov-18-1978
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adult
Aged
Alaska
DNA, Viral - isolation & purification
EBV
Female
Herpesvirus 4, Human
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms - analysis - microbiology
NPC
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2208.
PubMed ID
82107 View in PubMed
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Epstein-Barr virus infection and serological profile in Greenland Eskimo children.

https://arctichealth.org/en/permalink/ahliterature6957
Source
Acta Paediatr Scand. 1985 Sep;74(5):691-6
Publication Type
Article
Date
Sep-1985
Author
H. Albeck
T. Bille
H J Fenger
U. Narvestad
G S Sørensen
G. Henle
W. Henle
N. Højgaard Nielsen
J P Hart Hansen
Source
Acta Paediatr Scand. 1985 Sep;74(5):691-6
Date
Sep-1985
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Antibodies, Viral - analysis
Child
Child, Preschool
Greenland
Herpesvirus 4, Human - immunology
Humans
Infant
Infectious Mononucleosis - epidemiology - immunology
Inuits
Abstract
The Epstein-Barr virus (EBV)-specific antibody profile of 101 Greenland Eskimo children was determined. The proportion of children with serological evidence of recent or past primary EBV infections rose from 22% at 6 months of age to 79% at 24 months of age. All but 2 of 49 children more than 4 years of age proved seropositive. The geometric mean titre (GMT) of antibodies to the viral capsid antigen (VCA) was highest during the first 3 years of life and declined sharply to a lower, nearly constant level in older children. The GMT of antibodies to the nuclear antigen (EBNA), rose slowly during the first 4 years of life to its persistent level. None of the children had a history of illnesses comparable to infectious mononucleosis. The results have shown that in this population with an enhanced risk of nasopharyngeal carcinoma, primary EBV infection occurs at a very early age.
PubMed ID
2996288 View in PubMed
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Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland Eskimoes.

https://arctichealth.org/en/permalink/ahliterature4234
Source
Br J Cancer. 1982 Nov;46(5):721-8
Publication Type
Article
Date
Nov-1982
Author
A K Saemundsen
H. Albeck
J P Hansen
N H Nielsen
M. Anvret
W. Henle
G. Henle
K A Thomsen
H K Kristensen
G. Klein
Source
Br J Cancer. 1982 Nov;46(5):721-8
Date
Nov-1982
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antibodies, Viral - analysis
DNA, Viral - analysis
Female
Greenland
Herpesvirus 4, Human - immunology
Humans
Inuits
Male
Middle Aged
Nasopharyngeal Neoplasms - analysis - immunology - microbiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Salivary Gland Neoplasms - analysis - immunology - microbiology
Abstract
Biopsy specimens from nasopharyngeal carcinomas (NPC) or salivary-gland carcinomas (SGC) in Greenland Eskimoes were examined for the presence of Epstein-Barr virus (EBV) DNA and sera from the patients were tested for EBV-specific antibody titres. Six out of 7 NPCs and one from an undifferentiated SGG were positive for EBV DNA. The EBV-specific antibody spectra and titres of the patients with NPC or undifferentiated SGG conformed to the results of earlier studies in other high-incidence areas.
PubMed ID
6293523 View in PubMed
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Epstein-Barr virus-specific antibody titers in seven Alaskan Natives before and after diagnosis of nasopharyngeal carcinoma.

https://arctichealth.org/en/permalink/ahliterature4255
Source
International Journal of Cancer. 1980 Aug;26(2):133-7
Publication Type
Article
Date
Aug-1980
Author
A P Lanier
W. Henle
T R Bender
G. Henle
M L Talbot
Source
International Journal of Cancer. 1980 Aug;26(2):133-7
Date
Aug-1980
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adenoma, Pleomorphic - immunology
Adult
Aged
Alaska
Antibodies, Neoplasm - analysis
Antibodies, Viral - analysis
Comparative Study
EBV
Female
Follow-Up Studies
Head and Neck Neoplasms - immunology
Herpesvirus 4, Human - immunology
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Inuits
Male
Middle Aged
Nasopharyngeal Neoplasms - diagnosis - immunology
NPC
Parotid Neoplasms - immunology
Research Support, U.S. Gov't, P.H.S.
Serological surveys
Abstract
Results are presented of Epstein-Barr virus-specific serologic tests for seven Alaskan Native patients with nasopharyngeal carcinoma (NPC) from whom serum had been collected 2-10 years before diagnosis and up to 6 years after diagnosis. The pre-illness antibody spectra and titers of the NPC patients did not differ from those of controls. However, broadened antibody spectra and elevated titers were associated with the emergence of NPC disease, which in one case was present as early as 22 months before actual diagnosis. Increasing or continuously high antibody titers were associated with progression of the disease and death, whereas patients who maintained relatively low, stable antibody titers after treatment have remained well.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2213.
PubMed ID
6259065 View in PubMed
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Nasopharyngeal carcinoma in Alaskan Eskimos Indians, and Aleuts: a review of cases and study of Epstein-Barr virus, HLA, and environmental risk factors.

https://arctichealth.org/en/permalink/ahliterature3613
Source
Cancer. 1980 Nov 1;46(9):2100-6
Publication Type
Article
Date
Nov-1-1980
Author
A. Lanier
T. Bender
M. Talbot
S. Wilmeth
C. Tschopp
W. Henle
G. Henle
D. Ritter
P. Terasaki
Source
Cancer. 1980 Nov 1;46(9):2100-6
Date
Nov-1-1980
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adult
Aged
Alaska
Antigens, Viral - analysis
Blood groups, general
Carcinoma - epidemiology - immunology
Diet
EBV
Ethnic Groups
Female
HLA Antigens - analysis
Head and Neck Neoplasms - epidemiology
Herpesvirus 4, Human - immunology
HLA-typing
Humans
Indians, North American
Inuits
Male
Middle Aged
Nasopharyngeal Neoplasms - epidemiology - immunology
NPC
Risk
Smoking
Abstract
The records of thirty-one patients with nasopharyngeal carcinoma (NPC) diagnosed from 1966 through 1976 among the Alaskan native population (Eskimo, Aleut, Indian) were reviewed. There were 25 males and six females, which results in relatively high incidence rates per 100,000 of 13.5 for males and 3.7 for females. Clinical and pathologic features were similar to those found among southern Chinese NPC patients. Five-year survival rate was 48%. Antibodies to Epstein-Barr virus were higher in NPC patients than in patients with other tumors or matched controls. On histocompatibility testing Sin-2 was not detected, nor was there significantly increased frequency of A2. Instead, BW40 and a second locus blank occurred more often among NPC patients than among other groups. In response to a questionnaire, NPC patients more often reported use of salt fish in the childhood diet, smoking of cigarettes, and exposure to noxious inhalants than did controls, but the differences were not statistically significant.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage.
PubMed ID
6253051 View in PubMed
Less detail

Salivary gland cancer in Alaskan Natives, 1966-1980.

https://arctichealth.org/en/permalink/ahliterature4185
Source
Human Pathology. 1987 Oct;18(10):986-96
Publication Type
Article
Date
Oct-1987
Author
S. Krishnamurthy
A P Lanier
P. Dohan
J F Lanier
W. Henle
Author Affiliation
Arctic Investigations Laboratory, Centers for Disease Control, Anchorage, AK 99501.
Source
Human Pathology. 1987 Oct;18(10):986-96
Date
Oct-1987
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adult
Alaska
Antibodies, Viral - analysis
Autoantibodies - analysis
Autoimmunity
Benign lymphoepithelial lesion
EBV
Female
HLA Antigens - analysis
HLA-typing
Herpesvirus 4, Human - immunology
Humans
Inuits
Male
Malignant lymphoepithelial lesion
Middle Aged
Research Support, U.S. Gov't, P.H.S.
Salivary Gland Neoplasms - epidemiology - ethnology - immunology - pathology
Notes
Alaska Medical Library - From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 2182.
Erratum In: Hum Pathol 1988 Mar;19(3):328
PubMed ID
2820863 View in PubMed
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8 records – page 1 of 1.