The ADRA2B gene 301-303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 healthy residents of Kola Peninsula (68 N) aged 27-65 years. The genotypes were determined by PCR. The multiple regression analysis adjusted for age, BMI, heart rate, and blood pressure revealed that II genotype carriers had higher values of augmentation index, ejection duration and lower SEVR than DD homozygotes. Further sex stratified analysis showed that the associations existed only in men whereas in women the differences only tended to be significant. It is concluded that in northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers.
The ADRA2B gene 301-303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27-65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index ( P = 0.014), ejection duration ( P = 0.045), and lower SEVR ( P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men ( n = 33) whereas in women ( n = 30) the differences were suggestive ( P
OBJECTIVES: To assess associations between mean age at death from cardiovascular disease (myocardial infarction, acute heart failure, ischemic heart disease and stroke) and sex, education, socio-professional status, marital status, region of residence at birth, month and season of birth and of death in dependence of climatic conditions. DESIGN: A retrospective analysis of death certificates in two Siberian cities from 1971 to 1978 (Novosibirsk, south-western Siberia) and from 1968 to 1985 (Mirny, western Yakutia). METHODS: Analysis of variance, test for seasonality. RESULTS: A remarkable effect of birthplace on longevity was observed in Novosibirsk. West Russia-born decedents were older than their cause-of-death-matched counterparts born in Siberia. In this city, men died at younger age in spring months compared to the rest of the year. In Mirny, an extreme northern town with a very harsh climate, the life span depended on the duration of living in this region prior to death. CONCLUSION: There was some difference among cardiovascular diagnoses and between the two cities. However, overall, the results offer some support for theories suggesting that early "imprinting" is responsible for the association between life span and region/season of birth.
Mechanisms underlying effects of physical factors on twin births are unclear. The present work studied an association between monthly and yearly multiple birth rates (MBRs) in the Novosibirsk region, south-west Siberia, in relation to solar activity (sunspot numbers) and geomagnetic activity (Ap index) from 1957 to 2008. The difference was verified by comparing the yearly MBR observed in 3-year peaks (M = 7.36, SD = 0.33 per 1,000 births) and 3-year troughs (M = 8.10, SD = 0.31 per 1,000 births, p