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Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.

https://arctichealth.org/en/permalink/ahliterature287453
Source
Physiol Genomics. 2017 Dec 06;:physiolgenomics.00071.2017
Publication Type
Article
Date
Dec-06-2017
Author
Vladimir N Melnikov
Victor Baranov
Irina Suvorova
Sergey Krivoschekov
Source
Physiol Genomics. 2017 Dec 06;:physiolgenomics.00071.2017
Date
Dec-06-2017
Language
English
Publication Type
Article
Abstract
The ADRA2B gene 301-303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 healthy residents of Kola Peninsula (68 N) aged 27-65 years. The genotypes were determined by PCR. The multiple regression analysis adjusted for age, BMI, heart rate, and blood pressure revealed that II genotype carriers had higher values of augmentation index, ejection duration and lower SEVR than DD homozygotes. Further sex stratified analysis showed that the associations existed only in men whereas in women the differences only tended to be significant. It is concluded that in northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers.
PubMed ID
29212846 View in PubMed
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Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.

https://arctichealth.org/en/permalink/ahliterature297756
Source
Physiol Genomics. 2018 02 01; 50(2):100-101
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-01-2018
Author
Vladimir N Melnikov
Victor I Baranov
Irina Yu Suvorova
Sergey G Krivoschekov
Author Affiliation
Scientific Research Institute of Physiology and Basic Medicine , Novosibirsk , Russia.
Source
Physiol Genomics. 2018 02 01; 50(2):100-101
Date
02-01-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Aged
Female
Genotype
Hemodynamics - genetics - physiology
Humans
Male
Middle Aged
Polymorphism, Genetic - genetics
Receptors, Adrenergic, alpha-2 - genetics
Regression Analysis
Russia
Abstract
The ADRA2B gene 301-303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27-65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index ( P = 0.014), ejection duration ( P = 0.045), and lower SEVR ( P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men ( n = 33) whereas in women ( n = 30) the differences were suggestive ( P
PubMed ID
29212846 View in PubMed
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Life span of people who died from cardiovascular diseases in Siberia: a comparative study of two populations.

https://arctichealth.org/en/permalink/ahliterature5140
Source
Int J Circumpolar Health. 2003 Sep;62(3):296-307
Publication Type
Article
Date
Sep-2003
Author
Vladimir N Melnikov
Author Affiliation
Novosibirsk State University, Russia. mevlanic@nsk.ru
Source
Int J Circumpolar Health. 2003 Sep;62(3):296-307
Date
Sep-2003
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Arctic Regions
Cardiovascular Diseases - mortality
Comparative Study
Death Certificates
Female
Humans
Longevity
Male
Middle Aged
Residence Characteristics
Retrospective Studies
Risk factors
Seasons
Siberia - epidemiology
Time Factors
Abstract
OBJECTIVES: To assess associations between mean age at death from cardiovascular disease (myocardial infarction, acute heart failure, ischemic heart disease and stroke) and sex, education, socio-professional status, marital status, region of residence at birth, month and season of birth and of death in dependence of climatic conditions. DESIGN: A retrospective analysis of death certificates in two Siberian cities from 1971 to 1978 (Novosibirsk, south-western Siberia) and from 1968 to 1985 (Mirny, western Yakutia). METHODS: Analysis of variance, test for seasonality. RESULTS: A remarkable effect of birthplace on longevity was observed in Novosibirsk. West Russia-born decedents were older than their cause-of-death-matched counterparts born in Siberia. In this city, men died at younger age in spring months compared to the rest of the year. In Mirny, an extreme northern town with a very harsh climate, the life span depended on the duration of living in this region prior to death. CONCLUSION: There was some difference among cardiovascular diagnoses and between the two cities. However, overall, the results offer some support for theories suggesting that early "imprinting" is responsible for the association between life span and region/season of birth.
PubMed ID
14594204 View in PubMed
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Month of birth predicts lung cancer mortality in siberia.

https://arctichealth.org/en/permalink/ahliterature17554
Source
Epidemiology. 2004 Sep;15(5):645-6
Publication Type
Article
Date
Sep-2004

Reduced solar activity favors twin maternities.

https://arctichealth.org/en/permalink/ahliterature122702
Source
Twin Res Hum Genet. 2012 Feb;15(1):133-7
Publication Type
Article
Date
Feb-2012
Author
Vladimir N Melnikov
Author Affiliation
Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia. mevlanic@yandex.ru
Source
Twin Res Hum Genet. 2012 Feb;15(1):133-7
Date
Feb-2012
Language
English
Publication Type
Article
Keywords
Birth rate
Geological Phenomena
Humans
Regression Analysis
Siberia
Solar Activity
Abstract
Mechanisms underlying effects of physical factors on twin births are unclear. The present work studied an association between monthly and yearly multiple birth rates (MBRs) in the Novosibirsk region, south-west Siberia, in relation to solar activity (sunspot numbers) and geomagnetic activity (Ap index) from 1957 to 2008. The difference was verified by comparing the yearly MBR observed in 3-year peaks (M = 7.36, SD = 0.33 per 1,000 births) and 3-year troughs (M = 8.10, SD = 0.31 per 1,000 births, p
PubMed ID
22784464 View in PubMed
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