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Early glycaemic control for maintaining visual function in type 1 diabetes: The Oulu cohort study of diabetic retinopathy.

https://arctichealth.org/en/permalink/ahliterature290645
Source
Eur J Ophthalmol. 2018 Mar 01; :1120672117750053
Publication Type
Journal Article
Date
Mar-01-2018
Author
Nina Hautala
Mira Siiskonen
Virva Hannula
Kaisu Järvinen
Aura Falck
Author Affiliation
Department of Ophthalmology, PEDEGO Research Unit and Medical Research Center, Oulu University Hospital, Oulu University, Oulu, Finland.
Source
Eur J Ophthalmol. 2018 Mar 01; :1120672117750053
Date
Mar-01-2018
Language
English
Publication Type
Journal Article
Abstract
The purpose of this study was to evaluate the visual function and the ophthalmic status of young Finnish adults with long duration of type 1 diabetes in relation to the history of the metabolic control.
A population-based cohort of children with type 1 diabetes examined in the Northern Ostrobothnia hospital district in 1989 (n?=?216) was re-examined 18?years later. High-contrast visual acuity (best-corrected visual acuity), contrast sensitivity, refractive error, lens status, intraocular pressure, stage of diabetic retinopathy and received treatments were evaluated. The metabolic control was reflected by the mean of glycated haemoglobin A1 or glycated haemoglobin A1c values of the years 1983-1989 and 1992-2007, respectively.
In all, 96 men and 76 women age 30?±?3?years with type 1 diabetes duration of 23?±?4?years attended the re-evaluation. About 60% (103/172) had normal best-corrected visual acuity and 3% had low vision. Contrast sensitivity was abnormal in two-thirds. Half had myopia. Four patients had cataract surgery. Low childhood glycated haemoglobin A1 was indicative, and favourable glycated haemoglobin A1c during youth was a significant predictor of better contrast sensitivity and ocular state in adulthood.
The majority of the patients have useful vision, although minor functional impairments are commonly detectable. Long duration of type 1 diabetes in association with non-optimal glycaemic control threatens visual function already at young adulthood. Thus, strong emphasis to control diabetes from onset is important in maintaining good visual function.
PubMed ID
29554811 View in PubMed
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Early glycaemic control for maintaining visual function in type 1 diabetes: The Oulu cohort study of diabetic retinopathy.

https://arctichealth.org/en/permalink/ahliterature296633
Source
Eur J Ophthalmol. 2018 Nov; 28(6):684-689
Publication Type
Journal Article
Date
Nov-2018
Author
Nina Hautala
Mira Siiskonen
Virva Hannula
Kaisu Järvinen
Aura Falck
Author Affiliation
Department of Ophthalmology, PEDEGO Research Unit and Medical Research Center, Oulu University Hospital, Oulu University, Oulu, Finland.
Source
Eur J Ophthalmol. 2018 Nov; 28(6):684-689
Date
Nov-2018
Language
English
Publication Type
Journal Article
Keywords
Adult
Cohort Studies
Contrast Sensitivity - physiology
Diabetes Mellitus, Type 1 - complications
Diabetic Retinopathy - physiopathology
Female
Finland
Glycated Hemoglobin A - metabolism
Humans
Lens, Crystalline - physiopathology
Male
Refractive Errors
Time Factors
Vision Disorders - physiopathology
Visual Acuity - physiology
Young Adult
Abstract
The purpose of this study was to evaluate the visual function and the ophthalmic status of young Finnish adults with long duration of type 1 diabetes in relation to the history of the metabolic control.
A population-based cohort of children with type 1 diabetes examined in the Northern Ostrobothnia hospital district in 1989 (n?=?216) was re-examined 18?years later. High-contrast visual acuity (best-corrected visual acuity), contrast sensitivity, refractive error, lens status, intraocular pressure, stage of diabetic retinopathy and received treatments were evaluated. The metabolic control was reflected by the mean of glycated haemoglobin A1 or glycated haemoglobin A1c values of the years 1983-1989 and 1992-2007, respectively.
In all, 96 men and 76 women age 30?±?3?years with type 1 diabetes duration of 23?±?4?years attended the re-evaluation. About 60% (103/172) had normal best-corrected visual acuity and 3% had low vision. Contrast sensitivity was abnormal in two-thirds. Half had myopia. Four patients had cataract surgery. Low childhood glycated haemoglobin A1 was indicative, and favourable glycated haemoglobin A1c during youth was a significant predictor of better contrast sensitivity and ocular state in adulthood.
The majority of the patients have useful vision, although minor functional impairments are commonly detectable. Long duration of type 1 diabetes in association with non-optimal glycaemic control threatens visual function already at young adulthood. Thus, strong emphasis to control diabetes from onset is important in maintaining good visual function.
PubMed ID
29554811 View in PubMed
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Health-related quality of life--using the 15D instrument--of young adults with type 1 diabetes since childhood. Population-based Oulu cohort study of diabetic retinopathy.

https://arctichealth.org/en/permalink/ahliterature259207
Source
Acta Ophthalmol. 2014 May;92(3):205-8
Publication Type
Article
Date
May-2014
Author
Virva Hannula
Nina Hautala
Harri Sintonen
Aura Falck
Source
Acta Ophthalmol. 2014 May;92(3):205-8
Date
May-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Child
Child, Preschool
Diabetes Mellitus, Type 1 - complications - psychology
Diabetic Retinopathy - epidemiology - etiology - psychology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Male
Population Surveillance
Prevalence
Quality of Life
Questionnaires
Retrospective Studies
Visual acuity
Young Adult
Abstract
The aim of this study was to evaluate the health-related quality of life (HRQoL) of young adults with type 1 diabetes (T1D) since childhood using the 15D instrument. The possible impact of diabetic retinopathy (DR) and proliferative diabetic retinopathy (PDR) on the HRQoL was focused on.
During the years 1989-1990, the prevalence of DR was evaluated from ocular fundus photographs of a population-based cohort of children with T1D living in the Northern Osthrobothnia Hospital District, Finland. These 216 individuals were contacted 18 years later and invited for assessment of the 15D HRQoL as well as current stage of DR. The results were compared with age- and gender-standardized Finnish general population.
The 15D data were obtained from 123 patients aged 29±3 years with a duration of diabetes of 23±4 years. The mean 15D score was similar in the patients with T1D and the general population [0.954±0.062 versus 0.964±0.052, respectively (p=0.085)]. However, the subgroup of patients with PDR (N=38) had a statistically significantly lower mean 15D score than those subjects with nonproliferative or no DR [0.931±0.086 versus 0.965±0.044, respectively (p=0.026)].
Young adults with T1D since childhood had 15D HRQoL score equal to that of age- and gender-standardized general population as long as no more severe than nonproliferative DR was present. Presence of PDR, not T1D of long duration per se, significantly impaired the 15D score.
PubMed ID
23763986 View in PubMed
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Prevalence of diabetic retinopathy in young adults with type 1 diabetes since childhood: the Oulu cohort study of diabetic retinopathy.

https://arctichealth.org/en/permalink/ahliterature262791
Source
Acta Ophthalmol. 2014 Dec;92(8):749-52
Publication Type
Article
Date
Dec-2014
Author
Nina Hautala
Virva Hannula
Tapani Palosaari
Tapani Ebeling
Aura Falck
Source
Acta Ophthalmol. 2014 Dec;92(8):749-52
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Cohort Studies
Diabetes Mellitus, Type 1 - diagnosis - epidemiology
Diabetic Retinopathy - diagnosis - epidemiology
Female
Finland - epidemiology
Humans
Male
Prevalence
Time Factors
Young Adult
Abstract
To evaluate the prevalence and stage of diabetic retinopathy (DR) in a population-based cohort of young Finnish adults who have had type 1 diabetes (T1D) since childhood.
The cohort includes all 5- to 16-year-old patients with T1D who lived in the Northern Ostrobothnia Hospital District of Finland, in 1989 (n = 216). DR was evaluated from fundus photographs taken in 1989-1990 and again in 2007. The patients were 7 ± 4 years age (range 0-15 years) at the time of diagnosis of T1D, and the average duration of diabetes at the re-evaluation was 23 ± 4 years (range 17-32 years).
The prevalence of DR was analysed in 172 patients (80% of the original cohort) at 22-35 years. Proliferative DR (PDR) was observed in 35% (60/172) and non-proliferative DR in 59% (101/172), with no signs of DR being present in the remaining 6% (11/172) of the subjects. The prevalence of DR did not differ by gender (p = 0.356).
After the 18-year follow-up, a high prevalence of DR and PDR (94% and 35%, respectively) was found in patients who have had T1D since childhood, with no difference between the genders.
PubMed ID
24862935 View in PubMed
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Prevalence of retinopathy in Finnish children and adolescents with type 1 diabetes: a cross-sectional population-based retrospective study.

https://arctichealth.org/en/permalink/ahliterature101574
Source
Arch Dis Child. 2011 Jun 29;
Publication Type
Article
Date
Jun-29-2011
Author
Minna Kubin
Päivi Tossavainen
Virva Hannula
Sini Lahti
Nina Hautala
Aura Falck
Author Affiliation
Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.
Source
Arch Dis Child. 2011 Jun 29;
Date
Jun-29-2011
Language
English
Publication Type
Article
Abstract
Aim A population-based study was carried out to evaluate the prevalence and risk factors of diabetic retinopathy (DR) in children with type 1 diabetes (T1D) in The Northern Osthrobothnia Hospital District, Finland. The aim was to compare the current prevalence and the risk factors with those obtained in a study performed in a similar setting 17 years earlier. Methods and patients The prevalence of DR was evaluated from fundus photographs in a cross-sectional manner in children and adolescents with T1D (n=297) living in the Northern Osthrobothnia Hospital District on 1 January 2007. Results The prevalence of DR was 7.6% (12/158) in males and 16.5% (23/139) in females in the present study and 7.3% in males and 12.9% in females in the former study. The mean age of the patients was 11.9 and 11.8 years, and the mean duration of diabetes was 4.9 and 5.0 years in the present and the former study, respectively. DR was associated with older age (p
PubMed ID
21719439 View in PubMed
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Social well-being of young adults with type 1 diabetes since childhood. The Oulu cohort study of diabetic retinopathy.

https://arctichealth.org/en/permalink/ahliterature263953
Source
Scand J Public Health. 2015 Jun 18;
Publication Type
Article
Date
Jun-18-2015
Author
Virva Hannula
Nina M Hautala
Päivi Tossavainen
Aura Ak Falck
Source
Scand J Public Health. 2015 Jun 18;
Date
Jun-18-2015
Language
English
Publication Type
Article
Abstract
To evaluate the social performance of young adults with type 1 diabetes (T1D) since childhood with particular interest in its relation to the severity of diabetic retinopathy (DR).
The prevalence of DR was evaluated in a population-based Finnish cohort of children with T1D during 1989-1990. The subjects were contacted 18 years later for evaluation of DR, education, employment, and family relations.
136 of 216 subjects participated in the study in 2007 (mean age 30±3 years, mean diabetes duration 23±4 years, 78 men). There were 42 subjects (31%) with proliferative diabetic retinopathy (PDR). A university degree was held by 9%, a degree from a university of applied sciences by 33%, and 45% had a vocational school education; 7% were full-time students while 4% had received no education after comprehensive school. PDR was associated with lower education. Sixty percent of the subjects with PDR and 68% of those with non-PDR held full-time jobs. Four percent of the non-PDR group were unemployed while 26% of subjects with PDR were outside working life because of either unemployment or retirement. Seventy-one percent of the subjects had a spouse, and 60 subjects had a total of 119 children. PDR did not compromise the likelihood of having a spouse and children.
The majority of young adults with T1D take active roles in society by working and raising families. However, patients with PDR lacked secondary education significantly more often and were less likely to work than those with non-PDR.
PubMed ID
26088130 View in PubMed
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6 records – page 1 of 1.