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Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.

https://arctichealth.org/en/permalink/ahliterature297756
Source
Physiol Genomics. 2018 02 01; 50(2):100-101
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-01-2018
Author
Vladimir N Melnikov
Victor I Baranov
Irina Yu Suvorova
Sergey G Krivoschekov
Author Affiliation
Scientific Research Institute of Physiology and Basic Medicine , Novosibirsk , Russia.
Source
Physiol Genomics. 2018 02 01; 50(2):100-101
Date
02-01-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Aged
Female
Genotype
Hemodynamics - genetics - physiology
Humans
Male
Middle Aged
Polymorphism, Genetic - genetics
Receptors, Adrenergic, alpha-2 - genetics
Regression Analysis
Russia
Abstract
The ADRA2B gene 301-303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27-65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index ( P = 0.014), ejection duration ( P = 0.045), and lower SEVR ( P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men ( n = 33) whereas in women ( n = 30) the differences were suggestive ( P
PubMed ID
29212846 View in PubMed
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