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Environmental factors and risk of developing paediatric inflammatory bowel disease -- a population based study 2007-2009.

https://arctichealth.org/en/permalink/ahliterature122966
Source
J Crohns Colitis. 2013 Feb;7(1):79-88
Publication Type
Article
Date
Feb-2013

Infliximab dependency in a national cohort of children with Crohn's disease.

https://arctichealth.org/en/permalink/ahliterature29289
Source
J Pediatr Gastroenterol Nutr. 2006 Jan;42(1):40-5
Publication Type
Article
Date
Jan-2006
Author
Vibeke Wewer
Lene Riis
Ida Vind
Steffen Husby
Pia Munkholm
Anders Paerregaard
Author Affiliation
Department of Pediatrics and Medical Gastroenterology, H:S Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark. vibeke.wewer@hh.hosp.dk
Source
J Pediatr Gastroenterol Nutr. 2006 Jan;42(1):40-5
Date
Jan-2006
Language
English
Publication Type
Article
Abstract
AIM: The aim was to evaluate the pattern of responsiveness and to monitor side effects of episodic administration of infliximab in children with active Crohn's disease (CD) treated in Denmark from 1999 to 2003. MATERIAL AND METHODS: The National Danish Crohn Colitis Database of infliximab was used to identify all Danish CD patients treated at pediatric departments with infliximab. The clinical outcome was assessed by pattern recognition of the disease course 30 days after the first infliximab infusion and 90 days after intended end of treatment. RESULTS: During a 3 year period, infliximab was given to 24 CD patients (9 male/15 female) aged median 15.4 (range 9.8-18.6) years with a median disease duration of 26 (range 0.7-93) months and a median number of infusions of 6 (range 2-11). Five milligrams of infliximab per kilogram infusions were given intravenously. Immediate response was as follows: 8 (33%) patients achieved complete response (CR), 10 (42%) partial response (PR), and 6 (25%) no response (NR). Long-term response was as follows: 7 (29%) patients achieved prolonged response (PRO), defined as maintenance of CR or PR, 10 (42%) were infliximab dependent (ID), defined as relapse of symptoms requiring reinfusions of infliximab to regain CR or PR, and 6 (25%) had NR. Six (25%) patients needed surgery during or after treatment with infliximab. Side effects were seen in four (17%) patients. No serious events were noted. CONCLUSION: Seventy-one percent of the children appeared to benefit (PRO or ID) from infliximab treatment with minor side effects when given episodically. Among these patients, two response patterns were recognized: PRO after ending infliximab treatment (29%) or dependency on reinfusions of infliximab (42%).
PubMed ID
16385252 View in PubMed
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Infliximab dependency is related to decreased surgical rates in adult Crohn's disease patients.

https://arctichealth.org/en/permalink/ahliterature141255
Source
Eur J Gastroenterol Hepatol. 2010 Oct;22(10):1196-203
Publication Type
Article
Date
Oct-2010
Author
Natalia Pedersen
Dana Duricova
Martin Lenicek
Margarita Elkjaer
Martin Bortlik
Paal Skytt Andersen
Libor Vitek
Bogi Davidsen
Vibeke Wewer
Milan Lukas
Pia Munkholm
Author Affiliation
Gastroenterology Unit, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark. natalia.pedersen@zeniavej.dk
Source
Eur J Gastroenterol Hepatol. 2010 Oct;22(10):1196-203
Date
Oct-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Antibodies, Monoclonal - administration & dosage
Crohn Disease - drug therapy - genetics - surgery
Czech Republic
Denmark
Digestive System Surgical Procedures - utilization
Female
Gastrointestinal Agents - administration & dosage
Genotype
Humans
Male
Middle Aged
Phenotype
Predictive value of tests
Retrospective Studies
Treatment Outcome
Young Adult
Abstract
Infliximab dependency in children with Crohn's disease (CD) has recently been described and found to be associated with a decreased surgery rate.
To assess infliximab dependency of adult CD patients, evaluate the impact on surgery, and search for possible clinical and genetic predictors.
Two hundred and forty-five CD patients treated with infliximab were included from Danish and Czech Crohn Colitis Database (1999-2006). Infliximab response was assessed as immediate outcome, 1 month after infliximab start: complete, partial, and no response. Three months outcome, after last intended infusion: prolonged response (maintenance of complete/partial response), infliximab dependency (relapse requiring repeated infusions to regain complete/partial response or need of infliximab >12 months to sustain response).
Forty-seven percent obtained prolonged response, 29% were infliximab dependent and 24% nonresponders. The cumulative probability of surgery 40 months after infliximab start was 20% in prolonged responders, 23% in infliximab-dependent patients and 76% in nonresponders (P
PubMed ID
20739896 View in PubMed
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Paediatric inflammatory bowel disease during a 44-year period in Copenhagen County: occurrence, course and prognosis--a population-based study from the Danish Crohn Colitis Database.

https://arctichealth.org/en/permalink/ahliterature149844
Source
Eur J Gastroenterol Hepatol. 2009 Nov;21(11):1291-301
Publication Type
Article
Date
Nov-2009
Author
Christian Jakobsen
Anders Paerregaard
Pia Munkholm
Vibeke Wewer
Author Affiliation
Department of Paediatrics, Hvidovre University Hospital, Kettegaard Alle 30, Hvidovre, Copenhagen, Denmark. christian.jakobsen@hvh.regionh.dk
Source
Eur J Gastroenterol Hepatol. 2009 Nov;21(11):1291-301
Date
Nov-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Colectomy - trends - utilization
Colitis, Ulcerative - complications - epidemiology - pathology - therapy
Colorectal Neoplasms - epidemiology - etiology
Crohn Disease - epidemiology - pathology - therapy
Denmark - epidemiology
Epidemiologic Methods
Female
Glucocorticoids - therapeutic use
Humans
Inflammatory Bowel Diseases - complications - epidemiology - pathology - therapy
Male
Prognosis
Abstract
To describe the development in incidence, disease localization, activity, surgery and prognosis in two Danish paediatric population-based inflammatory bowel disease (IBD) cohorts comparing the time periods 1962-1987 (period I) and 1998-2006 (period II).
Incident IBD patients below 15 years of age were included. Disease localization was classified according to the Montreal classification for ulcerative colitis (UC) patients and into small bowel, large bowel and small and large bowel combined for Crohn's disease (CD) patients. Disease activity and surgery in the first 2 years after diagnosis were assessed. Standardized cancer incidence rates and standardized mortality rates were calculated.
One hundred and nineteen IBD patients (77 UC and 42 CD) were included. Comparing periods II and I, the incidence rate ratios were 0.81 [95% confidence interval (CI): 0.5-1.4] and 15.6 (95% CI: 7.5-32.7) in UC and CD, respectively. The number of UC patients with extensive disease (E3) increased from period I to II (46.7 vs. 94.1%, P
PubMed ID
19581873 View in PubMed
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Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators--a population-based study.

https://arctichealth.org/en/permalink/ahliterature133079
Source
Inflamm Bowel Dis. 2011 Aug;17(8):1731-40
Publication Type
Article
Date
Aug-2011
Author
Christian Jakobsen
Pia Munkholm
Anders Paerregaard
Vibeke Wewer
Author Affiliation
Department of Pediatrics, Hvidovre University Hospital, Copenhagen, Denmark. Christian.jakobsen@hvh.regionh.dk
Source
Inflamm Bowel Dis. 2011 Aug;17(8):1731-40
Date
Aug-2011
Language
English
Publication Type
Article
Keywords
6-Mercaptopurine - therapeutic use
Adolescent
Adrenal Cortex Hormones - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Azathioprine - therapeutic use
Child
Child, Preschool
Colitis, Ulcerative - drug therapy - surgery
Crohn Disease - drug therapy - surgery
Denmark
Female
Follow-Up Studies
Humans
Immunosuppressive Agents - therapeutic use
Infant
Male
Mesalamine - therapeutic use
Remission Induction
Time Factors
Treatment Outcome
Abstract
The aim was to investigate the impact of systemic steroid treatment (SST) and immunomodulators (IM) on disease course in children with inflammatory bowel disease (IBD).
All IBD patients in eastern Denmark
PubMed ID
21744428 View in PubMed
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Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators-A population-based study.

https://arctichealth.org/en/permalink/ahliterature99930
Source
Inflamm Bowel Dis. 2010 Dec 3;
Publication Type
Article
Date
Dec-3-2010
Author
Christian Jakobsen
Pia Munkholm
Anders Paerregaard
Vibeke Wewer
Author Affiliation
From the Department of Pediatrics, Hvidovre University Hospital, Copenhagen, Denmark.
Source
Inflamm Bowel Dis. 2010 Dec 3;
Date
Dec-3-2010
Language
English
Publication Type
Article
Abstract
BACKGROUND:: The aim was to investigate the impact of systemic steroid treatment (SST) and immunomodulators (IM) on disease course in children with inflammatory bowel disease (IBD). METHODS:: All IBD patients in eastern Denmark
PubMed ID
21132788 View in PubMed
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Surgery and postoperative recurrence in children with Crohn disease.

https://arctichealth.org/en/permalink/ahliterature273068
Source
J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):347-51
Publication Type
Article
Date
Mar-2015
Author
Lars F Hansen
Christian Jakobsen
Anders Paerregaard
Niels Qvist
Vibeke Wewer
Source
J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):347-51
Date
Mar-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cecum - surgery
Child
Cohort Studies
Colectomy - adverse effects
Combined Modality Therapy - adverse effects
Crohn Disease - physiopathology - prevention & control - surgery - therapy
Denmark
Female
Follow-Up Studies
Humans
Ileum - surgery
Male
Organ Sparing Treatments - adverse effects
Practice Patterns, Physicians'
Recurrence
Registries
Reoperation - adverse effects
Retrospective Studies
Severity of Illness Index
Survival Analysis
Young Adult
Abstract
The aim of this study was to describe surgery rates, complications, and risk of disease recurrence after surgery in paediatric Crohn disease (CD).
Children 10 years postoperatively, we found a high postoperative recurrence rate of disease and a frequent need for >1 intestinal resection.
PubMed ID
25373863 View in PubMed
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7 records – page 1 of 1.