Overall 50 children suffering from infectious-allergic bronchial asthma who live in ecologically contrasting regions were examined. Those children residing in unfavourable, in terms of ecological conditions, regions demonstrated diminution of the peripheral blood T-lymphocytes together with a decrease in their functional activity as well as in the activity of interleukin 2. It is in this group of children that immunomodulating effect of thymalin is less apparent. It is suggested that the relevant immune correction in such cases might be achieved through repeated courses of treatment with immunomodulating agents and rehabilitation of patients in favourable ecological conditions together with prescribing of other immunostimulators of selective action in respect of the T-link of the immunity system.
Patients with eosinophilic variant of bronchial asthma demonstrate high levels of fibrinolytic activity in their bronchial secretion along with low content in same of Ig A, as evidenced by findings obtained in the course of sanatorium treatment. There is usually no correlation between the above changes and routine methods of health resort treatment. The judicious employment in a complex of therapeutic measures of aerosols of hydrocarbonate of sodium and heparin promotes neutralization of cationic proteins and large major protein of eosinophiles in the bronchial lumen whereby there occurs normalization of Ig A levels in the sputum along with lowering of its fibrinolytic activity.