As many as 70 patients were examined under conditions of a cardio resuscitation unit to gain insight into relatedness of time of development of acute of myocardial infarction (AMI) to its forms and particular clinical picture. The highest risk of AMI development was recordable within the time interval of 6-12 hours with the existing dependence for morning probability of microfocal AMI, daytime probability of microfocal and transmural AMI, with significant reduction thereof within the interval of 18-24 hours. Lesser probability of AMI development within 18-24 hours was closely related to reduction of levels of aspartate aminotransferases, lactatdegidrogenases, and creatinphosphokinases in AMI patients within this time interval.
The article presents results of clinical and functional observations of 183 patients. The authors have studied coronary reserve features in women against age and organic pathology of the vascular-heart system. An analysis of dynamics of quantitative parameters of myocardial ischemia during hospitalization showed existence of the relation between male and female in allocation of phase repolarization changes and it is seen till 45 years. This relation is disappearing in more aged patients. Load test showed that the percent of the reached load decreased with increase in age, considerably conceding in women, quantitative changes of myocardium ischemia increased with age and with an insignificant prevalence in men. Positive test was seen with maximal frequency in patients with acute forms of IHD. An analysis of hemodynamics shifts in groups of patients with organic diseases has shown that analogical changes were with a stable orientation to decrease in election fraction.
Results of clinical and functional studies of 183 patients with organic patology of the cardiovascular system are presented in the article. Coronary reserve peculiarities in women were determined depending on their age. The analysis of dynamics of quantity indicators of myocardium ischemia at hospitalization has shown that patients aged till 45 years have sexual dependence of distribution of changes of repolarization phase, patients older age group it is not so determined. During carrying out of loading tests the percent of the reached loading decreased with age increase, considerably conceding in women, quantitative changes of myocardium ischemia increased with age with an insignificant prevalence in men. Positive test was observed with maximum frequency in patients with ischemic heart disease (IHD). The analysis of haemodynamic shifts in patients with organic diseases has shown that similar changes correlated with a stable tendency to decrease in fraction of ejection fraction.
As many as 65 patients with myocardial infarction were examined for efficacy of blockers of angiotensin receptors with making use of stress-echocardiography having been instituted on admission and two weeks following treatments administration. Irbesartan has been shown to be highly effective because of its positive impact on myocardial contractility.
With the purpose of studying the condition of haemodynamics and function of the right ventricle in 28 patients with unstable stenocardia paired transesophageal electrocardiostimulation and bicycle ergometry [correction of veloergometry] were done with recording of echocardiographic indicators at the height of stress-tests. Important changes were identified in the right ventricular ejection fraction peculiar to changes of end-diastolic and end-systolic volumes in conditions of simulating myocardial infarction.
The myocardial coronary reserve and functional state were studied in patients with ischemic heart disease concurrent with chronic choletistitis against the background of a stress-test (veloergometry). Particular features are discussed of hemodynamic changes in conducting exercise tolerance tests in coronary patients presenting with diseases that lead to a reduction in the myocardial coronary reserve and decrement in performance capability of the heart.
Overall, 72 female subjects presenting with chest pain and/or ST changes in ECG were studied. Average age of the examinees was 44.6 years, all the above women being less than 67 years old. Certain differences were found in those subjects presenting with non-Q-wave myocardial infarction, unstable angina, function disorders of the cardiovascular system, as per transesophageal electrocardiostimulation. Stress-tests results were studied for an objective appraisal to be done of the myocardium function state.
As many as 50 patients presenting with unstable angina were examined for clinicofunctional status, using bicycle ergometry [correction of veloergometry], transesophageal electrocardiostimulation and 24-hour Holter ECG monitoring during 1-yr follow-up. The results of exercise tests at enrollment into the study suggested a dramatic decrement in the patients' exercise tolerance, as to Holter, with the painless myocardial ischemia tending to be more common among them than the painful one. A follow-up study a year later showed the course of the illness to be most variable among those cases presenting with unstable angina. A correction of their management being warranted, the latter was then tailored to the individual on the basis of findings from a comprehensive evaluation of each of them at the original admission to a hospital.
The data obtained by the authors suggest that lipanor may correct those lipid metabolic disturbances that are most pronounced in each individual case. Moreover, the above drug is capable of lowering substantially the level of total blood cholesterol and atherogenic fractions of lipoproteins as early as at day 14 after its intake. Being associated with minimum adverse effects, and intended to be taken on a once-daily schedule, the drug will, we believe, come in wide use.