[A comparative morphometric analysis of the degree of thyrocyte aggregation in preoperative and postoperative cytological material from patients with the identical thyroid pathology]
The similarity of average parameters of thyrocyte aggregates and their distribution on histograms was revealed using comparative morphometric analysis of pre- and postoperative samples from thyroid glands of patients with identical histologic analyses. These regularities may be used as additional diagnostic criteria of thyroid cancer at both pre- and postoperative stages.
Using cytometry of lymphocytes, prolymphocytes and lymphoblasts in touch smears of biopsy and autopsy samples of thyroid, it was revealed that in cancer the small lymphocytes, in the total population of these lymphoid cells, comprise 0-2%, and on distributional histograms of lymphoid cells, according to the average diameter, the maximum was in the range of 9.6-11.7 microns. In benign malformations, goiters and autoimmune thyroiditis, and in the norm the percentage of small lymphocytes varied in the range of 10-44, with the maximum in the range of 7.5-9.6 microns. Histograms, built according to the space occupied by lymphoid cells, evidenced that in malignant thyroid disease a cupola-shaped character of distribution was peculiar, whereas in other pathologies and in norm the exponential relationship was revealed.
The results of surgical treatment in 175 patients (two patients were subjected to bilateral pulmonary resection) are reported. Fibrous-cavernous tuberculosis was observed in 92 patients. The complex of preoperative management comprised increased doses of ascorbic acid to prevent postoperative capillary hemorrhages. Postoperative complications developed in 23 patients, these were liquidated in 20 cases. There were 3 deaths. A complete cure was gained in 99 patients, considerable improvement--in 71, some improvement--in 2. Late results were followed up in 160 patients within the period from 1 to 4 years. The recurrent tuberculous process was noted in 6 cases.
