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Cataract development in Norwegian patients with congenital aniridia.

https://arctichealth.org/en/permalink/ahliterature112479
Source
Acta Ophthalmol. 2014 Mar;92(2):e165-7
Publication Type
Article
Date
Mar-2014
Author
Ulla Edén
Neil Lagali
Anette Dellby
Tor P Utheim
Ruth Riise
Xiangjun Chen
Per Fagerholm
Author Affiliation
Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, SwedenDepartment of Medical Biochemistry, Oslo University Hospital, Oslo, NorwaySchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USADepartment of Ophthalmology, Innland Hospital, Elverum, NorwaySynslaser Kirurgi AS, Oslo, Norway.
Source
Acta Ophthalmol. 2014 Mar;92(2):e165-7
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aniridia - complications - diagnosis
Cataract - complications - diagnosis
Cataract Extraction
Child
Child, Preschool
Humans
Middle Aged
Norway
Phenotype
Time Factors
Young Adult
PubMed ID
23826968 View in PubMed
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Corneal Involvement in Congenital Aniridia.

https://arctichealth.org/en/permalink/ahliterature96619
Source
Cornea. 2010 Jun 18;
Publication Type
Article
Date
Jun-18-2010
Author
Ulla Edén
Ruth Riise
Kristina Tornqvist
Author Affiliation
From the *Department of Ophthalmology, Lund University, Sweden; daggerDepartment of Medical Genetics, Rikshospitalet, University of Oslo, Norway.
Source
Cornea. 2010 Jun 18;
Date
Jun-18-2010
Language
English
Publication Type
Article
Abstract
PURPOSE:: The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made. METHODS:: A thorough search for the total number of patients with aniridia in Sweden and Norway was performed. One hundred eighty-one patients were identified and 124 (69%) of these were examined. Three artificial eyes, 16 eyes with corneal transplants, and 1 eye with a corneal limbal allograft were excluded from the study. All participating patients underwent clinical ophthalmologic examinations, including photographs, and their medical history was recorded. A slit lamp was used to examine the presence of keratopathy. RESULTS:: Visible keratopathy was found in 80% of the eyes. Keratopathy that caused impaired visual acuity was found in 26% of the eyes. The study displayed a significant correlation between the level of keratopathy and the patient's age. A significant correlation between the level of keratopathy and intraocular surgery exists. This is irrespective of the patient's age. The study also found that irrespective of the patient's age, a significant correlation between the level of keratopathy and impaired corneal sensitivity exists. CONCLUSIONS:: This research identified the presence of visible keratopathy in 80% of eyes. In addition, 26% of eyes had a keratopathy level that caused visual disturbances. The study showed that the prevalence and severity of keratopathy increased with the patient's age. Further conclusions are that intraocular surgery increases the severity of keratopathy and that the severity of keratopathy is correlated to reduced corneal sensitivity. Finally, extreme care should be taken when selecting patients for intraocular surgery because this procedure can trigger the development of keratopathy.
PubMed ID
20567200 View in PubMed
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