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The absolute risk of recurrent myocardial infarction is similar amongst both sexes: MONICA Iceland Study 1981-1999.

https://arctichealth.org/en/permalink/ahliterature51997
Source
Eur J Cardiovasc Prev Rehabil. 2004 Apr;11(2):121-4
Publication Type
Article
Date
Apr-2004
Author
Gunnar Sigurdsson
Nikulas Sigfusson
Inga Ingibjörg Gudmundsdottir
Uggi Agnarsson
Helgi Sigvaldason
Vilmundur Gudnason
Author Affiliation
Icelandic Heart Association, and Department of Internal Medicine, Landspitali University Hospital, Reykjavik, Iceland. gunnars@lanspital.is
Source
Eur J Cardiovasc Prev Rehabil. 2004 Apr;11(2):121-4
Date
Apr-2004
Language
English
Publication Type
Article
Keywords
Adult
Aged
Comparative Study
Female
Humans
Iceland - epidemiology
Incidence
Male
Middle Aged
Myocardial Infarction - epidemiology - etiology
Recurrence
Risk assessment
Sex Factors
Time Factors
Abstract
BACKGROUND: To do a gender comparison of absolute risk of recurrent myocardial infarction (MI). DESIGN: Registration of all first and second MI amongst Icelandic males and females 1981-1999. METHODS: The whole of Icelandic population, 40-74 years of age. RESULTS: The mean recurrence rate (second attack) for men was 45.7/1000 MI survivors/year and for women 39.0/1000 per year. The male/female (M/F) ratio was 1.17, 95% confidence interval 1.00-1.37, P = 0.05 and did not change significantly with age. The M/F ratio for first MI in comparison was two to seven, lowest in the oldest group. The recurrence rate decreased significantly and similarly in both sexes during the observation period. CONCLUSION: The absolute risk of MI is closely similar amongst both sexes and has decreased similarly suggesting that the same kind of secondary intervention is effective amongst both sexes in a general population.
PubMed ID
15187815 View in PubMed
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[Acute myocardial infarction among Icelanders forty years old and younger 2005-2009. Comparison with a study carried out 1980-1984].

https://arctichealth.org/en/permalink/ahliterature283430
Source
Laeknabladid. 2017 Januar;103(1):11-15
Publication Type
Article
Author
Bjorn Jakob Magnusson
Uggi Agnarsson
Thorarinn Guðnason
Gudmundur Ã?orgeirsson
Source
Laeknabladid. 2017 Januar;103(1):11-15
Language
Icelandic
Publication Type
Article
Keywords
Adult
Age of Onset
Cause of Death
Chi-Square Distribution
Comorbidity
Emergency medical services
Female
Genetic Predisposition to Disease
Hospital Mortality
Hospitals, University
Humans
Hypertension - epidemiology
Iceland - epidemiology
Incidence
Male
Myocardial Infarction - diagnosis - epidemiology - genetics - microbiology
Obesity - epidemiology
Pedigree
Risk assessment
Risk factors
Sex Factors
Smoking - adverse effects - epidemiology
Time Factors
Young Adult
Abstract
While acute myocardial infarction  (AMI) mostly is a disease of the elderly it also affects younger individuals, often with serious consequenses. In 1980-1984 a study was carried out on the incidence, risk factors, infarct location and distribution of atherosclerosis among Icelanders forty years and younger with AMI. Here we present the results of a similar study carried out for the five year period 2005-2009.
Medical and autopsy records of all individuals, forty years and younger, diagnosed with AMI (I21 in ICD-10) at Landspitali, National University Hospital 2005-2009, or suffering sudden cardiac death in Iceland during the same period were reviewed. Blood tests, electrocardiograms, echocardiograms, coronary angiograms and autopsy results were reviewed with respect to AMI-criteria. Statistical comparisons of ratios and means were carried out using Chi-square test and T-test, respectively.
38 individuals 40 years and younger, 32 males and 6 females, fulfilled the diagnostic criteria of AMI. Calculated incidence for the population at risk was 10/100.000/year (14/100.000/year in 1980-1984) and the mean age ±S.D. was 36.7±3.9. Three (7.9%) died suddenly before reaching hospital but of the 35 hospitalised patients 30 day mortality was zero, compared to nine (23.7%) pre-hospital deaths and two (6.9%) hospital deaths in 1980-1984. Thus, combined pre-hospital and in-hospital (30 day) mortality was 28.9% and 7.9% in the previous and recent time periods, respectively (p=0.02). In 2005-2009, 77.1% had a smoking history and 31.4% were hypertensive compared to 97% and 6.9% in 1980-85 (p=0.026 and p=0.015, respectively). Body mass index (BMI) was higher in the later period, 28.6±4,8 kg/m2 compared to 26.1±3.6 (mean±S.D.; p=0.04) but s-cholesterol was lower, 5.1±1.4 mmol/L compared to 6.3±1.16 ( mean±S.D.; p
PubMed ID
28497765 View in PubMed
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Declining coronary heart disease mortality in Iceland: contribution by incidence, recurrence and case fatality rate.

https://arctichealth.org/en/permalink/ahliterature53586
Source
Scand Cardiovasc J. 2002 Dec;36(6):337-41
Publication Type
Article
Date
Dec-2002
Author
Nikulas Sigfusson
Gunnar Sigurdsson
Uggi Agnarsson
Inga Ingibjörg Gudmundsdottir
Ingibjörg Stefansdottir
Helgi Sigvaldason
Vilmundur Gudnason
Author Affiliation
Icelandic Heart Association, Reykjavik, Iceland.
Source
Scand Cardiovasc J. 2002 Dec;36(6):337-41
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Computer Graphics
Coronary Disease - mortality
Female
Humans
Iceland - epidemiology
Incidence
Male
Medical Records
Middle Aged
Pilot Projects
Recurrence
Regression Analysis
Retrospective Studies
Survival Rate
Abstract
OBJECTIVE: To analyse to what extent the recent decline in coronary heart disease mortality in Iceland is due to changes in incidence, recurrence and case fatality rates. DESIGN: A countrywide registration of myocardial infarction (MI) in people aged 25-74 was performed in Iceland during 1981-1999 according to the MONICA protocol. Possible cases were found by review of all hospital discharge records, autopsy records and death certificates. RESULTS: MI death rate declined by 63% in males and 51% in females, most in the youngest age groups in men (86%) and least in the oldest (49%). In women there was not a significant difference in age groups. Overall the age-adjusted reduction in MI death rate was 55.4% in both sexes combined; of this 23.1% was due to incidence reduction, 22.8% to recurrence reduction and 11.6% to case fatality reduction. In the youngest age groups the decline in incidence contributed most to the decline in MI death rate (62% in men and 71% in women), but thereafter the decline in case fatality in men. In the older age groups decline in recurrence rate has greater weight. CONCLUSION: The recent decline in MI mortality under the age of 75 years in Iceland is due to reduction in incidence and recurrence rate by about 40% each and to reduction in case fatality by 20%.
PubMed ID
12626199 View in PubMed
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Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial.

https://arctichealth.org/en/permalink/ahliterature53159
Source
JAMA. 2005 May 11;293(18):2245-56
Publication Type
Article
Date
May-11-2005
Author
Hakon Hakonarson
Sverrir Thorvaldsson
Anna Helgadottir
Daniel Gudbjartsson
Florian Zink
Margret Andresdottir
Andrei Manolescu
David O Arnar
Karl Andersen
Axel Sigurdsson
Gestur Thorgeirsson
Asgeir Jonsson
Uggi Agnarsson
Halldora Bjornsdottir
Gizur Gottskalksson
Atli Einarsson
Hrefna Gudmundsdottir
Asdis E Adalsteinsdottir
Kolbeinn Gudmundsson
Kristleifur Kristjansson
Thordur Hardarson
Arni Kristinsson
Eric J Topol
Jeffrey Gulcher
Augustine Kong
Mark Gurney
Gudmundur Thorgeirsson
Kari Stefansson
Author Affiliation
Decode Genetics Inc, Reykjavik, Iceland. hakonh@decode.is
Source
JAMA. 2005 May 11;293(18):2245-56
Date
May-11-2005
Language
English
Publication Type
Article
Keywords
Aged
Biological Markers - metabolism
Carrier Proteins - antagonists & inhibitors - genetics
Coronary Arteriosclerosis - drug therapy - genetics - metabolism
Cross-Over Studies
Epoxide Hydrolases - genetics
Female
Humans
Leukotriene B4 - metabolism
Leukotriene E4 - metabolism
Lipoxygenase Inhibitors - therapeutic use
Male
Membrane Proteins - antagonists & inhibitors - genetics
Middle Aged
Myocardial Infarction - genetics - metabolism - prevention & control
Peroxidase - metabolism
Polymorphism, Single Nucleotide
Prospective Studies
Quinolines - therapeutic use
Research Support, Non-U.S. Gov't
Risk factors
Abstract
CONTEXT: Myocardial infarction (MI) is the leading cause of death in the world. Variants in the 5-lipoxygenase-activating protein (FLAP) gene are associated with risk of MI. OBJECTIVE: To determine the effect of an inhibitor of FLAP on levels of biomarkers associated with MI risk. DESIGN, SETTING, AND PATIENTS: A randomized, prospective, placebo-controlled, crossover trial of an inhibitor of FLAP (DG-031) in MI patients who carry at-risk variants in the FLAP gene or in the leukotriene A4 hydrolase gene. Of 268 patients screened, 191 were carriers of at-risk variants in FLAP (87%) or leukotriene A4 hydrolase (13%). Individuals were enrolled in April 2004 and were followed up by designated cardiologists from a university hospital in Iceland until September 2004. INTERVENTIONS: Patients were first randomized to receive 250 mg/d of DG-031, 500 mg/d of DG-031, 750 mg/d of DG-031, or placebo. After a 2-week washout period, patients received DG-031 if they had received placebo first or placebo if they had received DG-031 first. Treatment periods lasted for 4 weeks. MAIN OUTCOME MEASURES: Changes in levels of biomarkers associated with risk of MI. RESULTS: In response to 750 mg/d of DG-031, production of leukotriene B4 was significantly reduced by 26% (95% confidence interval [CI], 10%-39%; P = .003) and myeloperoxidase was significantly reduced by 12% (95% CI, 2%-21%; P = .02). The higher 2 doses of DG-031 produced a nonsignificant reduction in C-reactive protein (16%; 95% CI, -2% to 31%; P = .07) at 2 weeks. However, there was a more pronounced reduction (25%; 95% CI, 5%-40%; P = .02) in C-reactive protein at the end of the washout period that persisted for another 4 weeks thereafter. The FLAP inhibitor DG-031 was well tolerated and was not associated with any serious adverse events. CONCLUSION: In patients with specific at-risk variants of 2 genes in the leukotriene pathway, DG-031 led to significant and dose-dependent suppression of biomarkers that are associated with increased risk of MI events.
Notes
Comment In: JAMA. 2005 May 11;293(18):2277-915886385
PubMed ID
15886380 View in PubMed
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Localization of a susceptibility gene for common forms of stroke to 5q12.

https://arctichealth.org/en/permalink/ahliterature47590
Source
Am J Hum Genet. 2002 Mar;70(3):593-603
Publication Type
Article
Date
Mar-2002
Author
Solveig Gretarsdottir
Sigurlaug Sveinbjörnsdottir
Hjörtur H Jonsson
Finnbogi Jakobsson
Elisabet Einarsdottir
Uggi Agnarsson
Dana Shkolny
Gisli Einarsson
Herdis M Gudjonsdottir
Einar M Valdimarsson
Olafur B Einarsson
Gudmundur Thorgeirsson
Radinka Hadzic
Sif Jonsdottir
Sigridur Th Reynisdottir
Sigrun M Bjarnadottir
Thorunn Gudmundsdottir
Gudrun J Gudlaugsdottir
Ramanjit Gill
Klaus Lindpaintner
Jesus Sainz
Helgi H Hannesson
Gunnar Th Sigurdsson
Michael L Frigge
Augustine Kong
Vilmundur Gudnason
Kari Stefansson
Jeffrey R Gulcher
Author Affiliation
deCODE Genetics, Reykjavik, Iceland.
Source
Am J Hum Genet. 2002 Mar;70(3):593-603
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Alleles
Cerebrovascular Accident - complications - genetics
Chromosome Mapping
Chromosomes, Human, Pair 5 - genetics
Diabetes Complications
Diabetes Mellitus - genetics
Female
Genetic Markers - genetics
Genetic Predisposition to Disease
Genome, Human
Humans
Hypercholesterolemia - complications - genetics
Hypertension - complications - genetics
Iceland
Lod Score
Male
Pedigree
Risk factors
Abstract
Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.
PubMed ID
11833004 View in PubMed
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